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The map label for this gene is folK [H]

Identifier: 37678753

GI number: 37678753

Start: 550405

End: 550887

Strand: Direct

Name: folK [H]

Synonym: VV0569

Alternate gene names: 37678753

Gene position: 550405-550887 (Clockwise)

Preceding gene: 37678752

Following gene: 37678754

Centisome position: 16.41

GC content: 47.2

Gene sequence:

>483_bases
ATGAACACCGTCTATATCGGCGTAGGCAGCAATATTGAGCGAGAAAAGCACGCACGAGCCGCTTGGCAAGAGCTCACTTT
GCTTGGCGAAGCCTTACAAGCCTCACCGATATATGAATGTGCCGCTGTTGGTTTCGACAGCCATGCCTTTTTCAATTTTG
TCATTCGTCTCAATACGTCTATGACGTTAGAGGAATTGGCTTCTCAGCTCCGCCAAATCGAACTGCGATGGGGCCGAGAA
GAAAATGCAGCGAAGTATCAGGATCGAACACTGGATCTTGATATTGTGCTGTTCGGCGAATGCATTTCGAGCCAAAAGCC
TGAACTGCCTCGCAGTGATATCTTTAAATATCCCTTTGTCATACAACCGCTTTATGATTTGCAGCCGGATCTGGTGATTC
CAGGTGATGGCCGTACCGTGGAAGAGATTTGGCAAACTGCACGCGATCTCGACACATTGAAAGCGGTTGATTTTTCATTA
TAA

Upstream 100 bases:

>100_bases
TGACTCAATTCTCAGTGCCTTGGATTCGCATTCGCTTAGCTAAGCCGGGAGCTGTTCCACAAGCTCGCGCTGTGGGTGTG
GTGATTGAGCGAGGCCAAGC

Downstream 100 bases:

>100_bases
AAAACTGAGTAAACCATGAGTTATTTTGAAGCGTTTGTGTTGGCTTTGATTCAAGGCCTGACCGAGTTTTTGCCGATTTC
CAGTTCGGCGCATTTGATCC

Product: 7;8-dihydro-6-hydroxymethylpterin- pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MNTVYIGVGSNIEREKHARAAWQELTLLGEALQASPIYECAAVGFDSHAFFNFVIRLNTSMTLEELASQLRQIELRWGRE
ENAAKYQDRTLDLDIVLFGECISSQKPELPRSDIFKYPFVIQPLYDLQPDLVIPGDGRTVEEIWQTARDLDTLKAVDFSL

Sequences:

>Translated_160_residues
MNTVYIGVGSNIEREKHARAAWQELTLLGEALQASPIYECAAVGFDSHAFFNFVIRLNTSMTLEELASQLRQIELRWGRE
ENAAKYQDRTLDLDIVLFGECISSQKPELPRSDIFKYPFVIQPLYDLQPDLVIPGDGRTVEEIWQTARDLDTLKAVDFSL
>Mature_160_residues
MNTVYIGVGSNIEREKHARAAWQELTLLGEALQASPIYECAAVGFDSHAFFNFVIRLNTSMTLEELASQLRQIELRWGRE
ENAAKYQDRTLDLDIVLFGECISSQKPELPRSDIFKYPFVIQPLYDLQPDLVIPGDGRTVEEIWQTARDLDTLKAVDFSL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=159, Percent_Identity=35.2201257861635, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18253; Mature: 18253

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVYIGVGSNIEREKHARAAWQELTLLGEALQASPIYECAAVGFDSHAFFNFVIRLNTS
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEEEEEECCC
MTLEELASQLRQIELRWGREENAAKYQDRTLDLDIVLFGECISSQKPELPRSDIFKYPFV
CCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEHHHCCCCCCCCHHHHCCCCEE
IQPLYDLQPDLVIPGDGRTVEEIWQTARDLDTLKAVDFSL
ECHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTVYIGVGSNIEREKHARAAWQELTLLGEALQASPIYECAAVGFDSHAFFNFVIRLNTS
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEEEEEECCC
MTLEELASQLRQIELRWGREENAAKYQDRTLDLDIVLFGECISSQKPELPRSDIFKYPFV
CCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEHHHCCCCCCCCHHHHCCCCEE
IQPLYDLQPDLVIPGDGRTVEEIWQTARDLDTLKAVDFSL
ECHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1325970; 8202364; 9278503; 1657875; 2537812; 10378268; 10452528 [H]