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The map label for this gene is hsdM [C]

Identifier: 37679000

GI number: 37679000

Start: 819932

End: 821572

Strand: Direct

Name: hsdM [C]

Synonym: VV0816

Alternate gene names: 37679000

Gene position: 819932-821572 (Clockwise)

Preceding gene: 37678999

Following gene: 37679003

Centisome position: 24.44

GC content: 38.51

Gene sequence:

>1641_bases
ATGACTCAAGAACAATTAAACAAGTTAGGTAAAACTCTGTGGGATATCGCGGACACTCTGCGTGGTGCAATGAATGCTGA
TGATTTCCGTGACTATATGCTTTCTTTTCTGTTTTTACGTTACTTATCCGATAACTTCGAAGCAGCAGCAAAGAAAGAGT
TAGGGAAAGACTACCTTGATTTACCTAAAGATGTACTTAGGGATCTAAAAATGTCTAACCCGTTGGAAGTGTGGTATGAC
GAAAACCCTGATGACATCTCATTTTTTGAAACGCAAATGCGCCGTAAATTGCATTACATTATTAAGCCTGAGCATTTATG
GTCAAGTATCGCTGAAATGGCTAGGGTCCAAGATGATGAGTTGCTCAAAACGTTAGAAGAAGGTTTTAAGTACATTGAAA
ACGAAAGTTTTAACAGTAGCTTTCAAGGCTTGTTCTCTGAGATAAACTTAAACTCAGAAAAGTTAGGGAAAAAGCCATCA
GATCGTAATGCAAAGCTATGTACTATTATCCAAAAGGTTTCTGAAGGTATTGCTCAGTTTTCCACTGATACTGATATTTT
AGGGGATGCTTACGAATACCTGATTGGTGAGTTTGCTGCCAACGGTGGTAAGAAAGCTGGGGAGTTTTATACACCGCAAC
CAATATCAACCATCCTTTCGGAAATTGTCACATTAGACAGCCAAGAACCAAAGATGGGTAAAAAGAACAAATTAAACCGA
GTTTTGGACTTTGCTTGTGGTTCTGGTTCTTTGCTATTGAATGTGCGTAAACATATCACGGTTGCAGGTGGTAGCATCGG
TAAGATTTACGGACAAGAAAAAAATATTACTACCTATAACTTAGCCCGTATGAACATGTTGCTTCATGGAGTAAAGGATA
CAGAATTTGATATTTTCCATGGGGATACACTATTTAATGATTGGGAGCTGCTTAATGAAAAGAACCCAGCGAAAAAGCTA
AAGTTCGATGCTGTAGTTGCTAACCCACCATTTAGTTATCGATGGGAGTCAGATAGAGCCGAGTTTAAAGAAGATTTTCG
CTTCAAAAATCACGGCATAGCTCCTAAATCTGCTGCTGATTTTGCTTTTCTTTTACATGGTTTCCACTTTTTAAGTGATG
AAGGCACTATGGCTATTATCCTGCCTCATGGTGTCTTGTTTAGAAGTGGAGCGGAACAGCGCATACGCAGCAAGTTATTA
AAAGATGGGCACATTGATACCGTTATCGGCTTGCCTTCTAATCTGTTTTTCTCAACAGGTATTCCTGTTTGTATTCTCGT
ACTAAAAAAATGTAAGAAGTACGATGATGTTTTGTTTATAAATGCTAGTGATGAAGAGAACTTCGAAAAGGGTAAACGCC
AGAATAAGCTTCGCCCAGAAGACATTCAAAAGATAGTCGATACTTATAGGTTTAGAGATCAAGAGGAACGTTACTCTCGC
CGAGTTTCAATGGAAGAGATCGAGAAGAATGATTTCAACTTGAATATCTCGCGATACGTAAGTACAGCTAAAGCTGAAGC
TAAGGTGGATTTACAAGCAGAGCATAAGAAGCTCGTTGATATTGAAAAAAATATCAATGAAGCCTTAGACAAACATAATA
GCTTTCTCAAAGAACTTGGTTTGCCTCCGTTACCTAGATAG

Upstream 100 bases:

>100_bases
TTAAGCGATTTTATGGCAAATTACCGATTTAACCCAGATCTGTTCCCTGATACAGCAGAGCAACAACCAATAACAGAGCA
ATAAGTAGAGATATATTAAG

Downstream 100 bases:

>100_bases
CAATAGTTTGTAATCTGTTACAGGCTGCATACACAAATAAAGTGGTGCAGCCTTTATTATTTATTTTTGTCGATTAATTT
TAGATAACTTTCAACTGTTT

Product: type I restriction-modification system methyltransferase subunit

Products: NA

Alternate protein names: M.MpnORFDP [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTQEQLNKLGKTLWDIADTLRGAMNADDFRDYMLSFLFLRYLSDNFEAAAKKELGKDYLDLPKDVLRDLKMSNPLEVWYD
ENPDDISFFETQMRRKLHYIIKPEHLWSSIAEMARVQDDELLKTLEEGFKYIENESFNSSFQGLFSEINLNSEKLGKKPS
DRNAKLCTIIQKVSEGIAQFSTDTDILGDAYEYLIGEFAANGGKKAGEFYTPQPISTILSEIVTLDSQEPKMGKKNKLNR
VLDFACGSGSLLLNVRKHITVAGGSIGKIYGQEKNITTYNLARMNMLLHGVKDTEFDIFHGDTLFNDWELLNEKNPAKKL
KFDAVVANPPFSYRWESDRAEFKEDFRFKNHGIAPKSAADFAFLLHGFHFLSDEGTMAIILPHGVLFRSGAEQRIRSKLL
KDGHIDTVIGLPSNLFFSTGIPVCILVLKKCKKYDDVLFINASDEENFEKGKRQNKLRPEDIQKIVDTYRFRDQEERYSR
RVSMEEIEKNDFNLNISRYVSTAKAEAKVDLQAEHKKLVDIEKNINEALDKHNSFLKELGLPPLPR

Sequences:

>Translated_546_residues
MTQEQLNKLGKTLWDIADTLRGAMNADDFRDYMLSFLFLRYLSDNFEAAAKKELGKDYLDLPKDVLRDLKMSNPLEVWYD
ENPDDISFFETQMRRKLHYIIKPEHLWSSIAEMARVQDDELLKTLEEGFKYIENESFNSSFQGLFSEINLNSEKLGKKPS
DRNAKLCTIIQKVSEGIAQFSTDTDILGDAYEYLIGEFAANGGKKAGEFYTPQPISTILSEIVTLDSQEPKMGKKNKLNR
VLDFACGSGSLLLNVRKHITVAGGSIGKIYGQEKNITTYNLARMNMLLHGVKDTEFDIFHGDTLFNDWELLNEKNPAKKL
KFDAVVANPPFSYRWESDRAEFKEDFRFKNHGIAPKSAADFAFLLHGFHFLSDEGTMAIILPHGVLFRSGAEQRIRSKLL
KDGHIDTVIGLPSNLFFSTGIPVCILVLKKCKKYDDVLFINASDEENFEKGKRQNKLRPEDIQKIVDTYRFRDQEERYSR
RVSMEEIEKNDFNLNISRYVSTAKAEAKVDLQAEHKKLVDIEKNINEALDKHNSFLKELGLPPLPR
>Mature_545_residues
TQEQLNKLGKTLWDIADTLRGAMNADDFRDYMLSFLFLRYLSDNFEAAAKKELGKDYLDLPKDVLRDLKMSNPLEVWYDE
NPDDISFFETQMRRKLHYIIKPEHLWSSIAEMARVQDDELLKTLEEGFKYIENESFNSSFQGLFSEINLNSEKLGKKPSD
RNAKLCTIIQKVSEGIAQFSTDTDILGDAYEYLIGEFAANGGKKAGEFYTPQPISTILSEIVTLDSQEPKMGKKNKLNRV
LDFACGSGSLLLNVRKHITVAGGSIGKIYGQEKNITTYNLARMNMLLHGVKDTEFDIFHGDTLFNDWELLNEKNPAKKLK
FDAVVANPPFSYRWESDRAEFKEDFRFKNHGIAPKSAADFAFLLHGFHFLSDEGTMAIILPHGVLFRSGAEQRIRSKLLK
DGHIDTVIGLPSNLFFSTGIPVCILVLKKCKKYDDVLFINASDEENFEKGKRQNKLRPEDIQKIVDTYRFRDQEERYSRR
VSMEEIEKNDFNLNISRYVSTAKAEAKVDLQAEHKKLVDIEKNINEALDKHNSFLKELGLPPLPR

Specific function: Methylation of specific adenine residues; required for both restriction and modification activities [H]

COG id: COG0286

COG function: function code V; Type I restriction-modification system methyltransferase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790808, Length=366, Percent_Identity=23.4972677595628, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022749
- InterPro:   IPR003356
- InterPro:   IPR002052
- InterPro:   IPR002296
- InterPro:   IPR004546 [H]

Pfam domain/function: PF12161 HsdM_N; PF02384 N6_Mtase [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 62627; Mature: 62496

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure 
TQEQLNKLGKTLWDIADTLRGAMNADDFRDYMLSFLFLRYLSDNFEAAAKKELGKDYLD
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHH
LPKDVLRDLKMSNPLEVWYDENPDDISFFETQMRRKLHYIIKPEHLWSSIAEMARVQDDE
CCHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
LLKTLEEGFKYIENESFNSSFQGLFSEINLNSEKLGKKPSDRNAKLCTIIQKVSEGIAQF
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
STDTDILGDAYEYLIGEFAANGGKKAGEFYTPQPISTILSEIVTLDSQEPKMGKKNKLNR
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHH
VLDFACGSGSLLLNVRKHITVAGGSIGKIYGQEKNITTYNLARMNMLLHGVKDTEFDIFH
HHHHCCCCCCEEEEEEHHEEECCCCHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCEEEEE
GDTLFNDWELLNEKNPAKKLKFDAVVANPPFSYRWESDRAEFKEDFRFKNHGIAPKSAAD
CCCHHCHHHHHCCCCCHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHH
FAFLLHGFHFLSDEGTMAIILPHGVLFRSGAEQRIRSKLLKDGHIDTVIGLPSNLFFSTG
HHHHHHHHHHCCCCCCEEEEECCCHHHHCCHHHHHHHHHHCCCCCCEEECCCCCHHHHCC
IPVCILVLKKCKKYDDVLFINASDEENFEKGKRQNKLRPEDIQKIVDTYRFRDQEERYSR
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHH
RVSMEEIEKNDFNLNISRYVSTAKAEAKVDLQAEHKKLVDIEKNINEALDKHNSFLKELG
CCCHHHHHCCCCCEEHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPPLPR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]