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The map label for this gene is tdcB [H]

Identifier: 37523438

GI number: 37523438

Start: 4074539

End: 4075534

Strand: Reverse

Name: tdcB [H]

Synonym: gll3869

Alternate gene names: 37523438

Gene position: 4075534-4074539 (Counterclockwise)

Preceding gene: 37523440

Following gene: 37523432

Centisome position: 87.48

GC content: 63.55

Gene sequence:

>996_bases
ATGTCCTCATCCGCCCCCACTTTGCCGGTGAGTTTCGGCGATATCCAGGCGGCTGCTGACCGTTTGAGGGGAGTCGCTCA
CCGCACGCCGGTTCTGACTTCGCGTACGGTGGACGACCTGACTGGAGCGCAGGTCTTCTTCAAGTGCGAAAATTTCCAAC
GCATGGGGGCGTTCAAGTTCCGGGGAGCCTACAATGCCCTCTCGCAACTGGACAAAGCGCAAAGGCGGCGCGGGGTGCTC
GCCTACTCCTCCGGCAACCACGCCCAGGCGATTGCCCTGGCGGGACAAATCCTGGAGATTCCAACGACGATCGTGATGCC
CAGCGACGCTCCGGCGGTCAAGCGGCGTGCCACCGAAGGTTACGGCGGCGAGGTGATCCTTTACGAGCGGTCTGAAACCA
CCCGCGAAGCCCTCGCCGACCAACTGGCGCGCGAACGGGGACTGGCGGTGATCCCGCCCTTTGACCACCCCCAGGTGGTA
GCAGGGCAGGGAACCGCCGGATTGGAACTTTTCGAGCAGGTGGGGGCGCTCGATGTGCTCGTCGTCTGCTGCGGCGGGGG
CGGCTTGCTCTCAGGATGCGCCATCGCCGCGGCGGCCGTGAGCCCCGGTTGTCAGGTAGTCGGGGTCGAACCCGCGCAGG
CGGACGATGCGATGCGCTCGTTTTATACGGGCGTCCTGCACACAGTCCACAACCCCGCCACGATCGCCGATGGGGCGCGC
ACTCCATCGCTGGGAGCCGTCACCTTTCCACTGGTGCGCCACTACGTTCATCAGATGGTGACCGTGGAGGAGGAAGCGAT
CGTGCGGGCGATGCTGTTTTTGTGGGAGCGGCTCAAGATCGTCGTGGAGCCCACCGGTGCCCTTGGGGCGGCAGCCCTTT
TCGAAGGCCGGGTGCAGGCAGCGGACAGGCGCGTTGGAGTCATTATTAGCGGTGGCAACGTCGATTTGCAGCTTCTCCAT
GAATTCATACGCGATATCGATAAGGGGTACAGTTAA

Upstream 100 bases:

>100_bases
AAAAACATAAAAATCATAGAATGCATTTCGCATCAACGCTCTCCGCCCTGCGGAGGAAATCCGTCAGAATAAGGTGATCC
CGTTACCAAAAAGTGCTGCG

Downstream 100 bases:

>100_bases
GTCTCAACAATATTTACTCTCCACCTGAAAAATAAGTGAGTCTGTCAGCCAAGTCGTTGTAAAGCTGATCGAAGGTTAAG
CAGATGACTCTTTTTGAGTT

Product: serine/threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSSSAPTLPVSFGDIQAAADRLRGVAHRTPVLTSRTVDDLTGAQVFFKCENFQRMGAFKFRGAYNALSQLDKAQRRRGVL
AYSSGNHAQAIALAGQILEIPTTIVMPSDAPAVKRRATEGYGGEVILYERSETTREALADQLARERGLAVIPPFDHPQVV
AGQGTAGLELFEQVGALDVLVVCCGGGGLLSGCAIAAAAVSPGCQVVGVEPAQADDAMRSFYTGVLHTVHNPATIADGAR
TPSLGAVTFPLVRHYVHQMVTVEEEAIVRAMLFLWERLKIVVEPTGALGAAALFEGRVQAADRRVGVIISGGNVDLQLLH
EFIRDIDKGYS

Sequences:

>Translated_331_residues
MSSSAPTLPVSFGDIQAAADRLRGVAHRTPVLTSRTVDDLTGAQVFFKCENFQRMGAFKFRGAYNALSQLDKAQRRRGVL
AYSSGNHAQAIALAGQILEIPTTIVMPSDAPAVKRRATEGYGGEVILYERSETTREALADQLARERGLAVIPPFDHPQVV
AGQGTAGLELFEQVGALDVLVVCCGGGGLLSGCAIAAAAVSPGCQVVGVEPAQADDAMRSFYTGVLHTVHNPATIADGAR
TPSLGAVTFPLVRHYVHQMVTVEEEAIVRAMLFLWERLKIVVEPTGALGAAALFEGRVQAADRRVGVIISGGNVDLQLLH
EFIRDIDKGYS
>Mature_330_residues
SSSAPTLPVSFGDIQAAADRLRGVAHRTPVLTSRTVDDLTGAQVFFKCENFQRMGAFKFRGAYNALSQLDKAQRRRGVLA
YSSGNHAQAIALAGQILEIPTTIVMPSDAPAVKRRATEGYGGEVILYERSETTREALADQLARERGLAVIPPFDHPQVVA
GQGTAGLELFEQVGALDVLVVCCGGGGLLSGCAIAAAAVSPGCQVVGVEPAQADDAMRSFYTGVLHTVHNPATIADGART
PSLGAVTFPLVRHYVHQMVTVEEEAIVRAMLFLWERLKIVVEPTGALGAAALFEGRVQAADRRVGVIISGGNVDLQLLHE
FIRDIDKGYS

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=314, Percent_Identity=40.7643312101911, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI19923959, Length=142, Percent_Identity=35.2112676056338, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=39.5498392282958, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1790207, Length=296, Percent_Identity=34.7972972972973, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=34.0764331210191, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71991565, Length=321, Percent_Identity=35.8255451713396, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17537387, Length=309, Percent_Identity=34.3042071197411, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=51.0971786833856, Blast_Score=317, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6320930, Length=304, Percent_Identity=33.8815789473684, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319788, Length=290, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355833, Length=323, Percent_Identity=39.3188854489164, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24645328, Length=213, Percent_Identity=38.0281690140845, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35178; Mature: 35046

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSAPTLPVSFGDIQAAADRLRGVAHRTPVLTSRTVDDLTGAQVFFKCENFQRMGAFKF
CCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCHHHCCCCCC
RGAYNALSQLDKAQRRRGVLAYSSGNHAQAIALAGQILEIPTTIVMPSDAPAVKRRATEG
CHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCC
YGGEVILYERSETTREALADQLARERGLAVIPPFDHPQVVAGQGTAGLELFEQVGALDVL
CCCEEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHHCHHEEE
VVCCGGGGLLSGCAIAAAAVSPGCQVVGVEPAQADDAMRSFYTGVLHTVHNPATIADGAR
EEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
TPSLGAVTFPLVRHYVHQMVTVEEEAIVRAMLFLWERLKIVVEPTGALGAAALFEGRVQA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
ADRRVGVIISGGNVDLQLLHEFIRDIDKGYS
CCCEEEEEEECCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSSAPTLPVSFGDIQAAADRLRGVAHRTPVLTSRTVDDLTGAQVFFKCENFQRMGAFKF
CCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCHHHCCCCCC
RGAYNALSQLDKAQRRRGVLAYSSGNHAQAIALAGQILEIPTTIVMPSDAPAVKRRATEG
CHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCC
YGGEVILYERSETTREALADQLARERGLAVIPPFDHPQVVAGQGTAGLELFEQVGALDVL
CCCEEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHHCHHEEE
VVCCGGGGLLSGCAIAAAAVSPGCQVVGVEPAQADDAMRSFYTGVLHTVHNPATIADGAR
EEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
TPSLGAVTFPLVRHYVHQMVTVEEEAIVRAMLFLWERLKIVVEPTGALGAAALFEGRVQA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHH
ADRRVGVIISGGNVDLQLLHEFIRDIDKGYS
CCCEEEEEEECCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA