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The map label for this gene is fabH

Identifier: 37523261

GI number: 37523261

Start: 3900464

End: 3901453

Strand: Direct

Name: fabH

Synonym: glr3692

Alternate gene names: 37523261

Gene position: 3900464-3901453 (Clockwise)

Preceding gene: 37523260

Following gene: 37523262

Centisome position: 83.72

GC content: 66.46

Gene sequence:

>990_bases
TTGCCCGCGGTACAGATGACGGGTGTGGGCGGGGCTGTCCCTGCACAGGTCCTCACCAATTACCACCTCAGTGAACTGGT
CACCACCTCAGACGAGTGGATCGCTTCGCGCACCGGCATCCGCTCCCGGCGCATCCTAGCCCCCGGCCAGTCGCTCACCC
AGCTTGCCGCCCGCGCCGCCACCGACGCCCTTTCCCAGGCAGGCCGCTCTCCTCTCGACGTCGACTTGTTGATCCTGGCC
ACCTCCACCCCCGACGACCTGTTCGGCGGGGCCGCCCATCTACAGCACGAAATCGGGGCCGTGCGCGCCGTCGCCTTTGA
CCTGACTGCCGCCTGCTCGGGCTTTGTCTTTGCCCTGGCCACGGCGAGCCAGTTTGTACGCACAGGAACCTACCGCACGG
TGCTGGTGGTGGGAGCCGATGCCTTGTCGCGCTATACCGACTGGACCGATCGCGCCACCTGCGTGTTGTTTGGCGACGGG
GCCGGGGCGGCGCTGTTGGAGGCGGGGGAGGTTGAGGGTATTTTGGGCTTCGAGCTGCGCACCGACGGCGCCCGGGCGGG
CCACCTCAATATCCACTGCACGGCGGAGGCGGTGCCGCTGGCGGCTGACATGGCAGCCACGCGCGCCCGCTTTGCATCCA
TTACAATGAATGGCCGGGAGGTCTATCGTTTTGCCGTCGAGGCGGTGCCCGATTTGATCGAAAAGACCCTGGCCGCCTGC
GGAGTGGCTCCGGAACAGGTCAAAGCGTATTTGCTGCACCAGGCCAATCAGCGCATCCTCGACTCTGTCGCAAGCCGCCT
GCACGTTGCCCCCGAACGGATGGCGAGCAACCTCGCCGATTACGGCAACACTTCGAGCGCCTCGGTGCCGCTGATATTGC
AGGAGTGGGTGCAAGATGGACGCATCCGGGCGGGAGACCGGGTGGTCCTGGCGGGATTCGGCGCCGGGTTGAGTTGGGGA
GTGTTGCTGGCGCGCTGGGGACGGCTGTAG

Upstream 100 bases:

>100_bases
ACACTATGGCAAAGGAGCCTTCGGGCTCCTTTTTTGCGCATTTTGGCGGGGGAGTCCCCTTTGACCTTATGATCGAGGGA
GTGCTTTTCGGAGGAGACGC

Downstream 100 bases:

>100_bases
TGAGTTTCACGACACGGCAACGAGGCTGAAGGCCATGGCCAGAAAATTTGGAACGCTGCTTGCACCGGGTGGGAGTTGCC
CATGAGCCACTCTCTGTTCG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MPAVQMTGVGGAVPAQVLTNYHLSELVTTSDEWIASRTGIRSRRILAPGQSLTQLAARAATDALSQAGRSPLDVDLLILA
TSTPDDLFGGAAHLQHEIGAVRAVAFDLTAACSGFVFALATASQFVRTGTYRTVLVVGADALSRYTDWTDRATCVLFGDG
AGAALLEAGEVEGILGFELRTDGARAGHLNIHCTAEAVPLAADMAATRARFASITMNGREVYRFAVEAVPDLIEKTLAAC
GVAPEQVKAYLLHQANQRILDSVASRLHVAPERMASNLADYGNTSSASVPLILQEWVQDGRIRAGDRVVLAGFGAGLSWG
VLLARWGRL

Sequences:

>Translated_329_residues
MPAVQMTGVGGAVPAQVLTNYHLSELVTTSDEWIASRTGIRSRRILAPGQSLTQLAARAATDALSQAGRSPLDVDLLILA
TSTPDDLFGGAAHLQHEIGAVRAVAFDLTAACSGFVFALATASQFVRTGTYRTVLVVGADALSRYTDWTDRATCVLFGDG
AGAALLEAGEVEGILGFELRTDGARAGHLNIHCTAEAVPLAADMAATRARFASITMNGREVYRFAVEAVPDLIEKTLAAC
GVAPEQVKAYLLHQANQRILDSVASRLHVAPERMASNLADYGNTSSASVPLILQEWVQDGRIRAGDRVVLAGFGAGLSWG
VLLARWGRL
>Mature_328_residues
PAVQMTGVGGAVPAQVLTNYHLSELVTTSDEWIASRTGIRSRRILAPGQSLTQLAARAATDALSQAGRSPLDVDLLILAT
STPDDLFGGAAHLQHEIGAVRAVAFDLTAACSGFVFALATASQFVRTGTYRTVLVVGADALSRYTDWTDRATCVLFGDGA
GAALLEAGEVEGILGFELRTDGARAGHLNIHCTAEAVPLAADMAATRARFASITMNGREVYRFAVEAVPDLIEKTLAACG
VAPEQVKAYLLHQANQRILDSVASRLHVAPERMASNLADYGNTSSASVPLILQEWVQDGRIRAGDRVVLAGFGAGLSWGV
LLARWGRL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=323, Percent_Identity=39.6284829721362, Blast_Score=230, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_GLOVI (Q7NF35)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926638.1
- ProteinModelPortal:   Q7NF35
- SMR:   Q7NF35
- GeneID:   2602096
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr3692
- NMPDR:   fig|251221.1.peg.3692
- HOGENOM:   HBG649927
- OMA:   PERMASN
- ProtClustDB:   PRK09352
- BioCyc:   GVIO251221:GLR3692-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34697; Mature: 34566

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 253-253 ACT_SITE 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVQMTGVGGAVPAQVLTNYHLSELVTTSDEWIASRTGIRSRRILAPGQSLTQLAARAA
CCCEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHH
TDALSQAGRSPLDVDLLILATSTPDDLFGGAAHLQHEIGAVRAVAFDLTAACSGFVFALA
HHHHHHCCCCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TASQFVRTGTYRTVLVVGADALSRYTDWTDRATCVLFGDGAGAALLEAGEVEGILGFELR
HHHHHHHCCCCEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCCCEECCCCCCEEEEEEE
TDGARAGHLNIHCTAEAVPLAADMAATRARFASITMNGREVYRFAVEAVPDLIEKTLAAC
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHH
GVAPEQVKAYLLHQANQRILDSVASRLHVAPERMASNLADYGNTSSASVPLILQEWVQDG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
RIRAGDRVVLAGFGAGLSWGVLLARWGRL
CEECCCEEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PAVQMTGVGGAVPAQVLTNYHLSELVTTSDEWIASRTGIRSRRILAPGQSLTQLAARAA
CCEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHH
TDALSQAGRSPLDVDLLILATSTPDDLFGGAAHLQHEIGAVRAVAFDLTAACSGFVFALA
HHHHHHCCCCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TASQFVRTGTYRTVLVVGADALSRYTDWTDRATCVLFGDGAGAALLEAGEVEGILGFELR
HHHHHHHCCCCEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCCCEECCCCCCEEEEEEE
TDGARAGHLNIHCTAEAVPLAADMAATRARFASITMNGREVYRFAVEAVPDLIEKTLAAC
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHH
GVAPEQVKAYLLHQANQRILDSVASRLHVAPERMASNLADYGNTSSASVPLILQEWVQDG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
RIRAGDRVVLAGFGAGLSWGVLLARWGRL
CEECCCEEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292