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The map label for this gene is proA

Identifier: 37679043

GI number: 37679043

Start: 864293

End: 865543

Strand: Direct

Name: proA

Synonym: VV0859

Alternate gene names: 37679043

Gene position: 864293-865543 (Clockwise)

Preceding gene: 161486649

Following gene: 161486648

Centisome position: 25.77

GC content: 49.48

Gene sequence:

>1251_bases
GTGGATTTAATCACATTAGGTAAAGCGGCAAAAGATGCGGCTTTTCAGCTTGCCACCGCTTCTACGGCGCAAAAGAACAA
AGCATTGGCCATCATTGCAGATGAACTTGAAGCGAATGCGGCGGATATTTTGGCGGCAAACAGTAAAGATATCGAACTCG
GTCGACAAGCGGGTTTGAGCGAAGCGATGCTGGATCGTTTACTTTTGAATGAATCTCGCTTGAATGGCATCGCCAACGAT
GTACGTAACGTGATCAGCCTGACGGATCCGGTCGGTAGCGAAATCGACAGTAAAGTGTTAGAAAATGGCATGCAGTTGTC
ACGCCGTCGTGTGCCGCTTGGCGTGGTTGGTGTGATTTACGAAGCACGCCCAAATGTCACCATCGACATCGCGGCATTGT
GTCTAAAAACTGGCAATGCGAGCATCCTACGTGGCGGAAAAGAGACCTTCTTCTCCAACATGGAGTTGGTGAAGGTGATT
CAATCGGCGTTAGCGAAAGCTGGCTTGCCAGCGGCCTCCGTGCAGTACATTGAAAAACCGGATCGTGAGCTGGTCACTCA
ATTGCTGAAACTGGACGATTACGTTGACATGATCATCCCTCGTGGTGGCGCGGGGCTGCACAAAATGTGTAAAGAGAACA
GCACCATCCCAGTGATCATTGGTGGTTTCGGTATCAGCCATATTTTTGTTGATGAAACGGCTGATCTCGCGAAAAGCGTG
GATGTGGTGGAGAATGCAAAAGCTCAGCGTCCTTCCGCTTGTAATGCGCTGGATACCTTACTTGTTCATGAGCGTATCGC
AGAGCAGTTTCTTCCGATGCTGGTGGCAAAACTCAATGGCAAAGTAACTTTTGTTGTTGAGCCAAAAGCCAAAGCGTACA
TGACTAAAGCTGAACAGGTGCGTGATGCGAGTGAGGGTGATTTTGATACCGAATGGTTGAGTTACACGCTGGGAGTTAAA
GTGGTTGCGGATGTGCAAGAAGCGATCGACCACATGCGTGAACATAACGCGAGTCACTCTGATGCCATCATGACTAACCA
TCTGCAAAATGCTGAGTTGTTCATCAACTCGGCGGGCTCTGCGGCGGTGTATGTCAACGCATCGACTCGCTTTACCGATG
GCGCACAATTTGGTTTGGGCGCAGAAGTGGCAGTATCTACTCAGAAATTGCACGCACGCGGTCCAATGGGATTGGAAGAG
TTAACCAGTTACAAATGGGTTGGCAAGGCGAATTACCTTTCACGCGCGTAA

Upstream 100 bases:

>100_bases
TTCGATTCTGGGCTATGACTATGGTTCAGAAGTGATTCACCGTGACGACATGGTTGTCATTCAAGAATAGTCGCTCACCA
GAATCAAAGAGGACAACAAA

Downstream 100 bases:

>100_bases
GCGTAATCGAGTTTGAGTTAACATATCCGGTCTAAACCGTTTTGAAAAAGGGGCATCACGCCCCTTTTTGTTTTATTCGG
CCTAGCAATTCCGCTAAACT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MDLITLGKAAKDAAFQLATASTAQKNKALAIIADELEANAADILAANSKDIELGRQAGLSEAMLDRLLLNESRLNGIAND
VRNVISLTDPVGSEIDSKVLENGMQLSRRRVPLGVVGVIYEARPNVTIDIAALCLKTGNASILRGGKETFFSNMELVKVI
QSALAKAGLPAASVQYIEKPDRELVTQLLKLDDYVDMIIPRGGAGLHKMCKENSTIPVIIGGFGISHIFVDETADLAKSV
DVVENAKAQRPSACNALDTLLVHERIAEQFLPMLVAKLNGKVTFVVEPKAKAYMTKAEQVRDASEGDFDTEWLSYTLGVK
VVADVQEAIDHMREHNASHSDAIMTNHLQNAELFINSAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEE
LTSYKWVGKANYLSRA

Sequences:

>Translated_416_residues
MDLITLGKAAKDAAFQLATASTAQKNKALAIIADELEANAADILAANSKDIELGRQAGLSEAMLDRLLLNESRLNGIAND
VRNVISLTDPVGSEIDSKVLENGMQLSRRRVPLGVVGVIYEARPNVTIDIAALCLKTGNASILRGGKETFFSNMELVKVI
QSALAKAGLPAASVQYIEKPDRELVTQLLKLDDYVDMIIPRGGAGLHKMCKENSTIPVIIGGFGISHIFVDETADLAKSV
DVVENAKAQRPSACNALDTLLVHERIAEQFLPMLVAKLNGKVTFVVEPKAKAYMTKAEQVRDASEGDFDTEWLSYTLGVK
VVADVQEAIDHMREHNASHSDAIMTNHLQNAELFINSAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEE
LTSYKWVGKANYLSRA
>Mature_416_residues
MDLITLGKAAKDAAFQLATASTAQKNKALAIIADELEANAADILAANSKDIELGRQAGLSEAMLDRLLLNESRLNGIAND
VRNVISLTDPVGSEIDSKVLENGMQLSRRRVPLGVVGVIYEARPNVTIDIAALCLKTGNASILRGGKETFFSNMELVKVI
QSALAKAGLPAASVQYIEKPDRELVTQLLKLDDYVDMIIPRGGAGLHKMCKENSTIPVIIGGFGISHIFVDETADLAKSV
DVVENAKAQRPSACNALDTLLVHERIAEQFLPMLVAKLNGKVTFVVEPKAKAYMTKAEQVRDASEGDFDTEWLSYTLGVK
VVADVQEAIDHMREHNASHSDAIMTNHLQNAELFINSAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEE
LTSYKWVGKANYLSRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=418, Percent_Identity=37.799043062201, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI21361368, Length=418, Percent_Identity=37.799043062201, Blast_Score=248, Evalue=5e-66,
Organism=Escherichia coli, GI1786438, Length=421, Percent_Identity=57.4821852731591, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17569969, Length=402, Percent_Identity=33.0845771144279, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17569967, Length=402, Percent_Identity=33.0845771144279, Blast_Score=220, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324899, Length=419, Percent_Identity=38.4248210023866, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI21357643, Length=406, Percent_Identity=33.2512315270936, Blast_Score=233, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44774; Mature: 44774

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLITLGKAAKDAAFQLATASTAQKNKALAIIADELEANAADILAANSKDIELGRQAGLS
CCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHEEECCCCCHHHHHHCCHH
EAMLDRLLLNESRLNGIANDVRNVISLTDPVGSEIDSKVLENGMQLSRRRVPLGVVGVIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
EARPNVTIDIAALCLKTGNASILRGGKETFFSNMELVKVIQSALAKAGLPAASVQYIEKP
ECCCCCEEEEEHHHHHCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
DRELVTQLLKLDDYVDMIIPRGGAGLHKMCKENSTIPVIIGGFGISHIFVDETADLAKSV
CHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCHHHHHHHH
DVVENAKAQRPSACNALDTLLVHERIAEQFLPMLVAKLNGKVTFVVEPKAKAYMTKAEQV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
RDASEGDFDTEWLSYTLGVKVVADVQEAIDHMREHNASHSDAIMTNHLQNAELFINSAGS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCCC
AAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSYKWVGKANYLSRA
EEEEEECCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure
MDLITLGKAAKDAAFQLATASTAQKNKALAIIADELEANAADILAANSKDIELGRQAGLS
CCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHEEECCCCCHHHHHHCCHH
EAMLDRLLLNESRLNGIANDVRNVISLTDPVGSEIDSKVLENGMQLSRRRVPLGVVGVIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
EARPNVTIDIAALCLKTGNASILRGGKETFFSNMELVKVIQSALAKAGLPAASVQYIEKP
ECCCCCEEEEEHHHHHCCCHHHCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
DRELVTQLLKLDDYVDMIIPRGGAGLHKMCKENSTIPVIIGGFGISHIFVDETADLAKSV
CHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCHHHHHHHH
DVVENAKAQRPSACNALDTLLVHERIAEQFLPMLVAKLNGKVTFVVEPKAKAYMTKAEQV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
RDASEGDFDTEWLSYTLGVKVVADVQEAIDHMREHNASHSDAIMTNHLQNAELFINSAGS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCCC
AAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSYKWVGKANYLSRA
EEEEEECCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA