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The map label for this gene is obgE

Identifier: 37523944

GI number: 37523944

Start: 4607233

End: 4608240

Strand: Direct

Name: obgE

Synonym: glr4375

Alternate gene names: 37523944

Gene position: 4607233-4608240 (Clockwise)

Preceding gene: 37523941

Following gene: 37523945

Centisome position: 98.89

GC content: 65.08

Gene sequence:

>1008_bases
ATGCAGTTTATCGATCGATCAGAAATCGAGGTCGAAGGGGGCAGAGGCGGCGACGGTATGGTGGCCTACCGCCGCGAGAA
GTACGTGCCGGCGGGCGGGCCGGCGGGTGGAGACGGCGGCCACGGCGGCGCGGTGGTGCTGGAGGCAACCGCCAATTTGC
AGACGCTGCTCGACTTTAAGTACCGCCACCGCTTCGAAGCCGACGACGGCACCAAGGGCGGCCCCAAAAATCTCACCGGC
GCCAAGGGCAAAGATCTGGTGATTGCTGTTCCTTGCGGCACGGTGGTGCAGGATGCCGTGACCGGCGAGACGATAGGCGA
TCTTACCGAACCGGGCCAGCGGCTGGTAGTGGCGGTGGGGGGCCGGGGCGGCCACGGCAATACCCACTTTGCCAGCAACC
AGAACCGCGCCCCGGACTACGCCACCGAGGGCAGATTGGGCCAGCAGCGCAAGCTTTTGCTCGAATTGAAGCTGCTTGCC
GAAGTCGGGATTATCGGGCTGCCGAATGCCGGCAAATCGACGCTCATCTCGGTGCTCTCGGCGGCACGACCGCGCATCGC
GGACTACCCGTTTACGACCCTGGTGCCCAATCTGGGGGTGGTGCGCAAGGTGACCGGCGACGGGGTCGTCTTTGCCGACA
TTCCAGGGCTCATCGAGGGAGCCCACCAGGGAGTCGGGCTCGGGCACGAATTTTTGCGCCATATCGAGCGCACGCGCGTG
CTGGTGCAGCTGATTGCTCTGGACAGTGCCGATCCGTTGGCCGACTACCGGACGGTCATCGACGAACTGGGCCGCTACGG
CCGCGAGCTGCTCCACAAATCCCGGATCGTCGCCCTCAACAAAGCCGATGTCTGCCTGCCTGAGGAGGCGGAGCACTGGC
GGCGGATTTTATCGACCGAGACAGGCGAGCCGGTGCTGGTGATCTCAGCGGCAGCCAGAAGCAACCTCGACGCGCTGCTC
GCGCGGGTCTGGCAGGTTCTGGAGGCCCCCCAGGGTGTAACGACATAG

Upstream 100 bases:

>100_bases
TGCCAGTTGCCATGTCTCTCCTTCCCCGGGGGAGTGCCGCCCTTTTCGGTGCCGTTCGGTCCCGGCTGGCTACGATGGGA
TCTGAGCGAATAGGCGGGCG

Downstream 100 bases:

>100_bases
AAGGAGGTATCCCAAGTGCGCAGAAGACAGAGCCTGGGCCTGGTGGCCGTGCTTGCCTGCGGCATGCTTGCGGCGGGGGC
GGCGGGCAAAGTGAGCGAGG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MQFIDRSEIEVEGGRGGDGMVAYRREKYVPAGGPAGGDGGHGGAVVLEATANLQTLLDFKYRHRFEADDGTKGGPKNLTG
AKGKDLVIAVPCGTVVQDAVTGETIGDLTEPGQRLVVAVGGRGGHGNTHFASNQNRAPDYATEGRLGQQRKLLLELKLLA
EVGIIGLPNAGKSTLISVLSAARPRIADYPFTTLVPNLGVVRKVTGDGVVFADIPGLIEGAHQGVGLGHEFLRHIERTRV
LVQLIALDSADPLADYRTVIDELGRYGRELLHKSRIVALNKADVCLPEEAEHWRRILSTETGEPVLVISAAARSNLDALL
ARVWQVLEAPQGVTT

Sequences:

>Translated_335_residues
MQFIDRSEIEVEGGRGGDGMVAYRREKYVPAGGPAGGDGGHGGAVVLEATANLQTLLDFKYRHRFEADDGTKGGPKNLTG
AKGKDLVIAVPCGTVVQDAVTGETIGDLTEPGQRLVVAVGGRGGHGNTHFASNQNRAPDYATEGRLGQQRKLLLELKLLA
EVGIIGLPNAGKSTLISVLSAARPRIADYPFTTLVPNLGVVRKVTGDGVVFADIPGLIEGAHQGVGLGHEFLRHIERTRV
LVQLIALDSADPLADYRTVIDELGRYGRELLHKSRIVALNKADVCLPEEAEHWRRILSTETGEPVLVISAAARSNLDALL
ARVWQVLEAPQGVTT
>Mature_335_residues
MQFIDRSEIEVEGGRGGDGMVAYRREKYVPAGGPAGGDGGHGGAVVLEATANLQTLLDFKYRHRFEADDGTKGGPKNLTG
AKGKDLVIAVPCGTVVQDAVTGETIGDLTEPGQRLVVAVGGRGGHGNTHFASNQNRAPDYATEGRLGQQRKLLLELKLLA
EVGIIGLPNAGKSTLISVLSAARPRIADYPFTTLVPNLGVVRKVTGDGVVFADIPGLIEGAHQGVGLGHEFLRHIERTRV
LVQLIALDSADPLADYRTVIDELGRYGRELLHKSRIVALNKADVCLPEEAEHWRRILSTETGEPVLVISAAARSNLDALL
ARVWQVLEAPQGVTT

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=318, Percent_Identity=41.8238993710692, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI111955139, Length=306, Percent_Identity=39.2156862745098, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI111955063, Length=141, Percent_Identity=42.5531914893617, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4758796, Length=124, Percent_Identity=37.9032258064516, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789574, Length=317, Percent_Identity=51.4195583596215, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1787454, Length=97, Percent_Identity=38.1443298969072, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=320, Percent_Identity=37.5, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17552324, Length=303, Percent_Identity=28.7128712871287, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321962, Length=175, Percent_Identity=41.1428571428571, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319281, Length=105, Percent_Identity=40, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129375, Length=324, Percent_Identity=37.962962962963, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24585318, Length=290, Percent_Identity=36.551724137931, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356473, Length=138, Percent_Identity=34.7826086956522, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_GLOVI (Q7ND61)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_927321.1
- HSSP:   P44681
- ProteinModelPortal:   Q7ND61
- SMR:   Q7ND61
- GeneID:   2602778
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr4375
- NMPDR:   fig|251221.1.peg.4375
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- ProtClustDB:   PRK12299
- BioCyc:   GVIO251221:GLR4375-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 35661; Mature: 35661

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFIDRSEIEVEGGRGGDGMVAYRREKYVPAGGPAGGDGGHGGAVVLEATANLQTLLDFK
CCCCCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHH
YRHRFEADDGTKGGPKNLTGAKGKDLVIAVPCGTVVQDAVTGETIGDLTEPGQRLVVAVG
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHCCCCCCEEEEEEC
GRGGHGNTHFASNQNRAPDYATEGRLGQQRKLLLELKLLAEVGIIGLPNAGKSTLISVLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHH
AARPRIADYPFTTLVPNLGVVRKVTGDGVVFADIPGLIEGAHQGVGLGHEFLRHIERTRV
HCCCCCCCCCHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH
LVQLIALDSADPLADYRTVIDELGRYGRELLHKSRIVALNKADVCLPEEAEHWRRILSTE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCC
TGEPVLVISAAARSNLDALLARVWQVLEAPQGVTT
CCCCEEEEECCHHCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQFIDRSEIEVEGGRGGDGMVAYRREKYVPAGGPAGGDGGHGGAVVLEATANLQTLLDFK
CCCCCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHH
YRHRFEADDGTKGGPKNLTGAKGKDLVIAVPCGTVVQDAVTGETIGDLTEPGQRLVVAVG
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHCCCCCCEEEEEEC
GRGGHGNTHFASNQNRAPDYATEGRLGQQRKLLLELKLLAEVGIIGLPNAGKSTLISVLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHH
AARPRIADYPFTTLVPNLGVVRKVTGDGVVFADIPGLIEGAHQGVGLGHEFLRHIERTRV
HCCCCCCCCCHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH
LVQLIALDSADPLADYRTVIDELGRYGRELLHKSRIVALNKADVCLPEEAEHWRRILSTE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCC
TGEPVLVISAAARSNLDALLARVWQVLEAPQGVTT
CCCCEEEEECCHHCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292