Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 37523738

GI number: 37523738

Start: 4367122

End: 4368033

Strand: Reverse

Name: czcD [H]

Synonym: gll4169

Alternate gene names: 37523738

Gene position: 4368033-4367122 (Counterclockwise)

Preceding gene: 37523739

Following gene: 37523737

Centisome position: 93.75

GC content: 66.89

Gene sequence:

>912_bases
ATGGGAAGCGGACACGACCACGCCCATGCCCACGGACCCGCCGACCACAACCGCGCCTTTGCGATCGGCATCGCCTTGAA
TGTCGGTTTCGTGGTCATCGAGGCGGTCTACGGGATCCTGGCGGGCTCCCTGGCGCTGCTGGCGGACGCCGGGCACAACC
TCAGCGACGTGCTGGGGCTGGCCCTCGCCTGGGGGGCGAGCGTGCTCACCACCCGCCACCCCTCGCCGCGGCGCACCTAC
GGGCTTAGGCGTTCGTCGATTTTGGCCGCCCTGCTCAATGCCGTCACGCTGCTGGTCGCCGTGGGGGCTATTGCCTGGGA
GGCCGTCATCCGCCTGCAAGATCCCGGTCCGGTGGCGGGAGGCACCATCGTCTGGGTGGCGGCCGTCGGTGTGCTCGTCA
ACTCGGTGAGCGCCTATTTGTTCGTGAAAGGTCAGGCAGATCTCAATGTGCGGGGGGCCTTTTTGCACCTCGCCTCCGAC
GCGGCCGTGTCGCTGGGGACCGTGTTCGCTGGGGCCGCCATTCTGTTGACGGGGTGGGCCTGGCTCGACCCGGTCGTGAG
CCTGGTGATCGGTGTTGTGATCGTGGTGGGCACCTGGGGGCTGTTGGTGGACTCGCTGAATTTGGCCCTCGACGCGGTAC
CCGAGGGGATCGATCCCGAGGTGGTCAAAGCGTACCTGCAGAGTCTGCGCGGAGTGGGCGAAGTCCACGACCTGCACATC
TGGGCGATGAGCACCACCGAAACGGCCCTGACCGCCCACCTGGTAATCCCGGGCGGATTTCCCGGCGACGCCTTTCTGGC
CGCCACCTGCCGCCAACTGCACGATCGCTTCGGCATCGAGTATGCGACATTGCAGCTCGAGACGGGCGATCCTGCCCATC
CCTGCTGTCTGGCCCCGGATACCCAGGTTTGA

Upstream 100 bases:

>100_bases
CGCTTCGGCGAGCGCACCGCCCCTGCCCTCTCGCAGCAGGAGCGCGAGGCTCTCGGCCTGGATGGCATGCTGGTGGAACG
GTCCTAGGGGAAACACCGAG

Downstream 100 bases:

>100_bases
AATCCCAGAGGCGAGCCGCTCGGAGATTGTTGATGGACGAGACCGCAACCACCGCTTTTCCCTACCGCAAGATTCTCGTG
CCCTGCGCCGACGAGGTCAG

Product: cation efflux system protein CzcD-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MGSGHDHAHAHGPADHNRAFAIGIALNVGFVVIEAVYGILAGSLALLADAGHNLSDVLGLALAWGASVLTTRHPSPRRTY
GLRRSSILAALLNAVTLLVAVGAIAWEAVIRLQDPGPVAGGTIVWVAAVGVLVNSVSAYLFVKGQADLNVRGAFLHLASD
AAVSLGTVFAGAAILLTGWAWLDPVVSLVIGVVIVVGTWGLLVDSLNLALDAVPEGIDPEVVKAYLQSLRGVGEVHDLHI
WAMSTTETALTAHLVIPGGFPGDAFLAATCRQLHDRFGIEYATLQLETGDPAHPCCLAPDTQV

Sequences:

>Translated_303_residues
MGSGHDHAHAHGPADHNRAFAIGIALNVGFVVIEAVYGILAGSLALLADAGHNLSDVLGLALAWGASVLTTRHPSPRRTY
GLRRSSILAALLNAVTLLVAVGAIAWEAVIRLQDPGPVAGGTIVWVAAVGVLVNSVSAYLFVKGQADLNVRGAFLHLASD
AAVSLGTVFAGAAILLTGWAWLDPVVSLVIGVVIVVGTWGLLVDSLNLALDAVPEGIDPEVVKAYLQSLRGVGEVHDLHI
WAMSTTETALTAHLVIPGGFPGDAFLAATCRQLHDRFGIEYATLQLETGDPAHPCCLAPDTQV
>Mature_302_residues
GSGHDHAHAHGPADHNRAFAIGIALNVGFVVIEAVYGILAGSLALLADAGHNLSDVLGLALAWGASVLTTRHPSPRRTYG
LRRSSILAALLNAVTLLVAVGAIAWEAVIRLQDPGPVAGGTIVWVAAVGVLVNSVSAYLFVKGQADLNVRGAFLHLASDA
AVSLGTVFAGAAILLTGWAWLDPVVSLVIGVVIVVGTWGLLVDSLNLALDAVPEGIDPEVVKAYLQSLRGVGEVHDLHIW
AMSTTETALTAHLVIPGGFPGDAFLAATCRQLHDRFGIEYATLQLETGDPAHPCCLAPDTQV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=315, Percent_Identity=26.6666666666667, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI21361112, Length=310, Percent_Identity=29.0322580645161, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI21359890, Length=299, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI289803013, Length=279, Percent_Identity=27.2401433691756, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI289803009, Length=279, Percent_Identity=27.2401433691756, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI289803007, Length=279, Percent_Identity=27.2401433691756, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI289803003, Length=279, Percent_Identity=27.2401433691756, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI64762489, Length=279, Percent_Identity=27.2401433691756, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI14210520, Length=227, Percent_Identity=25.9911894273128, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786966, Length=289, Percent_Identity=37.0242214532872, Blast_Score=154, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI193210990, Length=315, Percent_Identity=28.8888888888889, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17555794, Length=325, Percent_Identity=28.6153846153846, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17555796, Length=299, Percent_Identity=29.0969899665552, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32564488, Length=308, Percent_Identity=26.9480519480519, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=120, Percent_Identity=36.6666666666667, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=118, Percent_Identity=38.135593220339, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=175, Percent_Identity=33.7142857142857, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583858, Length=330, Percent_Identity=29.3939393939394, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656728, Length=336, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656724, Length=336, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656720, Length=336, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656715, Length=336, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357035, Length=336, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584409, Length=152, Percent_Identity=28.2894736842105, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574430, Length=152, Percent_Identity=28.2894736842105, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585900, Length=144, Percent_Identity=29.8611111111111, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585898, Length=144, Percent_Identity=29.8611111111111, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585896, Length=144, Percent_Identity=29.8611111111111, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921672, Length=144, Percent_Identity=29.8611111111111, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24645863, Length=113, Percent_Identity=35.3982300884956, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 31387; Mature: 31255

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSGHDHAHAHGPADHNRAFAIGIALNVGFVVIEAVYGILAGSLALLADAGHNLSDVLGL
CCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ALAWGASVLTTRHPSPRRTYGLRRSSILAALLNAVTLLVAVGAIAWEAVIRLQDPGPVAG
HHHHCCHHEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
GTIVWVAAVGVLVNSVSAYLFVKGQADLNVRGAFLHLASDAAVSLGTVFAGAAILLTGWA
CHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
WLDPVVSLVIGVVIVVGTWGLLVDSLNLALDAVPEGIDPEVVKAYLQSLRGVGEVHDLHI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEE
WAMSTTETALTAHLVIPGGFPGDAFLAATCRQLHDRFGIEYATLQLETGDPAHPCCLAPD
EEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEECCCC
TQV
CCC
>Mature Secondary Structure 
GSGHDHAHAHGPADHNRAFAIGIALNVGFVVIEAVYGILAGSLALLADAGHNLSDVLGL
CCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ALAWGASVLTTRHPSPRRTYGLRRSSILAALLNAVTLLVAVGAIAWEAVIRLQDPGPVAG
HHHHCCHHEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
GTIVWVAAVGVLVNSVSAYLFVKGQADLNVRGAFLHLASDAAVSLGTVFAGAAILLTGWA
CHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
WLDPVVSLVIGVVIVVGTWGLLVDSLNLALDAVPEGIDPEVVKAYLQSLRGVGEVHDLHI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEE
WAMSTTETALTAHLVIPGGFPGDAFLAATCRQLHDRFGIEYATLQLETGDPAHPCCLAPD
EEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEECCCC
TQV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA