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The map label for this gene is zraS [C]

Identifier: 37523003

GI number: 37523003

Start: 3635481

End: 3637403

Strand: Direct

Name: zraS [C]

Synonym: glr3434

Alternate gene names: 37523003

Gene position: 3635481-3637403 (Clockwise)

Preceding gene: 37523002

Following gene: 37523005

Centisome position: 78.03

GC content: 63.13

Gene sequence:

>1923_bases
GTGAGGGCGATGGCGGCGATCAAAATTCTGTTAATCGAAGACAACCCCAGCGACGTCCGGCTGCTGCGCGAAATCTTAAA
GGACGCCCCGGCCGCGCGCTTCGAGTGGCGCGCGGCCGGGCGGCTTCAGGAAGCCGTCGCCGCTTTGGCCCACGAGCACT
TCGACGTGGTGTTGCTCGATCTCTCGCTGCCGGACAGCCGCGGCCTCGACAGCCTCATCGCCCTCAAGCCCTTTGCCGCC
GCCTTGCCGATTGTCGTGCTCACCGGCTTCGACGACGAGGCCCTGGCCACCGGGGCGATGCAACTGGGTGCCCAGGATTA
TCTGGTCAAAGGGCAGGTGACCGGTTCGCTCCTGGTGCGCTCGATCCGCTACGCCATCGAAAGACAGCGCGCCGAGCAAA
AGATCCACGAGCAGGCGGCCCTGCTCGATGTCGCCACCGACGCGATTTTGCTGAGGGATCTCGATAACCGGGTTGTGTTC
TGGAACCAAGGGGCCGAGCGGCTCTACGGCTGGAGTGCGGCTCAAGTGTTGGGCCAAACCGCGGCCGATCTTCTCTACGG
GCGCGGGCTGGTCGGAGCCGATGAAGCCCGACTTGCTGCTGAGGAGGTCTTCGCAACCGTCGTGGTGCGCGGTGAATGGC
AGGGCGAGTTGACCAAATTCACCCGCTCGGGCAAAAAACTGATTGCCCAGAGCCGCTGGACGCTGGTGCGCGACGAGCAG
GGCCGTCCCAAGTCGATTCTCACCGTCGATACCGACATCACCGAAAAAAAACAGCTCGAGGCAAAATTTCTGCGCGCCCA
GCGCCTGGAGAGCCTGGGCACCCTCGCGGGCGGTATCGCCCACGATCTCAACAACATCCTGACGCCCATCGTCGCAGCGG
CCCAACTGCTGCCTTTGCGGCTGACGGACCTCGACCAGCAGGACTTGCGCCTGCTCAGAATGCTCGAAGAAAATTCGCGC
CGCGGCAGCCATCTGGTCACCCAGATTCTCTCGTTTGCCCGGGGTATGGAGGGTCGGCGCACGATTTTACAGATTCGTCA
CCTGCTTGGGGAGGTGGGGCAGATTGTCCGGCAGACGTTCCCCAAGTCGATCGAGATTCGCATCGATGCGTCGGCGCAAG
ATCTCTGGACTATCCAGGCGGACGCCACCCAGATGCACCAGGTATTTATGAATCTGTGCGTCAATGCCCGCGATGCGATG
CCCGCAGGCGGCGTGCTCACCCTCACCGCCCGCAACTTGATTGTGGACGAGCATTACGCCCGGCTGATCCCGGATGCCGC
GGCCGGTGCCTACGTGGTGGTCACCGTCAGCGACACGGGCACGGGCATCACGCCTGAGATTGTCGAGAAGATTTTTGAAC
CGTTTTTTACGACCAAGGAGTTGGGCAAGGGTACCGGCCTCGGGCTTTCGACGGTGCTGGGCATCGTCAAGCACCACGGC
GGTTTTGTTGGGGTCTACAGTGAACCGGGCCGGGGCACCGAATTTCGGGTCCATTTGCCGGCGGCGGCGGGGAGCGAAGT
CGAGCCGGAGGCGCAAGCGGAACTGCCTGAGGGCTGCGGCGAACTGGTACTGGTGGTTGACGACGAGGCGGCCATTCTGG
AGGTGATCCGCACGGCGCTCGAAAGCCACAACTACCGTGTGGTGGGTGCCGGCAACGGTCTGGAGGCGATCGCCGCTTTA
CGCCACTCCCCGCAGGTGGTGCTGATCGACATGATGATGCCCGCCATGGACGGCCCGGCGGCAATTTTTGCTCTGCAGGA
CATCGACCCGCACCTGCCGGTGGTTGCGATGAGCGGCATTGCTCACGCCGAGCGGCCCAAAGCCCTCCACTCCACCCAGC
GGGCTTTTTTGACCAAACCGTTCACCGTGCCTGAGCTGCTCCTTGCGATCCATGAGGCTATCCATGGTCGTTCGGCTGCC
TGA

Upstream 100 bases:

>100_bases
CCAACTGTTACATTACCAAGCCCGTCGATTTCGGTGAGTTCCTCAAAATCGTGCGGTCGATCGAGGATTTTTGGTTCACG
GTCGTCAAGCTTCCCCCGAG

Downstream 100 bases:

>100_bases
GCGCTGTTGGACTCGGGTTTGCCCAGCCGGCGGTCGGCTGTGGGGCAGCTCAATGCAACGTTTTTTCCTTGACACCTGAA
ACCTGGCACCTGATACCTTC

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 640; Mature: 640

Protein sequence:

>640_residues
MRAMAAIKILLIEDNPSDVRLLREILKDAPAARFEWRAAGRLQEAVAALAHEHFDVVLLDLSLPDSRGLDSLIALKPFAA
ALPIVVLTGFDDEALATGAMQLGAQDYLVKGQVTGSLLVRSIRYAIERQRAEQKIHEQAALLDVATDAILLRDLDNRVVF
WNQGAERLYGWSAAQVLGQTAADLLYGRGLVGADEARLAAEEVFATVVVRGEWQGELTKFTRSGKKLIAQSRWTLVRDEQ
GRPKSILTVDTDITEKKQLEAKFLRAQRLESLGTLAGGIAHDLNNILTPIVAAAQLLPLRLTDLDQQDLRLLRMLEENSR
RGSHLVTQILSFARGMEGRRTILQIRHLLGEVGQIVRQTFPKSIEIRIDASAQDLWTIQADATQMHQVFMNLCVNARDAM
PAGGVLTLTARNLIVDEHYARLIPDAAAGAYVVVTVSDTGTGITPEIVEKIFEPFFTTKELGKGTGLGLSTVLGIVKHHG
GFVGVYSEPGRGTEFRVHLPAAAGSEVEPEAQAELPEGCGELVLVVDDEAAILEVIRTALESHNYRVVGAGNGLEAIAAL
RHSPQVVLIDMMMPAMDGPAAIFALQDIDPHLPVVAMSGIAHAERPKALHSTQRAFLTKPFTVPELLLAIHEAIHGRSAA

Sequences:

>Translated_640_residues
MRAMAAIKILLIEDNPSDVRLLREILKDAPAARFEWRAAGRLQEAVAALAHEHFDVVLLDLSLPDSRGLDSLIALKPFAA
ALPIVVLTGFDDEALATGAMQLGAQDYLVKGQVTGSLLVRSIRYAIERQRAEQKIHEQAALLDVATDAILLRDLDNRVVF
WNQGAERLYGWSAAQVLGQTAADLLYGRGLVGADEARLAAEEVFATVVVRGEWQGELTKFTRSGKKLIAQSRWTLVRDEQ
GRPKSILTVDTDITEKKQLEAKFLRAQRLESLGTLAGGIAHDLNNILTPIVAAAQLLPLRLTDLDQQDLRLLRMLEENSR
RGSHLVTQILSFARGMEGRRTILQIRHLLGEVGQIVRQTFPKSIEIRIDASAQDLWTIQADATQMHQVFMNLCVNARDAM
PAGGVLTLTARNLIVDEHYARLIPDAAAGAYVVVTVSDTGTGITPEIVEKIFEPFFTTKELGKGTGLGLSTVLGIVKHHG
GFVGVYSEPGRGTEFRVHLPAAAGSEVEPEAQAELPEGCGELVLVVDDEAAILEVIRTALESHNYRVVGAGNGLEAIAAL
RHSPQVVLIDMMMPAMDGPAAIFALQDIDPHLPVVAMSGIAHAERPKALHSTQRAFLTKPFTVPELLLAIHEAIHGRSAA
>Mature_640_residues
MRAMAAIKILLIEDNPSDVRLLREILKDAPAARFEWRAAGRLQEAVAALAHEHFDVVLLDLSLPDSRGLDSLIALKPFAA
ALPIVVLTGFDDEALATGAMQLGAQDYLVKGQVTGSLLVRSIRYAIERQRAEQKIHEQAALLDVATDAILLRDLDNRVVF
WNQGAERLYGWSAAQVLGQTAADLLYGRGLVGADEARLAAEEVFATVVVRGEWQGELTKFTRSGKKLIAQSRWTLVRDEQ
GRPKSILTVDTDITEKKQLEAKFLRAQRLESLGTLAGGIAHDLNNILTPIVAAAQLLPLRLTDLDQQDLRLLRMLEENSR
RGSHLVTQILSFARGMEGRRTILQIRHLLGEVGQIVRQTFPKSIEIRIDASAQDLWTIQADATQMHQVFMNLCVNARDAM
PAGGVLTLTARNLIVDEHYARLIPDAAAGAYVVVTVSDTGTGITPEIVEKIFEPFFTTKELGKGTGLGLSTVLGIVKHHG
GFVGVYSEPGRGTEFRVHLPAAAGSEVEPEAQAELPEGCGELVLVVDDEAAILEVIRTALESHNYRVVGAGNGLEAIAAL
RHSPQVVLIDMMMPAMDGPAAIFALQDIDPHLPVVAMSGIAHAERPKALHSTQRAFLTKPFTVPELLLAIHEAIHGRSAA

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=31.3253012048193, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788549, Length=365, Percent_Identity=25.7534246575342, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI48994928, Length=529, Percent_Identity=24.1965973534972, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1788713, Length=287, Percent_Identity=27.5261324041812, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1790300, Length=366, Percent_Identity=27.0491803278689, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=221, Percent_Identity=26.2443438914027, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=25.3012048192771, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69606; Mature: 69606

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMAAIKILLIEDNPSDVRLLREILKDAPAARFEWRAAGRLQEAVAALAHEHFDVVLLD
CCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEE
LSLPDSRGLDSLIALKPFAAALPIVVLTGFDDEALATGAMQLGAQDYLVKGQVTGSLLVR
ECCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHHHHH
SIRYAIERQRAEQKIHEQAALLDVATDAILLRDLDNRVVFWNQGAERLYGWSAAQVLGQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCCHHHHHCCHHHHHHHHH
AADLLYGRGLVGADEARLAAEEVFATVVVRGEWQGELTKFTRSGKKLIAQSRWTLVRDEQ
HHHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCC
GRPKSILTVDTDITEKKQLEAKFLRAQRLESLGTLAGGIAHDLNNILTPIVAAAQLLPLR
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTDLDQQDLRLLRMLEENSRRGSHLVTQILSFARGMEGRRTILQIRHLLGEVGQIVRQTF
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
PKSIEIRIDASAQDLWTIQADATQMHQVFMNLCVNARDAMPAGGVLTLTARNLIVDEHYA
CCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHH
RLIPDAAAGAYVVVTVSDTGTGITPEIVEKIFEPFFTTKELGKGTGLGLSTVLGIVKHHG
HHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
GFVGVYSEPGRGTEFRVHLPAAAGSEVEPEAQAELPEGCGELVLVVDDEAAILEVIRTAL
CEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
ESHNYRVVGAGNGLEAIAALRHSPQVVLIDMMMPAMDGPAAIFALQDIDPHLPVVAMSGI
HCCCEEEEECCCCHHHHHHHHCCCCEEEEEEHHCCCCCCEEEEEEECCCCCCCHHEECCC
AHAERPKALHSTQRAFLTKPFTVPELLLAIHEAIHGRSAA
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRAMAAIKILLIEDNPSDVRLLREILKDAPAARFEWRAAGRLQEAVAALAHEHFDVVLLD
CCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEE
LSLPDSRGLDSLIALKPFAAALPIVVLTGFDDEALATGAMQLGAQDYLVKGQVTGSLLVR
ECCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCEEEECCCHHHHHHH
SIRYAIERQRAEQKIHEQAALLDVATDAILLRDLDNRVVFWNQGAERLYGWSAAQVLGQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCCHHHHHCCHHHHHHHHH
AADLLYGRGLVGADEARLAAEEVFATVVVRGEWQGELTKFTRSGKKLIAQSRWTLVRDEQ
HHHHHHCCCCCCCCHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCC
GRPKSILTVDTDITEKKQLEAKFLRAQRLESLGTLAGGIAHDLNNILTPIVAAAQLLPLR
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTDLDQQDLRLLRMLEENSRRGSHLVTQILSFARGMEGRRTILQIRHLLGEVGQIVRQTF
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
PKSIEIRIDASAQDLWTIQADATQMHQVFMNLCVNARDAMPAGGVLTLTARNLIVDEHYA
CCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHH
RLIPDAAAGAYVVVTVSDTGTGITPEIVEKIFEPFFTTKELGKGTGLGLSTVLGIVKHHG
HHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
GFVGVYSEPGRGTEFRVHLPAAAGSEVEPEAQAELPEGCGELVLVVDDEAAILEVIRTAL
CEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
ESHNYRVVGAGNGLEAIAALRHSPQVVLIDMMMPAMDGPAAIFALQDIDPHLPVVAMSGI
HCCCEEEEECCCCHHHHHHHHCCCCEEEEEEHHCCCCCCEEEEEEECCCCCCCHHEECCC
AHAERPKALHSTQRAFLTKPFTVPELLLAIHEAIHGRSAA
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA