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The map label for this gene is mraW

Identifier: 37678790

GI number: 37678790

Start: 589928

End: 590878

Strand: Direct

Name: mraW

Synonym: VV0606

Alternate gene names: 37678790

Gene position: 589928-590878 (Clockwise)

Preceding gene: 37678789

Following gene: 37678791

Centisome position: 17.59

GC content: 48.37

Gene sequence:

>951_bases
ATGACTGACACATTCCAGCACATTTCCGTACTACTTCATGAATCTATTGATGGTCTCGCCATCAAGCCGGATGGTATTTA
CATTGATGGAACATTTGGTCGTGGTGGTCACAGCCGTACGATTCTTTCTAAACTTGGCGAACACGGTCGTCTGTACAGTA
TTGACCGAGATCCGCAAGCTATCGCGGAAGCGGGTAAAATTGATGATCCACGTTTTACTATCATTCATGGTCCTTTTTCA
GGAATGGCGAATTATGCCGAGCAATATGATTTAGTCGGTAAAGTGGATGGTGTGTTGTTGGATCTCGGCGTCTCCTCGCC
ACAACTCGATGACGCTGAGCGTGGCTTTAGCTTTATGAAAGACGGCCCGTTGGACATGCGTATGGACCCAACCTCGGGTA
TTCCAGTTTCTCAGTGGCTGATGGAAGCGGATTTGGACGACATTACGTGGGTGATTCGTGAGTTCGGTGAAGACAAACAT
GCCCGCCGCATTGCCAAAGCGATTGTTGCGCATCGCGAAGATGAAACCAAAGAGCCACTGACTCGCACGAGTCAATTGGC
AAAACTGATTTCGGAAGCGGCGCCAAAAAGCTTTAAAGAGAAAAAACACCCAGCGACTCGTGCGTTTCAAGCGTTTCGTA
TCTACATCAACAGTGAGCTTGAAGAGATCGATACCGCACTGAAAGGAGCGGCGAGTATTCTGGCACCAGAAGGGCGCTTA
TCGGTGATCAGCTTCCACTCTTTGGAAGACCGCATGGTGAAACGCTTTATGCGCAAAGAAAGTAAAGGGCCTGAAGTGCC
TCACGGTATCCCTCTGACCGAGGCGCAAATCAAAGCGTTAGGCAGTGCTAATATGAAAACGGTGGGTAAAGCGATCATGC
CAACAGCGCAAGAAATTGAACTGAATCCTCGTTCACGCAGCTCTGTGTTGAGAATTGCTGAAAAGCTTTAA

Upstream 100 bases:

>100_bases
GCTATATCACGCCTGAACTTTGTCAAATAGTGGCACTGAACAAGGAAATCAGTACACTAATGATTCGCCGCACAGGCTTT
GAATATTCAACGAGAAAACC

Downstream 100 bases:

>100_bases
TTTAAACCTATGCGTCAAGCCAAGCCAAATCTCGCCAAAGAAATTTTCTTCGACCTACTGACGGTAGGTCGAACGCCTTT
GATCTTGCTTGTCCTGATCT

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQAIAEAGKIDDPRFTIIHGPFS
GMANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMKDGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKH
ARRIAKAIVAHREDETKEPLTRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRL
SVISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIELNPRSRSSVLRIAEKL

Sequences:

>Translated_316_residues
MTDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQAIAEAGKIDDPRFTIIHGPFS
GMANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMKDGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKH
ARRIAKAIVAHREDETKEPLTRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRL
SVISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIELNPRSRSSVLRIAEKL
>Mature_315_residues
TDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQAIAEAGKIDDPRFTIIHGPFSG
MANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMKDGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKHA
RRIAKAIVAHREDETKEPLTRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRLS
VISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIELNPRSRSSVLRIAEKL

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=340, Percent_Identity=39.1176470588235, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI165377202, Length=199, Percent_Identity=40.2010050251256, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1786270, Length=316, Percent_Identity=62.6582278481013, Blast_Score=418, Evalue=1e-118,
Organism=Drosophila melanogaster, GI62472493, Length=335, Percent_Identity=36.1194029850746, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28571637, Length=335, Percent_Identity=36.1194029850746, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 34999; Mature: 34868

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQA
CCCHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEECCCHHH
IAEAGKIDDPRFTIIHGPFSGMANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMK
HHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHCCHHHC
DGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKHARRIAKAIVAHREDETKEPL
CCCCCEEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHH
TRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRL
HHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCE
SVISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIE
EEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCHHHEE
LNPRSRSSVLRIAEKL
CCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TDTFQHISVLLHESIDGLAIKPDGIYIDGTFGRGGHSRTILSKLGEHGRLYSIDRDPQA
CCHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEECCCHHH
IAEAGKIDDPRFTIIHGPFSGMANYAEQYDLVGKVDGVLLDLGVSSPQLDDAERGFSFMK
HHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCHHHCCHHHC
DGPLDMRMDPTSGIPVSQWLMEADLDDITWVIREFGEDKHARRIAKAIVAHREDETKEPL
CCCCCEEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHH
TRTSQLAKLISEAAPKSFKEKKHPATRAFQAFRIYINSELEEIDTALKGAASILAPEGRL
HHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCE
SVISFHSLEDRMVKRFMRKESKGPEVPHGIPLTEAQIKALGSANMKTVGKAIMPTAQEIE
EEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCHHHEE
LNPRSRSSVLRIAEKL
CCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA