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The map label for this gene is pyrC [H]

Identifier: 37523238

GI number: 37523238

Start: 3873914

End: 3875245

Strand: Direct

Name: pyrC [H]

Synonym: gvip497

Alternate gene names: 37523238

Gene position: 3873914-3875245 (Clockwise)

Preceding gene: 37523237

Following gene: 37523240

Centisome position: 83.15

GC content: 65.62

Gene sequence:

>1332_bases
GTGGTATTGATGGGCTCGCTGCTGCTGCGTGATATGCGCATGGTCCTCGACGACGGCTCGCTCTATGTGGGCGATCTGCT
CTGCCGCGACGGGCTTATCGCGGCCGTGGACCGCACGGTGAATGCCCCCGCCGATCGGGTAATCGACGGCGGGGGCCGGG
TGCTGCTGCCGGGGGTGATCGACCCGCAGGTGCACTTTCGCGAGCCGGGCAAAGAATACAAAGAAGATTTGCAAACCGGC
TCCTGGGCCTGTGCCCGCGGCGGCGTGACCTCGTTTTTGGAGATGCCCAACACTTCGCCTCCCACGACTACCGTCGAACG
CCTCGAAGACAAACTGGCGCGCGCGGCGAGCAAGTGCGTGGTCAACTACGGATTTTTCGTGGGCGCCACCGCCGACAATA
TCGAACAGTTGCAGCAGGCGGCGGGCCTCAGTTGCGGCGTCAAGATCTTTATGGGCGCTTCCACAGGCGATCTCCTCGTA
GACGATCCGGTAGCCCTTGAGCGCATCTTCAAAGAGGTGCCCCGCCTGATTGCCGTCCACGCCGAGGACGAAGCGCGCAT
CCGCGAGCGCACGCGGCTGTTTGCCGGGCGCAGCGACCCCCATGTCCACTCTCAACTGCGCGACAACGAGTGCGCGCGCC
TGGCCACCGCCCAGGCCCTGGAACTCTCGCGGCGCTACCGCAGGCGCCTGCACATCCTGCACCTGTCGGCGGCCGAGGAA
CTGGAATTGCTGAGAGCCGACAAACCCGCCTGGGTGACGGCCGAAGTGATCCCGCAGCACCTGTTTCTCTCGACGGCCGC
CTACGACACGATCGGCATGCGCGCCAAGCAAAATCCGCCCCTGCGCTCGGAAGCCGACCGTGAGGCGATGTGGGCGGGGT
TGCGCTCGGGGCTCATCGATTTTGTCGCCACCGACCACGCCCCGCACCTGCTGAGCGAAAAGGACCGCGATTACGCCGAA
GCCCCGGCCGGGATGCCCGGCGTCGAGACTTCGCTGCCCTTGATGCTCACGGCCCTGGCGCGCGGCGAGGTGAACTTCGA
GCAAATTGTCCGCTGGATGAGCCGGGGGGCGGCAAAAGCCTACGGTATCCCCAACAAAGGATCGCTGCGGCCCGGTTTTG
ACGCGGACCTGGTGCTGGTGGATCTGGAGCGCTATGAGCCGGTGCGCGCCGAGCGTATGGCGAGCAAATGCGGCTGGAGT
CCTTTTGAAGGCTGGTCGCTCACCGGCTGGCCGGTGCTCACGGTGGTCGGGGGCCGGGTGGCCTTCGAAGCAGGCGAGGT
GCAGACCGACACTCGCGGAAACGCCCTCAACTTTCGGCCGCTGGAATTCTGA

Upstream 100 bases:

>100_bases
GGGAAGCCTTACATTCATTGAAATCTCAATCCGAAGAGTCCCACTGATGTGATGCTCCCACGCCCCCCAGTATGCTGGTG
AAGCCTTGATGAACTAGGAA

Downstream 100 bases:

>100_bases
CCACGAAGATATTGATTTCGGGCGTCTCGCCGTAGTAGAGCTTCATCGCCCCCGGCCCGGGTAGTTTCAAAAACAGCTCG
CCTTCGGTTGCTTCGCGGGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MVLMGSLLLRDMRMVLDDGSLYVGDLLCRDGLIAAVDRTVNAPADRVIDGGGRVLLPGVIDPQVHFREPGKEYKEDLQTG
SWACARGGVTSFLEMPNTSPPTTTVERLEDKLARAASKCVVNYGFFVGATADNIEQLQQAAGLSCGVKIFMGASTGDLLV
DDPVALERIFKEVPRLIAVHAEDEARIRERTRLFAGRSDPHVHSQLRDNECARLATAQALELSRRYRRRLHILHLSAAEE
LELLRADKPAWVTAEVIPQHLFLSTAAYDTIGMRAKQNPPLRSEADREAMWAGLRSGLIDFVATDHAPHLLSEKDRDYAE
APAGMPGVETSLPLMLTALARGEVNFEQIVRWMSRGAAKAYGIPNKGSLRPGFDADLVLVDLERYEPVRAERMASKCGWS
PFEGWSLTGWPVLTVVGGRVAFEAGEVQTDTRGNALNFRPLEF

Sequences:

>Translated_443_residues
MVLMGSLLLRDMRMVLDDGSLYVGDLLCRDGLIAAVDRTVNAPADRVIDGGGRVLLPGVIDPQVHFREPGKEYKEDLQTG
SWACARGGVTSFLEMPNTSPPTTTVERLEDKLARAASKCVVNYGFFVGATADNIEQLQQAAGLSCGVKIFMGASTGDLLV
DDPVALERIFKEVPRLIAVHAEDEARIRERTRLFAGRSDPHVHSQLRDNECARLATAQALELSRRYRRRLHILHLSAAEE
LELLRADKPAWVTAEVIPQHLFLSTAAYDTIGMRAKQNPPLRSEADREAMWAGLRSGLIDFVATDHAPHLLSEKDRDYAE
APAGMPGVETSLPLMLTALARGEVNFEQIVRWMSRGAAKAYGIPNKGSLRPGFDADLVLVDLERYEPVRAERMASKCGWS
PFEGWSLTGWPVLTVVGGRVAFEAGEVQTDTRGNALNFRPLEF
>Mature_443_residues
MVLMGSLLLRDMRMVLDDGSLYVGDLLCRDGLIAAVDRTVNAPADRVIDGGGRVLLPGVIDPQVHFREPGKEYKEDLQTG
SWACARGGVTSFLEMPNTSPPTTTVERLEDKLARAASKCVVNYGFFVGATADNIEQLQQAAGLSCGVKIFMGASTGDLLV
DDPVALERIFKEVPRLIAVHAEDEARIRERTRLFAGRSDPHVHSQLRDNECARLATAQALELSRRYRRRLHILHLSAAEE
LELLRADKPAWVTAEVIPQHLFLSTAAYDTIGMRAKQNPPLRSEADREAMWAGLRSGLIDFVATDHAPHLLSEKDRDYAE
APAGMPGVETSLPLMLTALARGEVNFEQIVRWMSRGAAKAYGIPNKGSLRPGFDADLVLVDLERYEPVRAERMASKCGWS
PFEGWSLTGWPVLTVVGGRVAFEAGEVQTDTRGNALNFRPLEF

Specific function: Unknown

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=429, Percent_Identity=30.7692307692308, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI4503051, Length=449, Percent_Identity=25.1670378619154, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI62422571, Length=449, Percent_Identity=25.1670378619154, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4503379, Length=445, Percent_Identity=26.2921348314607, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4503375, Length=450, Percent_Identity=27.5555555555556, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI19923821, Length=450, Percent_Identity=24.6666666666667, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4503377, Length=459, Percent_Identity=23.5294117647059, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87082175, Length=464, Percent_Identity=29.9568965517241, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786722, Length=433, Percent_Identity=27.4826789838337, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI193204318, Length=424, Percent_Identity=30.4245283018868, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71989490, Length=454, Percent_Identity=26.8722466960352, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17539558, Length=449, Percent_Identity=25.6124721603563, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI86575075, Length=452, Percent_Identity=25.8849557522124, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=417, Percent_Identity=27.0983213429257, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24642586, Length=442, Percent_Identity=33.0316742081448, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI18859883, Length=469, Percent_Identity=28.7846481876333, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221377917, Length=453, Percent_Identity=25.60706401766, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137462, Length=450, Percent_Identity=26.2222222222222, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48771; Mature: 48771

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLMGSLLLRDMRMVLDDGSLYVGDLLCRDGLIAAVDRTVNAPADRVIDGGGRVLLPGVI
CEEHHHHHHHHHHHHHCCCCEEEHHHHHHCCHHHHHHHHCCCCHHHEECCCCEEEECCCC
DPQVHFREPGKEYKEDLQTGSWACARGGVTSFLEMPNTSPPTTTVERLEDKLARAASKCV
CCCCCCCCCCHHHHHHHCCCCCCHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
VNYGFFVGATADNIEQLQQAAGLSCGVKIFMGASTGDLLVDDPVALERIFKEVPRLIAVH
HHCCEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHEEEC
AEDEARIRERTRLFAGRSDPHVHSQLRDNECARLATAQALELSRRYRRRLHILHLSAAEE
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCHHH
LELLRADKPAWVTAEVIPQHLFLSTAAYDTIGMRAKQNPPLRSEADREAMWAGLRSGLID
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FVATDHAPHLLSEKDRDYAEAPAGMPGVETSLPLMLTALARGEVNFEQIVRWMSRGAAKA
HHHCCCCCHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
YGIPNKGSLRPGFDADLVLVDLERYEPVRAERMASKCGWSPFEGWSLTGWPVLTVVGGRV
CCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCEE
AFEAGEVQTDTRGNALNFRPLEF
EEECCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MVLMGSLLLRDMRMVLDDGSLYVGDLLCRDGLIAAVDRTVNAPADRVIDGGGRVLLPGVI
CEEHHHHHHHHHHHHHCCCCEEEHHHHHHCCHHHHHHHHCCCCHHHEECCCCEEEECCCC
DPQVHFREPGKEYKEDLQTGSWACARGGVTSFLEMPNTSPPTTTVERLEDKLARAASKCV
CCCCCCCCCCHHHHHHHCCCCCCHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
VNYGFFVGATADNIEQLQQAAGLSCGVKIFMGASTGDLLVDDPVALERIFKEVPRLIAVH
HHCCEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHEEEC
AEDEARIRERTRLFAGRSDPHVHSQLRDNECARLATAQALELSRRYRRRLHILHLSAAEE
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCHHH
LELLRADKPAWVTAEVIPQHLFLSTAAYDTIGMRAKQNPPLRSEADREAMWAGLRSGLID
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FVATDHAPHLLSEKDRDYAEAPAGMPGVETSLPLMLTALARGEVNFEQIVRWMSRGAAKA
HHHCCCCCHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
YGIPNKGSLRPGFDADLVLVDLERYEPVRAERMASKCGWSPFEGWSLTGWPVLTVVGGRV
CCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCEE
AFEAGEVQTDTRGNALNFRPLEF
EEECCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]