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The map label for this gene is dnaA

Identifier: 37678195

GI number: 37678195

Start: 7450

End: 8856

Strand: Direct

Name: dnaA

Synonym: VV0011

Alternate gene names: 37678195

Gene position: 7450-8856 (Clockwise)

Preceding gene: 37678194

Following gene: 37678196

Centisome position: 0.22

GC content: 49.68

Gene sequence:

>1407_bases
GTGTCATCTTCGCTTTGGTTGCAGTGTATGCAACGGCTTCAAGAAGAGCTACCAGCTACAGAATTCAGTATGTGGGTTCG
CCCGTTACAAGCGGAGCTCAATGACAATACGCTCACTCTGTTCGCGCCAAACCGCTTTGTTTTGGATTGGGTGCGAGACA
AATACCTCAATAGCATTAATCGTTTACTGCAAGAATATTGCGGTCATGACATTCCTAACTTGCGTTTTGAAGTCGGCAGC
CGTCCTATGGCTGCACCTAAGCCAGCACCAACCCGCACACCAGCGGATGTGGCGGCCGAATCGTCGGCACCCGCACAATT
GCAAGCGCGTAAGCCAGTACACAAAACTTGGGATGATGATGCTCAAGCGATCGCTGACATCAATCACCGCTCAAATGTGA
ACCCTAAGCATAAGTTCAATAACTTTGTCGAAGGTAAGTCGAACCAATTGGGTTTGGCCGCAGCACGTCAGGTGGCGGAT
AACCCAGGTGGGGCGTACAACCCACTGTTCTTATACGGCGGTACCGGTTTAGGTAAAACCCACTTGTTGCACGCCGTTGG
CAACGCCATTGTTGATAACAAGCCCAACGCCAAAGTGGTTTACATGCACTCGGAGCGTTTTGTGCAAGACATGGTTAAAG
CCCTGCAAAATAACGCAATTGAAGAGTTCAAACGTTACTATCGCAGTGTTGATGCTTTGCTTATCGATGACATTCAATTC
TTTGCCAACAAAGAGCGTTCGCAGGAAGAGTTCTTCCATACCTTTAACGCGCTATTGGAAGGCAACCAACAGATCATTCT
GACTTCGGATCGTTATCCAAAAGAGATCAGCGGGGTAGAAGATCGCCTGAAATCACGCTTTGGTTGGGGTTTGACGGTGG
CGATTGAGCCGCCAGAACTGGAAACCCGCGTGGCGATCTTGATGAAAAAAGCGGAAGATCACCAAATCCATCTTGCCGAT
GAAGTGGCGTTCTTTATTGCTAAGCGTCTGCGTTCTAATGTTCGTGAGCTAGAAGGGGCATTAAACCGCGTGATCGCCAA
TGCCAACTTTACTGGCCGCCCAATTACCATTGATTTTGTGCGTGAAGCACTGCGTGACCTATTGGCGCTGCAAGAGAAGC
TGGTGACCATCGACAACATTCAAAAGACGGTTGCGGAATACTACAAGATTAAAGTGGCCGATCTACTCTCTAAGCGCCGT
TCTCGCTCGGTTGCGCGTCCTCGCCAATTAGCCATGGCATTGGCCAAAGAGCTTACCAACCACAGCTTGCCGGAAATCGG
CGATGCGTTTGGTGGCCGTGACCACACCACCGTGCTGCACGCGTGTCGTAAGATTGAGCAGCTGCGTGAAGAGAGCCACG
ATATTAAAGAAGATTACTCTAACTTGATTCGCACCCTGTCGTCTTAA

Upstream 100 bases:

>100_bases
TCTTATTCACTGGATCGTTGATCAATCGCTGGCGATCTTGGTTATCAACAGGTAAAATTGCCAATCTTTTCAGATTAATT
TCGTACTCAGTGGGGGCACC

Downstream 100 bases:

>100_bases
TCGGTTAGAATGACACAATTCTAAACACTTTATTGAAGCGGACAGCGTAAAGAGCCAAGCATGAAATTTACTATCGCACG
TAGTCATTTTATTAAACCCC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSSSLWLQCMQRLQEELPATEFSMWVRPLQAELNDNTLTLFAPNRFVLDWVRDKYLNSINRLLQEYCGHDIPNLRFEVGS
RPMAAPKPAPTRTPADVAAESSAPAQLQARKPVHKTWDDDAQAIADINHRSNVNPKHKFNNFVEGKSNQLGLAAARQVAD
NPGGAYNPLFLYGGTGLGKTHLLHAVGNAIVDNKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQF
FANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEISGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKAEDHQIHLAD
EVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRR
SRSVARPRQLAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDYSNLIRTLSS

Sequences:

>Translated_468_residues
MSSSLWLQCMQRLQEELPATEFSMWVRPLQAELNDNTLTLFAPNRFVLDWVRDKYLNSINRLLQEYCGHDIPNLRFEVGS
RPMAAPKPAPTRTPADVAAESSAPAQLQARKPVHKTWDDDAQAIADINHRSNVNPKHKFNNFVEGKSNQLGLAAARQVAD
NPGGAYNPLFLYGGTGLGKTHLLHAVGNAIVDNKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQF
FANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEISGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKAEDHQIHLAD
EVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRR
SRSVARPRQLAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDYSNLIRTLSS
>Mature_467_residues
SSSLWLQCMQRLQEELPATEFSMWVRPLQAELNDNTLTLFAPNRFVLDWVRDKYLNSINRLLQEYCGHDIPNLRFEVGSR
PMAAPKPAPTRTPADVAAESSAPAQLQARKPVHKTWDDDAQAIADINHRSNVNPKHKFNNFVEGKSNQLGLAAARQVADN
PGGAYNPLFLYGGTGLGKTHLLHAVGNAIVDNKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFF
ANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEISGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKAEDHQIHLADE
VAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRS
RSVARPRQLAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDYSNLIRTLSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=474, Percent_Identity=83.5443037974684, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=230, Percent_Identity=26.5217391304348, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 53117; Mature: 52986

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSLWLQCMQRLQEELPATEFSMWVRPLQAELNDNTLTLFAPNRFVLDWVRDKYLNSIN
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHH
RLLQEYCGHDIPNLRFEVGSRPMAAPKPAPTRTPADVAAESSAPAQLQARKPVHKTWDDD
HHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHCCCCCCCCCCHH
AQAIADINHRSNVNPKHKFNNFVEGKSNQLGLAAARQVADNPGGAYNPLFLYGGTGLGKT
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHH
HLLHAVGNAIVDNKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQF
HHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEISGVEDRLKSRFGWGLTVAIEPPEL
HHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCH
ETRVAILMKKAEDHQIHLADEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFV
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHH
REALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQLAMALAKELTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
HSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDYSNLIRTLSS
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSSLWLQCMQRLQEELPATEFSMWVRPLQAELNDNTLTLFAPNRFVLDWVRDKYLNSIN
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHH
RLLQEYCGHDIPNLRFEVGSRPMAAPKPAPTRTPADVAAESSAPAQLQARKPVHKTWDDD
HHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHCCCCCCCCCCHH
AQAIADINHRSNVNPKHKFNNFVEGKSNQLGLAAARQVADNPGGAYNPLFLYGGTGLGKT
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCCHH
HLLHAVGNAIVDNKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQF
HHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEISGVEDRLKSRFGWGLTVAIEPPEL
HHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCH
ETRVAILMKKAEDHQIHLADEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFV
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHH
REALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQLAMALAKELTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
HSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDYSNLIRTLSS
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA