Click here to switch to the map view.

The map label for this gene is mrdA [H]

Identifier: 37522994

GI number: 37522994

Start: 3623163

End: 3625010

Strand: Reverse

Name: mrdA [H]

Synonym: gll3425

Alternate gene names: 37522994

Gene position: 3625010-3623163 (Counterclockwise)

Preceding gene: 37522998

Following gene: 37522993

Centisome position: 77.81

GC content: 64.88

Gene sequence:

>1848_bases
ATGGTGCTTCGATATGCTACAAGTGCACCAGAATCCGCAAGGGGAGCAAGTCTCGTGCAACTGCAGGCAGAGCGGCGCGA
CAAACGCACCAGCGGCGGCGACAACCGGGGATTGGTGCTGGCGGGGGTGGCGGCCCTGCTGTTGGGGGGTGTCGGGTTGC
GGCTGACCTATCTGCAGGTCATCCAGGGTCCACATCACCGCGAACTGGCCGAGAACAACCGCATCCGCCTGGTGCCCATT
CGCCCGCCCCGCGGCCGTATCCTCGATCGTTACGGTCGGGTGCTCGCCACCAACCGGCTTTCTTTTTCGGTGTTTCTAGA
ACCGATGCAGCTCAAGCCCAAGGAATGGCCCGCCGCACTGGCGCGTTTGAGCCTTTTTATCAAAGTGCCCGCCGACAAGC
TCGAAGAAAAGCTCAAAGCCGCCGGGTACAACTCGCCCTATCCCGTGCGCGTCTTGCAAAACGTCGAACCGCAGCTGGTG
ACCGTTTTGCGCGAGCACATCCAGGAGTTGCCGGGGGTCAAAGTCGACGTCGAGTGGATGCGCTTCTACCCGAACGGTCC
AGTCGCGAGCCATCTGCTGGGCTACACCGGTGAAATTTCAGAGCAGCAGCTGGCCGAACGCAAGGAGCAGGGCTACCGCC
TGGGGGACATCATCGGCAAAGCCGGTGTCGAGCGGCTGCTGGAGGAGAAATTGCACGGCGAGTGGGGCGGCGAACAGGTC
GAGGTGGACGCCGCCGGACAGGTGGTGCGCGTCATCGGCGAAGTGCAGCCCAAAGCCGGGCAGGACGTGCGCCTTTCGAT
CGACCTGGCGCTGCAAAAGACCGCCGAGGCCGCCCTCAACTCCCGCAAGAAGCGCGGAGCGGTGGTGGCGATGGACCCGC
GCAACGGCCAGGTTCTCGCCATCGCCTCCGCCCCCTCCTACGACGCCAACATTCTCTCGGGCCGAATTTCCGAGCAGGAC
TGGCGGCGCTTGCAGACCCCCGATCGGCCCCTGCTCAACCGGGCGGTGCGGCCTTACCCCACGGCGAGCACCTTCAAGAT
CATCATGACCGCCGCCGCGCTCGAAAGCGGCAAGTTCAACCCCAACAGCCGCCTGGCCACCTTCGGGGGACTGCGCATCG
GCGGGCGCGTCTTTCGCGATCACAACGGCCGCGGCTTCGGCACGATCGGTTTTATCCGTGCCCTCTCCCAAAGCAGCGAC
ACGTTTTACTATCAAGTGGGCCTGCGCATCGGTCCCGACGAGATTGCCAAGTGGTCGCGCAATTTTGGCTTCGGCAGCCG
CACCGACATCGGCCTGCAAAGCGAATCGCGCGGCCTAGTGCCCACCCCCGAGTGGCTGAAGCGCCGCTTCGGGCGCCAGT
GGTTCGGAGGGGACACCGCCAACACCTCGATCGGCCAGGGTATGGTGCTCTCGACCCCACTGCAAAACGCGGTCATGGTC
GGCGCCATCGCCAACGGCGGTTTCCGCGTGCAGCCCCATCTGGTGCTCGACAGCCGCCCGGGGCTCTCGCCGGTGGGGCT
CTCCCCCACCACCCTCGCCACGATCCGCCAGGGCCTCAGCGAGGTGGTCCGCAGCGGCACCGCCCGCCGCGCTCTGTCGA
TGCCCGATTTGCCCAACGCCGGTAAGACCGGCACTGCCGAACATGGTGCGCGCAAGGGCGGCCGCACCCACGCCCTCTAC
GTCGGCTACGCCCCCACCCCCGCCCCTGAGATTGCTGTATCCGTTTTGCTCGAGAACGGCGGCCATGGCGGCTCCGACGC
CGCCCCGATTGCAAAGAAAATTTACCAGACTTACTTCGTCGCCAGGGGTAAAAAAAGTGCTGCGCTCTCTCCAAAGCATG
TAGAATAA

Upstream 100 bases:

>100_bases
ACGATTGCCATCATGACGTACCGACGCCGCTCCGGGTGCCCGGCTCCCGGAGCGCCGACTTCTGCGGTTCACCCTAGCAC
ATCGAAGTGCCGGCGCTTCG

Downstream 100 bases:

>100_bases
GCGATTGAAATTCAGGCCCAAAGGCACTTCCAGCGATTCGCCCACCTGCTTTTGGACCTGATATTGCACGGTGAGGAGTT
TTTATGAACAAAGGTGAATT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MVLRYATSAPESARGASLVQLQAERRDKRTSGGDNRGLVLAGVAALLLGGVGLRLTYLQVIQGPHHRELAENNRIRLVPI
RPPRGRILDRYGRVLATNRLSFSVFLEPMQLKPKEWPAALARLSLFIKVPADKLEEKLKAAGYNSPYPVRVLQNVEPQLV
TVLREHIQELPGVKVDVEWMRFYPNGPVASHLLGYTGEISEQQLAERKEQGYRLGDIIGKAGVERLLEEKLHGEWGGEQV
EVDAAGQVVRVIGEVQPKAGQDVRLSIDLALQKTAEAALNSRKKRGAVVAMDPRNGQVLAIASAPSYDANILSGRISEQD
WRRLQTPDRPLLNRAVRPYPTASTFKIIMTAAALESGKFNPNSRLATFGGLRIGGRVFRDHNGRGFGTIGFIRALSQSSD
TFYYQVGLRIGPDEIAKWSRNFGFGSRTDIGLQSESRGLVPTPEWLKRRFGRQWFGGDTANTSIGQGMVLSTPLQNAVMV
GAIANGGFRVQPHLVLDSRPGLSPVGLSPTTLATIRQGLSEVVRSGTARRALSMPDLPNAGKTGTAEHGARKGGRTHALY
VGYAPTPAPEIAVSVLLENGGHGGSDAAPIAKKIYQTYFVARGKKSAALSPKHVE

Sequences:

>Translated_615_residues
MVLRYATSAPESARGASLVQLQAERRDKRTSGGDNRGLVLAGVAALLLGGVGLRLTYLQVIQGPHHRELAENNRIRLVPI
RPPRGRILDRYGRVLATNRLSFSVFLEPMQLKPKEWPAALARLSLFIKVPADKLEEKLKAAGYNSPYPVRVLQNVEPQLV
TVLREHIQELPGVKVDVEWMRFYPNGPVASHLLGYTGEISEQQLAERKEQGYRLGDIIGKAGVERLLEEKLHGEWGGEQV
EVDAAGQVVRVIGEVQPKAGQDVRLSIDLALQKTAEAALNSRKKRGAVVAMDPRNGQVLAIASAPSYDANILSGRISEQD
WRRLQTPDRPLLNRAVRPYPTASTFKIIMTAAALESGKFNPNSRLATFGGLRIGGRVFRDHNGRGFGTIGFIRALSQSSD
TFYYQVGLRIGPDEIAKWSRNFGFGSRTDIGLQSESRGLVPTPEWLKRRFGRQWFGGDTANTSIGQGMVLSTPLQNAVMV
GAIANGGFRVQPHLVLDSRPGLSPVGLSPTTLATIRQGLSEVVRSGTARRALSMPDLPNAGKTGTAEHGARKGGRTHALY
VGYAPTPAPEIAVSVLLENGGHGGSDAAPIAKKIYQTYFVARGKKSAALSPKHVE
>Mature_615_residues
MVLRYATSAPESARGASLVQLQAERRDKRTSGGDNRGLVLAGVAALLLGGVGLRLTYLQVIQGPHHRELAENNRIRLVPI
RPPRGRILDRYGRVLATNRLSFSVFLEPMQLKPKEWPAALARLSLFIKVPADKLEEKLKAAGYNSPYPVRVLQNVEPQLV
TVLREHIQELPGVKVDVEWMRFYPNGPVASHLLGYTGEISEQQLAERKEQGYRLGDIIGKAGVERLLEEKLHGEWGGEQV
EVDAAGQVVRVIGEVQPKAGQDVRLSIDLALQKTAEAALNSRKKRGAVVAMDPRNGQVLAIASAPSYDANILSGRISEQD
WRRLQTPDRPLLNRAVRPYPTASTFKIIMTAAALESGKFNPNSRLATFGGLRIGGRVFRDHNGRGFGTIGFIRALSQSSD
TFYYQVGLRIGPDEIAKWSRNFGFGSRTDIGLQSESRGLVPTPEWLKRRFGRQWFGGDTANTSIGQGMVLSTPLQNAVMV
GAIANGGFRVQPHLVLDSRPGLSPVGLSPTTLATIRQGLSEVVRSGTARRALSMPDLPNAGKTGTAEHGARKGGRTHALY
VGYAPTPAPEIAVSVLLENGGHGGSDAAPIAKKIYQTYFVARGKKSAALSPKHVE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=586, Percent_Identity=33.617747440273, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI1786272, Length=578, Percent_Identity=25.7785467128028, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66850; Mature: 66850

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRYATSAPESARGASLVQLQAERRDKRTSGGDNRGLVLAGVAALLLGGVGLRLTYLQV
CEEEEECCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
IQGPHHRELAENNRIRLVPIRPPRGRILDRYGRVLATNRLSFSVFLEPMQLKPKEWPAAL
HCCCCHHHHHCCCCEEEEECCCCCCHHHHHHCCEEEECCEEEEEEECHHHCCCCHHHHHH
ARLSLFIKVPADKLEEKLKAAGYNSPYPVRVLQNVEPQLVTVLREHIQELPGVKVDVEWM
HHHEEEEECCHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
RFYPNGPVASHLLGYTGEISEQQLAERKEQGYRLGDIIGKAGVERLLEEKLHGEWGGEQV
EECCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
EVDAAGQVVRVIGEVQPKAGQDVRLSIDLALQKTAEAALNSRKKRGAVVAMDPRNGQVLA
EECHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEE
IASAPSYDANILSGRISEQDWRRLQTPDRPLLNRAVRPYPTASTFKIIMTAAALESGKFN
EECCCCCCCHHHCCCCCHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
PNSRLATFGGLRIGGRVFRDHNGRGFGTIGFIRALSQSSDTFYYQVGLRIGPDEIAKWSR
CCCCEEEECCEEECCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECEECHHHHHHHHH
NFGFGSRTDIGLQSESRGLVPTPEWLKRRFGRQWFGGDTANTSIGQGMVLSTPLQNAVMV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEE
GAIANGGFRVQPHLVLDSRPGLSPVGLSPTTLATIRQGLSEVVRSGTARRALSMPDLPNA
EEEECCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
GKTGTAEHGARKGGRTHALYVGYAPTPAPEIAVSVLLENGGHGGSDAAPIAKKIYQTYFV
CCCCCCHHHHCCCCCEEEEEEECCCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHH
ARGKKSAALSPKHVE
HCCCCCCCCCCCCCC
>Mature Secondary Structure
MVLRYATSAPESARGASLVQLQAERRDKRTSGGDNRGLVLAGVAALLLGGVGLRLTYLQV
CEEEEECCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
IQGPHHRELAENNRIRLVPIRPPRGRILDRYGRVLATNRLSFSVFLEPMQLKPKEWPAAL
HCCCCHHHHHCCCCEEEEECCCCCCHHHHHHCCEEEECCEEEEEEECHHHCCCCHHHHHH
ARLSLFIKVPADKLEEKLKAAGYNSPYPVRVLQNVEPQLVTVLREHIQELPGVKVDVEWM
HHHEEEEECCHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
RFYPNGPVASHLLGYTGEISEQQLAERKEQGYRLGDIIGKAGVERLLEEKLHGEWGGEQV
EECCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
EVDAAGQVVRVIGEVQPKAGQDVRLSIDLALQKTAEAALNSRKKRGAVVAMDPRNGQVLA
EECHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEE
IASAPSYDANILSGRISEQDWRRLQTPDRPLLNRAVRPYPTASTFKIIMTAAALESGKFN
EECCCCCCCHHHCCCCCHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
PNSRLATFGGLRIGGRVFRDHNGRGFGTIGFIRALSQSSDTFYYQVGLRIGPDEIAKWSR
CCCCEEEECCEEECCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECEECHHHHHHHHH
NFGFGSRTDIGLQSESRGLVPTPEWLKRRFGRQWFGGDTANTSIGQGMVLSTPLQNAVMV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEE
GAIANGGFRVQPHLVLDSRPGLSPVGLSPTTLATIRQGLSEVVRSGTARRALSMPDLPNA
EEEECCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
GKTGTAEHGARKGGRTHALYVGYAPTPAPEIAVSVLLENGGHGGSDAAPIAKKIYQTYFV
CCCCCCHHHHCCCCCEEEEEEECCCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHH
ARGKKSAALSPKHVE
HCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]