Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 37523567

GI number: 37523567

Start: 4200756

End: 4201985

Strand: Reverse

Name: icd [H]

Synonym: gll3998

Alternate gene names: 37523567

Gene position: 4201985-4200756 (Counterclockwise)

Preceding gene: 37523571

Following gene: 37523566

Centisome position: 90.19

GC content: 62.11

Gene sequence:

>1230_bases
GTGTCCAAATTGACGGTGAAGACGACCGTGGTTGATATCGACGGCGATGAGATGACCCGGATTATCTGGGAGATGATCCA
GCAGAAGCTGCTCAGGCCGTATCTGGAGATGACGATCGAGCGCTACGACCTCGGCATCGAAAACCGTGACGCCACCGACG
ATCGGGTGACGGTGGAGGCGGCCGAGGCCGTTATGCGCCACGGCGTGGGTGTCAAGTGCGCCACGATCACCCCCGACGAA
GCACGCGTCAAAGAGTTCGGCCTCAAAAAAATGTGGAAGTCCCCCAACGGCACCATCCGCAACATCCTCGGGGGGACGGT
CTTTCGCGAGCCGATCATCTGTCGCAACATCCCGCGATTGGTGCCCGGCTGGACACGGCCTATCGTCGTCGCCCGCCACG
CCTTCGGCGATCAGTACCGGGCCACCGAGTACCGCGTGCCGGGGCCGGGAAAACTCAAACTCGTCTTTGAGCCGACCCAA
GGGGGCGAGCCGGTCGAGCAGACGGTTTTCGATTTCGCGGACAAAGGCGTCGCCCTGGGCATGTACAACCTCGATGTGTC
GATCGCCGGGTTTGCCAGGGCCTGCTTCAACTTTGCCCTGACCCGCAACTGGCCGGTGTACCTGTCGACCAAAAACACGA
TCCTCAAAGTCTACGACGGCAACTTTAAAGACATCTTCCAGAGCGTCTACGACAGCGAATTCAAGGCCGCCTTCGCGGAG
CGCGGTTTGAGTTACGAACACCGCCTGATCGACGACATGGTGGCCGCCGCCCTCAAATGGTCGGGCGGGTTTGTCTGGGC
CTGCAAGAACTACGACGGCGACGTGCAATCGGACGTGGTGGCGCAGGGCTTCGGCTCCCTCGGCTTGATGACTTCGATTT
TGCTCACTCCCGACGGCAAGTCGGTCGAGACCGAGGCCGCCCACGGCACAGTTACCCGCCACTACCGCCTGCACCAGCAG
GGCAAGCAGACTTCCACCAACCCGATCGCTTCGATTTTTGCCTGGAGCCGGGGACTTTGGTACCGCGGCCAGTTCGACGG
TACCCCGGAGATTTGCGCTTTTGCCGAATTGCTGGAGCACGTCTGCGTCGAGACGGTCGAGGCGGGCGAGATGACCAGGG
ATCTGGCGCTGCTGGTGAGCCCCGAGCAGCCGTACCTCACCACCGGCGCATTTATCGACGCCGTCGCCCGCAGGCTCGAC
GCCGCTTACGCAGAACGCTTCGCCGCCTGA

Upstream 100 bases:

>100_bases
AAGGAGACGGAGCTCGGTCATGGACGGATGTGCGATAGGATTCAGTGCACTTGCGTGTGCGTAGACTGTGACCTGCGAAG
CGAAGGGATAGCCGATGAGT

Downstream 100 bases:

>100_bases
CGCGGTCCTTCAACTGCCACCGAACCGGCAAGCGGTTCATCTACCGTGGATAGCGATGACTTGGGAAGCGATGGATATTG
CCTTCGGGCGGGAGGTCTGT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSKLTVKTTVVDIDGDEMTRIIWEMIQQKLLRPYLEMTIERYDLGIENRDATDDRVTVEAAEAVMRHGVGVKCATITPDE
ARVKEFGLKKMWKSPNGTIRNILGGTVFREPIICRNIPRLVPGWTRPIVVARHAFGDQYRATEYRVPGPGKLKLVFEPTQ
GGEPVEQTVFDFADKGVALGMYNLDVSIAGFARACFNFALTRNWPVYLSTKNTILKVYDGNFKDIFQSVYDSEFKAAFAE
RGLSYEHRLIDDMVAAALKWSGGFVWACKNYDGDVQSDVVAQGFGSLGLMTSILLTPDGKSVETEAAHGTVTRHYRLHQQ
GKQTSTNPIASIFAWSRGLWYRGQFDGTPEICAFAELLEHVCVETVEAGEMTRDLALLVSPEQPYLTTGAFIDAVARRLD
AAYAERFAA

Sequences:

>Translated_409_residues
MSKLTVKTTVVDIDGDEMTRIIWEMIQQKLLRPYLEMTIERYDLGIENRDATDDRVTVEAAEAVMRHGVGVKCATITPDE
ARVKEFGLKKMWKSPNGTIRNILGGTVFREPIICRNIPRLVPGWTRPIVVARHAFGDQYRATEYRVPGPGKLKLVFEPTQ
GGEPVEQTVFDFADKGVALGMYNLDVSIAGFARACFNFALTRNWPVYLSTKNTILKVYDGNFKDIFQSVYDSEFKAAFAE
RGLSYEHRLIDDMVAAALKWSGGFVWACKNYDGDVQSDVVAQGFGSLGLMTSILLTPDGKSVETEAAHGTVTRHYRLHQQ
GKQTSTNPIASIFAWSRGLWYRGQFDGTPEICAFAELLEHVCVETVEAGEMTRDLALLVSPEQPYLTTGAFIDAVARRLD
AAYAERFAA
>Mature_408_residues
SKLTVKTTVVDIDGDEMTRIIWEMIQQKLLRPYLEMTIERYDLGIENRDATDDRVTVEAAEAVMRHGVGVKCATITPDEA
RVKEFGLKKMWKSPNGTIRNILGGTVFREPIICRNIPRLVPGWTRPIVVARHAFGDQYRATEYRVPGPGKLKLVFEPTQG
GEPVEQTVFDFADKGVALGMYNLDVSIAGFARACFNFALTRNWPVYLSTKNTILKVYDGNFKDIFQSVYDSEFKAAFAER
GLSYEHRLIDDMVAAALKWSGGFVWACKNYDGDVQSDVVAQGFGSLGLMTSILLTPDGKSVETEAAHGTVTRHYRLHQQG
KQTSTNPIASIFAWSRGLWYRGQFDGTPEICAFAELLEHVCVETVEAGEMTRDLALLVSPEQPYLTTGAFIDAVARRLDA
AYAERFAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=411, Percent_Identity=61.5571776155718, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI28178832, Length=410, Percent_Identity=60.7317073170732, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17550822, Length=404, Percent_Identity=60.6435643564356, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17540874, Length=397, Percent_Identity=62.2166246851385, Blast_Score=529, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6320137, Length=403, Percent_Identity=61.5384615384615, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6323203, Length=407, Percent_Identity=59.95085995086, Blast_Score=513, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6324319, Length=403, Percent_Identity=58.0645161290323, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21356561, Length=406, Percent_Identity=60.3448275862069, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221330987, Length=406, Percent_Identity=60.3448275862069, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221330985, Length=406, Percent_Identity=60.3448275862069, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI28574947, Length=406, Percent_Identity=60.3448275862069, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24660849, Length=406, Percent_Identity=60.3448275862069, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24660856, Length=406, Percent_Identity=60.3448275862069, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221330983, Length=406, Percent_Identity=60.3448275862069, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24660868, Length=406, Percent_Identity=60.3448275862069, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24660860, Length=406, Percent_Identity=60.3448275862069, Blast_Score=529, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45664; Mature: 45532

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLTVKTTVVDIDGDEMTRIIWEMIQQKLLRPYLEMTIERYDLGIENRDATDDRVTVEA
CCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHH
AEAVMRHGVGVKCATITPDEARVKEFGLKKMWKSPNGTIRNILGGTVFREPIICRNIPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHCCCCCC
VPGWTRPIVVARHAFGDQYRATEYRVPGPGKLKLVFEPTQGGEPVEQTVFDFADKGVALG
CCCCCCCEEEEEHHCCCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEE
MYNLDVSIAGFARACFNFALTRNWPVYLSTKNTILKVYDGNFKDIFQSVYDSEFKAAFAE
EEECCEEHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
RGLSYEHRLIDDMVAAALKWSGGFVWACKNYDGDVQSDVVAQGFGSLGLMTSILLTPDGK
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHEEEECCCCC
SVETEAAHGTVTRHYRLHQQGKQTSTNPIASIFAWSRGLWYRGQFDGTPEICAFAELLEH
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
VCVETVEAGEMTRDLALLVSPEQPYLTTGAFIDAVARRLDAAYAERFAA
HHHHHHHHHHHHHCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKLTVKTTVVDIDGDEMTRIIWEMIQQKLLRPYLEMTIERYDLGIENRDATDDRVTVEA
CCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHH
AEAVMRHGVGVKCATITPDEARVKEFGLKKMWKSPNGTIRNILGGTVFREPIICRNIPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHCCCCCC
VPGWTRPIVVARHAFGDQYRATEYRVPGPGKLKLVFEPTQGGEPVEQTVFDFADKGVALG
CCCCCCCEEEEEHHCCCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEE
MYNLDVSIAGFARACFNFALTRNWPVYLSTKNTILKVYDGNFKDIFQSVYDSEFKAAFAE
EEECCEEHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
RGLSYEHRLIDDMVAAALKWSGGFVWACKNYDGDVQSDVVAQGFGSLGLMTSILLTPDGK
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHEEEECCCCC
SVETEAAHGTVTRHYRLHQQGKQTSTNPIASIFAWSRGLWYRGQFDGTPEICAFAELLEH
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
VCVETVEAGEMTRDLALLVSPEQPYLTTGAFIDAVARRLDAAYAERFAA
HHHHHHHHHHHHHCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]