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The map label for this gene is fabI [H]

Identifier: 37523757

GI number: 37523757

Start: 4385516

End: 4386292

Strand: Direct

Name: fabI [H]

Synonym: glr4188

Alternate gene names: 37523757

Gene position: 4385516-4386292 (Clockwise)

Preceding gene: 37523754

Following gene: 37523758

Centisome position: 94.13

GC content: 64.86

Gene sequence:

>777_bases
GTGATCACCCTCGCCGGCAAAAAGGCGCTCATCACCGGTATCGCCAACAACCGCTCGATCGCCTGGGCGATCGCCCAGGC
TTTTCACGCCGCCGGGGCAGCGCTCGCGGTCACCTACCTGCCCGACGAAAAAGGCCGCTTCGAGGCCAAGGTGCGCGAAT
TGAGCGCTCCGCTCGCCCCCGAGATCTTTGCCCCCTGCGATGTGCGCAGCGACGAGCAGATTGCCGCGCTGTTCGAGACG
ATTGCCCAGAAGTGGGGACAGCTCGACATTCTGGTGCACTGCCTGGCTTTTGGCAACAAAGAAGACTTGCAGGGACCGTT
TACCGGCGTTACCCGCGACGGCTACGGCCTGGCGATGGAGGTGAGCGCCTTTTCGCTCATCGCCCTGGCGAGTCAAGCCG
CGCCGCTGATGCCGGAAGGGGGCAGCATTTTGACGCTGACGTACATCGGGTCGGTGCGGGCGATGAGCGGCTACGGCGTG
ATGGGGCCGGCCAAGGCCGCCCTGGAGGCGAACACCCGCTACCTGGCCGCCGAACTGGGGGCCAAAAACCTGCGGGTCAA
CGCCGTATCCGCCGGCCCTATCCGCACCCTCGCCGCCTCGGGTGTCGGCAACATCCACGAGGCCATCCACAAAACCGAAG
AGATGTCCGCCATCAAGCGGGCGGTCCGCCAGGAAGAAGTGGCCAATACGGTGCTGTTTCTGGCAAGCGATCTGGCCTCC
GCCATCACCGGCCAGACCATCTACGTCGACTGCGGCTTCAGCATTATGGGGGGCTAG

Upstream 100 bases:

>100_bases
GGCTCAAATGGCCGATTCTCGAAGTCGACCTGGGCGATCAGTTCCCCCGGCGCTACTTCCCGGAACACCATCTTCGGCGC
GACACCACAGGAGAACGGAC

Downstream 100 bases:

>100_bases
TGGAAGGCGCGCTGCTGGTGGTGCTCACCACCGTTCCGGACCACGCAAGCGGGATTGCCATTGCCCGTACCCTGGTCGAA
CGCCGTCTTGTTGCCTGCGC

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MITLAGKKALITGIANNRSIAWAIAQAFHAAGAALAVTYLPDEKGRFEAKVRELSAPLAPEIFAPCDVRSDEQIAALFET
IAQKWGQLDILVHCLAFGNKEDLQGPFTGVTRDGYGLAMEVSAFSLIALASQAAPLMPEGGSILTLTYIGSVRAMSGYGV
MGPAKAALEANTRYLAAELGAKNLRVNAVSAGPIRTLAASGVGNIHEAIHKTEEMSAIKRAVRQEEVANTVLFLASDLAS
AITGQTIYVDCGFSIMGG

Sequences:

>Translated_258_residues
MITLAGKKALITGIANNRSIAWAIAQAFHAAGAALAVTYLPDEKGRFEAKVRELSAPLAPEIFAPCDVRSDEQIAALFET
IAQKWGQLDILVHCLAFGNKEDLQGPFTGVTRDGYGLAMEVSAFSLIALASQAAPLMPEGGSILTLTYIGSVRAMSGYGV
MGPAKAALEANTRYLAAELGAKNLRVNAVSAGPIRTLAASGVGNIHEAIHKTEEMSAIKRAVRQEEVANTVLFLASDLAS
AITGQTIYVDCGFSIMGG
>Mature_258_residues
MITLAGKKALITGIANNRSIAWAIAQAFHAAGAALAVTYLPDEKGRFEAKVRELSAPLAPEIFAPCDVRSDEQIAALFET
IAQKWGQLDILVHCLAFGNKEDLQGPFTGVTRDGYGLAMEVSAFSLIALASQAAPLMPEGGSILTLTYIGSVRAMSGYGV
MGPAKAALEANTRYLAAELGAKNLRVNAVSAGPIRTLAASGVGNIHEAIHKTEEMSAIKRAVRQEEVANTVLFLASDLAS
AITGQTIYVDCGFSIMGG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=28.90625, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI7705925, Length=256, Percent_Identity=29.6875, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=28.957528957529, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787545, Length=253, Percent_Identity=42.6877470355731, Blast_Score=217, Evalue=6e-58,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=31.3725490196078, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789378, Length=257, Percent_Identity=29.5719844357977, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI2367365, Length=254, Percent_Identity=29.5275590551181, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786812, Length=271, Percent_Identity=29.1512915129151, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=116, Percent_Identity=40.5172413793103, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=202, Percent_Identity=29.7029702970297, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=264, Percent_Identity=32.5757575757576, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=30.7392996108949, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=270, Percent_Identity=29.2592592592593, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=262, Percent_Identity=29.7709923664122, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=274, Percent_Identity=30.6569343065693, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=273, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=28.5185185185185, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=279, Percent_Identity=28.3154121863799, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=277, Percent_Identity=30.3249097472924, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21357041, Length=206, Percent_Identity=29.126213592233, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644337, Length=120, Percent_Identity=36.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644339, Length=268, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27024; Mature: 27024

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLAGKKALITGIANNRSIAWAIAQAFHAAGAALAVTYLPDEKGRFEAKVRELSAPLAP
CEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
EIFAPCDVRSDEQIAALFETIAQKWGQLDILVHCLAFGNKEDLQGPFTGVTRDGYGLAME
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCCEEEE
VSAFSLIALASQAAPLMPEGGSILTLTYIGSVRAMSGYGVMGPAKAALEANTRYLAAELG
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHCCCEEEEECCC
AKNLRVNAVSAGPIRTLAASGVGNIHEAIHKTEEMSAIKRAVRQEEVANTVLFLASDLAS
CCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITGQTIYVDCGFSIMGG
HHCCCEEEEEECCEECCC
>Mature Secondary Structure
MITLAGKKALITGIANNRSIAWAIAQAFHAAGAALAVTYLPDEKGRFEAKVRELSAPLAP
CEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCC
EIFAPCDVRSDEQIAALFETIAQKWGQLDILVHCLAFGNKEDLQGPFTGVTRDGYGLAME
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCCEEEE
VSAFSLIALASQAAPLMPEGGSILTLTYIGSVRAMSGYGVMGPAKAALEANTRYLAAELG
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHCCCEEEEECCC
AKNLRVNAVSAGPIRTLAASGVGNIHEAIHKTEEMSAIKRAVRQEEVANTVLFLASDLAS
CCCEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITGQTIYVDCGFSIMGG
HHCCCEEEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8391534; 11759840 [H]