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The map label for this gene is iscR [H]

Identifier: 37678938

GI number: 37678938

Start: 760084

End: 760635

Strand: Direct

Name: iscR [H]

Synonym: VV0754

Alternate gene names: 37678938

Gene position: 760084-760635 (Clockwise)

Preceding gene: 37678937

Following gene: 37678939

Centisome position: 22.66

GC content: 47.83

Gene sequence:

>552_bases
ATGGAAAAATCCGTATCATTACAAACAGTGTGGATACGGTGTGATATGAAACTGACATCTAAAGGAAGATATGCGGTAAC
GGCAATGCTGGATGTGGCACTGCATTCGCAAAAAAGTCCTGTACCTCTGGCTGATATTTCCGAGCGTCAGGGGATTTCGC
TCTCTTACTTAGAGCAACTTTTTTCCAAACTGCGTAAAGCGGGTTTGGTCGCGAGTGTTCGTGGTCCTGGCGGTGGTTAC
CGTCTTGGCGCAGACGCATTTACCATTTCAATTGGAACGGTGATCGCGGCCGTTGACGAATCGGTTGACGCAACTAAGTG
TCAGGGCAAAGGAGATTGCCAAGGCGGCACTCGCTGCCTTACTCATACACTTTGGCGTGACCTGAGTTCGCGCATTACAG
ACTTCCTAAACAACATCACGCTTGGCGAGCTCATGAGTGATAATGAAGTCATCGAAATTTCCGACCGTCAGGATATTGAT
CTTGCGGTAAATCATGGGTTGGCTAACAAAACAATTAACACCGCGCCCATCGGTGTAAATTTCCGCTCTTAA

Upstream 100 bases:

>100_bases
GGTAGAAAAGAGCATCAATAAGCAATAGTATCCCTGCTATTCATAGGGATGAATACCTGACTATTTTAGTCAAATAAATA
CTTGACCATTTTAGTCGGGT

Downstream 100 bases:

>100_bases
GCGGCCAAAAAGTTTACATTGGAGTGAAGAATGAAACTGCCTATTTATCTAGACTATTCGGCAACTTGCCCGGTAGATCC
ACGTGTCGCTGAGAAAATGG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MEKSVSLQTVWIRCDMKLTSKGRYAVTAMLDVALHSQKSPVPLADISERQGISLSYLEQLFSKLRKAGLVASVRGPGGGY
RLGADAFTISIGTVIAAVDESVDATKCQGKGDCQGGTRCLTHTLWRDLSSRITDFLNNITLGELMSDNEVIEISDRQDID
LAVNHGLANKTINTAPIGVNFRS

Sequences:

>Translated_183_residues
MEKSVSLQTVWIRCDMKLTSKGRYAVTAMLDVALHSQKSPVPLADISERQGISLSYLEQLFSKLRKAGLVASVRGPGGGY
RLGADAFTISIGTVIAAVDESVDATKCQGKGDCQGGTRCLTHTLWRDLSSRITDFLNNITLGELMSDNEVIEISDRQDID
LAVNHGLANKTINTAPIGVNFRS
>Mature_183_residues
MEKSVSLQTVWIRCDMKLTSKGRYAVTAMLDVALHSQKSPVPLADISERQGISLSYLEQLFSKLRKAGLVASVRGPGGGY
RLGADAFTISIGTVIAAVDESVDATKCQGKGDCQGGTRCLTHTLWRDLSSRITDFLNNITLGELMSDNEVIEISDRQDID
LAVNHGLANKTINTAPIGVNFRS

Specific function: Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins [H]

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=142, Percent_Identity=77.4647887323944, Blast_Score=207, Evalue=5e-55,
Organism=Escherichia coli, GI1790621, Length=135, Percent_Identity=29.6296296296296, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010242
- InterPro:   IPR000944
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 19786; Mature: 19786

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSVSLQTVWIRCDMKLTSKGRYAVTAMLDVALHSQKSPVPLADISERQGISLSYLEQL
CCCCCEEEEEEEEEEEEECCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FSKLRKAGLVASVRGPGGGYRLGADAFTISIGTVIAAVDESVDATKCQGKGDCQGGTRCL
HHHHHHCCCEEEECCCCCCEEECCCEEEEEHHHHEEHHCCCCCCCCCCCCCCCCCCHHHH
THTLWRDLSSRITDFLNNITLGELMSDNEVIEISDRQDIDLAVNHGLANKTINTAPIGVN
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCEEEE
FRS
ECC
>Mature Secondary Structure
MEKSVSLQTVWIRCDMKLTSKGRYAVTAMLDVALHSQKSPVPLADISERQGISLSYLEQL
CCCCCEEEEEEEEEEEEECCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FSKLRKAGLVASVRGPGGGYRLGADAFTISIGTVIAAVDESVDATKCQGKGDCQGGTRCL
HHHHHHCCCEEEECCCCCCEEECCCEEEEEHHHHEEHHCCCCCCCCCCCCCCCCCCHHHH
THTLWRDLSSRITDFLNNITLGELMSDNEVIEISDRQDIDLAVNHGLANKTINTAPIGVN
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCEEEECCCCCCCCCCCCCEEEE
FRS
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA