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The map label for this gene is glmS [H]

Identifier: 37678686

GI number: 37678686

Start: 489047

End: 490879

Strand: Direct

Name: glmS [H]

Synonym: VV0502

Alternate gene names: 37678686

Gene position: 489047-490879 (Clockwise)

Preceding gene: 37678685

Following gene: 37678691

Centisome position: 14.58

GC content: 49.54

Gene sequence:

>1833_bases
ATGTGTGGAATCGTTGGTGCCGTTGCACAGCGTGATGTCGCAGAGATCTTGGTTGAAGGTCTACGTCGTTTAGAATACCG
CGGTTATGACTCTGCGGGTGTTGCAGTGGTTGATAGCCAATCCAACCTAACTCGAATTCGTCGCTTGGGTAAAGTACAAG
AATTGGCGGATGCTGTGGATCAAGCCGAGGTCGTTGGTGGGACGGGGATCGCGCACACGCGTTGGGCGACTCATGGTGAG
CCTTCTGAGATCAACGCGCACCCACATCAGTCGGGCGACATCAGTGTGGTGCACAACGGTATTATTGAAAACCATGAAAC
GCTACGTGAGTTGTTGCAATCTCGTGGCTATGTGTTTGAATCTCAAACGGATACAGAAGTGATCGCTCACTTGGTCGAGT
GGGAGTTGCGTACAGCAGCGTCATTACTTGAAGCCGTACAAAAAACCGTTAAACAATTGGAAGGTGCTTACGGCACGGTT
GTCTTGGATCGTAACGATCCTTCGCGCATCGTGGTGGCTCGTTCTGGTAGTCCGATTGTGATTGGTTTTGGTGTGGGTGA
AAACTTCCTTGCTTCCGACCAACTGGCACTGCTTAACGTAACTCGCCGCTTTATGTACCTAGAAGAAGGGGACGTTGCAG
AAATTACGCGCCGTGAGGTTGCGGTATATGATGCATTGGGTGAGCGTGTTGAGCGTGAGATTGCCGAATCAAACGCTGAG
CATGATGCGGGTGATAAAGGTCAATACCGTCACTTCATGCAAAAAGAAATTTACGAGCAGCCGACGGCACTGATCAACAC
CATGGAAGGGCGTATTACCGCAGATTCCGTGGTGACCGAAGCCATTGGTGTTAATGCAGCTGAGATCCTAAGCAAAGTTG
AGCACGTTCAGATCGTCGCATGTGGCACCTCTTACAATGCGGGCATGACAGCGCGTTACTGGTTCGAAGACATTGCTGGT
GTGAGCTGTGATGTGGAAATTGCTTCGGAATTTCGCTACCGCAAGTTTGTGACTCGTCCAAACAGCCTGCTTATTACGTT
ATCTCAATCGGGTGAAACGGCGGATACTCTTGCAGCTTTGCGACTAGCAAAAGAAAAAGGGTATATGGCGGCCATGACCA
TCTGTAACGTGGCGGGGTCATCTTTGGTCCGTGAATCTGACTTTGCCTTTATGACTCGTGCAGGGGTGGAGATTGGTGTC
GCTTCTACCAAGGCGTTTACAACCCAATTGGCCGCTCTACTTATGCTGGTGACGGCGCTGGGTAAACAACAAGGCCGTAT
CAGTAAAGAAAAGGAAAAAGAGATCGTAGAAGCGTTGCACGCGTTACCTAAGCAAATCAACGCAGCACTCTCTTTTGAAA
AAGACATTGAAGCCTTGGCGACAGATTTTGCAGATAAGCACCACACCTTGTTCCTTGGTCGTGGTGAGTTCTATCCCATT
GCAATGGAAGCGTCTTTGAAACTGAAAGAAATCTCTTACATTCACGCTGAAGCGTACGCGGCGGGTGAGCTTAAACACGG
TCCTCTTGCGTTGATTGATGCAGACATGCCTGTGGTGGTAGTCGCGCCAAGTAACGATCTTCTCGAGAAGTTAAAATCTA
ACGTTGAAGAAGTGCGTGCACGCGGTGGTCTTTTGTATGTATTTGCGGATGCGGACGCAGGGTTCGAGGGCGATGAAACC
ATGAAGATCATCACTATGCCTCACGTGAGTGAAATCACTGCAGCAATCTACTACACCATTCCAATGCAATTGCTCTCGTA
CTACGTGGCGTTGATCAAAGGAACGGACGTTGACCAACCTCGTAACCTAGCGAAAGCGGTCACGGTAGAATAA

Upstream 100 bases:

>100_bases
AAGCCAATGGCGTGCGCGTCATCTGTGCCTAATCTTTTTCCTCGTAACGACTTTTGCTTGCGAAGTACGAGGAAGCAAAA
AATAAAAATGGAGATAAAAC

Downstream 100 bases:

>100_bases
TCGTTTTGAAAGAATGCGATGAGCCGAGGTGTTGTCACCTCGGCTTTTTTGTTTTAACGCAGAGGTGCAGAGGAAAGGGA
AGTCGGTTTAAAAGAGATAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDSQSNLTRIRRLGKVQELADAVDQAEVVGGTGIAHTRWATHGE
PSEINAHPHQSGDISVVHNGIIENHETLRELLQSRGYVFESQTDTEVIAHLVEWELRTAASLLEAVQKTVKQLEGAYGTV
VLDRNDPSRIVVARSGSPIVIGFGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREVAVYDALGERVEREIAESNAE
HDAGDKGQYRHFMQKEIYEQPTALINTMEGRITADSVVTEAIGVNAAEILSKVEHVQIVACGTSYNAGMTARYWFEDIAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGVEIGV
ASTKAFTTQLAALLMLVTALGKQQGRISKEKEKEIVEALHALPKQINAALSFEKDIEALATDFADKHHTLFLGRGEFYPI
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNDLLEKLKSNVEEVRARGGLLYVFADADAGFEGDET
MKIITMPHVSEITAAIYYTIPMQLLSYYVALIKGTDVDQPRNLAKAVTVE

Sequences:

>Translated_610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDSQSNLTRIRRLGKVQELADAVDQAEVVGGTGIAHTRWATHGE
PSEINAHPHQSGDISVVHNGIIENHETLRELLQSRGYVFESQTDTEVIAHLVEWELRTAASLLEAVQKTVKQLEGAYGTV
VLDRNDPSRIVVARSGSPIVIGFGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREVAVYDALGERVEREIAESNAE
HDAGDKGQYRHFMQKEIYEQPTALINTMEGRITADSVVTEAIGVNAAEILSKVEHVQIVACGTSYNAGMTARYWFEDIAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGVEIGV
ASTKAFTTQLAALLMLVTALGKQQGRISKEKEKEIVEALHALPKQINAALSFEKDIEALATDFADKHHTLFLGRGEFYPI
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNDLLEKLKSNVEEVRARGGLLYVFADADAGFEGDET
MKIITMPHVSEITAAIYYTIPMQLLSYYVALIKGTDVDQPRNLAKAVTVE
>Mature_610_residues
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDSQSNLTRIRRLGKVQELADAVDQAEVVGGTGIAHTRWATHGE
PSEINAHPHQSGDISVVHNGIIENHETLRELLQSRGYVFESQTDTEVIAHLVEWELRTAASLLEAVQKTVKQLEGAYGTV
VLDRNDPSRIVVARSGSPIVIGFGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREVAVYDALGERVEREIAESNAE
HDAGDKGQYRHFMQKEIYEQPTALINTMEGRITADSVVTEAIGVNAAEILSKVEHVQIVACGTSYNAGMTARYWFEDIAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGVEIGV
ASTKAFTTQLAALLMLVTALGKQQGRISKEKEKEIVEALHALPKQINAALSFEKDIEALATDFADKHHTLFLGRGEFYPI
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNDLLEKLKSNVEEVRARGGLLYVFADADAGFEGDET
MKIITMPHVSEITAAIYYTIPMQLLSYYVALIKGTDVDQPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=37.4269005847953, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=36.7198838896952, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI29570798, Length=259, Percent_Identity=24.7104247104247, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=70.4918032786885, Blast_Score=900, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=174, Percent_Identity=28.735632183908, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=37.3549883990719, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=37.5, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=37.5, Blast_Score=269, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=462, Percent_Identity=37.6623376623377, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=32.4009324009324, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=37.7450980392157, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=36.8876080691643, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI28573187, Length=259, Percent_Identity=25.0965250965251, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24659598, Length=141, Percent_Identity=30.4964539007092, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66663; Mature: 66663

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDSQSNLTRIRRLGKVQELADAVD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
QAEVVGGTGIAHTRWATHGEPSEINAHPHQSGDISVVHNGIIENHETLRELLQSRGYVFE
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCCEEE
SQTDTEVIAHLVEWELRTAASLLEAVQKTVKQLEGAYGTVVLDRNDPSRIVVARSGSPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEE
IGFGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREVAVYDALGERVEREIAESNAE
EEECCCCCCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HDAGDKGQYRHFMQKEIYEQPTALINTMEGRITADSVVTEAIGVNAAEILSKVEHVQIVA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHCEEEEEE
CGTSYNAGMTARYWFEDIAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGVEIGVASTKAFTTQLAALLMLVTAL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
GKQQGRISKEKEKEIVEALHALPKQINAALSFEKDIEALATDFADKHHTLFLGRGEFYPI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEE
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNDLLEKLKSNVEEVRA
EEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGLLYVFADADAGFEGDETMKIITMPHVSEITAAIYYTIPMQLLSYYVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RNLAKAVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDVAEILVEGLRRLEYRGYDSAGVAVVDSQSNLTRIRRLGKVQELADAVD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
QAEVVGGTGIAHTRWATHGEPSEINAHPHQSGDISVVHNGIIENHETLRELLQSRGYVFE
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCHHCCHHHHHHHHHHCCCEEE
SQTDTEVIAHLVEWELRTAASLLEAVQKTVKQLEGAYGTVVLDRNDPSRIVVARSGSPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEE
IGFGVGENFLASDQLALLNVTRRFMYLEEGDVAEITRREVAVYDALGERVEREIAESNAE
EEECCCCCCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HDAGDKGQYRHFMQKEIYEQPTALINTMEGRITADSVVTEAIGVNAAEILSKVEHVQIVA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHCEEEEEE
CGTSYNAGMTARYWFEDIAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGVEIGVASTKAFTTQLAALLMLVTAL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
GKQQGRISKEKEKEIVEALHALPKQINAALSFEKDIEALATDFADKHHTLFLGRGEFYPI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEE
AMEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNDLLEKLKSNVEEVRA
EEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGLLYVFADADAGFEGDETMKIITMPHVSEITAAIYYTIPMQLLSYYVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RNLAKAVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]