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The map label for this gene is degU [H]

Identifier: 37523973

GI number: 37523973

Start: 4630817

End: 4631506

Strand: Direct

Name: degU [H]

Synonym: glr4404

Alternate gene names: 37523973

Gene position: 4630817-4631506 (Clockwise)

Preceding gene: 37523972

Following gene: 37523974

Centisome position: 99.39

GC content: 63.04

Gene sequence:

>690_bases
ATGTCCGCGATCCGCGTAGTTCTGGTAGAAGATCACGACCTCACCCGCGCCGGAATGCGCATGACGCTTCAGCAGCACGA
CAGCGTGCAGGTGGTGGGCGAGGCGGCGAACGGCCAAGACGGATTGAAGCTCATCTCCAAAGAAAAGCCCGACATCGCCA
TCGTTGATATTGGCCTGCCGGATATCGACGGTATCGAGGTGACCCGCCGCCTCAAAGCCGAAGACCCCGAGGTGCGGGTG
CTGATTCTCACCCTGCGCGACAACGACCAGACGGTGCTTGCCGCCTTTGCCGCCGGGGCCGATTCGTACTGCATGAAGGA
CATCGGCTCGGCGGACCTATTCGCGGCTTTGCAGACCACCCGCGAGGGCCACTCCTGGATCGATCCATCCATCGCCCGCA
CGGTGCTGGGGCAGATCGGCAGCCAGCCCGCCGCTGGAACCAGTACTGTGCAGATCAATGCTGCCGAACCCGAGTTCACC
CAGATCCTCGAAGCCTCGCCCCTGACTGAGCGCGAACTGGAGGTGCTGCAGCTGATTGTCGAGGGCCGCTCCAATCAGGA
TATTGCCGACCAGCTCTACATCACTGTAGGCACCGTCAAGACCCACGTGCGCAATATCCTCAGCAAGCTGTGCGCCGACG
ACCGCACCCAGGCGGCGGTGACCGCGCTACGCGCCGGGTTGGTGCGTTAG

Upstream 100 bases:

>100_bases
GAACCGCAACTGTACTCGGCGACATATCTCTTCAGACAAGTGGCCGCTGCTGGTGCCCGGTTCTATGATGAGTCGCATAC
ACCCGGAGACAAGGCCTCAC

Downstream 100 bases:

>100_bases
AACCCCTTCCTGTAGTGCCAATTTGCCCGAGCACGCTACAATTAGCGGAACGTGAGCAGGTGGCCATGCAGGAACGCTTT
CCCAATCAGTTTCCACAACC

Product: two-component response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSAIRVVLVEDHDLTRAGMRMTLQQHDSVQVVGEAANGQDGLKLISKEKPDIAIVDIGLPDIDGIEVTRRLKAEDPEVRV
LILTLRDNDQTVLAAFAAGADSYCMKDIGSADLFAALQTTREGHSWIDPSIARTVLGQIGSQPAAGTSTVQINAAEPEFT
QILEASPLTERELEVLQLIVEGRSNQDIADQLYITVGTVKTHVRNILSKLCADDRTQAAVTALRAGLVR

Sequences:

>Translated_229_residues
MSAIRVVLVEDHDLTRAGMRMTLQQHDSVQVVGEAANGQDGLKLISKEKPDIAIVDIGLPDIDGIEVTRRLKAEDPEVRV
LILTLRDNDQTVLAAFAAGADSYCMKDIGSADLFAALQTTREGHSWIDPSIARTVLGQIGSQPAAGTSTVQINAAEPEFT
QILEASPLTERELEVLQLIVEGRSNQDIADQLYITVGTVKTHVRNILSKLCADDRTQAAVTALRAGLVR
>Mature_228_residues
SAIRVVLVEDHDLTRAGMRMTLQQHDSVQVVGEAANGQDGLKLISKEKPDIAIVDIGLPDIDGIEVTRRLKAEDPEVRVL
ILTLRDNDQTVLAAFAAGADSYCMKDIGSADLFAALQTTREGHSWIDPSIARTVLGQIGSQPAAGTSTVQINAAEPEFTQ
ILEASPLTERELEVLQLIVEGRSNQDIADQLYITVGTVKTHVRNILSKLCADDRTQAAVTALRAGLVR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=225, Percent_Identity=30.6666666666667, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1788521, Length=223, Percent_Identity=29.5964125560538, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787473, Length=215, Percent_Identity=29.3023255813954, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=24.1545893719807, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1786747, Length=211, Percent_Identity=27.9620853080569, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082052, Length=149, Percent_Identity=31.5436241610738, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790102, Length=207, Percent_Identity=27.536231884058, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787375, Length=115, Percent_Identity=34.7826086956522, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786911, Length=120, Percent_Identity=39.1666666666667, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788546, Length=217, Percent_Identity=23.963133640553, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790860, Length=216, Percent_Identity=28.2407407407407, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24733; Mature: 24602

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIRVVLVEDHDLTRAGMRMTLQQHDSVQVVGEAANGQDGLKLISKEKPDIAIVDIGLP
CCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCCEEEEECCCC
DIDGIEVTRRLKAEDPEVRVLILTLRDNDQTVLAAFAAGADSYCMKDIGSADLFAALQTT
CCCCHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHH
REGHSWIDPSIARTVLGQIGSQPAAGTSTVQINAAEPEFTQILEASPLTERELEVLQLIV
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHH
EGRSNQDIADQLYITVGTVKTHVRNILSKLCADDRTQAAVTALRAGLVR
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAIRVVLVEDHDLTRAGMRMTLQQHDSVQVVGEAANGQDGLKLISKEKPDIAIVDIGLP
CCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCCEEEEECCCC
DIDGIEVTRRLKAEDPEVRVLILTLRDNDQTVLAAFAAGADSYCMKDIGSADLFAALQTT
CCCCHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHH
REGHSWIDPSIARTVLGQIGSQPAAGTSTVQINAAEPEFTQILEASPLTERELEVLQLIV
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHH
EGRSNQDIADQLYITVGTVKTHVRNILSKLCADDRTQAAVTALRAGLVR
CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]