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The map label for this gene is proA

Identifier: 37523492

GI number: 37523492

Start: 4117096

End: 4118355

Strand: Reverse

Name: proA

Synonym: gvip531

Alternate gene names: 37523492

Gene position: 4118355-4117096 (Counterclockwise)

Preceding gene: 37523493

Following gene: 37523491

Centisome position: 88.4

GC content: 62.54

Gene sequence:

>1260_bases
GTGGAATCTTCGCTTTACGAAACCCTCAAAGTCACGGCGCAGCGGGCACAGCGCTCGACGATGGCGCTTGCTCAAGTGCC
TTCAGGAATCAAAAACAAGGCGCTACGCGCCATGGCCCGTTCGCTGCGCACCGCCCACAGCGAAATCCTCGAATCGAACA
CGACGGATCTCGAATTCGGTCGCCAGATGGGCCTTTCTGAGACGTTGCTCGACCGGCTGAAGCTGACTCCCCAGCGCCTC
GAAGGTATGGCGCTTTCTTTGGAGCAAATCGCCGCACTCAAAGATCCGGTGGGTGAAATCGTGGGCGGCTGGCGGCACCC
CGAGGGCCTGGAAATCGTGCGGGTGCGGGTGCCGCTGGGCCTCATCGGGATCATCTACGAGGCACGCCCCAATGTTACCG
CCGACGCCATCGGCCTGTGCCTCAAGTCCGGCAATGGAGTGCTCTTGAAAGGCGGCAAAGAAGCCGAAAATTCCAACCAG
GCCATCAGTTCTGTCCTCAAAGCCGCCGCCTACGAACAGGGCATTCCGGAAGGCTGCATCGAGCAGCTGCCCGGCGAGCG
GGCGGTGGTCGAGGCGCTGATTCGCCTTAATCCGTATCTGGCCCTGGTGATCCCCCGGGGAGGGCACTCGCTCATCGACT
TTGTCGTGCGCAACGCGACTGTGCCGGTGCTGGAGACGGGGGTGGGCAACTGCCACATCTACGTCGCCGCCTCCGCCGAT
CTGGAGATGGCCCGCCGCATCGTCATCAACGCCAAGGTCCAGCGCCCCTCGGTCTGCAACGCCGCCGAGAAGCTGCTGGT
GCACCGAGACACGGTGGTGACGCATTTGGCCCCGCTGCTGGAGGATCTGCACGCCCACGGTATTGAAGTGCGCGGCTGCC
CGCGCACCGTTGCCTTCGACCCGAAGGTCAAAAGTGCCGGTGAAGAAGACTGGGGCAAGGAGTACCTCGACAAAATCATC
GCCATCAAAGTGGTCGATTCGACCCGTGAAGCGATCGACTGGATCAACCACTACGGCACCCGCCACTCAGAAGCGATCGT
CACCGCCAACTACGAGGAAGCCCGTCGCTTCACCGCCGCTATCGACGCGGCGGCGGTCTACGTCAACGCCTCGACCCGTT
TTACCGACGGCGGCGAATTCGGCTTCGGGGCCGAGATTGGCATTTCTACCCAAAAGTTGCACGCGCGCGGGCCGGTGGGC
CTCGTGGAACTGACCACCACCAAATATGTTGTGAGCGGTTCCGGCCAGATCCGGCCCTGA

Upstream 100 bases:

>100_bases
TGCGATTACGGTGGTGTTGACGCTGATCGTGCTGATCTTCTGGCTGGCCCGCCGTTCTAGACCCTAGAGATCACTACAGT
TCTTGCGGAAACCTTTGCAG

Downstream 100 bases:

>100_bases
GGCTGGACACTCGCCACCTTTTGCCTTACACTCGATATCTGTTGCCTTGCGGCAGCCGGGTGGATACTGGGAGGCTTGCT
TCCTAAGTCCCTTTGCCTGA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MESSLYETLKVTAQRAQRSTMALAQVPSGIKNKALRAMARSLRTAHSEILESNTTDLEFGRQMGLSETLLDRLKLTPQRL
EGMALSLEQIAALKDPVGEIVGGWRHPEGLEIVRVRVPLGLIGIIYEARPNVTADAIGLCLKSGNGVLLKGGKEAENSNQ
AISSVLKAAAYEQGIPEGCIEQLPGERAVVEALIRLNPYLALVIPRGGHSLIDFVVRNATVPVLETGVGNCHIYVAASAD
LEMARRIVINAKVQRPSVCNAAEKLLVHRDTVVTHLAPLLEDLHAHGIEVRGCPRTVAFDPKVKSAGEEDWGKEYLDKII
AIKVVDSTREAIDWINHYGTRHSEAIVTANYEEARRFTAAIDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPVG
LVELTTTKYVVSGSGQIRP

Sequences:

>Translated_419_residues
MESSLYETLKVTAQRAQRSTMALAQVPSGIKNKALRAMARSLRTAHSEILESNTTDLEFGRQMGLSETLLDRLKLTPQRL
EGMALSLEQIAALKDPVGEIVGGWRHPEGLEIVRVRVPLGLIGIIYEARPNVTADAIGLCLKSGNGVLLKGGKEAENSNQ
AISSVLKAAAYEQGIPEGCIEQLPGERAVVEALIRLNPYLALVIPRGGHSLIDFVVRNATVPVLETGVGNCHIYVAASAD
LEMARRIVINAKVQRPSVCNAAEKLLVHRDTVVTHLAPLLEDLHAHGIEVRGCPRTVAFDPKVKSAGEEDWGKEYLDKII
AIKVVDSTREAIDWINHYGTRHSEAIVTANYEEARRFTAAIDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPVG
LVELTTTKYVVSGSGQIRP
>Mature_419_residues
MESSLYETLKVTAQRAQRSTMALAQVPSGIKNKALRAMARSLRTAHSEILESNTTDLEFGRQMGLSETLLDRLKLTPQRL
EGMALSLEQIAALKDPVGEIVGGWRHPEGLEIVRVRVPLGLIGIIYEARPNVTADAIGLCLKSGNGVLLKGGKEAENSNQ
AISSVLKAAAYEQGIPEGCIEQLPGERAVVEALIRLNPYLALVIPRGGHSLIDFVVRNATVPVLETGVGNCHIYVAASAD
LEMARRIVINAKVQRPSVCNAAEKLLVHRDTVVTHLAPLLEDLHAHGIEVRGCPRTVAFDPKVKSAGEEDWGKEYLDKII
AIKVVDSTREAIDWINHYGTRHSEAIVTANYEEARRFTAAIDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPVG
LVELTTTKYVVSGSGQIRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=419, Percent_Identity=37.708830548926, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI62912457, Length=419, Percent_Identity=37.708830548926, Blast_Score=250, Evalue=2e-66,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=42.8921568627451, Blast_Score=338, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17569969, Length=411, Percent_Identity=35.2798053527981, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17569967, Length=411, Percent_Identity=35.2798053527981, Blast_Score=240, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=35.5971896955504, Blast_Score=255, Evalue=7e-69,
Organism=Drosophila melanogaster, GI21357643, Length=418, Percent_Identity=35.1674641148325, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_GLOVI (Q7NEF6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926869.1
- ProteinModelPortal:   Q7NEF6
- SMR:   Q7NEF6
- GeneID:   2602326
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3923
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- BioCyc:   GVIO251221:GLL3923-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45316; Mature: 45316

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESSLYETLKVTAQRAQRSTMALAQVPSGIKNKALRAMARSLRTAHSEILESNTTDLEFG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RQMGLSETLLDRLKLTPQRLEGMALSLEQIAALKDPVGEIVGGWRHPEGLEIVRVRVPLG
HHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEEECCC
LIGIIYEARPNVTADAIGLCLKSGNGVLLKGGKEAENSNQAISSVLKAAAYEQGIPEGCI
EEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
EQLPGERAVVEALIRLNPYLALVIPRGGHSLIDFVVRNATVPVLETGVGNCHIYVAASAD
HHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEECCCCCEEEEEEECCC
LEMARRIVINAKVQRPSVCNAAEKLLVHRDTVVTHLAPLLEDLHAHGIEVRGCPRTVAFD
HHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEC
PKVKSAGEEDWGKEYLDKIIAIKVVDSTREAIDWINHYGTRHSEAIVTANYEEARRFTAA
CCCCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHH
IDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPVGLVELTTTKYVVSGSGQIRP
HHEEEEEEECCCEECCCCCCCCCCEECCCHHHHHCCCCCEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MESSLYETLKVTAQRAQRSTMALAQVPSGIKNKALRAMARSLRTAHSEILESNTTDLEFG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RQMGLSETLLDRLKLTPQRLEGMALSLEQIAALKDPVGEIVGGWRHPEGLEIVRVRVPLG
HHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEEECCC
LIGIIYEARPNVTADAIGLCLKSGNGVLLKGGKEAENSNQAISSVLKAAAYEQGIPEGCI
EEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
EQLPGERAVVEALIRLNPYLALVIPRGGHSLIDFVVRNATVPVLETGVGNCHIYVAASAD
HHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCEEECCCCCEEEEEEECCC
LEMARRIVINAKVQRPSVCNAAEKLLVHRDTVVTHLAPLLEDLHAHGIEVRGCPRTVAFD
HHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEC
PKVKSAGEEDWGKEYLDKIIAIKVVDSTREAIDWINHYGTRHSEAIVTANYEEARRFTAA
CCCCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHH
IDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPVGLVELTTTKYVVSGSGQIRP
HHEEEEEEECCCEECCCCCCCCCCEECCCHHHHHCCCCCEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292