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The map label for this gene is mraY

Identifier: 37523307

GI number: 37523307

Start: 3949409

End: 3950461

Strand: Reverse

Name: mraY

Synonym: gll3738

Alternate gene names: 37523307

Gene position: 3950461-3949409 (Counterclockwise)

Preceding gene: 37523309

Following gene: 37523306

Centisome position: 84.79

GC content: 65.62

Gene sequence:

>1053_bases
ATGGAACTGGTTTCACGCCCTCCTACAGGCTGGCTCTCCGCCCTCGCGGCGGGCGCTATCGTCAGCGCCGCCATCGCCTG
GCTCGCTCCTGCCCAACTGGTTGTATTCGGCCTCACGCTGCTGCTGGTGGCCCTCACCGGCTTCGCGGCCGTGCCTTTAC
TGCGACGCTGGAAGGCGCGGCAATTCATCCGCGAGGACGGCCCCCGGTCGCACCTCAAAAAAGCGGGCACCCCGACGATG
GGGGGGATCTTTTTTATTCCCTGGGCGCTGGTGGTGCCCTTTGCCTTTGCCGGCTGGAATCCGGAACTGATCGCCGCCGT
CGCCCTGGCCACCTCCTACGGGTTGGTAGGCTGGATCGACGATTTTCAGATCATCCGCCGGCAGTCGAATAACGGCATTA
CCCCCCGCCAGAAGATGCTGCTGCTGATTGGCGCCGGGGTGGCTTTTTGCCTTTTTCATGGCCTGAGCGGCCACGGCACC
GCCACTTTCGGCCTGGGAGAGTTGGGGATTTTGTTCTGGCCGCTGGCGCTTTTAGCCCTCACCGGCACCGCCAATGCCGT
CAACATCACCGACGGCCTGGACGGTCTGGCGGGGGGAACCGGCGCCATCGCCGCCACCGTCCTCGGGTTGATTGTGATCG
CTACCCACCCGGCGCTCGCGGTGCTCTGCTTCGCCCTGGCCGGCGCCTGCCTGGGGTTTTTGGTCCACAATCGCCACAAG
GCCACGGTCTTCATGGGCGACACCGGCTCGCTCGCCATCGGCGGAGCGCTCGCGGCGGTGGCAGTCTTGAGTGGTCAACT
GGTCGCCCTTGCCCTTGTGGGGGGGGTCTTTGTGGTCGAAGCCCTCTCGGTGATCGCCCAGGTCGGTTACTTCAAAGCCA
CCAAGGGACCGGACGGCAAGGGCAAGCGCCTGCTGCGCATGGCCCCGCTGCACCACCACTTCGAACTGGGCGGTCTGCAC
GAGACCCAGGTGGTGGCCCGCTTTTATCTGGCGGGGGCGTCGTTGGCCCTGCTCACCTGGTGGCTGCATACAGGATGGCC
ACCCAGTGCCTGA

Upstream 100 bases:

>100_bases
TCCACCGCTTCGAGGATGAGCGCTTGTGCTTCTTCGACGGAAATCATAAATATGATGTAAGGCGCTGCCTTCTAGCCTAG
CGCCAACCCCAATCCACACC

Downstream 100 bases:

>100_bases
ACCGATGGACATCTACTCCAGCAGCGGCACTTTGGCCGCGCTCACGGTCACCAGCCTTGCGGAGTCGCTGCGATGGTACA
GGGATGCCCTCGGTTTCGAG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MELVSRPPTGWLSALAAGAIVSAAIAWLAPAQLVVFGLTLLLVALTGFAAVPLLRRWKARQFIREDGPRSHLKKAGTPTM
GGIFFIPWALVVPFAFAGWNPELIAAVALATSYGLVGWIDDFQIIRRQSNNGITPRQKMLLLIGAGVAFCLFHGLSGHGT
ATFGLGELGILFWPLALLALTGTANAVNITDGLDGLAGGTGAIAATVLGLIVIATHPALAVLCFALAGACLGFLVHNRHK
ATVFMGDTGSLAIGGALAAVAVLSGQLVALALVGGVFVVEALSVIAQVGYFKATKGPDGKGKRLLRMAPLHHHFELGGLH
ETQVVARFYLAGASLALLTWWLHTGWPPSA

Sequences:

>Translated_350_residues
MELVSRPPTGWLSALAAGAIVSAAIAWLAPAQLVVFGLTLLLVALTGFAAVPLLRRWKARQFIREDGPRSHLKKAGTPTM
GGIFFIPWALVVPFAFAGWNPELIAAVALATSYGLVGWIDDFQIIRRQSNNGITPRQKMLLLIGAGVAFCLFHGLSGHGT
ATFGLGELGILFWPLALLALTGTANAVNITDGLDGLAGGTGAIAATVLGLIVIATHPALAVLCFALAGACLGFLVHNRHK
ATVFMGDTGSLAIGGALAAVAVLSGQLVALALVGGVFVVEALSVIAQVGYFKATKGPDGKGKRLLRMAPLHHHFELGGLH
ETQVVARFYLAGASLALLTWWLHTGWPPSA
>Mature_350_residues
MELVSRPPTGWLSALAAGAIVSAAIAWLAPAQLVVFGLTLLLVALTGFAAVPLLRRWKARQFIREDGPRSHLKKAGTPTM
GGIFFIPWALVVPFAFAGWNPELIAAVALATSYGLVGWIDDFQIIRRQSNNGITPRQKMLLLIGAGVAFCLFHGLSGHGT
ATFGLGELGILFWPLALLALTGTANAVNITDGLDGLAGGTGAIAATVLGLIVIATHPALAVLCFALAGACLGFLVHNRHK
ATVFMGDTGSLAIGGALAAVAVLSGQLVALALVGGVFVVEALSVIAQVGYFKATKGPDGKGKRLLRMAPLHHHFELGGLH
ETQVVARFYLAGASLALLTWWLHTGWPPSA

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=331, Percent_Identity=39.5770392749245, Blast_Score=187, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_GLOVI (Q7NEY9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926684.1
- GeneID:   2602142
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll3738
- NMPDR:   fig|251221.1.peg.3738
- HOGENOM:   HBG708263
- OMA:   TFWQFRN
- ProtClustDB:   PRK00108
- BioCyc:   GVIO251221:GLL3738-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 36421; Mature: 36421

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x108cc41c)-; HASH(0x17b8f778)-; HASH(0x17e43c94)-; HASH(0x1798e914)-; HASH(0x17440938)-; HASH(0x163175e4)-; HASH(0x17dbefe0)-; HASH(0x17ca6f04)-; HASH(0x16f3ace8)-; HASH(0x170a28dc)-; HASH(0x16d68a2c)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVSRPPTGWLSALAAGAIVSAAIAWLAPAQLVVFGLTLLLVALTGFAAVPLLRRWKAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFIREDGPRSHLKKAGTPTMGGIFFIPWALVVPFAFAGWNPELIAAVALATSYGLVGWID
HHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
DFQIIRRQSNNGITPRQKMLLLIGAGVAFCLFHGLSGHGTATFGLGELGILFWPLALLAL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHH
TGTANAVNITDGLDGLAGGTGAIAATVLGLIVIATHPALAVLCFALAGACLGFLVHNRHK
HCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
ATVFMGDTGSLAIGGALAAVAVLSGQLVALALVGGVFVVEALSVIAQVGYFKATKGPDGK
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GKRLLRMAPLHHHFELGGLHETQVVARFYLAGASLALLTWWLHTGWPPSA
CCHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MELVSRPPTGWLSALAAGAIVSAAIAWLAPAQLVVFGLTLLLVALTGFAAVPLLRRWKAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFIREDGPRSHLKKAGTPTMGGIFFIPWALVVPFAFAGWNPELIAAVALATSYGLVGWID
HHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
DFQIIRRQSNNGITPRQKMLLLIGAGVAFCLFHGLSGHGTATFGLGELGILFWPLALLAL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHH
TGTANAVNITDGLDGLAGGTGAIAATVLGLIVIATHPALAVLCFALAGACLGFLVHNRHK
HCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
ATVFMGDTGSLAIGGALAAVAVLSGQLVALALVGGVFVVEALSVIAQVGYFKATKGPDGK
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GKRLLRMAPLHHHFELGGLHETQVVARFYLAGASLALLTWWLHTGWPPSA
CCHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292