Click here to switch to the map view.

The map label for this gene is fcl [C]

Identifier: 37523361

GI number: 37523361

Start: 4001043

End: 4001999

Strand: Direct

Name: fcl [C]

Synonym: glr3792

Alternate gene names: 37523361

Gene position: 4001043-4001999 (Clockwise)

Preceding gene: 37523359

Following gene: 37523362

Centisome position: 85.88

GC content: 65.31

Gene sequence:

>957_bases
ATGCAAACGGACTTCGAGCGCGCCAAGATCCTGGTGAGCGGCGCGGGCGGCTTTCTCGGACGCCACGTCGTCGAACAACT
GCTGGCCCGGGGCGCCCGGGCGCAGAACCTGGTGACCCCGCGCTCGGGCGAACTGGACCTGCGCGAGCCGGACGCCTGCG
CGCGGGCCGTCGAAGGCATGGACCTGGTAATCCACCTGGCGGCCAAGGTGGGCGGTATCGGCCTCAACCGCGAAAAACCG
GCCGAACTCTACTACGACAACCTGATGATGGGTACCCATCTCATCCACCAGAGCTACAAAGCCGGTGTGGGCAAATTTGT
CTGTGTGGGCACGATCTGCGCCTACCCGAAGTTCACCCCGGTGCCCTTCCGCGAGGACGATCTCTGGAACGGCTACCCCG
AGGAGACCAACGCCCCCTACGGCGTCGCCAAAAAAGCCCTGCTGGTGCAGTTGCAGGCCTACCGGGCGCAGTACGGCTTC
AACGGCATCTACCTGCTGCCGGTCAACCTCTACGGCCCCTGGGACAATTTCGACCCGAAAAGCTCCCACGTCATCCCGGC
GCTCATTTACAAAATCGCCCAGGCCAAACAGGCGGGACAGAAGACGTTGCCCGTGTGGGGCGACGGCAGTCCGACGCGGG
AGTTTCTCTATGTCGATGATGCGGCGGCCGGTATCGTCGAAGCCGCCCGCACTTACGACGGAGCGGAGCCGGTCAACCTG
GGCACCGGCGCAGAGATTTCCATCCGGGATCTGGTGGAGATGCTGTGCGAGCTGATGGATTTCAAAGGCGAAATTCTCTG
GGAGACCGACAAGCCCAACGGCCAGCCCCGCCGCTGCCTCGACACCTCCCGGGCTCGCGCCGAGTTCGGCTTTGCCGCCA
GCACCGGCCTGGCCGAGGGCCTGCGGCGCACCCTCGAATGGTACGCCCGCCACGGCGAGCGCCTGAGCCTCGTCTAG

Upstream 100 bases:

>100_bases
GACCTACCGATGCTACGACATTCCCGCCCGCTTGGTAAACTCGGCCGCCCACGGCCGCGCACGGTACACTGATCTACGAC
CTGAGAGGGGCCTCTTCGCG

Downstream 100 bases:

>100_bases
CGCTATCTATTTGCATCTATAGGAACTTTCTGAAGGTCCGCGCCAGGCGCGGGCTTTTTTTTCACGATTACCGTTATCGA
CAGGCCAACTATGGAACCGA

Product: GDP-fucose synthetase

Products: GDP-4-dehydro-6-deoxy-D-mannose; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MQTDFERAKILVSGAGGFLGRHVVEQLLARGARAQNLVTPRSGELDLREPDACARAVEGMDLVIHLAAKVGGIGLNREKP
AELYYDNLMMGTHLIHQSYKAGVGKFVCVGTICAYPKFTPVPFREDDLWNGYPEETNAPYGVAKKALLVQLQAYRAQYGF
NGIYLLPVNLYGPWDNFDPKSSHVIPALIYKIAQAKQAGQKTLPVWGDGSPTREFLYVDDAAAGIVEAARTYDGAEPVNL
GTGAEISIRDLVEMLCELMDFKGEILWETDKPNGQPRRCLDTSRARAEFGFAASTGLAEGLRRTLEWYARHGERLSLV

Sequences:

>Translated_318_residues
MQTDFERAKILVSGAGGFLGRHVVEQLLARGARAQNLVTPRSGELDLREPDACARAVEGMDLVIHLAAKVGGIGLNREKP
AELYYDNLMMGTHLIHQSYKAGVGKFVCVGTICAYPKFTPVPFREDDLWNGYPEETNAPYGVAKKALLVQLQAYRAQYGF
NGIYLLPVNLYGPWDNFDPKSSHVIPALIYKIAQAKQAGQKTLPVWGDGSPTREFLYVDDAAAGIVEAARTYDGAEPVNL
GTGAEISIRDLVEMLCELMDFKGEILWETDKPNGQPRRCLDTSRARAEFGFAASTGLAEGLRRTLEWYARHGERLSLV
>Mature_318_residues
MQTDFERAKILVSGAGGFLGRHVVEQLLARGARAQNLVTPRSGELDLREPDACARAVEGMDLVIHLAAKVGGIGLNREKP
AELYYDNLMMGTHLIHQSYKAGVGKFVCVGTICAYPKFTPVPFREDDLWNGYPEETNAPYGVAKKALLVQLQAYRAQYGF
NGIYLLPVNLYGPWDNFDPKSSHVIPALIYKIAQAKQAGQKTLPVWGDGSPTREFLYVDDAAAGIVEAARTYDGAEPVNL
GTGAEISIRDLVEMLCELMDFKGEILWETDKPNGQPRRCLDTSRARAEFGFAASTGLAEGLRRTLEWYARHGERLSLV

Specific function: Putative nucleotide sugar epimerase/dehydrogenase [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=312, Percent_Identity=32.6923076923077, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI7657641, Length=330, Percent_Identity=24.8484848484848, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI42516563, Length=331, Percent_Identity=23.5649546827795, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788365, Length=322, Percent_Identity=35.4037267080745, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI48994969, Length=343, Percent_Identity=24.4897959183673, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788353, Length=348, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786974, Length=341, Percent_Identity=26.099706744868, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17554428, Length=310, Percent_Identity=29.0322580645161, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17568069, Length=340, Percent_Identity=24.1176470588235, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922778, Length=310, Percent_Identity=28.7096774193548, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21356223, Length=323, Percent_Identity=24.4582043343653, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 1.1.1.271

Molecular weight: Translated: 35051; Mature: 35051

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDFERAKILVSGAGGFLGRHVVEQLLARGARAQNLVTPRSGELDLREPDACARAVEGM
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCH
DLVIHLAAKVGGIGLNREKPAELYYDNLMMGTHLIHQSYKAGVGKFVCVGTICAYPKFTP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
VPFREDDLWNGYPEETNAPYGVAKKALLVQLQAYRAQYGFNGIYLLPVNLYGPWDNFDPK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCC
SSHVIPALIYKIAQAKQAGQKTLPVWGDGSPTREFLYVDDAAAGIVEAARTYDGAEPVNL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCC
GTGAEISIRDLVEMLCELMDFKGEILWETDKPNGQPRRCLDTSRARAEFGFAASTGLAEG
CCCCEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LRRTLEWYARHGERLSLV
HHHHHHHHHHCCCEECCC
>Mature Secondary Structure
MQTDFERAKILVSGAGGFLGRHVVEQLLARGARAQNLVTPRSGELDLREPDACARAVEGM
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCH
DLVIHLAAKVGGIGLNREKPAELYYDNLMMGTHLIHQSYKAGVGKFVCVGTICAYPKFTP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
VPFREDDLWNGYPEETNAPYGVAKKALLVQLQAYRAQYGFNGIYLLPVNLYGPWDNFDPK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCC
SSHVIPALIYKIAQAKQAGQKTLPVWGDGSPTREFLYVDDAAAGIVEAARTYDGAEPVNL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCC
GTGAEISIRDLVEMLCELMDFKGEILWETDKPNGQPRRCLDTSRARAEFGFAASTGLAEG
CCCCEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LRRTLEWYARHGERLSLV
HHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-L-fucose; NADP+

Specific reaction: GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]