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The map label for this gene is glyA

Identifier: 37523938

GI number: 37523938

Start: 4601877

End: 4603157

Strand: Direct

Name: glyA

Synonym: gvip567

Alternate gene names: 37523938

Gene position: 4601877-4603157 (Clockwise)

Preceding gene: 37523936

Following gene: 37523940

Centisome position: 98.77

GC content: 66.59

Gene sequence:

>1281_bases
ATGCCTGTGAGTGACGATCTGCTGCGCGCAACCGATCCGCTGGTGGCTGGCTGGATCGACCGGGAACTGAACCGGCAGCG
CTCCCACCTGGAACTGATTGCCAGCGAGAACTTTACTTCTGCGGCGGTGATGGCTGCTCAGGGCTCGGTGCTCACCAACA
AATACGCCGAGGGACTGCCCAGCAAGCGCTACTACGGCGGCTGCGAATTCGTCGACGCCGTCGAGCAAATTGCCATCGAC
CGGGCCAAGGCGCTCTTCGGCGCCGCCCACGCCAACGTGCAGCCCCACTCGGGCGCGCAGGCGAATGCGGCGGTCTTTCT
GGCGCTCTTGGAGCGCGGCGACAAGATTCTGGGCATGGACCTCAGCCACGGCGGCCACCTCACCCACGGCTCACCCGTGA
ACCAGTCGGGCATTTACTTCGAGGCGCTCCACTACGGCGTCGATCCTGCAAGCCACCGCATCGACTTCGATCAAGTACGC
GAACTGGCCCATGCCCACCGCCCGAAACTGATTATCTGCGGCTACTCGGCCTACCCGCGCGTGATCGATTTCGAGTGCTT
CCGCGAGATCGCAGACGAAGTGGGAGCCTACTTGCTCGCCGACATCGCCCACATCGCCGGGCTGGTGGTGGCGGGGGTGC
ACCCCAATCCGATTCCCCACTGCGACGTGGTCACCACCACCACCCACAAGACCCTGCGCGGGCCGCGCGGGGGCCTCATC
CTCACCCGCGACGAGGCCCTGGGCAAGCGGTTCGACAAAGCGGTCTTCCCCGGCACCCAGGGCGGTCCCCTCGAGCACGT
GATTGCCGCGAAAGCCGTCGCCTTCGGCGAAGCCCTGCAGCCCGAGTTTAAGACCTACGCCGCCGATGTGGTGGCCAACG
CCCGCGCCCTGGCCGAGCGCCTGACGGCCCGCGGCCTGACCCTGGTCTCCGGCGGCACCGACAACCACCTGATGCTGGTG
GACCTGCGCTCGGTGGACCTCACCGGCAAGCAGGCCGACCTGCTGATGAGCGATGTGAACATCACCACCAACAAAAACAC
GATCCCCTTCGATCCGCAGTCGCCCTTTGTGACCAGTGGCCTGCGCCTGGGCTCCCCGGCGATGACCACCCGCGGCCTGG
GAACAACCGAATTCGGCGAAATCGGCGAGATCATCGCCAACCGCCTCACCCAGCCCACCGACGCCAGGGTCGTAGCCGAC
TGCCTGGAGCGGGTCGCATCGCTGTGCACGCGCTTCGCGCTCTACCCGCACCTCGGCCGAGTGGTGGCCCCGGTGGGCTA
G

Upstream 100 bases:

>100_bases
TGCAACCGTCGCTCAATCCTGGATTTTTTGACTTCAGCCGCAGACGCACCGCCGATATGCTATCGATCGAGGGTGGTTTA
TTATATTGCCCGCGAGGTAC

Downstream 100 bases:

>100_bases
TAGCCCCCCCGGCGGACGGCCGCGCGCGATTCGATCACAAATTCCGGTATCTGGGCGAGTTGTTCCTCGTCCAGCTGATA
CTGCTCGCATACCAGGCTCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MPVSDDLLRATDPLVAGWIDRELNRQRSHLELIASENFTSAAVMAAQGSVLTNKYAEGLPSKRYYGGCEFVDAVEQIAID
RAKALFGAAHANVQPHSGAQANAAVFLALLERGDKILGMDLSHGGHLTHGSPVNQSGIYFEALHYGVDPASHRIDFDQVR
ELAHAHRPKLIICGYSAYPRVIDFECFREIADEVGAYLLADIAHIAGLVVAGVHPNPIPHCDVVTTTTHKTLRGPRGGLI
LTRDEALGKRFDKAVFPGTQGGPLEHVIAAKAVAFGEALQPEFKTYAADVVANARALAERLTARGLTLVSGGTDNHLMLV
DLRSVDLTGKQADLLMSDVNITTNKNTIPFDPQSPFVTSGLRLGSPAMTTRGLGTTEFGEIGEIIANRLTQPTDARVVAD
CLERVASLCTRFALYPHLGRVVAPVG

Sequences:

>Translated_426_residues
MPVSDDLLRATDPLVAGWIDRELNRQRSHLELIASENFTSAAVMAAQGSVLTNKYAEGLPSKRYYGGCEFVDAVEQIAID
RAKALFGAAHANVQPHSGAQANAAVFLALLERGDKILGMDLSHGGHLTHGSPVNQSGIYFEALHYGVDPASHRIDFDQVR
ELAHAHRPKLIICGYSAYPRVIDFECFREIADEVGAYLLADIAHIAGLVVAGVHPNPIPHCDVVTTTTHKTLRGPRGGLI
LTRDEALGKRFDKAVFPGTQGGPLEHVIAAKAVAFGEALQPEFKTYAADVVANARALAERLTARGLTLVSGGTDNHLMLV
DLRSVDLTGKQADLLMSDVNITTNKNTIPFDPQSPFVTSGLRLGSPAMTTRGLGTTEFGEIGEIIANRLTQPTDARVVAD
CLERVASLCTRFALYPHLGRVVAPVG
>Mature_425_residues
PVSDDLLRATDPLVAGWIDRELNRQRSHLELIASENFTSAAVMAAQGSVLTNKYAEGLPSKRYYGGCEFVDAVEQIAIDR
AKALFGAAHANVQPHSGAQANAAVFLALLERGDKILGMDLSHGGHLTHGSPVNQSGIYFEALHYGVDPASHRIDFDQVRE
LAHAHRPKLIICGYSAYPRVIDFECFREIADEVGAYLLADIAHIAGLVVAGVHPNPIPHCDVVTTTTHKTLRGPRGGLIL
TRDEALGKRFDKAVFPGTQGGPLEHVIAAKAVAFGEALQPEFKTYAADVVANARALAERLTARGLTLVSGGTDNHLMLVD
LRSVDLTGKQADLLMSDVNITTNKNTIPFDPQSPFVTSGLRLGSPAMTTRGLGTTEFGEIGEIIANRLTQPTDARVVADC
LERVASLCTRFALYPHLGRVVAPVG

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=401, Percent_Identity=48.8778054862843, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI261862352, Length=401, Percent_Identity=48.8778054862843, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI261862350, Length=401, Percent_Identity=48.8778054862843, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI261862348, Length=401, Percent_Identity=48.8778054862843, Blast_Score=351, Evalue=8e-97,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=49.1271820448878, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862346, Length=401, Percent_Identity=48.1296758104738, Blast_Score=334, Evalue=7e-92,
Organism=Homo sapiens, GI22547189, Length=387, Percent_Identity=47.5452196382429, Blast_Score=308, Evalue=5e-84,
Organism=Escherichia coli, GI1788902, Length=399, Percent_Identity=58.8972431077694, Blast_Score=463, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI25144732, Length=402, Percent_Identity=46.7661691542289, Blast_Score=348, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=402, Percent_Identity=46.7661691542289, Blast_Score=347, Evalue=6e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=407, Percent_Identity=46.1916461916462, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6323087, Length=426, Percent_Identity=42.9577464788732, Blast_Score=326, Evalue=5e-90,
Organism=Drosophila melanogaster, GI24640005, Length=392, Percent_Identity=46.9387755102041, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=392, Percent_Identity=46.9387755102041, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_GLOVI (Q7ND67)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_927315.1
- ProteinModelPortal:   Q7ND67
- SMR:   Q7ND67
- GeneID:   2602772
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.4369
- HOGENOM:   HBG301263
- OMA:   GMIASEL
- ProtClustDB:   PRK00011
- BioCyc:   GVIO251221:GLR4369-MONOMER
- BRENDA:   2.1.2.1
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45704; Mature: 45572

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSDDLLRATDPLVAGWIDRELNRQRSHLELIASENFTSAAVMAAQGSVLTNKYAEGLP
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHCCC
SKRYYGGCEFVDAVEQIAIDRAKALFGAAHANVQPHSGAQANAAVFLALLERGDKILGMD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEE
LSHGGHLTHGSPVNQSGIYFEALHYGVDPASHRIDFDQVRELAHAHRPKLIICGYSAYPR
CCCCCCCCCCCCCCCCCCEEEHHHHCCCHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCC
VIDFECFREIADEVGAYLLADIAHIAGLVVAGVHPNPIPHCDVVTTTTHKTLRGPRGGLI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEECCHHHHCCCCCCEE
LTRDEALGKRFDKAVFPGTQGGPLEHVIAAKAVAFGEALQPEFKTYAADVVANARALAER
EECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LTARGLTLVSGGTDNHLMLVDLRSVDLTGKQADLLMSDVNITTNKNTIPFDPQSPFVTSG
HHHCCEEEEECCCCCEEEEEEECCCCCCCCHHHHEEECCEEEECCCCCCCCCCCCHHHCC
LRLGSPAMTTRGLGTTEFGEIGEIIANRLTQPTDARVVADCLERVASLCTRFALYPHLGR
CCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAPVG
HHCCCC
>Mature Secondary Structure 
PVSDDLLRATDPLVAGWIDRELNRQRSHLELIASENFTSAAVMAAQGSVLTNKYAEGLP
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHCCC
SKRYYGGCEFVDAVEQIAIDRAKALFGAAHANVQPHSGAQANAAVFLALLERGDKILGMD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEE
LSHGGHLTHGSPVNQSGIYFEALHYGVDPASHRIDFDQVRELAHAHRPKLIICGYSAYPR
CCCCCCCCCCCCCCCCCCEEEHHHHCCCHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCC
VIDFECFREIADEVGAYLLADIAHIAGLVVAGVHPNPIPHCDVVTTTTHKTLRGPRGGLI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEECCHHHHCCCCCCEE
LTRDEALGKRFDKAVFPGTQGGPLEHVIAAKAVAFGEALQPEFKTYAADVVANARALAER
EECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LTARGLTLVSGGTDNHLMLVDLRSVDLTGKQADLLMSDVNITTNKNTIPFDPQSPFVTSG
HHHCCEEEEECCCCCEEEEEEECCCCCCCCHHHHEEECCEEEECCCCCCCCCCCCHHHCC
LRLGSPAMTTRGLGTTEFGEIGEIIANRLTQPTDARVVADCLERVASLCTRFALYPHLGR
CCCCCCCHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VVAPVG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292