Click here to switch to the map view.

The map label for this gene is murC

Identifier: 37678799

GI number: 37678799

Start: 600550

End: 602010

Strand: Direct

Name: murC

Synonym: VV0615

Alternate gene names: 37678799

Gene position: 600550-602010 (Clockwise)

Preceding gene: 37678798

Following gene: 37678800

Centisome position: 17.9

GC content: 48.73

Gene sequence:

>1461_bases
ATGACTATTCAACACAAGCAAGATCTTGCACAGATTCGCGCTATGGTCCCAGAGATGCGCCGAGTGAAATCCATCCACTT
CATTGGTATTGGTGGCGCAGGCATGAGCGGCATTGCCGAAGTGTTGCTCAATGAAGGGTATCAAATCACCGGCTCTGATA
TTGCGGAAAATGCCGTCACTGAGCGCTTGGCTCAAAAAGGGGCGAAAGTGTATATCGGCCACCAAGCGACGAATGTTGCA
GAGGCGAGTGTTGTTGTTGTCTCAACAGCGATCAATGAAGCGAACCCAGAAGTCAAAGCGGCGCGTGAAGCTCGCATTCC
GGTTGTTCGCCGTGCAGAAATGTTGGCGGAACTGATGCGTTTTCGTCATGGTATCGCCGTCGCGGGTACGCATGGTAAAA
CCACCACGACAGCATTGGTGACGCAAATTTATTCAGAAGCGGGACTGGATCCAACGTTCGTAAATGGAGGCCTGGTAAAA
AGTGCAGGTACCAATGCGCGTTTAGGTTCTAGTCGCATTTTGATTGCTGAAGCCGATGAAAGTGATGCGTCGTTTTTACA
TTTGCAACCGATGGTGTGTATTGTCACAAACATTGAAGCTGACCATATGGATACCTATGGCGGTGACTTTGAAACACTAA
AACAAACCTTCATCGACTTCTTACACAATTTGCCGTTTTATGGTCAGGCGATAGTTTGTATTGATGATCCGGTGATTCGC
GAGTTGATCCCACGCATCAGTCGTCAAGTCATTACTTACGGCTTCTCGGAAGATGCCGACGTTCGCATTGAGAATTACCA
TCAAGAAGGCCAGCAAGGAAAATTTACCGTGGTCCGCAAAGATTGCGAAGCGCTGGATATTACCCTAAATATTCCTGGCC
GCCACAATGCATTGAATGCCGCTGCGGCCATTGCTGTTGCAACGGAAGATGAAATTGGCGATGACGCGATCCTTGCAGCC
ATGATTGGTACTCAAGGCACAGGTCGCCGTTTTGAACATCTAGGTGAGTTCGAAACAGGCAATGGCAACGTAATGCTGGT
TGATGATTATGGCCATCACCCAACCGAGGTGGATGTGACCATTCATGCCGCTCGTAATGGTTGGCAAGACAAACGTCTAG
TGATGATTTTCCAACCCCACCGTTACAGCCGTACCCGAGATCTCTACGATGATTTCGCGAACGTGCTTGAGCAGGTTGAT
GTGTTGGTCATGTTGGATGTGTACGCGGCGGGTGAAAAAGCGATCGCTGGCGCGGACAGTCGTTCATTGTGCCGCACGAT
TCGCAGCCGTGGAAAAATCGACCCTATTTTTGTTGCAGATACCCAACAACTGCCAGAGGTATTGGCGAACATTTTACAAG
AAGGCGATCTGTTATTAGCACAAGGTGCGGGGGATATTGGTAAAGTCGCCCGACAATTGGCAGCACTTGAGCTAAATATC
AGTAATATGAAAGCAAAATAG

Upstream 100 bases:

>100_bases
ATGGCGCTTCACGCCCGAGCAGCAGCACAAAATAATGCCGACCAAGTTGTGGCGGATGCAATTGTCGCCCTAACTGAACA
GAAATAAAGAGAACAGGTTA

Downstream 100 bases:

>100_bases
CCATTTGTGGCGGATATTAAGCAGTTAGTAACGCAGATCTCGTATTTGCGATAACTTCGTTGCGATTTCTCTCTATCAAT
GTTTGATAGTTTACAAGAGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTIQHKQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAENAVTERLAQKGAKVYIGHQATNVA
EASVVVVSTAINEANPEVKAAREARIPVVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
SAGTNARLGSSRILIAEADESDASFLHLQPMVCIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAIVCIDDPVIR
ELIPRISRQVITYGFSEDADVRIENYHQEGQQGKFTVVRKDCEALDITLNIPGRHNALNAAAAIAVATEDEIGDDAILAA
MIGTQGTGRRFEHLGEFETGNGNVMLVDDYGHHPTEVDVTIHAARNGWQDKRLVMIFQPHRYSRTRDLYDDFANVLEQVD
VLVMLDVYAAGEKAIAGADSRSLCRTIRSRGKIDPIFVADTQQLPEVLANILQEGDLLLAQGAGDIGKVARQLAALELNI
SNMKAK

Sequences:

>Translated_486_residues
MTIQHKQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAENAVTERLAQKGAKVYIGHQATNVA
EASVVVVSTAINEANPEVKAAREARIPVVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
SAGTNARLGSSRILIAEADESDASFLHLQPMVCIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAIVCIDDPVIR
ELIPRISRQVITYGFSEDADVRIENYHQEGQQGKFTVVRKDCEALDITLNIPGRHNALNAAAAIAVATEDEIGDDAILAA
MIGTQGTGRRFEHLGEFETGNGNVMLVDDYGHHPTEVDVTIHAARNGWQDKRLVMIFQPHRYSRTRDLYDDFANVLEQVD
VLVMLDVYAAGEKAIAGADSRSLCRTIRSRGKIDPIFVADTQQLPEVLANILQEGDLLLAQGAGDIGKVARQLAALELNI
SNMKAK
>Mature_485_residues
TIQHKQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAENAVTERLAQKGAKVYIGHQATNVAE
ASVVVVSTAINEANPEVKAAREARIPVVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKS
AGTNARLGSSRILIAEADESDASFLHLQPMVCIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAIVCIDDPVIRE
LIPRISRQVITYGFSEDADVRIENYHQEGQQGKFTVVRKDCEALDITLNIPGRHNALNAAAAIAVATEDEIGDDAILAAM
IGTQGTGRRFEHLGEFETGNGNVMLVDDYGHHPTEVDVTIHAARNGWQDKRLVMIFQPHRYSRTRDLYDDFANVLEQVDV
LVMLDVYAAGEKAIAGADSRSLCRTIRSRGKIDPIFVADTQQLPEVLANILQEGDLLLAQGAGDIGKVARQLAALELNIS
NMKAK

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=478, Percent_Identity=71.3389121338912, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=469, Percent_Identity=26.865671641791, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52951; Mature: 52820

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQHKQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAENAVT
CCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHCCCCEECCCHHHHHHHH
ERLAQKGAKVYIGHQATNVAEASVVVVSTAINEANPEVKAAREARIPVVRRAEMLAELMR
HHHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
FRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADE
HHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVCIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAIVCIDDPVIR
CCCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELIPRISRQVITYGFSEDADVRIENYHQEGQQGKFTVVRKDCEALDITLNIPGRHNALNA
HHHHHHHHHHEEECCCCCCCEEEEHHHCCCCCCCEEEEECCCCEEEEEEECCCCCCCHHH
AAAIAVATEDEIGDDAILAAMIGTQGTGRRFEHLGEFETGNGNVMLVDDYGHHPTEVDVT
HHEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHCCCEECCCCCEEEEECCCCCCCEEEEE
IHAARNGWQDKRLVMIFQPHRYSRTRDLYDDFANVLEQVDVLVMLDVYAAGEKAIAGADS
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCCCCCH
RSLCRTIRSRGKIDPIFVADTQQLPEVLANILQEGDLLLAQGAGDIGKVARQLAALELNI
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHEEEH
SNMKAK
HCCCCC
>Mature Secondary Structure 
TIQHKQDLAQIRAMVPEMRRVKSIHFIGIGGAGMSGIAEVLLNEGYQITGSDIAENAVT
CCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHCCCCEECCCHHHHHHHH
ERLAQKGAKVYIGHQATNVAEASVVVVSTAINEANPEVKAAREARIPVVRRAEMLAELMR
HHHHHCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
FRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADE
HHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVCIVTNIEADHMDTYGGDFETLKQTFIDFLHNLPFYGQAIVCIDDPVIR
CCCCEEEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELIPRISRQVITYGFSEDADVRIENYHQEGQQGKFTVVRKDCEALDITLNIPGRHNALNA
HHHHHHHHHHEEECCCCCCCEEEEHHHCCCCCCCEEEEECCCCEEEEEEECCCCCCCHHH
AAAIAVATEDEIGDDAILAAMIGTQGTGRRFEHLGEFETGNGNVMLVDDYGHHPTEVDVT
HHEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHCCCEECCCCCEEEEECCCCCCCEEEEE
IHAARNGWQDKRLVMIFQPHRYSRTRDLYDDFANVLEQVDVLVMLDVYAAGEKAIAGADS
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCCCCCH
RSLCRTIRSRGKIDPIFVADTQQLPEVLANILQEGDLLLAQGAGDIGKVARQLAALELNI
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHEEEH
SNMKAK
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA