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The map label for this gene is envZ [H]

Identifier: 37679275

GI number: 37679275

Start: 1093685

End: 1095127

Strand: Direct

Name: envZ [H]

Synonym: VV1091

Alternate gene names: 37679275

Gene position: 1093685-1095127 (Clockwise)

Preceding gene: 37679274

Following gene: 37679276

Centisome position: 32.6

GC content: 51.14

Gene sequence:

>1443_bases
TTGGAGATGAAGAGGTTTCGCCCCAACTCCTTGGTTGCCAGAACGCTGTTGCTCACCTTGCTCGCGGTGGTGATAGCTCA
AGGGATCGCCACCGCTATCTGGTATAGCGAGTCCAAACAGAAAGAGCTGCAAGGCATTCGCTCGGCGTCGGAAAGCATGG
CGGGCATGTTTGCCTCGACGGTGACCTTTTTCCAATCCTTACCCGTGCGTTATCGTCATATCGTGCTGGATCAGATCCGC
AATATGGGCGGCACGCGCTTTTTCGTCTCTTTCAATAAACAGAAGCTGACCGTTGAGCCGATTGCCGATACACCGTTAAA
ACTGGCTTCGGTGCTGGCCGTTGAAAGTGTGCTGCAGCAAAAACTCACCAAGGTCGCCTCAATCTCCGTTGACTTCTCGC
ATCCGCAAAATTTACGTTTGCTGAAAGACGACATCTATCTGCATGACCTACCCAAATCGTGGGCGCACCACACGCTCACT
TTGGAACCGATCAATCCCCCCGTGTTGGTGGTGCAAATTGAGTTAGAAAGTCACGAGTGGATCTACATTGCCGCGCTGCT
TCCCGCACCTTATTTGACCTTAGATGACACCATTTTAGGGCGTGAGCAGATCTTGTTTCTCTTCTTCTCAACCACGCTAT
TGTTAGTGTTGACTTACACCATGATCCGTCGCCAGGTGAAGCCGCTCAAGCGCTTAGCCAAAGCGGCCAATGAAATGAGC
ATCAATATCGAGCAGCCGCCGTTGCAAGAGGAAGGAGCGAGTGAGCTGGTGACAGCCACGCGCGCGTTTAATCGCATGCA
GCAGCGTATTCGCCGTTATGTGGCAGACCGAGAGCATCTTTTTTCCGCCATTTCTCACGATCTCAAAACGCCGATCACCC
GTTTGCGCATTCGAGCCGAGTTGCTCGAAGATGACACCAAACGCAGCAAGTTCAATCGCGATCTCGATGATTTAGAGATG
ATGGTCAAAGGGGCGCTGCAGTGTGTGCGCGATACCGATTTGCATGAGAACAACGACTACATCGATCTCAATGCGATGAT
CGAGCATGTGATTGATACCTATAATCAGCACCACACTCAGGTCCATTTTCGTCCCATCATCATGGCGCCTATGGTGGCCA
AGCCTCTAGCGATAAAGCGCGTGCTCACCAATTTGATCGACAACGCGGTGAAATATGGTGAACAAGCGGTGGTGACACTC
GAACACAGTGAGGAGTGGATTTACATCACTATTGATGACCAAGGGCCGGGAATTGCGGAAGCGCAATTAGAGGCCGTGTT
TGAACCCTATTTCCGCTTAGCAAAGGACAGTGAAGGGCATGGATTAGGCTTAGGTATCTGCCGAAACATCTTACACGGAC
ATGGTGGAGATCTCATTATTAGCAATCTGCCGCAGGGTGGTTTACGTGCGCAAGTGCTGATTCCTAAAGGGCTGGAAGTG
TAA

Upstream 100 bases:

>100_bases
AACGCCTGGGCGACAGTGCGCGCTACCCACACTACATCAAAACCATGCGCGGGAATGGCTATATTTTGTCGGTGCCTGTT
AGCTACGAACATTGAGGTGA

Downstream 100 bases:

>100_bases
TGTAACAAAGGTGTTACTTTGTGGTTACGGTTTGTTGCAATGCGTATCTCCAGTTATGGATAGACTGCTCAATATCAGGC
ATGACCTGATCTGTCTAATC

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MEMKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVTFFQSLPVRYRHIVLDQIR
NMGGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLT
LEPINPPVLVVQIELESHEWIYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMS
INIEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELLEDDTKRSKFNRDLDDLEM
MVKGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHHTQVHFRPIIMAPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTL
EHSEEWIYITIDDQGPGIAEAQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV

Sequences:

>Translated_480_residues
MEMKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVTFFQSLPVRYRHIVLDQIR
NMGGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLT
LEPINPPVLVVQIELESHEWIYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMS
INIEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELLEDDTKRSKFNRDLDDLEM
MVKGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHHTQVHFRPIIMAPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTL
EHSEEWIYITIDDQGPGIAEAQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV
>Mature_480_residues
MEMKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFASTVTFFQSLPVRYRHIVLDQIR
NMGGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQKLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLT
LEPINPPVLVVQIELESHEWIYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMS
INIEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAELLEDDTKRSKFNRDLDDLEM
MVKGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHHTQVHFRPIIMAPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTL
EHSEEWIYITIDDQGPGIAEAQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=31.6725978647687, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=30.4832713754647, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=26.7100977198697, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=32.15859030837, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=200, Percent_Identity=29, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=22.8571428571429, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=283, Percent_Identity=24.7349823321555, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=325, Percent_Identity=24, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=24.8322147651007, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=24.7899159663866, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=289, Percent_Identity=24.5674740484429, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=232, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=283, Percent_Identity=25.4416961130742, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=23.3766233766234, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=22.7106227106227, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54441; Mature: 54441

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFAST
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VTFFQSLPVRYRHIVLDQIRNMGGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQ
HHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
KLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLTLEPINPPVLVVQIELESHEW
HHHHHHHEEEECCCCCCCEEECCCHHEECCCHHHCCCEEEEECCCCCEEEEEEEECCCCE
IYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMS
EEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
INIEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAE
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LLEDDTKRSKFNRDLDDLEMMVKGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHHTQ
HHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCCCE
VHFRPIIMAPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTLEHSEEWIYITIDDQGPGIAE
EEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCHHH
AQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MEMKRFRPNSLVARTLLLTLLAVVIAQGIATAIWYSESKQKELQGIRSASESMAGMFAST
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
VTFFQSLPVRYRHIVLDQIRNMGGTRFFVSFNKQKLTVEPIADTPLKLASVLAVESVLQQ
HHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
KLTKVASISVDFSHPQNLRLLKDDIYLHDLPKSWAHHTLTLEPINPPVLVVQIELESHEW
HHHHHHHEEEECCCCCCCEEECCCHHEECCCHHHCCCEEEEECCCCCEEEEEEEECCCCE
IYIAALLPAPYLTLDDTILGREQILFLFFSTTLLLVLTYTMIRRQVKPLKRLAKAANEMS
EEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
INIEQPPLQEEGASELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRIRAE
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LLEDDTKRSKFNRDLDDLEMMVKGALQCVRDTDLHENNDYIDLNAMIEHVIDTYNQHHTQ
HHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCCCE
VHFRPIIMAPMVAKPLAIKRVLTNLIDNAVKYGEQAVVTLEHSEEWIYITIDDQGPGIAE
EEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCHHH
AQLEAVFEPYFRLAKDSEGHGLGLGICRNILHGHGGDLIISNLPQGGLRAQVLIPKGLEV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]