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The map label for this gene is hup [H]

Identifier: 37522993

GI number: 37522993

Start: 3622789

End: 3623079

Strand: Reverse

Name: hup [H]

Synonym: gsl3424

Alternate gene names: 37522993

Gene position: 3623079-3622789 (Counterclockwise)

Preceding gene: 37522994

Following gene: 37522992

Centisome position: 77.76

GC content: 60.82

Gene sequence:

>291_bases
ATGAACAAAGGTGAATTAGTGGACGCCGTCGCCAAGAAAGCCAAGCTGGCCAAAAAGGACGTCGATGCGATCGTGGGTGC
GGCCTTCGATGTGATTGTCGAAGCGGTCTCGCGGGGCGACAAAGTCACCCTGGTGGGTTTCGGTTCGTTTGAACCGCGCA
AGCGCGCCGCCCGCGAAGGCCGCAATCCCAAGACCCGCGAGAAGATGACCATCGCCGCGACGACCGTGCCGGCTTTTTCG
GCGGGCAAGCAGTTTCGAGAAGCCGTCTCCGGTTCTGCCCAAGCGGACTAA

Upstream 100 bases:

>100_bases
CAAAGCATGTAGAATAAGCGATTGAAATTCAGGCCCAAAGGCACTTCCAGCGATTCGCCCACCTGCTTTTGGACCTGATA
TTGCACGGTGAGGAGTTTTT

Downstream 100 bases:

>100_bases
GTGATTCAAACACCCCTTCCTGCCCACGGCGGCGACCGCCAATGGGCGGCACGGATCGCCCGCTGCCGCATCGAAGAACT
TGTGGATTTCTCTGCCAGCA

Product: DNA binding protein HU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 96; Mature: 96

Protein sequence:

>96_residues
MNKGELVDAVAKKAKLAKKDVDAIVGAAFDVIVEAVSRGDKVTLVGFGSFEPRKRAAREGRNPKTREKMTIAATTVPAFS
AGKQFREAVSGSAQAD

Sequences:

>Translated_96_residues
MNKGELVDAVAKKAKLAKKDVDAIVGAAFDVIVEAVSRGDKVTLVGFGSFEPRKRAAREGRNPKTREKMTIAATTVPAFS
AGKQFREAVSGSAQAD
>Mature_96_residues
MNKGELVDAVAKKAKLAKKDVDAIVGAAFDVIVEAVSRGDKVTLVGFGSFEPRKRAAREGRNPKTREKMTIAATTVPAFS
AGKQFREAVSGSAQAD

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. It is essential for heterocyst differentiation [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=46.0674157303371, Blast_Score=85, Evalue=9e-19,
Organism=Escherichia coli, GI1786644, Length=94, Percent_Identity=46.8085106382979, Blast_Score=81, Evalue=1e-17,
Organism=Escherichia coli, GI1788005, Length=96, Percent_Identity=34.375, Blast_Score=63, Evalue=3e-12,
Organism=Escherichia coli, GI1787141, Length=88, Percent_Identity=34.0909090909091, Blast_Score=62, Evalue=5e-12,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 10136; Mature: 10136

Theoretical pI: Translated: 10.70; Mature: 10.70

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGELVDAVAKKAKLAKKDVDAIVGAAFDVIVEAVSRGDKVTLVGFGSFEPRKRAAREG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCC
RNPKTREKMTIAATTVPAFSAGKQFREAVSGSAQAD
CCCCCHHHEEEHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNKGELVDAVAKKAKLAKKDVDAIVGAAFDVIVEAVSRGDKVTLVGFGSFEPRKRAAREG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCC
RNPKTREKMTIAATTVPAFSAGKQFREAVSGSAQAD
CCCCCHHHEEEHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655556; 7748931; 11759840 [H]