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The map label for this gene is obgE

Identifier: 37678656

GI number: 37678656

Start: 457173

End: 458339

Strand: Direct

Name: obgE

Synonym: VV0472

Alternate gene names: 37678656

Gene position: 457173-458339 (Clockwise)

Preceding gene: 37678655

Following gene: 37678657

Centisome position: 13.63

GC content: 46.36

Gene sequence:

>1167_bases
ATGAAATTCGTTGATGAAGCGGTAATTAAAGTTCAAGCTGGCGACGGCGGAAACGGTGTTGTAAGTTTCTGGCGTGAAAA
ATTCGTGACCAAAGGTGGCCCAGATGGCGGCGACGGTGGTGACGGTGGTGATGTATACATCCAAGCTGACGAAAACTTAA
ATACGCTGATTGACTACCGTTTTCAACGCTTCTATGAAGCGGAGCGTGGCCAAAACGGTAGTGGTGGTAACTGTACCGGT
AAACGTGGTAAAGACATTACTTTACGCGTGCCAGTTGGTACACGTGCAGTCGATATTCATACTAATGAAATTGTGGCGGA
AGTCGCTGAGCACGGAAAGAAAGTCATGGTCGCCAAAGGCGGCTGGCATGGTTTAGGTAACACGCGTTTTAAATCGTCAG
TGAACCGCGCGCCACGTCAGAAAACCATGGGTACAAAAGGTGAGATTCGCGAATTGCGTTTGGAGCTATTGCTATTGGCT
GATGTGGGTATGTTAGGTTTGCCGAATGCTGGTAAATCAACCTTTATCCGCGCTGTCTCTGCAGCGAAACCGAAAGTCGC
GGATTACCCGTTTACTACCTTGATCCCAAGTCTCGGTGTTGTGAGTGTTGTTCCTGAGAAAAGCTTTGTTGTTGCTGATA
TTCCAGGGTTGATTGAAGGTGCGGCTGATGGCGCTGGTTTGGGGATTCGTTTCCTTAAACACTTAGAACGTTGTCGTGTA
CTGCTGCATATGATCGATATTTTCCCAATTGATCAATCGGATCCTGTACAAAATGCGCTGACCATCATTGATGAGTTAGA
GCAATACAGCGAGAAATTGGCCAATAAACCTCGTTGGTTAGTATTTAACAAGGTGGATCTTGTTAGCGAAGAGCAAGCGG
ATGAGATCATTCAAGAAGTGATTGATGCGCTAGGCTGGGAAGAGCAATACTTCAAGATCTCTGCGGTAAATCGCCAGGGT
ACTAAAGAGCTTTGTTACAAACTCGCTGACTTTATGGAACAGTTGCCACGTGAAGAGCAAGAAGTCTCTGAAGAAGAGAA
AGTGAACTTCATGTGGGATTACCACCCAGATGCAAATCAAGGCGAAGTTATCACTGAAGATGATGACGACTGGGATGACT
GGGACGATGAAGAAGATGACGGTCACGTTATCTACGTTCGTGAGTAA

Upstream 100 bases:

>100_bases
CAGTCGACATATTCAAAGCACCCTCTCATGGTGTCTTCGATCTGTCATCTGCTAAAATGTAGTGATATTGATTTACGGGC
GAAAGTAGCCGGAGTAAGAA

Downstream 100 bases:

>100_bases
TCGAGATATTACCATTAAAAGCCGCAATATTATTTGCGGCTTTTTTGCATCTAAATCATGTTTAGTCCGATTTTTTTCGG
GCAGAATATTTGTTTTTCGA

Product: GTPase ObgE

Products: NA

Alternate protein names: CgtA; GTP-binding protein Obg [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKFVDEAVIKVQAGDGGNGVVSFWREKFVTKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYEAERGQNGSGGNCTG
KRGKDITLRVPVGTRAVDIHTNEIVAEVAEHGKKVMVAKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEIRELRLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LLHMIDIFPIDQSDPVQNALTIIDELEQYSEKLANKPRWLVFNKVDLVSEEQADEIIQEVIDALGWEEQYFKISAVNRQG
TKELCYKLADFMEQLPREEQEVSEEEKVNFMWDYHPDANQGEVITEDDDDWDDWDDEEDDGHVIYVRE

Sequences:

>Translated_388_residues
MKFVDEAVIKVQAGDGGNGVVSFWREKFVTKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYEAERGQNGSGGNCTG
KRGKDITLRVPVGTRAVDIHTNEIVAEVAEHGKKVMVAKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEIRELRLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LLHMIDIFPIDQSDPVQNALTIIDELEQYSEKLANKPRWLVFNKVDLVSEEQADEIIQEVIDALGWEEQYFKISAVNRQG
TKELCYKLADFMEQLPREEQEVSEEEKVNFMWDYHPDANQGEVITEDDDDWDDWDDEEDDGHVIYVRE
>Mature_388_residues
MKFVDEAVIKVQAGDGGNGVVSFWREKFVTKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYEAERGQNGSGGNCTG
KRGKDITLRVPVGTRAVDIHTNEIVAEVAEHGKKVMVAKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEIRELRLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LLHMIDIFPIDQSDPVQNALTIIDELEQYSEKLANKPRWLVFNKVDLVSEEQADEIIQEVIDALGWEEQYFKISAVNRQG
TKELCYKLADFMEQLPREEQEVSEEEKVNFMWDYHPDANQGEVITEDDDDWDDWDDEEDDGHVIYVRE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=328, Percent_Identity=40.2439024390244, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI111955139, Length=352, Percent_Identity=32.6704545454545, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI111955063, Length=208, Percent_Identity=35.5769230769231, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI58761500, Length=131, Percent_Identity=32.0610687022901, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=33.8582677165354, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789574, Length=357, Percent_Identity=69.4677871148459, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=31.7829457364341, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=328, Percent_Identity=37.1951219512195, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17552324, Length=312, Percent_Identity=30.7692307692308, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=131, Percent_Identity=33.587786259542, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321962, Length=166, Percent_Identity=38.5542168674699, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=30.952380952381, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585318, Length=356, Percent_Identity=34.5505617977528, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129375, Length=285, Percent_Identity=38.9473684210526, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24640873, Length=129, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640877, Length=129, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640875, Length=129, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 43202; Mature: 43202

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEAVIKVQAGDGGNGVVSFWREKFVTKGGPDGGDGGDGGDVYIQADENLNTLIDYR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
FQRFYEAERGQNGSGGNCTGKRGKDITLRVPVGTRAVDIHTNEIVAEVAEHGKKVMVAKG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRAPRQKTMGTKGEIRELRLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHMIDIFPIDQSDPVQNALTIIDELEQYSEKLANKPRWLVFNKVDLVSEEQADEIIQEV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHHHHHH
IDALGWEEQYFKISAVNRQGTKELCYKLADFMEQLPREEQEVSEEEKVNFMWDYHPDANQ
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHCEEEEEEECCCCCC
GEVITEDDDDWDDWDDEEDDGHVIYVRE
CCEEECCCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKFVDEAVIKVQAGDGGNGVVSFWREKFVTKGGPDGGDGGDGGDVYIQADENLNTLIDYR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
FQRFYEAERGQNGSGGNCTGKRGKDITLRVPVGTRAVDIHTNEIVAEVAEHGKKVMVAKG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRAPRQKTMGTKGEIRELRLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHMIDIFPIDQSDPVQNALTIIDELEQYSEKLANKPRWLVFNKVDLVSEEQADEIIQEV
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHHHHHH
IDALGWEEQYFKISAVNRQGTKELCYKLADFMEQLPREEQEVSEEEKVNFMWDYHPDANQ
HHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHCEEEEEEECCCCCC
GEVITEDDDDWDDWDDEEDDGHVIYVRE
CCEEECCCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11160812 [H]