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The map label for this gene is hisG

Identifier: 37522952

GI number: 37522952

Start: 3592407

End: 3593051

Strand: Direct

Name: hisG

Synonym: gvip462

Alternate gene names: 37522952

Gene position: 3592407-3593051 (Clockwise)

Preceding gene: 37522951

Following gene: 37522955

Centisome position: 77.11

GC content: 62.95

Gene sequence:

>645_bases
ATGAATATCACTATCGCCTTACCCAAAGGGGCCTTGCTCAAGGGTACGATCGCCCGCCTGCAGGCTATCGGCATCGACTT
TGGCGAATTTCTCGAAGGCTCCAACCGGTTGTTGCGCCTTGAAGATCGTTCGGGCCGCTACGAGGGTCTGCTGGTGCGCG
CCCAGGATGTGCCGGTGTACGTCGCCTACGGCCAGGCCCAGGTGGGGATAGTGGGTTTTGACGTCCTCAAAGAAAAGCAA
CTGCCCGTCGCCCAGGTGGCGGATCTCGGGTTTGGCTACTGCCGCATGTCGGTGGCAGTCAAAAGTGACAGCCCCTACCG
CAGTGTGCAGGATCTGCCCGCCCACTGCCGGGTGGCCTCCAAATTCACCACCTGCGCCAGGAGCTACTTCGAGGAGCGGG
AACTGCCCGTGGAGCTGATTCCCCTCTACGGCTCGGTGGAACTTGCCCCGCTCACCGGCATGGCCGAGGCGATCGTGGAC
CTGGTGTCCACGGGCCGCACCCTCAAGGACAACGGCCTAGTCGAACTCGAAAAAATCTTCGACAGCACCGCCCGGCTGAT
TGCCCATCCGCTCAGCTACCGGCTGGGACGGGTGGGCCTGCACGAACTATTGGGGCAGATCCGGACGGCGGCGGTCCCGG
CCTAG

Upstream 100 bases:

>100_bases
TGCCGGGCTTCTCGCTGGGCAACAAGCAGCCTTTGCCCGAGCCTTTTCAGCGCTCCGAAAACAACCGCGACCAGGAGCCC
CCTTCGACGACGGGCTGGCG

Downstream 100 bases:

>100_bases
CGCTGTAGCTGCATGAAGAACATCATCACTACGCCGGGCAGGCTTGCCAGGCCAAACAGCAGCAGGCCCAGACAGATAAG
CTTGTCGATCATTCCGGCCA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MNITIALPKGALLKGTIARLQAIGIDFGEFLEGSNRLLRLEDRSGRYEGLLVRAQDVPVYVAYGQAQVGIVGFDVLKEKQ
LPVAQVADLGFGYCRMSVAVKSDSPYRSVQDLPAHCRVASKFTTCARSYFEERELPVELIPLYGSVELAPLTGMAEAIVD
LVSTGRTLKDNGLVELEKIFDSTARLIAHPLSYRLGRVGLHELLGQIRTAAVPA

Sequences:

>Translated_214_residues
MNITIALPKGALLKGTIARLQAIGIDFGEFLEGSNRLLRLEDRSGRYEGLLVRAQDVPVYVAYGQAQVGIVGFDVLKEKQ
LPVAQVADLGFGYCRMSVAVKSDSPYRSVQDLPAHCRVASKFTTCARSYFEERELPVELIPLYGSVELAPLTGMAEAIVD
LVSTGRTLKDNGLVELEKIFDSTARLIAHPLSYRLGRVGLHELLGQIRTAAVPA
>Mature_214_residues
MNITIALPKGALLKGTIARLQAIGIDFGEFLEGSNRLLRLEDRSGRYEGLLVRAQDVPVYVAYGQAQVGIVGFDVLKEKQ
LPVAQVADLGFGYCRMSVAVKSDSPYRSVQDLPAHCRVASKFTTCARSYFEERELPVELIPLYGSVELAPLTGMAEAIVD
LVSTGRTLKDNGLVELEKIFDSTARLIAHPLSYRLGRVGLHELLGQIRTAAVPA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=147, Percent_Identity=39.4557823129252, Blast_Score=85, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=140, Percent_Identity=32.8571428571429, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_GLOVI (Q7NFZ1)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926329.1
- ProteinModelPortal:   Q7NFZ1
- SMR:   Q7NFZ1
- GeneID:   2601787
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3383
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   GVIO251221:GLR3383-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23330; Mature: 23330

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITIALPKGALLKGTIARLQAIGIDFGEFLEGSNRLLRLEDRSGRYEGLLVRAQDVPVY
CEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCEEEEEEEECCCCEE
VAYGQAQVGIVGFDVLKEKQLPVAQVADLGFGYCRMSVAVKSDSPYRSVQDLPAHCRVAS
EEECCEEEEEEEHHHHHCCCCCHHHHHHCCCCEEEEEEEEECCCCCHHHHCCCHHHHHHH
KFTTCARSYFEERELPVELIPLYGSVELAPLTGMAEAIVDLVSTGRTLKDNGLVELEKIF
HHHHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHCCCEECCCCCCHHHHHH
DSTARLIAHPLSYRLGRVGLHELLGQIRTAAVPA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNITIALPKGALLKGTIARLQAIGIDFGEFLEGSNRLLRLEDRSGRYEGLLVRAQDVPVY
CEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCEEEEEEEECCCCEE
VAYGQAQVGIVGFDVLKEKQLPVAQVADLGFGYCRMSVAVKSDSPYRSVQDLPAHCRVAS
EEECCEEEEEEEHHHHHCCCCCHHHHHHCCCCEEEEEEEEECCCCCHHHHCCCHHHHHHH
KFTTCARSYFEERELPVELIPLYGSVELAPLTGMAEAIVDLVSTGRTLKDNGLVELEKIF
HHHHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHCCCEECCCCCCHHHHHH
DSTARLIAHPLSYRLGRVGLHELLGQIRTAAVPA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292