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The map label for this gene is cysG [H]

Identifier: 37678594

GI number: 37678594

Start: 404460

End: 405335

Strand: Direct

Name: cysG [H]

Synonym: VV0410

Alternate gene names: 37678594

Gene position: 404460-405335 (Clockwise)

Preceding gene: 37678588

Following gene: 37678595

Centisome position: 12.06

GC content: 48.97

Gene sequence:

>876_bases
ATGAGCATGGCAGACAAGGACACAGCAACGGTTTTCCCCTTTAAGCGCCCTAGCGTTGTGGCAAGTAATCCTACGGCTGG
CCGTTATGGTCACAGCCAGCTCAAGCATGGTGAAGTGGCTTTAGTCGGTGCGGGTCCGGGTGACCCGGAGCTACTGACGC
TCAAAGCACTCAATTATCTACAGCAAGCCGAAGTCGTGCTGTACGACTACCTCGTCTCTGATGAGATCATGGCTCTGGTA
CCCAATGACGCCATTTTAGTGTGTGTCGGTAAGCGAGCGGGTCACCACAGCGTGCCTCAAGAGAAAACCAACCAACTCCT
CGTGGACTTTGCCAAGCAAGGTTACAAAGTCGTGCGCATCAAAGGGGGGGATCCGTTTGTTTTTGGCCGTGGCGGCGAAG
AACTAGAAGTGTTAGCCGATGCTGGCATTACCTTTCAAGTGGTCCCAGGTATTACTGCCGCAGCGGGTGCCACAGCGTAT
GCGGGCATACCGCTTACCCATCGTGATTACGCACAATCCGCTATGTTTATTACAGGGCATCTCAAAGCAGAAAGTGACCA
ATTGGATTGGTCGACTCTGGCAAGAGGGCAGCAAACACTGGTGATTTATATGGGGTTGATGAAGTCGAATTACATTCAAG
AACAATTGATCAAACACGGTCGTAGAGCACAAACACCGATTGCAATTATCGAACGTGGAACTCAGTTGTCACAGAAAGTT
TTTAAAGGTCAATTGTCGGAACTTGCTGATTTAGCTAAGAAAGCAGAGGCTCCAGCACTGATTGTGATCGGTGAAGTGGT
GCAGTTGTCTCAGAAATTAGATTGGTTCTTATCTGGTACTCGAATCAACAATAGTGCTATTGCCAACTCAATATAA

Upstream 100 bases:

>100_bases
GTTTTTTCTTAGCAGTTTTTTGAATAAAAAATGAAATTTTAGAATTTCAGGTAATATGAAGAGCTCGCCATAATGCGCTT
ATCAATAGTTCGATGGAAAG

Downstream 100 bases:

>100_bases
TCGTTACCAAAGATTTAGGGATACGTATAAGCCAAAAGGTTTAAAAAGGAAATAACTATGGATCAACAACGCCTGACTCA
CTTGAAGCAGCTGGAAGCAG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSMADKDTATVFPFKRPSVVASNPTAGRYGHSQLKHGEVALVGAGPGDPELLTLKALNYLQQAEVVLYDYLVSDEIMALV
PNDAILVCVGKRAGHHSVPQEKTNQLLVDFAKQGYKVVRIKGGDPFVFGRGGEELEVLADAGITFQVVPGITAAAGATAY
AGIPLTHRDYAQSAMFITGHLKAESDQLDWSTLARGQQTLVIYMGLMKSNYIQEQLIKHGRRAQTPIAIIERGTQLSQKV
FKGQLSELADLAKKAEAPALIVIGEVVQLSQKLDWFLSGTRINNSAIANSI

Sequences:

>Translated_291_residues
MSMADKDTATVFPFKRPSVVASNPTAGRYGHSQLKHGEVALVGAGPGDPELLTLKALNYLQQAEVVLYDYLVSDEIMALV
PNDAILVCVGKRAGHHSVPQEKTNQLLVDFAKQGYKVVRIKGGDPFVFGRGGEELEVLADAGITFQVVPGITAAAGATAY
AGIPLTHRDYAQSAMFITGHLKAESDQLDWSTLARGQQTLVIYMGLMKSNYIQEQLIKHGRRAQTPIAIIERGTQLSQKV
FKGQLSELADLAKKAEAPALIVIGEVVQLSQKLDWFLSGTRINNSAIANSI
>Mature_290_residues
SMADKDTATVFPFKRPSVVASNPTAGRYGHSQLKHGEVALVGAGPGDPELLTLKALNYLQQAEVVLYDYLVSDEIMALVP
NDAILVCVGKRAGHHSVPQEKTNQLLVDFAKQGYKVVRIKGGDPFVFGRGGEELEVLADAGITFQVVPGITAAAGATAYA
GIPLTHRDYAQSAMFITGHLKAESDQLDWSTLARGQQTLVIYMGLMKSNYIQEQLIKHGRRAQTPIAIIERGTQLSQKVF
KGQLSELADLAKKAEAPALIVIGEVVQLSQKLDWFLSGTRINNSAIANSI

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=241, Percent_Identity=60.9958506224066, Blast_Score=302, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322922, Length=236, Percent_Identity=33.0508474576271, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 31413; Mature: 31281

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMADKDTATVFPFKRPSVVASNPTAGRYGHSQLKHGEVALVGAGPGDPELLTLKALNYL
CCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHH
QQAEVVLYDYLVSDEIMALVPNDAILVCVGKRAGHHSVPQEKTNQLLVDFAKQGYKVVRI
HHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEE
KGGDPFVFGRGGEELEVLADAGITFQVVPGITAAAGATAYAGIPLTHRDYAQSAMFITGH
ECCCEEEECCCCCEEEEEECCCCEEEECCCCCHHCCCCCCCCCCCCCHHHHCCEEEEEEE
LKAESDQLDWSTLARGQQTLVIYMGLMKSNYIQEQLIKHGRRAQTPIAIIERGTQLSQKV
EECCCCCCCHHHHHCCCEEEEEEEEHHHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHHH
FKGQLSELADLAKKAEAPALIVIGEVVQLSQKLDWFLSGTRINNSAIANSI
HHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHEEECCEECCCHHCCCC
>Mature Secondary Structure 
SMADKDTATVFPFKRPSVVASNPTAGRYGHSQLKHGEVALVGAGPGDPELLTLKALNYL
CCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHH
QQAEVVLYDYLVSDEIMALVPNDAILVCVGKRAGHHSVPQEKTNQLLVDFAKQGYKVVRI
HHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEEE
KGGDPFVFGRGGEELEVLADAGITFQVVPGITAAAGATAYAGIPLTHRDYAQSAMFITGH
ECCCEEEECCCCCEEEEEECCCCEEEECCCCCHHCCCCCCCCCCCCCHHHHCCEEEEEEE
LKAESDQLDWSTLARGQQTLVIYMGLMKSNYIQEQLIKHGRRAQTPIAIIERGTQLSQKV
EECCCCCCCHHHHHCCCEEEEEEEEHHHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHHH
FKGQLSELADLAKKAEAPALIVIGEVVQLSQKLDWFLSGTRINNSAIANSI
HHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHEEECCEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA