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The map label for this gene is spkF [H]

Identifier: 37523586

GI number: 37523586

Start: 4219697

End: 4220578

Strand: Direct

Name: spkF [H]

Synonym: glr4017

Alternate gene names: 37523586

Gene position: 4219697-4220578 (Clockwise)

Preceding gene: 37523585

Following gene: 37523587

Centisome position: 90.57

GC content: 60.54

Gene sequence:

>882_bases
ATGCCTATCGTCGAATCGATGGTGGTCCAGAATTGTTACCGCCCGGTGCGCCTTTTGGGAGCAAACGGAACGCGGCAGAC
CTGGCTTGCGGCGGAGGAAAAGACTGGACAAACCGTGACGCTCAAGGCGCTTTATTTCGGCGAGGGTGCGCTGTGGCAAG
ATTTTAAGCTTTTCGAGCGCGAGGCTGAGACGCTGCAGTCACTTTCCCACTCCCGCATCCCCCGCCAGCGCGACGCCTTC
TGGTGGGAGCAGCCGGAGGGCAACTACTTTTGTCTCATCCAGGATTTCATCCCCGGCCAGTCGCTGGAGGCAAGTGTGCG
CAACCTCGGTCCCCTGCCGGAGGCTGAAGTACGCACCATTGCCGCCGAGGTGCTTGAAATTTTGATCTATCTGCACCGAC
AGTCGCCGCCGGTGATCCATCGCGACCTCACCCCCGCCAATCTCATTTGGGGCGAAGACGGACGAATTTATTTGATCGAC
TTTGGTGCGGTACAGGCGGTAAGCGCTCCCGAGAAAACGATGACGGTGGTGGGCACCTACCGGCTATATGCCCCCGGAGC
AGTTCGAGGGCCGCACGGTCCCTGCGTCAGATCTGTTCGGCCTCGGGGCGACGCTGCTTTTTTTGCTCACCGGGATCAAT
CCTGGGGAACTGCCCCGCGAGAACTTTCGGATCCGCCTGGGGGAGAGGGCGAGCGCCGGTCTGAAGCCCTGGCTGGAGCG
AATGCTCGATCCCGATTTGCAGTACCGTTTTGCGAGTGCTTGCGCCGCCCACGAAGCACTCGATCGGCAGGAAAATCGGC
CTGTGCCGACAGTGAGCGGTCAACCAACCGGCAGCTGCATTGCCCTGAAGCGAACTGCCGAACGACTCACCATCGAGGTT
GA

Upstream 100 bases:

>100_bases
CTGTACGATGTGCCCGCGGGTGCTTAGCCGCTCGCTGCCTAGGCAAGCCGCAAAGCAGCCAATATACTAAAAAGAACGAC
CGGGCTCATACACCTGACCG

Downstream 100 bases:

>100_bases
AGGTCGGCGGCTGCAGTTGCGGGATTTCTATGTCGCCCTTGCCCAAATGGCTCTCCAGTTTCCGCAAATGTTCCTGAGTT
TCAATCAGGAGAACTCTTCT

Product: serine/threonine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPIVESMVVQNCYRPVRLLGANGTRQTWLAAEEKTGQTVTLKALYFGEGALWQDFKLFEREAETLQSLSHSRIPRQRDAF
WWEQPEGNYFCLIQDFIPGQSLEASVRNLGPLPEAEVRTIAAEVLEILIYLHRQSPPVIHRDLTPANLIWGEDGRIYLID
FGAVQAVSAPEKTMTVVGTYRLYAPGAVRGPHGPCVRSVRPRGDAAFFAHRDQSWGTAPRELSDPPGGEGERRSEALAGA
NARSRFAVPFCECLRRPRSTRSAGKSACADSERSTNRQLHCPEANCRTTHHRG

Sequences:

>Translated_293_residues
MPIVESMVVQNCYRPVRLLGANGTRQTWLAAEEKTGQTVTLKALYFGEGALWQDFKLFEREAETLQSLSHSRIPRQRDAF
WWEQPEGNYFCLIQDFIPGQSLEASVRNLGPLPEAEVRTIAAEVLEILIYLHRQSPPVIHRDLTPANLIWGEDGRIYLID
FGAVQAVSAPEKTMTVVGTYRLYAPGAVRGPHGPCVRSVRPRGDAAFFAHRDQSWGTAPRELSDPPGGEGERRSEALAGA
NARSRFAVPFCECLRRPRSTRSAGKSACADSERSTNRQLHCPEANCRTTHHRG
>Mature_292_residues
PIVESMVVQNCYRPVRLLGANGTRQTWLAAEEKTGQTVTLKALYFGEGALWQDFKLFEREAETLQSLSHSRIPRQRDAFW
WEQPEGNYFCLIQDFIPGQSLEASVRNLGPLPEAEVRTIAAEVLEILIYLHRQSPPVIHRDLTPANLIWGEDGRIYLIDF
GAVQAVSAPEKTMTVVGTYRLYAPGAVRGPHGPCVRSVRPRGDAAFFAHRDQSWGTAPRELSDPPGGEGERRSEALAGAN
ARSRFAVPFCECLRRPRSTRSAGKSACADSERSTNRQLHCPEANCRTTHHRG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI217330634, Length=171, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71981370, Length=190, Percent_Identity=27.8947368421053, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115532658, Length=190, Percent_Identity=27.8947368421053, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71981364, Length=190, Percent_Identity=27.8947368421053, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71983636, Length=183, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6325117, Length=135, Percent_Identity=34.8148148148148, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077548, Length=106, Percent_Identity=33.9622641509434, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62512112, Length=106, Percent_Identity=33.9622641509434, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329689, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329685, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329681, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281359801, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329687, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329683, Length=106, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442 [H]

Pfam domain/function: PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32709; Mature: 32578

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVESMVVQNCYRPVRLLGANGTRQTWLAAEEKTGQTVTLKALYFGEGALWQDFKLFER
CCHHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHH
EAETLQSLSHSRIPRQRDAFWWEQPEGNYFCLIQDFIPGQSLEASVRNLGPLPEAEVRTI
HHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHH
AAEVLEILIYLHRQSPPVIHRDLTPANLIWGEDGRIYLIDFGAVQAVSAPEKTMTVVGTY
HHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEEEECCCEEECCCCCCEEEEEEEE
RLYAPGAVRGPHGPCVRSVRPRGDAAFFAHRDQSWGTAPRELSDPPGGEGERRSEALAGA
EEECCCCCCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
NARSRFAVPFCECLRRPRSTRSAGKSACADSERSTNRQLHCPEANCRTTHHRG
CCCCEECCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PIVESMVVQNCYRPVRLLGANGTRQTWLAAEEKTGQTVTLKALYFGEGALWQDFKLFER
CHHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHH
EAETLQSLSHSRIPRQRDAFWWEQPEGNYFCLIQDFIPGQSLEASVRNLGPLPEAEVRTI
HHHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHH
AAEVLEILIYLHRQSPPVIHRDLTPANLIWGEDGRIYLIDFGAVQAVSAPEKTMTVVGTY
HHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEEEECCCEEECCCCCCEEEEEEEE
RLYAPGAVRGPHGPCVRSVRPRGDAAFFAHRDQSWGTAPRELSDPPGGEGERRSEALAGA
EEECCCCCCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
NARSRFAVPFCECLRRPRSTRSAGKSACADSERSTNRQLHCPEANCRTTHHRG
CCCCEECCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12168951; 8905231 [H]