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The map label for this gene is pyrC [H]

Identifier: 37523391

GI number: 37523391

Start: 4027081

End: 4028304

Strand: Reverse

Name: pyrC [H]

Synonym: gvip513

Alternate gene names: 37523391

Gene position: 4028304-4027081 (Counterclockwise)

Preceding gene: 37523392

Following gene: 37523385

Centisome position: 86.46

GC content: 67.97

Gene sequence:

>1224_bases
GTGAGCCGCGTTCTCTTTCGGCAGGTCCGCAGACTCGATCCGGATACCGGGACCGACTCGATCGCCGATTGGCTCTGGGA
CAGTGCGACAGGTCGGGCTGAGCCTACGGGCGATCCCGCCGTCCGGGCCGACCGCGCGATCGATGGCGCCGGCCGCTTGA
TTCTTGCCCCGACCCTGTGCGATCTGTACGTCCGCTCGGGCGAGCCGGGGCACGAGGAGCGCGAAGATCTCGCATCGCTC
GCCGCGGCGGCGGCGGCCGGCGGCTACAGCCAGGTGGCGATTTTGCCCCACACCGAGCCGCCTGTCGACGACCCTGCCCA
GGTCGATTTTCTGCGCAGGCACTTTCCTGCAGGACCGGTAGAAGCCCTGGTACTCGGGGCGATCAGCCGCAATTGCGCAG
GGGAAGCCCTGGCGGAAGTGAGTAGTTTGCTGGAGGCGGGCGTGGTCGGCTTTACCGACGCGAGGCCGCTCGCCAACTGG
GCGCTCCTGAGGCGCTTTCTCGATTACGCCGCGGTGCTGGAGCGGCCGGTGCTCGTCTGGCCCTGCTTTGCTCCACTGGC
AACCGGGATTGCCCTCGAAGGCGACTGGGCCATTCGCCTGGGGCTTGCGGGCCGCCCGCCCCAGGCCGAGGGCATTGCCC
TGGCCGGTGTACTCGAACTGGTGCGCCTCACGGGCACAGCCGTGCACCTGATGCGCCTCTCCACCGCCCGTTCCGTCGAG
ATGGCGGCACAGGCGAAGGCCGACGGGTTGCCCGTCACCGCGAGTACTACCGTTCATCATCTGGTCCACGCGAGCCCCGA
TTTGGCCGAGTACGACCCGAACCTGCGCTTCGAGCCGCCCCTGGGCAACCCGGCGGATCGCGCGGCCCTGGTGGCCGCTC
TGGAGGCAGGGATCATCGACGCGGTCGCCTCCGACCATACCCCCTGGACCTATGAAGAGAAGACGCTTCCCTTTTCCCAG
GCTCCCCCCGGTGCCATCGCCCTCGAACTGGTTCTACCGCTGGTGTGGAATCTGGTGCGAGAGGGCCGACTTACTCCTTT
GCGCGCCTGGGAAGCCCTCAGCAGCGCACCGCGCCGCATCCTGGCGCTTAAACATCCCCAGGTCCTCGTGCTCTTCGACC
CGGACAAGACCTGGGTTCCCGGAACCGACACCCTCCACAGCCGCTCGCTGGCGACCGCCTGGCTGGGCCGAACGGTGCAG
GGCAGGGTACTCGAAGTCTTTTGA

Upstream 100 bases:

>100_bases
TGGTTATTGCCATTGCCTTTATTCCGCTGGCGCTGTTCTTTGCCACGCGCAACGGCTTCTACAACACCGATCGCTACCAC
GGCAACGGTTCCGCCCACTA

Downstream 100 bases:

>100_bases
TGGCACCTGCGAATATCAATGCACGTAAACCCGCCCTATTTCGGTCGAAAATTCAGTTTGATCTTGTGAGCAGATTGGTC
TTTGGAACTTCCACCCACGA

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 42 kDa non-catalytic chain [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSRVLFRQVRRLDPDTGTDSIADWLWDSATGRAEPTGDPAVRADRAIDGAGRLILAPTLCDLYVRSGEPGHEEREDLASL
AAAAAAGGYSQVAILPHTEPPVDDPAQVDFLRRHFPAGPVEALVLGAISRNCAGEALAEVSSLLEAGVVGFTDARPLANW
ALLRRFLDYAAVLERPVLVWPCFAPLATGIALEGDWAIRLGLAGRPPQAEGIALAGVLELVRLTGTAVHLMRLSTARSVE
MAAQAKADGLPVTASTTVHHLVHASPDLAEYDPNLRFEPPLGNPADRAALVAALEAGIIDAVASDHTPWTYEEKTLPFSQ
APPGAIALELVLPLVWNLVREGRLTPLRAWEALSSAPRRILALKHPQVLVLFDPDKTWVPGTDTLHSRSLATAWLGRTVQ
GRVLEVF

Sequences:

>Translated_407_residues
MSRVLFRQVRRLDPDTGTDSIADWLWDSATGRAEPTGDPAVRADRAIDGAGRLILAPTLCDLYVRSGEPGHEEREDLASL
AAAAAAGGYSQVAILPHTEPPVDDPAQVDFLRRHFPAGPVEALVLGAISRNCAGEALAEVSSLLEAGVVGFTDARPLANW
ALLRRFLDYAAVLERPVLVWPCFAPLATGIALEGDWAIRLGLAGRPPQAEGIALAGVLELVRLTGTAVHLMRLSTARSVE
MAAQAKADGLPVTASTTVHHLVHASPDLAEYDPNLRFEPPLGNPADRAALVAALEAGIIDAVASDHTPWTYEEKTLPFSQ
APPGAIALELVLPLVWNLVREGRLTPLRAWEALSSAPRRILALKHPQVLVLFDPDKTWVPGTDTLHSRSLATAWLGRTVQ
GRVLEVF
>Mature_406_residues
SRVLFRQVRRLDPDTGTDSIADWLWDSATGRAEPTGDPAVRADRAIDGAGRLILAPTLCDLYVRSGEPGHEEREDLASLA
AAAAAGGYSQVAILPHTEPPVDDPAQVDFLRRHFPAGPVEALVLGAISRNCAGEALAEVSSLLEAGVVGFTDARPLANWA
LLRRFLDYAAVLERPVLVWPCFAPLATGIALEGDWAIRLGLAGRPPQAEGIALAGVLELVRLTGTAVHLMRLSTARSVEM
AAQAKADGLPVTASTTVHHLVHASPDLAEYDPNLRFEPPLGNPADRAALVAALEAGIIDAVASDHTPWTYEEKTLPFSQA
PPGAIALELVLPLVWNLVREGRLTPLRAWEALSSAPRRILALKHPQVLVLFDPDKTWVPGTDTLHSRSLATAWLGRTVQG
RVLEVF

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=408, Percent_Identity=30.8823529411765, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI1786722, Length=405, Percent_Identity=23.4567901234568, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082175, Length=220, Percent_Identity=27.7272727272727, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=356, Percent_Identity=30.3370786516854, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322218, Length=377, Percent_Identity=24.4031830238727, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24642586, Length=375, Percent_Identity=27.4666666666667, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004722 [H]

Pfam domain/function: NA

EC number: 3.5.2.3

Molecular weight: Translated: 43608; Mature: 43477

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLFRQVRRLDPDTGTDSIADWLWDSATGRAEPTGDPAVRADRAIDGAGRLILAPTLC
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECHHH
DLYVRSGEPGHEEREDLASLAAAAAAGGYSQVAILPHTEPPVDDPAQVDFLRRHFPAGPV
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHH
EALVLGAISRNCAGEALAEVSSLLEAGVVGFTDARPLANWALLRRFLDYAAVLERPVLVW
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
PCFAPLATGIALEGDWAIRLGLAGRPPQAEGIALAGVLELVRLTGTAVHLMRLSTARSVE
ECHHHHHCCEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAAQAKADGLPVTASTTVHHLVHASPDLAEYDPNLRFEPPLGNPADRAALVAALEAGIID
HHHHHCCCCCCEEHHHHHHHHHHCCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHH
AVASDHTPWTYEEKTLPFSQAPPGAIALELVLPLVWNLVREGRLTPLRAWEALSSAPRRI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHE
LALKHPQVLVLFDPDKTWVPGTDTLHSRSLATAWLGRTVQGRVLEVF
EEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SRVLFRQVRRLDPDTGTDSIADWLWDSATGRAEPTGDPAVRADRAIDGAGRLILAPTLC
CHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECHHH
DLYVRSGEPGHEEREDLASLAAAAAAGGYSQVAILPHTEPPVDDPAQVDFLRRHFPAGPV
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHH
EALVLGAISRNCAGEALAEVSSLLEAGVVGFTDARPLANWALLRRFLDYAAVLERPVLVW
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
PCFAPLATGIALEGDWAIRLGLAGRPPQAEGIALAGVLELVRLTGTAVHLMRLSTARSVE
ECHHHHHCCEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAAQAKADGLPVTASTTVHHLVHASPDLAEYDPNLRFEPPLGNPADRAALVAALEAGIID
HHHHHCCCCCCEEHHHHHHHHHHCCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHH
AVASDHTPWTYEEKTLPFSQAPPGAIALELVLPLVWNLVREGRLTPLRAWEALSSAPRRI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHE
LALKHPQVLVLFDPDKTWVPGTDTLHSRSLATAWLGRTVQGRVLEVF
EEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]