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The map label for this gene is 37523258

Identifier: 37523258

GI number: 37523258

Start: 3896971

End: 3898419

Strand: Reverse

Name: 37523258

Synonym: gll3689

Alternate gene names: NA

Gene position: 3898419-3896971 (Counterclockwise)

Preceding gene: 37523259

Following gene: 37523257

Centisome position: 83.67

GC content: 64.39

Gene sequence:

>1449_bases
ATGACCGCCGCCCAGGATTCGCGAAGCCCGTATGCGTCGGCCGATTGGGCCGGAGGGTACCGCACCCTTGAAGCCGAGCA
GGCCTATGTCATCGACGCTATCGAAGGCACAATTCCGGCCGAGCTTACGGGCACTCTCTTTCGCAACGGCCCGGGCCGCT
TCGAGCGCGGCGGGGTGTCCTACAAGCACCCGTTTGACGGCGACGGCATGATCTCGGCGGTCCGCTTCGCGGGCGGCCGG
GCTCACTTCCAGAACCGCTTCGTGCGCACCGAGGGCTTTATCCAAGAATCGGCGGCCGGGCGGATTCTAAGCAAAAACGT
TTTCGGCACCCTCAGGCCCGGCGGATTCTGGGCAAACGCCTTCGACTTCGGCTTCAAGAACGTCGCCAATACCGGCGTCG
TCTACCACGGCGGCCGGCTTCTGGCGCTTTGGGAGGCCGCTCCTCCCCACCGCCTCGACCCGGCGAGCCTCGAAACGTTT
GGCCTGGACGATCTCGCCGGGGCCCTCTGCGGCGGCAAACCCTTCGCCGCCCACCCCCGCCTCGATCCTGCGACCGGCGA
TTTGATTTCCTTTGGGGTGCGCACCGGCCTGCAGACGGTTCTGTATATCTACCGCCTCTCCCCCGACGGCGGCGTGCGCG
TCGAGAGCGAGCACACCGTGCCGGGTTTTGCCTTCGTGCACGATTTTGCCCTAACCGAGAACTACTGGGTCTTCTTCCAG
AACCCGATGGCCCTCGATCCGCTGCCGTTTGTGCTGGGTTTCAAGGCGGCCGGGGAATGTCTGCGCCTCGCCCCCGGCGA
ACCGACGCGAATACTGCTCATTCCAAGAAACGGCGGGCCGGTGCAGACGATTGCCACCGAACCATTCTTTGTCTTTCACC
ACGTCAACGCCTTCGAACGGGAGGGCCGGATCGTCGTCGACAGCATCCGCTACGAAGAATACATCACCACCCAGGAGGAC
CGCGATTTTCGCCAGACCGACTTCAGCCGGTTGCCGGAAGGCTGGATCTGGCGCACGCAGATCGACCCGGTCAAAGGTCG
TGTGGAAGCCCGACCCCTACTCAGGCGCTCGGCCGAATTTCCCCAGGTGCATCCCGATCGCGTCGGGCGTCCCTACCGCT
TCGCCTTTGCCGCCGCTGTCCACGCGGAGGGCGGCAACGCCCCTTTGCAGGCCATCGCCAAACTCGATGTCGAAACGGGT
CGGGCGGAATTTCACAGCTTTGCCCCGTCCGGGTTCGTCAGCGAACCGATCTTCGTGCCCCGCCCGGACGGTACTGCCGA
AGACGACGGCTGGCTATTGGCGATGGTCTACGATGCCCGGCGCGACAGGAGCGATCTGTGGATCCTGGACGGCCGGGATC
TCACCTGCCTGACCCGCCTCGGCCTCAAGCACCACGTCCCCTACAGCCTGCACGGCACCTTTGTTCCCGAAGTGTTTGTC
CATTTTTGA

Upstream 100 bases:

>100_bases
GGTTCCCTGCAGCCGCTGGTGGTGCTGCCGACGCTTTGAGCGCACAAGGCCGAGGGTTTGTTAACATTTGAAACGAACTG
TTTGCCGGAGGCGAGCCGCC

Downstream 100 bases:

>100_bases
ATTGCGAACTTGCCAGGCCGCGTCCCGGCCCCTGACGGCCTCCAAGGCCCGCGCCTGCGCACTTGTAGACTGGAACTGGA
TCCCATCCGATGGAGTCTGT

Product: lignostilbene-alpha,beta-dioxygenase

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTAAQDSRSPYASADWAGGYRTLEAEQAYVIDAIEGTIPAELTGTLFRNGPGRFERGGVSYKHPFDGDGMISAVRFAGGR
AHFQNRFVRTEGFIQESAAGRILSKNVFGTLRPGGFWANAFDFGFKNVANTGVVYHGGRLLALWEAAPPHRLDPASLETF
GLDDLAGALCGGKPFAAHPRLDPATGDLISFGVRTGLQTVLYIYRLSPDGGVRVESEHTVPGFAFVHDFALTENYWVFFQ
NPMALDPLPFVLGFKAAGECLRLAPGEPTRILLIPRNGGPVQTIATEPFFVFHHVNAFEREGRIVVDSIRYEEYITTQED
RDFRQTDFSRLPEGWIWRTQIDPVKGRVEARPLLRRSAEFPQVHPDRVGRPYRFAFAAAVHAEGGNAPLQAIAKLDVETG
RAEFHSFAPSGFVSEPIFVPRPDGTAEDDGWLLAMVYDARRDRSDLWILDGRDLTCLTRLGLKHHVPYSLHGTFVPEVFV
HF

Sequences:

>Translated_482_residues
MTAAQDSRSPYASADWAGGYRTLEAEQAYVIDAIEGTIPAELTGTLFRNGPGRFERGGVSYKHPFDGDGMISAVRFAGGR
AHFQNRFVRTEGFIQESAAGRILSKNVFGTLRPGGFWANAFDFGFKNVANTGVVYHGGRLLALWEAAPPHRLDPASLETF
GLDDLAGALCGGKPFAAHPRLDPATGDLISFGVRTGLQTVLYIYRLSPDGGVRVESEHTVPGFAFVHDFALTENYWVFFQ
NPMALDPLPFVLGFKAAGECLRLAPGEPTRILLIPRNGGPVQTIATEPFFVFHHVNAFEREGRIVVDSIRYEEYITTQED
RDFRQTDFSRLPEGWIWRTQIDPVKGRVEARPLLRRSAEFPQVHPDRVGRPYRFAFAAAVHAEGGNAPLQAIAKLDVETG
RAEFHSFAPSGFVSEPIFVPRPDGTAEDDGWLLAMVYDARRDRSDLWILDGRDLTCLTRLGLKHHVPYSLHGTFVPEVFV
HF
>Mature_481_residues
TAAQDSRSPYASADWAGGYRTLEAEQAYVIDAIEGTIPAELTGTLFRNGPGRFERGGVSYKHPFDGDGMISAVRFAGGRA
HFQNRFVRTEGFIQESAAGRILSKNVFGTLRPGGFWANAFDFGFKNVANTGVVYHGGRLLALWEAAPPHRLDPASLETFG
LDDLAGALCGGKPFAAHPRLDPATGDLISFGVRTGLQTVLYIYRLSPDGGVRVESEHTVPGFAFVHDFALTENYWVFFQN
PMALDPLPFVLGFKAAGECLRLAPGEPTRILLIPRNGGPVQTIATEPFFVFHHVNAFEREGRIVVDSIRYEEYITTQEDR
DFRQTDFSRLPEGWIWRTQIDPVKGRVEARPLLRRSAEFPQVHPDRVGRPYRFAFAAAVHAEGGNAPLQAIAKLDVETGR
AEFHSFAPSGFVSEPIFVPRPDGTAEDDGWLLAMVYDARRDRSDLWILDGRDLTCLTRLGLKHHVPYSLHGTFVPEVFVH
F

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI74027270, Length=513, Percent_Identity=27.6803118908382, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4506591, Length=534, Percent_Identity=25.0936329588015, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI82617624, Length=522, Percent_Identity=24.1379310344828, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI82617628, Length=522, Percent_Identity=23.5632183908046, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32564756, Length=508, Percent_Identity=25.9842519685039, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71998242, Length=511, Percent_Identity=26.027397260274, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646669, Length=331, Percent_Identity=29.0030211480363, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 53465; Mature: 53334

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAQDSRSPYASADWAGGYRTLEAEQAYVIDAIEGTIPAELTGTLFRNGPGRFERGGVS
CCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCC
YKHPFDGDGMISAVRFAGGRAHFQNRFVRTEGFIQESAAGRILSKNVFGTLRPGGFWANA
CCCCCCCCCCEEEEECCCCHHHHHHCEEHHHCCHHHHHCCCEEECCCCEEECCCCEECCH
FDFGFKNVANTGVVYHGGRLLALWEAAPPHRLDPASLETFGLDDLAGALCGGKPFAAHPR
HHHCHHHHCCCCEEEECCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHHCCCCCCCCCC
LDPATGDLISFGVRTGLQTVLYIYRLSPDGGVRVESEHTVPGFAFVHDFALTENYWVFFQ
CCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEECCCCCCCEEEEEEEEECCCEEEEEC
NPMALDPLPFVLGFKAAGECLRLAPGEPTRILLIPRNGGPVQTIATEPFFVFHHVNAFER
CCCCCCCCCHHHHHHHHCCEEECCCCCCCEEEEEECCCCCEEEEECCCEEEEEECCHHHH
EGRIVVDSIRYEEYITTQEDRDFRQTDFSRLPEGWIWRTQIDPVKGRVEARPLLRRSAEF
CCCEEEEEEEHHHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCC
PQVHPDRVGRPYRFAFAAAVHAEGGNAPLQAIAKLDVETGRAEFHSFAPSGFVSEPIFVP
CCCCHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEE
RPDGTAEDDGWLLAMVYDARRDRSDLWILDGRDLTCLTRLGLKHHVPYSLHGTFVPEVFV
CCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCEEHHHHCCHHHCCCEEECCCCCCHHEE
HF
CC
>Mature Secondary Structure 
TAAQDSRSPYASADWAGGYRTLEAEQAYVIDAIEGTIPAELTGTLFRNGPGRFERGGVS
CCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCC
YKHPFDGDGMISAVRFAGGRAHFQNRFVRTEGFIQESAAGRILSKNVFGTLRPGGFWANA
CCCCCCCCCCEEEEECCCCHHHHHHCEEHHHCCHHHHHCCCEEECCCCEEECCCCEECCH
FDFGFKNVANTGVVYHGGRLLALWEAAPPHRLDPASLETFGLDDLAGALCGGKPFAAHPR
HHHCHHHHCCCCEEEECCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHHCCCCCCCCCC
LDPATGDLISFGVRTGLQTVLYIYRLSPDGGVRVESEHTVPGFAFVHDFALTENYWVFFQ
CCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEECCCCCCCEEEEEEEEECCCEEEEEC
NPMALDPLPFVLGFKAAGECLRLAPGEPTRILLIPRNGGPVQTIATEPFFVFHHVNAFER
CCCCCCCCCHHHHHHHHCCEEECCCCCCCEEEEEECCCCCEEEEECCCEEEEEECCHHHH
EGRIVVDSIRYEEYITTQEDRDFRQTDFSRLPEGWIWRTQIDPVKGRVEARPLLRRSAEF
CCCEEEEEEEHHHHCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCC
PQVHPDRVGRPYRFAFAAAVHAEGGNAPLQAIAKLDVETGRAEFHSFAPSGFVSEPIFVP
CCCCHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEE
RPDGTAEDDGWLLAMVYDARRDRSDLWILDGRDLTCLTRLGLKHHVPYSLHGTFVPEVFV
CCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCEEHHHHCCHHHCCCEEECCCCCCHHEE
HF
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]