Click here to switch to the map view.

The map label for this gene is fpg

Identifier: 37522976

GI number: 37522976

Start: 3607819

End: 3608673

Strand: Reverse

Name: fpg

Synonym: gvip464

Alternate gene names: 37522976

Gene position: 3608673-3607819 (Counterclockwise)

Preceding gene: 37522977

Following gene: 37522975

Centisome position: 77.46

GC content: 65.03

Gene sequence:

>855_bases
GTGCCCGAATTGCCCGAAGTCGAGACACTGCGCCGCGACCTCCTCATCCACCTGCCCGGCGAACGGGTGGTGGGCGTGGA
GGTTTTGCGCAGCGATTCGGTGGGTTACCCCGCCGATCCGGCGATTTTTATTGAACAGATGCAAGGCCAGATCTTCAGCG
ACAGGATGCTTCGGCGCGGCAAGTACCTGCTGCTCTACTTCGCGCGCGGGGCGGCCCTGGGAGTGCACCTGCGCATGTCG
GGCAGGTTGCTCTGGCGCTGTGGCGAAGCTCCCCTTGAACCCCATACCAGAGTCCGGATACCCATGGCGAGCGGTCACGA
ACTGCGCTTTGAGGACATGCGCGTCTTCGGTCGGCTCTGGCTGATTCCGGTGGGGGTGCCCCCGGAGCGGGTGATGGGTG
GGCTCACCCGGCTCGGTCCCGAGCCTTTTGCTGAGATGTTCGACGGCCCATACCTGGCGGGGCGCTTTGCGGGGCGCAAC
CAGCCGGTCAAAAGCGCCCTACTCGATCAGCAACTGGTGGCGGGAGTAGGGAACATTTATGCCGATGAGGCCCTCTTCAG
CAGTGGCATCCATCCTGCCCTGCCCGTAGGCGGGCTCGATGCGGCTGCCCTCGAACGGCTGCATCGAGCCGTAGTCAAGG
TGCTCGAAGCGGGCATCGCGCAGCGGGGCGCGACGTTGCGCAACTATACCGACGCCCAGGGCATCAACGGCAACTACGCC
GGCACTGCCTGGGTGTATGGACGCAAAGGCCAACCCTGCCGCGTGTGCAATACCCCGATCGAGCGCATCCGGCTGGCGGG
CCGCTCGACCCACTTCTGCCCCACCTGCCAGCGCGCCCAGCAATCAGTACAATAA

Upstream 100 bases:

>100_bases
GACGATCTACCCGGTGACGGTCCGCTTCGAGAAGGTCAATTACTCGGGGATCAACACCAACAACTTTGGCGTCAGCGAAC
TGGAAGAAGTCGAAGCCTAA

Downstream 100 bases:

>100_bases
AGCTCAACACGGGGAATTCTGCTCCAGCCATGCCGTTATGACAGCCAATCTTCTGACCCGGACCCGATCGACTGCCAGGC
TGCAGGTGCTCAAGCCCCTA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MPELPEVETLRRDLLIHLPGERVVGVEVLRSDSVGYPADPAIFIEQMQGQIFSDRMLRRGKYLLLYFARGAALGVHLRMS
GRLLWRCGEAPLEPHTRVRIPMASGHELRFEDMRVFGRLWLIPVGVPPERVMGGLTRLGPEPFAEMFDGPYLAGRFAGRN
QPVKSALLDQQLVAGVGNIYADEALFSSGIHPALPVGGLDAAALERLHRAVVKVLEAGIAQRGATLRNYTDAQGINGNYA
GTAWVYGRKGQPCRVCNTPIERIRLAGRSTHFCPTCQRAQQSVQ

Sequences:

>Translated_284_residues
MPELPEVETLRRDLLIHLPGERVVGVEVLRSDSVGYPADPAIFIEQMQGQIFSDRMLRRGKYLLLYFARGAALGVHLRMS
GRLLWRCGEAPLEPHTRVRIPMASGHELRFEDMRVFGRLWLIPVGVPPERVMGGLTRLGPEPFAEMFDGPYLAGRFAGRN
QPVKSALLDQQLVAGVGNIYADEALFSSGIHPALPVGGLDAAALERLHRAVVKVLEAGIAQRGATLRNYTDAQGINGNYA
GTAWVYGRKGQPCRVCNTPIERIRLAGRSTHFCPTCQRAQQSVQ
>Mature_283_residues
PELPEVETLRRDLLIHLPGERVVGVEVLRSDSVGYPADPAIFIEQMQGQIFSDRMLRRGKYLLLYFARGAALGVHLRMSG
RLLWRCGEAPLEPHTRVRIPMASGHELRFEDMRVFGRLWLIPVGVPPERVMGGLTRLGPEPFAEMFDGPYLAGRFAGRNQ
PVKSALLDQQLVAGVGNIYADEALFSSGIHPALPVGGLDAAALERLHRAVVKVLEAGIAQRGATLRNYTDAQGINGNYAG
TAWVYGRKGQPCRVCNTPIERIRLAGRSTHFCPTCQRAQQSVQ

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=278, Percent_Identity=41.3669064748201, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1786932, Length=293, Percent_Identity=26.962457337884, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_GLOVI (Q7NFW7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926353.1
- ProteinModelPortal:   Q7NFW7
- SMR:   Q7NFW7
- GeneID:   2601811
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3407
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- BioCyc:   GVIO251221:GLL3407-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31345; Mature: 31214

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 268-268 BINDING 95-95 BINDING 114-114 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETLRRDLLIHLPGERVVGVEVLRSDSVGYPADPAIFIEQMQGQIFSDRMLRRG
CCCCCHHHHHHHHEEEECCCCCEEEHEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCC
KYLLLYFARGAALGVHLRMSGRLLWRCGEAPLEPHTRVRIPMASGHELRFEDMRVFGRLW
CEEEEEEECCCEEEEEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCEEE
LIPVGVPPERVMGGLTRLGPEPFAEMFDGPYLAGRFAGRNQPVKSALLDQQLVAGVGNIY
EEECCCCHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
ADEALFSSGIHPALPVGGLDAAALERLHRAVVKVLEAGIAQRGATLRNYTDAQGINGNYA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
GTAWVYGRKGQPCRVCNTPIERIRLAGRSTHFCPTCQRAQQSVQ
CEEEEECCCCCCCCHHCCCHHHHHHCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
PELPEVETLRRDLLIHLPGERVVGVEVLRSDSVGYPADPAIFIEQMQGQIFSDRMLRRG
CCCCHHHHHHHHEEEECCCCCEEEHEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCC
KYLLLYFARGAALGVHLRMSGRLLWRCGEAPLEPHTRVRIPMASGHELRFEDMRVFGRLW
CEEEEEEECCCEEEEEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCEEE
LIPVGVPPERVMGGLTRLGPEPFAEMFDGPYLAGRFAGRNQPVKSALLDQQLVAGVGNIY
EEECCCCHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
ADEALFSSGIHPALPVGGLDAAALERLHRAVVKVLEAGIAQRGATLRNYTDAQGINGNYA
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCC
GTAWVYGRKGQPCRVCNTPIERIRLAGRSTHFCPTCQRAQQSVQ
CEEEEECCCCCCCCHHCCCHHHHHHCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292