Click here to switch to the map view.

The map label for this gene is thsB [H]

Identifier: 37523317

GI number: 37523317

Start: 3959301

End: 3960818

Strand: Direct

Name: thsB [H]

Synonym: glr3748

Alternate gene names: 37523317

Gene position: 3959301-3960818 (Clockwise)

Preceding gene: 37523316

Following gene: 37523318

Centisome position: 84.98

GC content: 71.61

Gene sequence:

>1518_bases
GTGACCGCCGAGGGACACCTGAAGGTGCTGCGCACCAATATTGCCGCCGTGCGGGCGATCGTCGAGACCGTGGCGGGCAC
CCTGGGGCCGAAGGGCCTCGACGTGTTGCTGGTGGACGATGCGGGCCGCATGACCCTCACCAACGACGGCGTCGAAATCC
TCGGGCAGCTCGACGCCCAGCATCCGGCCGCCCGCCTGGTCATCCAGGTGGCCGAGGCCCAGGACCGCAGCGTCGGCGAC
GGCACCACCACCGCCACGGTCCTGGCTGGGGCGCTGCTCGATGCTTGCCTGGAGCGCGTCGAGCAGGGCATCGCCATCAA
TGCGCTGATCGCGGGTCTGCGCGCCGGGGTGCAAGCGGCCCTCGACGCTCTGCGCAGCGCCGCTGTGCCTGTCACGGACC
TGGCCGATCCGCGGGTGCCGGCTGTCACCCGCATCGCCGCGCGCGGCGACGAGGCCATTGCCCGGATCGTCTGGGAGGCG
GCGAACCACATCGGCTTCGAGCGCCTGCGCGCCGGGCGCGTGCGCCTCGGCGAACTGGTCAGCTCCCGCGTGGGCGAATC
CCACCGCTGGATCGAAGGCCTGGTCCTTGCCAAGCAGCCGCTGCAGTTGCCGCCGGAGGGTTTTTCCCGGACTGGGGGCG
TGCTGGTACTTTCTGACCCCTTCGAATCCGAGAGCTTCGATGCCCAGGTGCTCGCCACCGAGGGGGGGTTTGCCCGCTAC
CTCGAAGCCCAGGAGCAGTTGCGCCGCCGGGTGCAGGTCCTCGTCGAGGCTGGGGTGGTGCTGTTGGTGTGCGAAAAGAG
CATTTCCCCAACGGCCGAACCGCTCTTGGCCGAGGCGGGGATCGTGGCCCTGCAGCGAATCCTGCGCCGCGACAGCGAGC
GGACGGCCGGCTTCAGCGGCGCGGTGCCGGTGCGCCAGGGCCAGCTGGCCCGGGGGGCGACCGCCCTGGCCCCGGTATTG
GGCAAGGCGACGGTGCGCTACGAACGCCCTTCCCAGAAGCTCGTCCTCAGCGCCGGGGGTGGGGAGCCCCTGGCGGCGAT
GATCGTCGGTGCGGTGAGCGCCGAGGTGGCCGCCGAACTGGAGCGCGTCGCCGTCGACGCCTGCAGCGCGCTGCAGGCCG
CCCTCACCTCGGGGGTGGTGACGGGCGGCGGGGTGGCGGAACTGGCGAGCCGCCGGGCGGTGAGCGCCCTGGCTGCGCGC
ACCGAGGGGGTGGTGCGCTACGGCATCGAGGCGGTGGCCGCCGCCCTGCGCAGGCCCCTGGAGCAGATCGTGAGCAACAG
TGGCTATTCGGCCCTCGAAAAAGTTGCCCAGTTGGAGGCGATGCACCAGCGCACCGCCAACCCGCACCTGGGCATCGACT
GCGAGAACGGCGAGGTGGTCGATCTGTGGCAAGCCGGGGTGATCGACCCGCTGGCGGTCAAGACCTGCGCCCTCGAAGCG
GCGGCCGAAATCGCCGAACGCATCCTGCGCATCCAGACCGTCGTGCGCCGCCGCGAAACTCCTCCCGGGGGCGCTTGA

Upstream 100 bases:

>100_bases
TCGATTACGCCGCCCTCGACCCGTGGGTGACCTTTCACATCTGGGAGCACATGCGGGCGCTGGTGGAGCCTGAGAACGAA
GGCTTCGAGGGGTTGCTGGT

Downstream 100 bases:

>100_bases
ATTGCCCAAAAAATAGGCGAAGATCGACTCTACCAGGCGTCAAAGGATCCTAGCGCGCTATGTCGCGGCTCAACCCGGTG
CAAGTGGCGGCACTTGTCAC

Product: thermosome-like protein

Products: NA

Alternate protein names: Chaperonin subunit beta; Thermosome subunit 2 [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTAEGHLKVLRTNIAAVRAIVETVAGTLGPKGLDVLLVDDAGRMTLTNDGVEILGQLDAQHPAARLVIQVAEAQDRSVGD
GTTTATVLAGALLDACLERVEQGIAINALIAGLRAGVQAALDALRSAAVPVTDLADPRVPAVTRIAARGDEAIARIVWEA
ANHIGFERLRAGRVRLGELVSSRVGESHRWIEGLVLAKQPLQLPPEGFSRTGGVLVLSDPFESESFDAQVLATEGGFARY
LEAQEQLRRRVQVLVEAGVVLLVCEKSISPTAEPLLAEAGIVALQRILRRDSERTAGFSGAVPVRQGQLARGATALAPVL
GKATVRYERPSQKLVLSAGGGEPLAAMIVGAVSAEVAAELERVAVDACSALQAALTSGVVTGGGVAELASRRAVSALAAR
TEGVVRYGIEAVAAALRRPLEQIVSNSGYSALEKVAQLEAMHQRTANPHLGIDCENGEVVDLWQAGVIDPLAVKTCALEA
AAEIAERILRIQTVVRRRETPPGGA

Sequences:

>Translated_505_residues
MTAEGHLKVLRTNIAAVRAIVETVAGTLGPKGLDVLLVDDAGRMTLTNDGVEILGQLDAQHPAARLVIQVAEAQDRSVGD
GTTTATVLAGALLDACLERVEQGIAINALIAGLRAGVQAALDALRSAAVPVTDLADPRVPAVTRIAARGDEAIARIVWEA
ANHIGFERLRAGRVRLGELVSSRVGESHRWIEGLVLAKQPLQLPPEGFSRTGGVLVLSDPFESESFDAQVLATEGGFARY
LEAQEQLRRRVQVLVEAGVVLLVCEKSISPTAEPLLAEAGIVALQRILRRDSERTAGFSGAVPVRQGQLARGATALAPVL
GKATVRYERPSQKLVLSAGGGEPLAAMIVGAVSAEVAAELERVAVDACSALQAALTSGVVTGGGVAELASRRAVSALAAR
TEGVVRYGIEAVAAALRRPLEQIVSNSGYSALEKVAQLEAMHQRTANPHLGIDCENGEVVDLWQAGVIDPLAVKTCALEA
AAEIAERILRIQTVVRRRETPPGGA
>Mature_504_residues
TAEGHLKVLRTNIAAVRAIVETVAGTLGPKGLDVLLVDDAGRMTLTNDGVEILGQLDAQHPAARLVIQVAEAQDRSVGDG
TTTATVLAGALLDACLERVEQGIAINALIAGLRAGVQAALDALRSAAVPVTDLADPRVPAVTRIAARGDEAIARIVWEAA
NHIGFERLRAGRVRLGELVSSRVGESHRWIEGLVLAKQPLQLPPEGFSRTGGVLVLSDPFESESFDAQVLATEGGFARYL
EAQEQLRRRVQVLVEAGVVLLVCEKSISPTAEPLLAEAGIVALQRILRRDSERTAGFSGAVPVRQGQLARGATALAPVLG
KATVRYERPSQKLVLSAGGGEPLAAMIVGAVSAEVAAELERVAVDACSALQAALTSGVVTGGGVAELASRRAVSALAART
EGVVRYGIEAVAAALRRPLEQIVSNSGYSALEKVAQLEAMHQRTANPHLGIDCENGEVVDLWQAGVIDPLAVKTCALEAA
AEIAERILRIQTVVRRRETPPGGA

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI63162572, Length=518, Percent_Identity=27.6061776061776, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI57863257, Length=514, Percent_Identity=27.6264591439689, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI24307939, Length=536, Percent_Identity=25.7462686567164, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI38455427, Length=519, Percent_Identity=25.8188824662813, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI5453607, Length=515, Percent_Identity=25.631067961165, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI58761484, Length=470, Percent_Identity=26.3829787234043, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI58331173, Length=516, Percent_Identity=26.3565891472868, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI4502643, Length=519, Percent_Identity=26.2042389210019, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI302058290, Length=506, Percent_Identity=25.6916996047431, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI261399877, Length=492, Percent_Identity=24.390243902439, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI48762932, Length=523, Percent_Identity=22.7533460803059, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI302058292, Length=508, Percent_Identity=23.8188976377953, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI5453603, Length=123, Percent_Identity=41.4634146341463, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI58331171, Length=512, Percent_Identity=24.0234375, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI57863259, Length=261, Percent_Identity=28.3524904214559, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI41399285, Length=157, Percent_Identity=33.7579617834395, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI31542947, Length=157, Percent_Identity=33.7579617834395, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790586, Length=168, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25148561, Length=518, Percent_Identity=25.8687258687259, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI25147750, Length=500, Percent_Identity=28.6, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25144674, Length=512, Percent_Identity=26.3671875, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17564182, Length=518, Percent_Identity=26.4478764478764, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17532603, Length=523, Percent_Identity=25.2390057361377, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17532601, Length=535, Percent_Identity=26.9158878504673, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI32566944, Length=416, Percent_Identity=25.2403846153846, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71998178, Length=554, Percent_Identity=22.5631768953069, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25144678, Length=546, Percent_Identity=26.1904761904762, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25144680, Length=330, Percent_Identity=28.4848484848485, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555558, Length=148, Percent_Identity=34.4594594594595, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193210679, Length=148, Percent_Identity=34.4594594594595, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322446, Length=525, Percent_Identity=26.0952380952381, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6322524, Length=522, Percent_Identity=24.3295019157088, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6322350, Length=524, Percent_Identity=24.8091603053435, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322049, Length=510, Percent_Identity=25.0980392156863, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320058, Length=518, Percent_Identity=23.1660231660232, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320393, Length=540, Percent_Identity=24.4444444444444, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320418, Length=109, Percent_Identity=43.1192660550459, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322452, Length=533, Percent_Identity=22.5140712945591, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323288, Length=189, Percent_Identity=29.1005291005291, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18858175, Length=531, Percent_Identity=29.1902071563089, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28571140, Length=531, Percent_Identity=29.1902071563089, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17647245, Length=524, Percent_Identity=25.5725190839695, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24652903, Length=522, Percent_Identity=25.6704980842912, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24647512, Length=513, Percent_Identity=27.4853801169591, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24647510, Length=513, Percent_Identity=27.4853801169591, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24649027, Length=515, Percent_Identity=26.9902912621359, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24649029, Length=515, Percent_Identity=26.9902912621359, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24645179, Length=492, Percent_Identity=24.1869918699187, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24583944, Length=524, Percent_Identity=23.0916030534351, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI18859933, Length=526, Percent_Identity=25.4752851711027, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19921848, Length=112, Percent_Identity=33.9285714285714, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24641193, Length=156, Percent_Identity=32.0512820512821, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641191, Length=156, Percent_Identity=32.0512820512821, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550936, Length=156, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550132, Length=156, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550935, Length=156, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 52784; Mature: 52653

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEGHLKVLRTNIAAVRAIVETVAGTLGPKGLDVLLVDDAGRMTLTNDGVEILGQLDAQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCHHHHHHHCCC
HPAARLVIQVAEAQDRSVGDGTTTATVLAGALLDACLERVEQGIAINALIAGLRAGVQAA
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LDALRSAAVPVTDLADPRVPAVTRIAARGDEAIARIVWEAANHIGFERLRAGRVRLGELV
HHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
SSRVGESHRWIEGLVLAKQPLQLPPEGFSRTGGVLVLSDPFESESFDAQVLATEGGFARY
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHH
LEAQEQLRRRVQVLVEAGVVLLVCEKSISPTAEPLLAEAGIVALQRILRRDSERTAGFSG
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
AVPVRQGQLARGATALAPVLGKATVRYERPSQKLVLSAGGGEPLAAMIVGAVSAEVAAEL
CCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
ERVAVDACSALQAALTSGVVTGGGVAELASRRAVSALAARTEGVVRYGIEAVAAALRRPL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIVSNSGYSALEKVAQLEAMHQRTANPHLGIDCENGEVVDLWQAGVIDPLAVKTCALEA
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEHHHCCCCCHHHHHHHHHHH
AAEIAERILRIQTVVRRRETPPGGA
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TAEGHLKVLRTNIAAVRAIVETVAGTLGPKGLDVLLVDDAGRMTLTNDGVEILGQLDAQ
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCHHHHHHHCCC
HPAARLVIQVAEAQDRSVGDGTTTATVLAGALLDACLERVEQGIAINALIAGLRAGVQAA
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LDALRSAAVPVTDLADPRVPAVTRIAARGDEAIARIVWEAANHIGFERLRAGRVRLGELV
HHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
SSRVGESHRWIEGLVLAKQPLQLPPEGFSRTGGVLVLSDPFESESFDAQVLATEGGFARY
HHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHH
LEAQEQLRRRVQVLVEAGVVLLVCEKSISPTAEPLLAEAGIVALQRILRRDSERTAGFSG
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
AVPVRQGQLARGATALAPVLGKATVRYERPSQKLVLSAGGGEPLAAMIVGAVSAEVAAEL
CCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
ERVAVDACSALQAALTSGVVTGGGVAELASRRAVSALAARTEGVVRYGIEAVAAALRRPL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIVSNSGYSALEKVAQLEAMHQRTANPHLGIDCENGEVVDLWQAGVIDPLAVKTCALEA
HHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEHHHCCCCCHHHHHHHHHHH
AAEIAERILRIQTVVRRRETPPGGA
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]