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The map label for this gene is serA [H]

Identifier: 37523345

GI number: 37523345

Start: 3983612

End: 3984544

Strand: Direct

Name: serA [H]

Synonym: glr3776

Alternate gene names: 37523345

Gene position: 3983612-3984544 (Clockwise)

Preceding gene: 37523344

Following gene: 37523346

Centisome position: 85.5

GC content: 66.77

Gene sequence:

>933_bases
ATGCGCGTCCTGGTCACCTGCCCGCCGATGCTGCGGCGCATCGAGCACTTTAAAGACCACTTCGAAGCGCGAGGGGCCGA
GGTGTATTGCCCGCCGGTAGTACAGACACTCTCGGTTGCTGAACTGGTCGATCTATTGCCCGGCTTCGACGGCTGGATCA
TCGGCGACGACCCGGCGACGCGGGCAGTCTTCGCAGCCGGAGTGCGCGGGCGGCTCAAGGCGGCGGTCAAGTGGGGCGTG
GGTGTCGACAACGTCGATTTTGCCGCCGCCCGCGCTCTGGGCATTCCGATTGCCAACACCCCGGCGATGTTCGGGGCCGA
AGTGGCGGATGTGGCCGTCTCCTACGTGACGGCCCTGGCGCGCGAGACGTTTTCTGTCGACCGGGAGGTGCGCGCCGGTG
GCTGGCCGAAGCCCTGCGGCGTCTCACTGGCGGGCAAAACCGTCGCTCTGGTCGGGTTTGGGGATATCGGCAAAGCCACT
GCCCGGCGTCTTGTCGCAGCCGAGATGCGCGTCATCGCCTACGACCCGCGCTATGTCCCGGAGGCGGGTTCTGAGGCGGT
CGAGCCGGCCCTGTGGCCCGAGCGCCTCGGCGAGGCCGATTTTATCGTCTTCACCTGCGCCCTCACCCCCGAAAACCGTC
ACATGCTCGGGGTCGCAGCGTTTGGGCTGACCAAGCCCGGTGTGCGCGTCGTCAATGTCGCCCGCGGACCGCTCATCGAC
GAGCAGGCGCTGATTGTGGCCCTGGCAAGCGGCCGGGTGCATTCGGCCGCTCTCGATGTCTTCGAAGTGGAACCGCTCGC
GGCCGATTCGCCCCTGCGCGCTCACGAGCGCTGCATTTTCGGCTCCCACAACGCCTCGAACACCGCCGATGCCGTCGAGC
GCGCAAGCTTCAAGGCGATGGCGCTGCTGTTCGGTTTTTTGGGGATCGACTGA

Upstream 100 bases:

>100_bases
TTCGAGACGCCCCGGCGCGAGTCCGCCGACATCGACGATCAAGAAGGCTGGGACATTGCCGAGATGATCGCCCGCACCCT
GTACCCTGCCGTTGTCTAAA

Downstream 100 bases:

>100_bases
GTGCCGACGACCGCAGTGATCACCGGCGCCAACGGCGGTATCGGACGGGCGCTCTGCTCGGTCTTCAAGGCCGCCGGCCA
CCGGGTGGTGGCTCTCGATG

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRVLVTCPPMLRRIEHFKDHFEARGAEVYCPPVVQTLSVAELVDLLPGFDGWIIGDDPATRAVFAAGVRGRLKAAVKWGV
GVDNVDFAAARALGIPIANTPAMFGAEVADVAVSYVTALARETFSVDREVRAGGWPKPCGVSLAGKTVALVGFGDIGKAT
ARRLVAAEMRVIAYDPRYVPEAGSEAVEPALWPERLGEADFIVFTCALTPENRHMLGVAAFGLTKPGVRVVNVARGPLID
EQALIVALASGRVHSAALDVFEVEPLAADSPLRAHERCIFGSHNASNTADAVERASFKAMALLFGFLGID

Sequences:

>Translated_310_residues
MRVLVTCPPMLRRIEHFKDHFEARGAEVYCPPVVQTLSVAELVDLLPGFDGWIIGDDPATRAVFAAGVRGRLKAAVKWGV
GVDNVDFAAARALGIPIANTPAMFGAEVADVAVSYVTALARETFSVDREVRAGGWPKPCGVSLAGKTVALVGFGDIGKAT
ARRLVAAEMRVIAYDPRYVPEAGSEAVEPALWPERLGEADFIVFTCALTPENRHMLGVAAFGLTKPGVRVVNVARGPLID
EQALIVALASGRVHSAALDVFEVEPLAADSPLRAHERCIFGSHNASNTADAVERASFKAMALLFGFLGID
>Mature_310_residues
MRVLVTCPPMLRRIEHFKDHFEARGAEVYCPPVVQTLSVAELVDLLPGFDGWIIGDDPATRAVFAAGVRGRLKAAVKWGV
GVDNVDFAAARALGIPIANTPAMFGAEVADVAVSYVTALARETFSVDREVRAGGWPKPCGVSLAGKTVALVGFGDIGKAT
ARRLVAAEMRVIAYDPRYVPEAGSEAVEPALWPERLGEADFIVFTCALTPENRHMLGVAAFGLTKPGVRVVNVARGPLID
EQALIVALASGRVHSAALDVFEVEPLAADSPLRAHERCIFGSHNASNTADAVERASFKAMALLFGFLGID

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=267, Percent_Identity=35.5805243445693, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI6912396, Length=264, Percent_Identity=32.5757575757576, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI145580578, Length=231, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4557499, Length=231, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4557497, Length=231, Percent_Identity=32.4675324675325, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI61743967, Length=231, Percent_Identity=32.4675324675325, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI145580575, Length=231, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI87082289, Length=227, Percent_Identity=34.8017621145374, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=32.8185328185328, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789279, Length=233, Percent_Identity=27.4678111587983, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=32.5670498084291, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=203, Percent_Identity=30.5418719211823, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=200, Percent_Identity=32, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=220, Percent_Identity=28.1818181818182, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=250, Percent_Identity=29.2, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=163, Percent_Identity=30.0613496932515, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=278, Percent_Identity=33.8129496402878, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28571528, Length=256, Percent_Identity=32.8125, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=206, Percent_Identity=35.9223300970874, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646448, Length=206, Percent_Identity=35.9223300970874, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646452, Length=206, Percent_Identity=35.9223300970874, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646450, Length=206, Percent_Identity=35.9223300970874, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62472511, Length=206, Percent_Identity=35.9223300970874, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28574286, Length=224, Percent_Identity=30.3571428571429, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=30.2158273381295, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45552429, Length=323, Percent_Identity=28.4829721362229, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585514, Length=322, Percent_Identity=27.3291925465839, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574282, Length=322, Percent_Identity=27.3291925465839, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45551003, Length=322, Percent_Identity=28.2608695652174, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574284, Length=325, Percent_Identity=27.3846153846154, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32943; Mature: 32943

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVTCPPMLRRIEHFKDHFEARGAEVYCPPVVQTLSVAELVDLLPGFDGWIIGDDPAT
CEEEEECCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCEEECCCCHH
RAVFAAGVRGRLKAAVKWGVGVDNVDFAAARALGIPIANTPAMFGAEVADVAVSYVTALA
HHHHHHCHHHHHHHHEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
RETFSVDREVRAGGWPKPCGVSLAGKTVALVGFGDIGKATARRLVAAEMRVIAYDPRYVP
HHHHHCCCHHHCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCCC
EAGSEAVEPALWPERLGEADFIVFTCALTPENRHMLGVAAFGLTKPGVRVVNVARGPLID
CCCCHHCCCCCCHHHCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCCCC
EQALIVALASGRVHSAALDVFEVEPLAADSPLRAHERCIFGSHNASNTADAVERASFKAM
CCEEEEEEECCCCCHHHHCEEEECCCCCCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHH
ALLFGFLGID
HHHHHHHCCC
>Mature Secondary Structure
MRVLVTCPPMLRRIEHFKDHFEARGAEVYCPPVVQTLSVAELVDLLPGFDGWIIGDDPAT
CEEEEECCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCEEECCCCHH
RAVFAAGVRGRLKAAVKWGVGVDNVDFAAARALGIPIANTPAMFGAEVADVAVSYVTALA
HHHHHHCHHHHHHHHEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
RETFSVDREVRAGGWPKPCGVSLAGKTVALVGFGDIGKATARRLVAAEMRVIAYDPRYVP
HHHHHCCCHHHCCCCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHEEEEECCCCCC
EAGSEAVEPALWPERLGEADFIVFTCALTPENRHMLGVAAFGLTKPGVRVVNVARGPLID
CCCCHHCCCCCCHHHCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCCCC
EQALIVALASGRVHSAALDVFEVEPLAADSPLRAHERCIFGSHNASNTADAVERASFKAM
CCEEEEEEECCCCCHHHHCEEEECCCCCCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHH
ALLFGFLGID
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]