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The map label for this gene is dsbD [H]

Identifier: 37523532

GI number: 37523532

Start: 4158475

End: 4160601

Strand: Direct

Name: dsbD [H]

Synonym: glr3963

Alternate gene names: 37523532

Gene position: 4158475-4160601 (Clockwise)

Preceding gene: 37523531

Following gene: 37523533

Centisome position: 89.26

GC content: 67.09

Gene sequence:

>2127_bases
ATGCGCTGGTTGACTTTTGTGATGTTTTGGTTTGCGGTCGGGTTTGCGGTCCTCACCGTGCCGGTAGCCGCTATCCCGGT
GCGCTCCGCCCATACCGAGGCTGAACTCATCTCGGAGGTGCGCTCGGTCCAGCCGGGCCGGCCTTTTTGGGTGGCGCTGC
GCCTGAAGATGGATCCCGAGTGGCACACCTACTGGCTCAATCCGGGGGACTCGGGCACGGCGACCACGCTGCAATGGCAA
CAGCCCGCCGGGATACAGGCCGGTCCCCTCCGCTGGCCCTATCCCCAGCGCATCGCCGCCCCGCCTCTCGCAAGTTACGG
ATACGAGGGGACGGTCTATCTGCTGAGCGAAATCCAGGCGCCCGCGGATCTCAAGCCCGGAGCAAAACTGGCGCTGCGCG
CCAAAGCCGAGTGGCTGGAGTGCAAAGTAGAGTGCCTACCGGGGGCGGGCACCGTCGCCCTCGAATTGCCGGTTCAGGCG
GAGGCTACTGCACCGTCGGTCCACGCCGATGCGATCGCTGCCGCCCGCGGCCGTCTGCCGGTGACCATTGCCGATTGGAA
GCTGCGCGCGGCGGTGCAGGAGGGGCAGCTCATCCTGCGCGCCACCCGGCCCGAGTGGTTCGCAGGTGAAATCGGTCCGG
TGACCTTTTTCCCGGAGCAAGACCTGCTGATTGAACCGGCGGCCCCCCAGGTGCTCGAAGTGCGTCCCGACGGCTTTTTG
CTCAAGCTCAAGCGCTCCGCCGTCTCGACGGCGACCCCTGAGCGCATTGCGGGCGTGCTGGTGGCTCCTGCCGGTTGGCG
CGGCGCTGGGTCGGAGCAGGCTCTGAGCGTCCGGGTCGCCCTTGAACCGGTCGCCGCCGTGCTGAGCGCCGGGGCGCCGG
ATCTGGCCGGGCTGCTGGTGGCGGTGGGTTTCGCTTTTTTGGGCGGGATGATCTTGAACCTGATGCCCTGCGTGCTGCCG
GTGCTCTCGATCAAGGTGCTGGGTTTCGTGCAGGAGGCGCGCACAGGCCACGCCTGGCGCTACGGCCTTGCCTTTACCGC
CGGGGTGCTCGCCTCCTTCTGGCTTTTGGCCGGCGGATTGCTGCTGTTGCGCGCCGGAGGCGAACAACTGGGGTGGGGCT
TCCAGCTGCAGTCGCCGCCTTTTCTGGTGATCCTCTGCGCGGTGCTCTTTTTGTTCGGATTGAATCTTTTTGGCATCTTC
GAGGTGGGTACTTCGCTGACCCGCCTGGGGGGAGCCGGTCCGGCCGGCGGCCTGGGCGGTTCGTTTTTTAGCGGGGTGCT
CGCCACTACCGTCGCCACCCCCTGCACCGCCCCGTTTATGGGCTCGGCCCTCGGTTATGCCCTCACCCAACCTGTCTGGG
CAGCATTGCTGGTCTTCACCGCCCTGGGCCTCGGCATGGCGAGCCCCTATTTGCTGCTTTCGCTCTCGCCTGCGCTCCTG
CGCTTCGTGCCCAAGCCGGGTGCCTGGATGGAGACCTTCAAGCAGGCGATGGGCTTTTTGCTGATGGGCACCGTCGTCTG
GCTGGGCTGGGTACTGGGCCTGCAGGCCGGGGTGAGTGCTCTGGCGGCGCTGCTGGCCGCCCTGGTGGTGCTCGGAGCCG
CCGCCTGGGCGCTCGGCAAATGGGGCCACATGGCGGCTCCTGCCCCCACCCGCCTGACCGCCCGGGTGCTCGCCGCCCTC
GGGATCGTCGGGGCGCTGGGCGTTGCTCTGGTCGGAGTCGAGCAGCAGTCCGCCGCTTCCTCCGGACCGACCCAGGCGAC
GGCAACTCCCTCCGAGGGCATCCGTTGGGAAGCATTCTCCCCACAGCGGGTAGCCGCCCTGCGCGCTGCCGGCACGCCGG
TATTCATCGATTTCACCGCCGCCTGGTGCCTGAGTTGCCAGGTCAACGAGCGCGTCGCCTTCAGCTCGCCCCAGGTGCGC
GAAGCCTTTGCCAGGGGCGGCTTTGTGATGCTCAAAGCCGACTGGACCAAGCGCGATGCCGCGATTGCCCAGGCGCTGGC
ACAATTTGGCCGCAGCGGCGTCCCTCTCTATGTGCTCTATGGCCCAACCGCCGGTGCCCCGCCCCGGATTTTGCCCGAAG
TGCTCACTCCGGATATCATCGTGAAGGCACTTCAAGAATTGTCATAA

Upstream 100 bases:

>100_bases
ACTTTTACGACCGCCGCCCCGGCGGGTCACCTCTCGGCCATCGGCCGTGACGGATGCTTTATAACGTTCCTCACGATGCT
GTCGCGCTGCGGTTTGTAAT

Downstream 100 bases:

>100_bases
ATCCCGAACTTCTTACCAGGAGACTGCGAATGAAGAGGAAAGCGTTTGTGATGGCCGCCTTGAGCCTGGCACTGGTCGCT
GCGAACGTCTCGACGGTGCA

Product: thiol-disulfide interchange protein DsbD-like protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 708; Mature: 708

Protein sequence:

>708_residues
MRWLTFVMFWFAVGFAVLTVPVAAIPVRSAHTEAELISEVRSVQPGRPFWVALRLKMDPEWHTYWLNPGDSGTATTLQWQ
QPAGIQAGPLRWPYPQRIAAPPLASYGYEGTVYLLSEIQAPADLKPGAKLALRAKAEWLECKVECLPGAGTVALELPVQA
EATAPSVHADAIAAARGRLPVTIADWKLRAAVQEGQLILRATRPEWFAGEIGPVTFFPEQDLLIEPAAPQVLEVRPDGFL
LKLKRSAVSTATPERIAGVLVAPAGWRGAGSEQALSVRVALEPVAAVLSAGAPDLAGLLVAVGFAFLGGMILNLMPCVLP
VLSIKVLGFVQEARTGHAWRYGLAFTAGVLASFWLLAGGLLLLRAGGEQLGWGFQLQSPPFLVILCAVLFLFGLNLFGIF
EVGTSLTRLGGAGPAGGLGGSFFSGVLATTVATPCTAPFMGSALGYALTQPVWAALLVFTALGLGMASPYLLLSLSPALL
RFVPKPGAWMETFKQAMGFLLMGTVVWLGWVLGLQAGVSALAALLAALVVLGAAAWALGKWGHMAAPAPTRLTARVLAAL
GIVGALGVALVGVEQQSAASSGPTQATATPSEGIRWEAFSPQRVAALRAAGTPVFIDFTAAWCLSCQVNERVAFSSPQVR
EAFARGGFVMLKADWTKRDAAIAQALAQFGRSGVPLYVLYGPTAGAPPRILPEVLTPDIIVKALQELS

Sequences:

>Translated_708_residues
MRWLTFVMFWFAVGFAVLTVPVAAIPVRSAHTEAELISEVRSVQPGRPFWVALRLKMDPEWHTYWLNPGDSGTATTLQWQ
QPAGIQAGPLRWPYPQRIAAPPLASYGYEGTVYLLSEIQAPADLKPGAKLALRAKAEWLECKVECLPGAGTVALELPVQA
EATAPSVHADAIAAARGRLPVTIADWKLRAAVQEGQLILRATRPEWFAGEIGPVTFFPEQDLLIEPAAPQVLEVRPDGFL
LKLKRSAVSTATPERIAGVLVAPAGWRGAGSEQALSVRVALEPVAAVLSAGAPDLAGLLVAVGFAFLGGMILNLMPCVLP
VLSIKVLGFVQEARTGHAWRYGLAFTAGVLASFWLLAGGLLLLRAGGEQLGWGFQLQSPPFLVILCAVLFLFGLNLFGIF
EVGTSLTRLGGAGPAGGLGGSFFSGVLATTVATPCTAPFMGSALGYALTQPVWAALLVFTALGLGMASPYLLLSLSPALL
RFVPKPGAWMETFKQAMGFLLMGTVVWLGWVLGLQAGVSALAALLAALVVLGAAAWALGKWGHMAAPAPTRLTARVLAAL
GIVGALGVALVGVEQQSAASSGPTQATATPSEGIRWEAFSPQRVAALRAAGTPVFIDFTAAWCLSCQVNERVAFSSPQVR
EAFARGGFVMLKADWTKRDAAIAQALAQFGRSGVPLYVLYGPTAGAPPRILPEVLTPDIIVKALQELS
>Mature_708_residues
MRWLTFVMFWFAVGFAVLTVPVAAIPVRSAHTEAELISEVRSVQPGRPFWVALRLKMDPEWHTYWLNPGDSGTATTLQWQ
QPAGIQAGPLRWPYPQRIAAPPLASYGYEGTVYLLSEIQAPADLKPGAKLALRAKAEWLECKVECLPGAGTVALELPVQA
EATAPSVHADAIAAARGRLPVTIADWKLRAAVQEGQLILRATRPEWFAGEIGPVTFFPEQDLLIEPAAPQVLEVRPDGFL
LKLKRSAVSTATPERIAGVLVAPAGWRGAGSEQALSVRVALEPVAAVLSAGAPDLAGLLVAVGFAFLGGMILNLMPCVLP
VLSIKVLGFVQEARTGHAWRYGLAFTAGVLASFWLLAGGLLLLRAGGEQLGWGFQLQSPPFLVILCAVLFLFGLNLFGIF
EVGTSLTRLGGAGPAGGLGGSFFSGVLATTVATPCTAPFMGSALGYALTQPVWAALLVFTALGLGMASPYLLLSLSPALL
RFVPKPGAWMETFKQAMGFLLMGTVVWLGWVLGLQAGVSALAALLAALVVLGAAAWALGKWGHMAAPAPTRLTARVLAAL
GIVGALGVALVGVEQQSAASSGPTQATATPSEGIRWEAFSPQRVAALRAAGTPVFIDFTAAWCLSCQVNERVAFSSPQVR
EAFARGGFVMLKADWTKRDAAIAQALAQFGRSGVPLYVLYGPTAGAPPRILPEVLTPDIIVKALQELS

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=405, Percent_Identity=28.8888888888889, Blast_Score=109, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 74519; Mature: 74519

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWLTFVMFWFAVGFAVLTVPVAAIPVRSAHTEAELISEVRSVQPGRPFWVALRLKMDPE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCC
WHTYWLNPGDSGTATTLQWQQPAGIQAGPLRWPYPQRIAAPPLASYGYEGTVYLLSEIQA
EEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCHHHCCCCCEEEEEECCCC
PADLKPGAKLALRAKAEWLECKVECLPGAGTVALELPVQAEATAPSVHADAIAAARGRLP
CCCCCCCCCEEEEEHHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCC
VTIADWKLRAAVQEGQLILRATRPEWFAGEIGPVTFFPEQDLLIEPAAPQVLEVRPDGFL
EEEECCHHHHHHHCCCEEEEECCCCCCCCCCCCEEECCCCCCEECCCCCCEEEECCCCEE
LKLKRSAVSTATPERIAGVLVAPAGWRGAGSEQALSVRVALEPVAAVLSAGAPDLAGLLV
EEEEHHHHCCCCHHHHCEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHHH
AVGFAFLGGMILNLMPCVLPVLSIKVLGFVQEARTGHAWRYGLAFTAGVLASFWLLAGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCC
LLLRAGGEQLGWGFQLQSPPFLVILCAVLFLFGLNLFGIFEVGTSLTRLGGAGPAGGLGG
EEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SFFSGVLATTVATPCTAPFMGSALGYALTQPVWAALLVFTALGLGMASPYLLLSLSPALL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHH
RFVPKPGAWMETFKQAMGFLLMGTVVWLGWVLGLQAGVSALAALLAALVVLGAAAWALGK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WGHMAAPAPTRLTARVLAALGIVGALGVALVGVEQQSAASSGPTQATATPSEGIRWEAFS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCEEECCC
PQRVAALRAAGTPVFIDFTAAWCLSCQVNERVAFSSPQVREAFARGGFVMLKADWTKRDA
CHHHHHHHHCCCCEEEEEHHHHEEEEECCCCEECCCCHHHHHHHCCCEEEEEECCCHHHH
AIAQALAQFGRSGVPLYVLYGPTAGAPPRILPEVLTPDIIVKALQELS
HHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MRWLTFVMFWFAVGFAVLTVPVAAIPVRSAHTEAELISEVRSVQPGRPFWVALRLKMDPE
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCC
WHTYWLNPGDSGTATTLQWQQPAGIQAGPLRWPYPQRIAAPPLASYGYEGTVYLLSEIQA
EEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCHHHCCCCCEEEEEECCCC
PADLKPGAKLALRAKAEWLECKVECLPGAGTVALELPVQAEATAPSVHADAIAAARGRLP
CCCCCCCCCEEEEEHHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCC
VTIADWKLRAAVQEGQLILRATRPEWFAGEIGPVTFFPEQDLLIEPAAPQVLEVRPDGFL
EEEECCHHHHHHHCCCEEEEECCCCCCCCCCCCEEECCCCCCEECCCCCCEEEECCCCEE
LKLKRSAVSTATPERIAGVLVAPAGWRGAGSEQALSVRVALEPVAAVLSAGAPDLAGLLV
EEEEHHHHCCCCHHHHCEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHHH
AVGFAFLGGMILNLMPCVLPVLSIKVLGFVQEARTGHAWRYGLAFTAGVLASFWLLAGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCC
LLLRAGGEQLGWGFQLQSPPFLVILCAVLFLFGLNLFGIFEVGTSLTRLGGAGPAGGLGG
EEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SFFSGVLATTVATPCTAPFMGSALGYALTQPVWAALLVFTALGLGMASPYLLLSLSPALL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHH
RFVPKPGAWMETFKQAMGFLLMGTVVWLGWVLGLQAGVSALAALLAALVVLGAAAWALGK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WGHMAAPAPTRLTARVLAALGIVGALGVALVGVEQQSAASSGPTQATATPSEGIRWEAFS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCEEECCC
PQRVAALRAAGTPVFIDFTAAWCLSCQVNERVAFSSPQVREAFARGGFVMLKADWTKRDA
CHHHHHHHHCCCCEEEEEHHHHEEEEECCCCEECCCCHHHHHHHCCCEEEEEECCCHHHH
AIAQALAQFGRSGVPLYVLYGPTAGAPPRILPEVLTPDIIVKALQELS
HHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA