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The map label for this gene is aroC

Identifier: 37522962

GI number: 37522962

Start: 3598876

End: 3600063

Strand: Direct

Name: aroC

Synonym: gvip463

Alternate gene names: 37522962

Gene position: 3598876-3600063 (Clockwise)

Preceding gene: 37522961

Following gene: 37522963

Centisome position: 77.25

GC content: 67.26

Gene sequence:

>1188_bases
ATGCTGCGCTTTTTGACCGCCGGGGAGTCCCACGGGCCGGGGCTGACGATCATTGTCGAGGGCATCCCCGCCGACTTGCC
CCTGTTGGCCGAAGACATCGACCGGGATCTGGCCCGCCGCCAGGTGGGTTTCGGCCGGGGCGGCCGGATGAGCATCGAGA
CCGATCGGGTCACCTTTCGGGGTGGCGTGCGGTTGGGCCGCACGATCGGTTCGCCCATCGCCATGACCCTCGAAAACCGC
GACTTTAAAAACTGGGAAGTGCCGATGTCGGTTTCCCCTGTGGATCTCGACGACGAGGCGGTGCGCGCCCAACTGGAGGC
CAAGCGCATCACCCGACTGCGCCCCGGCCACGCCGACTACCCGGGGGCGGTCAAGTACGGCCTCGCCGACGTGCGCAACA
TCCTGGAGCGCTCCAGTGCCCGCGAGACCGCCTCGCGCGTCGCGGCCGGGGCGATTGCCAAGCAACTGCTGCGCCAATTC
AACGTCCATGTCCACTCCCACGTCGTCGAAATCGGCGGCGTCGGGGCGGGCGAATCCGTCCGTCCCGCCTTGCCCACCTT
CGAGGAGTGGAAAGACCTGTTCGAGCGCGTCGATCAGAATGATCTTCGCTGTCACCCGGATCTCTACGAGCGGTTGCGCT
CGCGCGTCGTCGAGGCGGCCAAGGGCGGCTACACCCTGGGGGGTGCCGTGGAACTGGCGGCCTACGGCGAGATTCCGGTG
GGCCTCGGCTCCCACGTCCACTACGACCGGCGCATCGACGGACTATTGGCCGGGGCGGCAATGTCGGTGCACACCGTCAA
GGCGGTGGAAGTGGGTATCGGCACCGCCGCCGCCCGCGAGACGGGCGCCGATGTCCAGGATGAATTTATCAATGCAGCAG
GCGAAATCGCCCGCACGAGCAACCACGCAGGCGGTATCGAGGGCGGGATGACCAACGGCCAGCCGGTGCTCCTGCGCGCC
TACCTCAAGCCGTTACCCACCATGCGTAAGGCCCTCAGGTCGATCGACCTGGTCAGCCGCGAACCGTTCGAAGCCCACTA
CGAGCGCTCCGACACCTGCGCCGTACCCGCCGGGGGCGTCGTGTGCGAAGCGATGATGGCCATCGTGCTTGCCCAAGAAC
TGCAGCGCAAACTGGGCGGCGATTCGCTGGGGGAAATGCTGCGCCACGCCGGACGCACGCACGCCTGA

Upstream 100 bases:

>100_bases
CGAGCCAAGGGCCGTCAAAGCTTTTCGCGATACCCTGCGGGAAGTGCGCTAAAATCCGATTTCGCCGATAAGGTGTGCCT
TAGACCTGTTCAGGAAGACC

Downstream 100 bases:

>100_bases
AAACCGCCGGCCCCTGCGTTGTCCTTGTGGTAATCTGTCCACAAAGGAGATTGCCATGAAGCCGATCTTGAATGTTGCCG
ATGCCCCGATTCGCCGGCTC

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MLRFLTAGESHGPGLTIIVEGIPADLPLLAEDIDRDLARRQVGFGRGGRMSIETDRVTFRGGVRLGRTIGSPIAMTLENR
DFKNWEVPMSVSPVDLDDEAVRAQLEAKRITRLRPGHADYPGAVKYGLADVRNILERSSARETASRVAAGAIAKQLLRQF
NVHVHSHVVEIGGVGAGESVRPALPTFEEWKDLFERVDQNDLRCHPDLYERLRSRVVEAAKGGYTLGGAVELAAYGEIPV
GLGSHVHYDRRIDGLLAGAAMSVHTVKAVEVGIGTAAARETGADVQDEFINAAGEIARTSNHAGGIEGGMTNGQPVLLRA
YLKPLPTMRKALRSIDLVSREPFEAHYERSDTCAVPAGGVVCEAMMAIVLAQELQRKLGGDSLGEMLRHAGRTHA

Sequences:

>Translated_395_residues
MLRFLTAGESHGPGLTIIVEGIPADLPLLAEDIDRDLARRQVGFGRGGRMSIETDRVTFRGGVRLGRTIGSPIAMTLENR
DFKNWEVPMSVSPVDLDDEAVRAQLEAKRITRLRPGHADYPGAVKYGLADVRNILERSSARETASRVAAGAIAKQLLRQF
NVHVHSHVVEIGGVGAGESVRPALPTFEEWKDLFERVDQNDLRCHPDLYERLRSRVVEAAKGGYTLGGAVELAAYGEIPV
GLGSHVHYDRRIDGLLAGAAMSVHTVKAVEVGIGTAAARETGADVQDEFINAAGEIARTSNHAGGIEGGMTNGQPVLLRA
YLKPLPTMRKALRSIDLVSREPFEAHYERSDTCAVPAGGVVCEAMMAIVLAQELQRKLGGDSLGEMLRHAGRTHA
>Mature_395_residues
MLRFLTAGESHGPGLTIIVEGIPADLPLLAEDIDRDLARRQVGFGRGGRMSIETDRVTFRGGVRLGRTIGSPIAMTLENR
DFKNWEVPMSVSPVDLDDEAVRAQLEAKRITRLRPGHADYPGAVKYGLADVRNILERSSARETASRVAAGAIAKQLLRQF
NVHVHSHVVEIGGVGAGESVRPALPTFEEWKDLFERVDQNDLRCHPDLYERLRSRVVEAAKGGYTLGGAVELAAYGEIPV
GLGSHVHYDRRIDGLLAGAAMSVHTVKAVEVGIGTAAARETGADVQDEFINAAGEIARTSNHAGGIEGGMTNGQPVLLRA
YLKPLPTMRKALRSIDLVSREPFEAHYERSDTCAVPAGGVVCEAMMAIVLAQELQRKLGGDSLGEMLRHAGRTHA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=383, Percent_Identity=35.2480417754569, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321290, Length=381, Percent_Identity=29.9212598425197, Blast_Score=139, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_GLOVI (Q7NFY1)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926339.1
- HSSP:   O66493
- ProteinModelPortal:   Q7NFY1
- SMR:   Q7NFY1
- GeneID:   2601797
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3393
- HOGENOM:   HBG292336
- OMA:   GSEAHDE
- ProtClustDB:   PRK05382
- BioCyc:   GVIO251221:GLR3393-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 42639; Mature: 42639

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFLTAGESHGPGLTIIVEGIPADLPLLAEDIDRDLARRQVGFGRGGRMSIETDRVTFR
CCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEE
GGVRLGRTIGSPIAMTLENRDFKNWEVPMSVSPVDLDDEAVRAQLEAKRITRLRPGHADY
CCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
PGAVKYGLADVRNILERSSARETASRVAAGAIAKQLLRQFNVHVHSHVVEIGGVGAGESV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCC
RPALPTFEEWKDLFERVDQNDLRCHPDLYERLRSRVVEAAKGGYTLGGAVELAAYGEIPV
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCC
GLGSHVHYDRRIDGLLAGAAMSVHTVKAVEVGIGTAAARETGADVQDEFINAAGEIARTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
NHAGGIEGGMTNGQPVLLRAYLKPLPTMRKALRSIDLVSREPFEAHYERSDTCAVPAGGV
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHH
VCEAMMAIVLAQELQRKLGGDSLGEMLRHAGRTHA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLRFLTAGESHGPGLTIIVEGIPADLPLLAEDIDRDLARRQVGFGRGGRMSIETDRVTFR
CCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEE
GGVRLGRTIGSPIAMTLENRDFKNWEVPMSVSPVDLDDEAVRAQLEAKRITRLRPGHADY
CCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
PGAVKYGLADVRNILERSSARETASRVAAGAIAKQLLRQFNVHVHSHVVEIGGVGAGESV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCCCC
RPALPTFEEWKDLFERVDQNDLRCHPDLYERLRSRVVEAAKGGYTLGGAVELAAYGEIPV
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCC
GLGSHVHYDRRIDGLLAGAAMSVHTVKAVEVGIGTAAARETGADVQDEFINAAGEIARTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
NHAGGIEGGMTNGQPVLLRAYLKPLPTMRKALRSIDLVSREPFEAHYERSDTCAVPAGGV
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHH
VCEAMMAIVLAQELQRKLGGDSLGEMLRHAGRTHA
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292