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The map label for this gene is gntR [H]

Identifier: 37678241

GI number: 37678241

Start: 68267

End: 69334

Strand: Direct

Name: gntR [H]

Synonym: VV0057

Alternate gene names: 37678241

Gene position: 68267-69334 (Clockwise)

Preceding gene: 37678240

Following gene: 37678245

Centisome position: 2.04

GC content: 51.59

Gene sequence:

>1068_bases
GTGTGTGAGGATCGGATTGGTCATAATGTTACAAGTAACATTAATGACAAAAATCTTTTTATGGCTCAACACAATAAGAA
ACCGCGCACCACTTTGCAGGATGTGGCGGATCAAGTCGGCGTGACCAAGATGACGGTATCGCGTTACATGCGCAATCCCG
ATTCGGTGGCGGAAAAGACCCGCGAGAAAATCGCTACTGCGATTGAACAGATGGGGTACATCGAGAACCGTGCCCCAGCG
ATGTTGTCGAAATCCTCTAGCCGAGCAATTGGGATCCTGCTGCCTTCTTTGTCCAACCAAATTTTTGCTTCCTTTGTTCA
GGGCATTGAAACCGTCACCAAAGCGCATGGTTATGAAACCCTCTTGGCGCACTTTAGCTACGATGAGCTGGAAGAGGAGC
GCAAAATCGCGTCGCTGCTCTCTTATCAGGTCGATGGCCTGATCTTAACTGAAAGCCACCACACCGAACGCACCTTACAG
ATGATCAAAAACGCAGGCATTCCCGTAGTGGAAACCATGGAACTGCCAGCGCAGCCAATCGATATGGCAGTGGGGTTAAA
CCACGAAGATGCCTCTTACAGCGTGGTTAAACGCATGTTGGCTTCGGGTAAGCGCACCATTGTGTATTTTGGTGCACGCT
TGGATACGCGTACCAAACTGCGTATGCAAGGCTATGATCGCGCCATGCGTGAAGCTGGCTTAGAGCCGAAACACGTGCTG
ACGGGCGAACACTCCAGTTTCTCGTTGGCGGATGAGCTGTTAGAGCGTGCCTTGGTGACGTATCCAGAGATGGACGGGGT
CTTTTGTACCAATGATGACATCGCCATCGGTACCTTGCTGTGCGCGCAGCAGCGTGGCATTGAAGTGCCGAAGCAACTGG
CCATTGTGGGCTACAACGCCTTGGATATCGGCCAGACGATTCGTCCGAAATTGACCAGTGTCGATACGCCGCGTTTTCAA
ATTGGTGAGAAAAGTGCCGAGTTGTTGCTGGCCCGTTTGCGCGGTGAAACGTTGGAACAAAATGTGGTGGATATGGGCTA
CCGCATTACCGCCGGCGAGAGTGTGTAA

Upstream 100 bases:

>100_bases
TAGCAAACCCGCCGATAAACGCCTCGATTTCTCCTGCCAGTTAGGGGAGATGGCGCAGGGGAAGATCACATTGGTGGGTT
TTTAGCACTGCACCTTAGTT

Downstream 100 bases:

>100_bases
CTGGGTCGATGTGATGAAAACCAAGGGCGCGATAAACGCGCCCTTGCTGATCAGACGATAAAACTCGCACCGTGTTCGGC
GCTAGACACCGATTGGCGAA

Product: gluconate utilization system Gnt-I transcriptional repressor

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MCEDRIGHNVTSNINDKNLFMAQHNKKPRTTLQDVADQVGVTKMTVSRYMRNPDSVAEKTREKIATAIEQMGYIENRAPA
MLSKSSSRAIGILLPSLSNQIFASFVQGIETVTKAHGYETLLAHFSYDELEEERKIASLLSYQVDGLILTESHHTERTLQ
MIKNAGIPVVETMELPAQPIDMAVGLNHEDASYSVVKRMLASGKRTIVYFGARLDTRTKLRMQGYDRAMREAGLEPKHVL
TGEHSSFSLADELLERALVTYPEMDGVFCTNDDIAIGTLLCAQQRGIEVPKQLAIVGYNALDIGQTIRPKLTSVDTPRFQ
IGEKSAELLLARLRGETLEQNVVDMGYRITAGESV

Sequences:

>Translated_355_residues
MCEDRIGHNVTSNINDKNLFMAQHNKKPRTTLQDVADQVGVTKMTVSRYMRNPDSVAEKTREKIATAIEQMGYIENRAPA
MLSKSSSRAIGILLPSLSNQIFASFVQGIETVTKAHGYETLLAHFSYDELEEERKIASLLSYQVDGLILTESHHTERTLQ
MIKNAGIPVVETMELPAQPIDMAVGLNHEDASYSVVKRMLASGKRTIVYFGARLDTRTKLRMQGYDRAMREAGLEPKHVL
TGEHSSFSLADELLERALVTYPEMDGVFCTNDDIAIGTLLCAQQRGIEVPKQLAIVGYNALDIGQTIRPKLTSVDTPRFQ
IGEKSAELLLARLRGETLEQNVVDMGYRITAGESV
>Mature_355_residues
MCEDRIGHNVTSNINDKNLFMAQHNKKPRTTLQDVADQVGVTKMTVSRYMRNPDSVAEKTREKIATAIEQMGYIENRAPA
MLSKSSSRAIGILLPSLSNQIFASFVQGIETVTKAHGYETLLAHFSYDELEEERKIASLLSYQVDGLILTESHHTERTLQ
MIKNAGIPVVETMELPAQPIDMAVGLNHEDASYSVVKRMLASGKRTIVYFGARLDTRTKLRMQGYDRAMREAGLEPKHVL
TGEHSSFSLADELLERALVTYPEMDGVFCTNDDIAIGTLLCAQQRGIEVPKQLAIVGYNALDIGQTIRPKLTSVDTPRFQ
IGEKSAELLLARLRGETLEQNVVDMGYRITAGESV

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=330, Percent_Identity=50.9090909090909, Blast_Score=354, Evalue=6e-99,
Organism=Escherichia coli, GI1790715, Length=331, Percent_Identity=45.0151057401813, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=27.4390243902439, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790194, Length=323, Percent_Identity=28.1733746130031, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787948, Length=332, Percent_Identity=26.5060240963855, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789068, Length=297, Percent_Identity=26.2626262626263, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788474, Length=308, Percent_Identity=26.9480519480519, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1787580, Length=325, Percent_Identity=24.3076923076923, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=23.0240549828179, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786540, Length=321, Percent_Identity=24.2990654205607, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786268, Length=314, Percent_Identity=26.7515923566879, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787906, Length=257, Percent_Identity=26.0700389105058, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790689, Length=318, Percent_Identity=23.8993710691824, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 39476; Mature: 39476

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCEDRIGHNVTSNINDKNLFMAQHNKKPRTTLQDVADQVGVTKMTVSRYMRNPDSVAEKT
CCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHH
REKIATAIEQMGYIENRAPAMLSKSSSRAIGILLPSLSNQIFASFVQGIETVTKAHGYET
HHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHH
LLAHFSYDELEEERKIASLLSYQVDGLILTESHHTERTLQMIKNAGIPVVETMELPAQPI
HHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCC
DMAVGLNHEDASYSVVKRMLASGKRTIVYFGARLDTRTKLRMQGYDRAMREAGLEPKHVL
CEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEE
TGEHSSFSLADELLERALVTYPEMDGVFCTNDDIAIGTLLCAQQRGIEVPKQLAIVGYNA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHEEECCCH
LDIGQTIRPKLTSVDTPRFQIGEKSAELLLARLRGETLEQNVVDMGYRITAGESV
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCC
>Mature Secondary Structure
MCEDRIGHNVTSNINDKNLFMAQHNKKPRTTLQDVADQVGVTKMTVSRYMRNPDSVAEKT
CCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHH
REKIATAIEQMGYIENRAPAMLSKSSSRAIGILLPSLSNQIFASFVQGIETVTKAHGYET
HHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHH
LLAHFSYDELEEERKIASLLSYQVDGLILTESHHTERTLQMIKNAGIPVVETMELPAQPI
HHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCC
DMAVGLNHEDASYSVVKRMLASGKRTIVYFGARLDTRTKLRMQGYDRAMREAGLEPKHVL
CEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEE
TGEHSSFSLADELLERALVTYPEMDGVFCTNDDIAIGTLLCAQQRGIEVPKQLAIVGYNA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHEEECCCH
LDIGQTIRPKLTSVDTPRFQIGEKSAELLLARLRGETLEQNVVDMGYRITAGESV
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]