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The map label for this gene is argD [H]

Identifier: 37523418

GI number: 37523418

Start: 4055904

End: 4057223

Strand: Direct

Name: argD [H]

Synonym: glr3849

Alternate gene names: 37523418

Gene position: 4055904-4057223 (Clockwise)

Preceding gene: 37523417

Following gene: 37523419

Centisome position: 87.05

GC content: 66.44

Gene sequence:

>1320_bases
ATGCTCAGTCTGCCCACCAAAGAGGCTTCTTTGCCCCGCGTCCCGCGCCTGGTGGGACCTCTACCCGGCCCCCGCGCCCA
GGCCCTTATTGCCCGCGACGAAGCGGTCACCTCGCCTTCCTACACCCGCGGTTACCCACTGGTGGCCGCCCGCGGCGAAG
GCTGCATGCTCGAAGACGTAGACGGCAACGTCTTTTTGGATCTGACCGCCGGGATCGCCGTCACCGCCACCGGCCACGCC
CATCCGGTGGTCGTGCGCGCCATCCAGGAGCAGGCCGCCAATCTGCTGCACATGTCGGGCACCGACTTTTATTACGAACC
GATGGCTGAACTGGCTGAGGCCCTGTGCGAGCGCGCTCCCTTCCCGACGGCGGCAGGCCGCCCCCGCGCCCGGGTGTTCT
TCAGCAATTCCGGCGCCGAATCGAACGAAGGGGCGCTGAAGCTGGCGCGCTACTACACCGGCCGCCAGCAGGTAGTAGCC
TTTTTGGGAGCCTTCCACGGCCGCACCTACGGAGCGATGTCGCTCACCGGCTCCAGGGCCGTGCAGCGCCAGGGTTTCGG
CCCGCTGGTACCCGGGATCAGCCACATTCCCTACGGCACCCACGCGAGCCTCGACTACCTCGAAGACAAACTGTTCCCGG
CGGTGTTGCCTCCTGAAGAGATAGCGGCCATCGTCGTCGAATCGATCCAGGGCGAAGGCGGCTATATCGTGCCGGAGGAC
GGCTTTCATGAGCGCATCCGCCAGATTTGCACCCGCCACGGCATCTTGATGGTGGTGGACGAGGTGCAGGCGGGCATGGG
CCGCACCGGCAAGCTCTTTGCCATCGAGCACTGGGGGGTCCAGCCCGATATCGTCACCCTCGCCAAGGGCATCGCGAGCG
GCCTGCCCCTGGGGGCCATCCTATCGCGGCCCGAGATCATGACCTGGCCCGCCGGGTCACACGCGACGACGTTTGGGGGC
AACCCGGTCGCCTGTGCCGCCGCCAACGCCACGCTCAAGCTTTTGGAAGCGGGGCTCATCGAGAACGCCGAGCGCATGGG
ACGTGTCCTCCAGGCGGGGCTGGGCCAATTGGCCGATCGCTTCTCCTTTGTCTCGGCTTCTCGGGGCAAGGGCCTGATGG
TGGCCGTCGATCTATTCGACGCGGCGGGCAACCTCGATCGCGAGCGGCGCGACCAGATCGTCGATCTGGCCTTTTACAGG
GGGCTGTTGCTGCTGGGTTGCGGCAAGGCGGCCATCCGCTTCTGCCCGCCGCTGGTGATCGACGCCGACCAGGTCCGGGT
CGCCCTCGACATACTCCGTCAAATCTTCGAGGAGCAATAG

Upstream 100 bases:

>100_bases
CCGTGCTGGATGTGTTTTCTGAATGGAAGACCGTCTACGTCGATTTTTCCGGTCAACTACAGCGCGCCCAGATCGACAAC
CGTTCGTGAGGACTACCCCG

Downstream 100 bases:

>100_bases
ACAGATAAATGAACGCTCTTGCGGCACAACAACTGTGGGCGAAGCTATGGGCGAAGTACCAGGCGCGGGTCGCCTACGCC
CGCACTTACCAGCGGATGAT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLSLPTKEASLPRVPRLVGPLPGPRAQALIARDEAVTSPSYTRGYPLVAARGEGCMLEDVDGNVFLDLTAGIAVTATGHA
HPVVVRAIQEQAANLLHMSGTDFYYEPMAELAEALCERAPFPTAAGRPRARVFFSNSGAESNEGALKLARYYTGRQQVVA
FLGAFHGRTYGAMSLTGSRAVQRQGFGPLVPGISHIPYGTHASLDYLEDKLFPAVLPPEEIAAIVVESIQGEGGYIVPED
GFHERIRQICTRHGILMVVDEVQAGMGRTGKLFAIEHWGVQPDIVTLAKGIASGLPLGAILSRPEIMTWPAGSHATTFGG
NPVACAAANATLKLLEAGLIENAERMGRVLQAGLGQLADRFSFVSASRGKGLMVAVDLFDAAGNLDRERRDQIVDLAFYR
GLLLLGCGKAAIRFCPPLVIDADQVRVALDILRQIFEEQ

Sequences:

>Translated_439_residues
MLSLPTKEASLPRVPRLVGPLPGPRAQALIARDEAVTSPSYTRGYPLVAARGEGCMLEDVDGNVFLDLTAGIAVTATGHA
HPVVVRAIQEQAANLLHMSGTDFYYEPMAELAEALCERAPFPTAAGRPRARVFFSNSGAESNEGALKLARYYTGRQQVVA
FLGAFHGRTYGAMSLTGSRAVQRQGFGPLVPGISHIPYGTHASLDYLEDKLFPAVLPPEEIAAIVVESIQGEGGYIVPED
GFHERIRQICTRHGILMVVDEVQAGMGRTGKLFAIEHWGVQPDIVTLAKGIASGLPLGAILSRPEIMTWPAGSHATTFGG
NPVACAAANATLKLLEAGLIENAERMGRVLQAGLGQLADRFSFVSASRGKGLMVAVDLFDAAGNLDRERRDQIVDLAFYR
GLLLLGCGKAAIRFCPPLVIDADQVRVALDILRQIFEEQ
>Mature_439_residues
MLSLPTKEASLPRVPRLVGPLPGPRAQALIARDEAVTSPSYTRGYPLVAARGEGCMLEDVDGNVFLDLTAGIAVTATGHA
HPVVVRAIQEQAANLLHMSGTDFYYEPMAELAEALCERAPFPTAAGRPRARVFFSNSGAESNEGALKLARYYTGRQQVVA
FLGAFHGRTYGAMSLTGSRAVQRQGFGPLVPGISHIPYGTHASLDYLEDKLFPAVLPPEEIAAIVVESIQGEGGYIVPED
GFHERIRQICTRHGILMVVDEVQAGMGRTGKLFAIEHWGVQPDIVTLAKGIASGLPLGAILSRPEIMTWPAGSHATTFGG
NPVACAAANATLKLLEAGLIENAERMGRVLQAGLGQLADRFSFVSASRGKGLMVAVDLFDAAGNLDRERRDQIVDLAFYR
GLLLLGCGKAAIRFCPPLVIDADQVRVALDILRQIFEEQ

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=405, Percent_Identity=34.0740740740741, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=31.5909090909091, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI284507298, Length=314, Percent_Identity=36.624203821656, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI188536080, Length=468, Percent_Identity=26.2820512820513, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI38679950, Length=468, Percent_Identity=26.2820512820513, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI38679946, Length=468, Percent_Identity=26.2820512820513, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24119277, Length=456, Percent_Identity=29.6052631578947, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI37574042, Length=443, Percent_Identity=27.0880361173815, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=28.0927835051546, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI226442705, Length=443, Percent_Identity=26.1851015801354, Blast_Score=132, Evalue=8e-31,
Organism=Escherichia coli, GI1789016, Length=407, Percent_Identity=38.5749385749386, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=39.3564356435644, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=38.1313131313131, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI145693181, Length=391, Percent_Identity=38.618925831202, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=36.6925064599483, Blast_Score=218, Evalue=7e-58,
Organism=Escherichia coli, GI1786991, Length=313, Percent_Identity=34.8242811501597, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786349, Length=323, Percent_Identity=30.9597523219814, Blast_Score=122, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=442, Percent_Identity=33.710407239819, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=32.4942791762014, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=36.9337979094077, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71992977, Length=426, Percent_Identity=28.8732394366197, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17541228, Length=470, Percent_Identity=25.9574468085106, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71981843, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=32.7790973871734, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=32.6086956521739, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6321456, Length=472, Percent_Identity=25.2118644067797, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324386, Length=344, Percent_Identity=24.1279069767442, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21357415, Length=426, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=33.4090909090909, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574759, Length=435, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21356575, Length=381, Percent_Identity=32.2834645669291, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI281366494, Length=463, Percent_Identity=25.9179265658747, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24667139, Length=463, Percent_Identity=25.9179265658747, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24667143, Length=463, Percent_Identity=25.9179265658747, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 46991; Mature: 46991

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLPTKEASLPRVPRLVGPLPGPRAQALIARDEAVTSPSYTRGYPLVAARGEGCMLEDV
CCCCCCCCCCCCCCCHHHCCCCCCCHHEEEECCHHCCCCCCCCCCCEEEECCCCCEEEEC
DGNVFLDLTAGIAVTATGHAHPVVVRAIQEQAANLLHMSGTDFYYEPMAELAEALCERAP
CCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCC
FPTAAGRPRARVFFSNSGAESNEGALKLARYYTGRQQVVAFLGAFHGRTYGAMSLTGSRA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCHH
VQRQGFGPLVPGISHIPYGTHASLDYLEDKLFPAVLPPEEIAAIVVESIQGEGGYIVPED
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEECCCC
GFHERIRQICTRHGILMVVDEVQAGMGRTGKLFAIEHWGVQPDIVTLAKGIASGLPLGAI
CHHHHHHHHHHHCCEEEEEEHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHH
LSRPEIMTWPAGSHATTFGGNPVACAAANATLKLLEAGLIENAERMGRVLQAGLGQLADR
HCCCCEEECCCCCCCEECCCCCEEEEECHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
FSFVSASRGKGLMVAVDLFDAAGNLDRERRDQIVDLAFYRGLLLLGCGKAAIRFCPPLVI
HHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEE
DADQVRVALDILRQIFEEQ
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSLPTKEASLPRVPRLVGPLPGPRAQALIARDEAVTSPSYTRGYPLVAARGEGCMLEDV
CCCCCCCCCCCCCCCHHHCCCCCCCHHEEEECCHHCCCCCCCCCCCEEEECCCCCEEEEC
DGNVFLDLTAGIAVTATGHAHPVVVRAIQEQAANLLHMSGTDFYYEPMAELAEALCERAP
CCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCC
FPTAAGRPRARVFFSNSGAESNEGALKLARYYTGRQQVVAFLGAFHGRTYGAMSLTGSRA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCHH
VQRQGFGPLVPGISHIPYGTHASLDYLEDKLFPAVLPPEEIAAIVVESIQGEGGYIVPED
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEECCCC
GFHERIRQICTRHGILMVVDEVQAGMGRTGKLFAIEHWGVQPDIVTLAKGIASGLPLGAI
CHHHHHHHHHHHCCEEEEEEHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHH
LSRPEIMTWPAGSHATTFGGNPVACAAANATLKLLEAGLIENAERMGRVLQAGLGQLADR
HCCCCEEECCCCCCCEECCCCCEEEEECHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
FSFVSASRGKGLMVAVDLFDAAGNLDRERRDQIVDLAFYRGLLLLGCGKAAIRFCPPLVI
HHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEE
DADQVRVALDILRQIFEEQ
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]