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The map label for this gene is glmS [C]

Identifier: 37523901

GI number: 37523901

Start: 4567339

End: 4568136

Strand: Direct

Name: glmS [C]

Synonym: glr4332

Alternate gene names: 37523901

Gene position: 4567339-4568136 (Clockwise)

Preceding gene: 37523900

Following gene: 37523902

Centisome position: 98.03

GC content: 60.28

Gene sequence:

>798_bases
ATGTGCCGCCTACTTGCCTACCAGGGAGCACCCGTCGCCCTCGCCGATCTGATCGAAAAACCCGAACATTCGCTTTGCGT
GCAGAGCTACCAGCCCAAGGAAATGACCTCCGGCCTGCTCAACGCCGACGGTTTTGGTTTCGGCTGGTACGACCCGGCGC
GCGACAGTCGGCCGTTTCGTTTTCGCAGCACCCAGCCCATCTGGGCCGACGCCAACCTGGGATCGCTCGGCCGCTACGTC
CACTCGAGCTGTGTGCTCGCCAACGTCAGAAGCGCCACCCCCGGCCTGGCCGTCGACTTGAGCAACTGCCAGCCCTTCGC
CTTCGAGCGCATCCTGGGCCTGCACAACGGATTCATTCAGAACTTTCGCCAGACCCTTTACCGCCCCATCCGCGACAGCC
TGGACGATCCATTCTACAAAGCGATCGACGGCAGCACCGACTCCGAACATGTCTTTGCCTTTGTGCTCAACACCTGGGAG
CGTCAAGGCGGCACCCTCGAAGACGCCCTTACCGAATCGATCCGCACCCTGGCTGTTTGGGCCGCCAAAGAGTCCGTGTC
GGTATCTTTGAATTTGATCTTCGCCGATGGCGAGCGGCTGGTAGCTTCGCGTTACGCCAATCGCCCGGAGGCACCCACGT
TGTACTGGCTGGCAGACGACCCTACTTTCCCGGAAGCGACGATCATTGCTTCCGAACCGCTGTTTGCCTCTAGAGGGTGG
CAGTGCGTACCGCCTGGAAGCGTTCTCACAGTTGATGCTGAGTCGAAGATAAGTGTGCAGCCTATCGAGATGTCATAG

Upstream 100 bases:

>100_bases
GGCGGCGCGTTGATCGTAGGCTGGATCTGCCTGGCCCTATTCAGCGCCAACTTAAAGTGACCGTGCGCTGCTGACCACCC
GACACCGGAACCTACCCACT

Downstream 100 bases:

>100_bases
AATTCCTAAATAAGCGGCAGCAGGACGAGCCGCTTGAAGGTATATCCAAATGCAAAAGTGTTTAATTGTCCAGGTTTTGG
GCAACAGCGATATACAAATT

Product: hypothetical protein

Products: D-Glucosamine 6-phosphate; L-Glutamate [C]

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MCRLLAYQGAPVALADLIEKPEHSLCVQSYQPKEMTSGLLNADGFGFGWYDPARDSRPFRFRSTQPIWADANLGSLGRYV
HSSCVLANVRSATPGLAVDLSNCQPFAFERILGLHNGFIQNFRQTLYRPIRDSLDDPFYKAIDGSTDSEHVFAFVLNTWE
RQGGTLEDALTESIRTLAVWAAKESVSVSLNLIFADGERLVASRYANRPEAPTLYWLADDPTFPEATIIASEPLFASRGW
QCVPPGSVLTVDAESKISVQPIEMS

Sequences:

>Translated_265_residues
MCRLLAYQGAPVALADLIEKPEHSLCVQSYQPKEMTSGLLNADGFGFGWYDPARDSRPFRFRSTQPIWADANLGSLGRYV
HSSCVLANVRSATPGLAVDLSNCQPFAFERILGLHNGFIQNFRQTLYRPIRDSLDDPFYKAIDGSTDSEHVFAFVLNTWE
RQGGTLEDALTESIRTLAVWAAKESVSVSLNLIFADGERLVASRYANRPEAPTLYWLADDPTFPEATIIASEPLFASRGW
QCVPPGSVLTVDAESKISVQPIEMS
>Mature_265_residues
MCRLLAYQGAPVALADLIEKPEHSLCVQSYQPKEMTSGLLNADGFGFGWYDPARDSRPFRFRSTQPIWADANLGSLGRYV
HSSCVLANVRSATPGLAVDLSNCQPFAFERILGLHNGFIQNFRQTLYRPIRDSLDDPFYKAIDGSTDSEHVFAFVLNTWE
RQGGTLEDALTESIRTLAVWAAKESVSVSLNLIFADGERLVASRYANRPEAPTLYWLADDPTFPEATIIASEPLFASRGW
QCVPPGSVLTVDAESKISVQPIEMS

Specific function: Catalyzes The First Step In Hexosamine Metabolism, Converting Fructose-6p Into Glucosamine-6p Using Glutamine As A Nitrogen Source. [C]

COG id: COG0121

COG function: function code R; Predicted glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-2 domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6324138, Length=305, Percent_Identity=30.4918032786885, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017808
- InterPro:   IPR017932 [H]

Pfam domain/function: NA

EC number: 2.6.1.16 [C]

Molecular weight: Translated: 29325; Mature: 29325

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCRLLAYQGAPVALADLIEKPEHSLCVQSYQPKEMTSGLLNADGFGFGWYDPARDSRPFR
CCEEEECCCCCCHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEE
FRSTQPIWADANLGSLGRYVHSSCVLANVRSATPGLAVDLSNCQPFAFERILGLHNGFIQ
ECCCCCEEECCCCCHHHHHHHHHHHEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
NFRQTLYRPIRDSLDDPFYKAIDGSTDSEHVFAFVLNTWERQGGTLEDALTESIRTLAVW
HHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEEEHHHHCCCCHHHHHHHHHHHHHHE
AAKESVSVSLNLIFADGERLVASRYANRPEAPTLYWLADDPTFPEATIIASEPLFASRGW
EECCCEEEEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEECCCCHHCCCC
QCVPPGSVLTVDAESKISVQPIEMS
EECCCCCEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MCRLLAYQGAPVALADLIEKPEHSLCVQSYQPKEMTSGLLNADGFGFGWYDPARDSRPFR
CCEEEECCCCCCHHHHHHCCCCHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEE
FRSTQPIWADANLGSLGRYVHSSCVLANVRSATPGLAVDLSNCQPFAFERILGLHNGFIQ
ECCCCCEEECCCCCHHHHHHHHHHHEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
NFRQTLYRPIRDSLDDPFYKAIDGSTDSEHVFAFVLNTWERQGGTLEDALTESIRTLAVW
HHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEEEHHHHCCCCHHHHHHHHHHHHHHE
AAKESVSVSLNLIFADGERLVASRYANRPEAPTLYWLADDPTFPEATIIASEPLFASRGW
EECCCEEEEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEECCCCHHCCCC
QCVPPGSVLTVDAESKISVQPIEMS
EECCCCCEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): 1140 [C]

Specific activity: NA

Km value (mM): 0.65 {glutamine}} 2 {fructose} [C]

Substrates: D-Fructose 6-phosphate; L-Glutamine [C]

Specific reaction: D-Fructose 6-phosphate + L-Glutamine --> D-Glucosamine 6-phosphate + L-Glutamate [C]

General reaction: Amino group transfer [C]

Inhibitor: 5, 5'-Dithiobis (2-nitrobenzoate); 6-Diazo-5-oxo-L-norleucine; Anticapsin; Azaserine; Dithiodiformamidine; Dithiodinicotinic acid; Iodoacetamide; N-Ethyl maleimide; N3-(4-Methoxyfumaroyl)-L-2, 3-diaminopropanoic acid [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]