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The map label for this gene is hemC

Identifier: 37522781

GI number: 37522781

Start: 3421125

End: 3422111

Strand: Direct

Name: hemC

Synonym: gvip442

Alternate gene names: 37522781

Gene position: 3421125-3422111 (Clockwise)

Preceding gene: 37522774

Following gene: 37522784

Centisome position: 73.43

GC content: 65.25

Gene sequence:

>987_bases
GTGTCCCGCACAGTGATTATCGGTTCGCGCGATTCGCAACTGGCCCTCGTTCAGACCCACTGGGTACGCGACGAACTGCA
GCGCGCCCACCCGGACATCCGGTTTGAAATTGTCGAGATGAAAACCCAGGGCGACAAGATTCTCGATGTCGCCCTCGCCA
AGATTGGCGACAAGGGGCTTTTTACCAAAGAGCTCGAAAGCGCCATGCTCGAGAAGCGCACGGACCTCGCCGTGCACTCG
CTGAAGGATCTGCCCACGGCGCTGCCGCCGGGGCTCATCCTGGGTGCAATCACCGAGCGCGAAGATCCGAGCGATGCGGT
GATCGTGCGCCGGGGACTTGAAGCTGCGGGGCTTGCCGATCTGCCCGAGGGGGCGGTCGTCGGCACTTCTTCTTTGCGCC
GCCTCGCCCAACTCAAGCATCACTACGGCGAACGCCTGCGCTTTCAGGACATCCGGGGCAATCTCAACACGCGCTTGCGC
AAGCTGGATGAGGGCCGCTACGACGCGATTGTGCTCGCCGTGGCAGGCATGCGGCGCTTGGGCTGGTCCGAGCGGATCAG
CGAAGTGCTCTCCCCAGACATCTCGCTGCACGCCGTAGGCCAGGGTGCTCTAGGTATCGAGTGCCGCGAAGCGGACGGGG
AGATCCTGGACTTGCTGACAGTTCTCAACCACCCCCCGACCGCCCGGCGCTGCCGGGCGGAGCGGGCCATGCTGCGCGCC
CTCGAAGGCGGCTGCCAGGTACCGATCGGCGTGTACACCGAACTGGACGACAGCGGTCGGCTCACCCTGCAAGGTATCGT
CGCTTCCCTGGACGGCCGGAATATGGCGCGCGCCTGCCGCAGCGGTCCCGGCGACGCCCCTGAGGCTCTTGGCCGGGCTG
TGGCGGAAGATCTTAAAGCGGCGGGCGCCCAGGCGATCCTTGATCAAATTTTTGTCCTCGTTCGCTCTCCCGGGGTGATC
GCTCCTGGTGCCGCGCCGGCCTCATGA

Upstream 100 bases:

>100_bases
TGCGCAGGCGGATCATCGCAGGAGACTCGGCAGGCAAACGTTTTCAGTGTACCTGCTCTTGCAGATATGCTAGGAAAGCT
TTGCGGTTGGAGGTGGCGGC

Downstream 100 bases:

>100_bases
ACTGGCAGCCGGCTGCGAATCGCGAAAGTAATAGCGATCGAGCGCTTCGGTGGTGCCGAGACTGCGCAGCGCCTGCTCGG
CAGTGCGCACCAGCGCTTCG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSRTVIIGSRDSQLALVQTHWVRDELQRAHPDIRFEIVEMKTQGDKILDVALAKIGDKGLFTKELESAMLEKRTDLAVHS
LKDLPTALPPGLILGAITEREDPSDAVIVRRGLEAAGLADLPEGAVVGTSSLRRLAQLKHHYGERLRFQDIRGNLNTRLR
KLDEGRYDAIVLAVAGMRRLGWSERISEVLSPDISLHAVGQGALGIECREADGEILDLLTVLNHPPTARRCRAERAMLRA
LEGGCQVPIGVYTELDDSGRLTLQGIVASLDGRNMARACRSGPGDAPEALGRAVAEDLKAAGAQAILDQIFVLVRSPGVI
APGAAPAS

Sequences:

>Translated_328_residues
MSRTVIIGSRDSQLALVQTHWVRDELQRAHPDIRFEIVEMKTQGDKILDVALAKIGDKGLFTKELESAMLEKRTDLAVHS
LKDLPTALPPGLILGAITEREDPSDAVIVRRGLEAAGLADLPEGAVVGTSSLRRLAQLKHHYGERLRFQDIRGNLNTRLR
KLDEGRYDAIVLAVAGMRRLGWSERISEVLSPDISLHAVGQGALGIECREADGEILDLLTVLNHPPTARRCRAERAMLRA
LEGGCQVPIGVYTELDDSGRLTLQGIVASLDGRNMARACRSGPGDAPEALGRAVAEDLKAAGAQAILDQIFVLVRSPGVI
APGAAPAS
>Mature_327_residues
SRTVIIGSRDSQLALVQTHWVRDELQRAHPDIRFEIVEMKTQGDKILDVALAKIGDKGLFTKELESAMLEKRTDLAVHSL
KDLPTALPPGLILGAITEREDPSDAVIVRRGLEAAGLADLPEGAVVGTSSLRRLAQLKHHYGERLRFQDIRGNLNTRLRK
LDEGRYDAIVLAVAGMRRLGWSERISEVLSPDISLHAVGQGALGIECREADGEILDLLTVLNHPPTARRCRAERAMLRAL
EGGCQVPIGVYTELDDSGRLTLQGIVASLDGRNMARACRSGPGDAPEALGRAVAEDLKAAGAQAILDQIFVLVRSPGVIA
PGAAPAS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=336, Percent_Identity=49.1071428571429, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI66933009, Length=336, Percent_Identity=49.1071428571429, Blast_Score=295, Evalue=3e-80,
Organism=Escherichia coli, GI48994974, Length=305, Percent_Identity=51.8032786885246, Blast_Score=278, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6319996, Length=318, Percent_Identity=40.8805031446541, Blast_Score=226, Evalue=3e-60,
Organism=Drosophila melanogaster, GI20130425, Length=280, Percent_Identity=48.5714285714286, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_GLOVI (Q7NGF7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926158.1
- ProteinModelPortal:   Q7NGF7
- SMR:   Q7NGF7
- GeneID:   2601613
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3212
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   GVIO251221:GLR3212-MONOMER
- BRENDA:   2.5.1.61
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 35364; Mature: 35233

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTVIIGSRDSQLALVQTHWVRDELQRAHPDIRFEIVEMKTQGDKILDVALAKIGDKGL
CCCEEEEECCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCC
FTKELESAMLEKRTDLAVHSLKDLPTALPPGLILGAITEREDPSDAVIVRRGLEAAGLAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEHHCCCCCCCCHHHHHCCCCCCCCCC
LPEGAVVGTSSLRRLAQLKHHYGERLRFQDIRGNLNTRLRKLDEGRYDAIVLAVAGMRRL
CCCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHC
GWSERISEVLSPDISLHAVGQGALGIECREADGEILDLLTVLNHPPTARRCRAERAMLRA
CHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
LEGGCQVPIGVYTELDDSGRLTLQGIVASLDGRNMARACRSGPGDAPEALGRAVAEDLKA
HHCCCCCCEEEEEEECCCCCEEHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
AGAQAILDQIFVLVRSPGVIAPGAAPAS
CCHHHHHHHHHHHHCCCCEECCCCCCCC
>Mature Secondary Structure 
SRTVIIGSRDSQLALVQTHWVRDELQRAHPDIRFEIVEMKTQGDKILDVALAKIGDKGL
CCEEEEECCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCC
FTKELESAMLEKRTDLAVHSLKDLPTALPPGLILGAITEREDPSDAVIVRRGLEAAGLAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEHHCCCCCCCCHHHHHCCCCCCCCCC
LPEGAVVGTSSLRRLAQLKHHYGERLRFQDIRGNLNTRLRKLDEGRYDAIVLAVAGMRRL
CCCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHC
GWSERISEVLSPDISLHAVGQGALGIECREADGEILDLLTVLNHPPTARRCRAERAMLRA
CHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
LEGGCQVPIGVYTELDDSGRLTLQGIVASLDGRNMARACRSGPGDAPEALGRAVAEDLKA
HHCCCCCCEEEEEEECCCCCEEHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
AGAQAILDQIFVLVRSPGVIAPGAAPAS
CCHHHHHHHHHHHHCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292