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The map label for this gene is ubiE

Identifier: 37678361

GI number: 37678361

Start: 188429

End: 189211

Strand: Direct

Name: ubiE

Synonym: VV0177

Alternate gene names: 37678361

Gene position: 188429-189211 (Clockwise)

Preceding gene: 37678360

Following gene: 37678362

Centisome position: 5.62

GC content: 46.1

Gene sequence:

>783_bases
ATGACGGACATCAGCGTGCAATCGAATACAGCTTTAGAATCATCAGAAACCACGCATTTTGGTTTCACTACCGTAGCGAA
AGAAGAAAAAGTCGCTAAGGTTGCTCAAGTATTTCATTCAGTCGCAGCCAAATACGACATTATGAACGACCTGATGTCAG
GGGGAATTCATCGTTTGTGGAAGCGCTTTACCATCGATTGCAGTGGTGCTCGTCCTGGTCAGAGAGTATTAGATTTAGGT
GGTGGCACAGGCGATTTGACGGCCAAGTTTTCCCGTATCGTGGGTGAAAAGGGCCATGTCATTCTTGCCGACATCAATAA
TTCTATGCTCAATGTCGGTCGTGACAAGCTACGAGACAGCGGCATTGTCGGTAACGTTCATTACGTACAAGCGAATGCCG
AGGAATTGCCATTTCCGGATGATTACTTTGATATCATTACCATCAGTTTCTGCCTACGTAACGTGACTGACAAAGATAAA
GCGCTTCGTTCGATGTTCCGAGTGCTCAAGCCGGGTGGTCGTTTGTTGGTATTGGAATTTTCCAAACCTGTCTTTGACCC
GTTATCTAAGGTGTATGACGCGTACTCTTTCCACCTATTACCGAAGATGGGTGAATTAGTCGCGAACGATGCCGATAGCT
ACCGTTACTTGGCCGAATCGATTCGCATGCACCCTGATCAAGAAACCCTTAAGGGCATGATGCAAGAAGCGGGCTTTGAA
AATACCTCATACTACAATTTGACGGGTGGTATTGTTGCCCTGCATCGTGGCTACAAATTTTAG

Upstream 100 bases:

>100_bases
GACATCCCGTTGAGGATAAAGTAAACTATTCGACCGCAGTCTTGGGCCAAGAAAACCATTTCGGCCCTCAATCGAACCGC
ACTGCCCAAGAGGAAAAATA

Downstream 100 bases:

>100_bases
GAGCCTCCATGCCATTTGAACCACTCATTACCGCAGTGATTGAAACTAGCCTCAATGTGCTGGTGAAAGACAATCCGGAT
CTCGAAAAGCGTTTATTACG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTDISVQSNTALESSETTHFGFTTVAKEEKVAKVAQVFHSVAAKYDIMNDLMSGGIHRLWKRFTIDCSGARPGQRVLDLG
GGTGDLTAKFSRIVGEKGHVILADINNSMLNVGRDKLRDSGIVGNVHYVQANAEELPFPDDYFDIITISFCLRNVTDKDK
ALRSMFRVLKPGGRLLVLEFSKPVFDPLSKVYDAYSFHLLPKMGELVANDADSYRYLAESIRMHPDQETLKGMMQEAGFE
NTSYYNLTGGIVALHRGYKF

Sequences:

>Translated_260_residues
MTDISVQSNTALESSETTHFGFTTVAKEEKVAKVAQVFHSVAAKYDIMNDLMSGGIHRLWKRFTIDCSGARPGQRVLDLG
GGTGDLTAKFSRIVGEKGHVILADINNSMLNVGRDKLRDSGIVGNVHYVQANAEELPFPDDYFDIITISFCLRNVTDKDK
ALRSMFRVLKPGGRLLVLEFSKPVFDPLSKVYDAYSFHLLPKMGELVANDADSYRYLAESIRMHPDQETLKGMMQEAGFE
NTSYYNLTGGIVALHRGYKF
>Mature_259_residues
TDISVQSNTALESSETTHFGFTTVAKEEKVAKVAQVFHSVAAKYDIMNDLMSGGIHRLWKRFTIDCSGARPGQRVLDLGG
GTGDLTAKFSRIVGEKGHVILADINNSMLNVGRDKLRDSGIVGNVHYVQANAEELPFPDDYFDIITISFCLRNVTDKDKA
LRSMFRVLKPGGRLLVLEFSKPVFDPLSKVYDAYSFHLLPKMGELVANDADSYRYLAESIRMHPDQETLKGMMQEAGFEN
TSYYNLTGGIVALHRGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=277, Percent_Identity=46.2093862815885, Blast_Score=240, Evalue=9e-64,
Organism=Escherichia coli, GI48994983, Length=248, Percent_Identity=79.8387096774193, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557039, Length=253, Percent_Identity=43.8735177865613, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323526, Length=268, Percent_Identity=42.1641791044776, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24641702, Length=258, Percent_Identity=45.3488372093023, Blast_Score=238, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_VIBVU (Q8DDP9)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_759884.1
- ProteinModelPortal:   Q8DDP9
- SMR:   Q8DDP9
- GeneID:   1177847
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_0909
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- BioCyc:   VVUL216895:VV1_0909-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 28971; Mature: 28840

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDISVQSNTALESSETTHFGFTTVAKEEKVAKVAQVFHSVAAKYDIMNDLMSGGIHRLW
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRFTIDCSGARPGQRVLDLGGGTGDLTAKFSRIVGEKGHVILADINNSMLNVGRDKLRDS
HHHEEECCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHHHHCC
GIVGNVHYVQANAEELPFPDDYFDIITISFCLRNVTDKDKALRSMFRVLKPGGRLLVLEF
CCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEC
SKPVFDPLSKVYDAYSFHLLPKMGELVANDADSYRYLAESIRMHPDQETLKGMMQEAGFE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
NTSYYNLTGGIVALHRGYKF
CCCEEEECCCEEEECCCCCC
>Mature Secondary Structure 
TDISVQSNTALESSETTHFGFTTVAKEEKVAKVAQVFHSVAAKYDIMNDLMSGGIHRLW
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRFTIDCSGARPGQRVLDLGGGTGDLTAKFSRIVGEKGHVILADINNSMLNVGRDKLRDS
HHHEEECCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHHHHCC
GIVGNVHYVQANAEELPFPDDYFDIITISFCLRNVTDKDKALRSMFRVLKPGGRLLVLEF
CCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEC
SKPVFDPLSKVYDAYSFHLLPKMGELVANDADSYRYLAESIRMHPDQETLKGMMQEAGFE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
NTSYYNLTGGIVALHRGYKF
CCCEEEECCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA