Click here to switch to the map view.

The map label for this gene is ahcY

Identifier: 37522752

GI number: 37522752

Start: 3391414

End: 3392700

Strand: Direct

Name: ahcY

Synonym: glr3183

Alternate gene names: 37522752

Gene position: 3391414-3392700 (Clockwise)

Preceding gene: 37522749

Following gene: 37522754

Centisome position: 72.79

GC content: 63.25

Gene sequence:

>1287_bases
ATGACAGCAGTAAAGACCCCAATCCAGGTGCGCTACGAAGTTCGCAACCTCGAACTGGCGGCTGAAGGCAGACAGCGTAT
CGAATGGGCGGCGCGCGAGATGCCCGTGCTCAAACAATTGCGCCAGCGTTTTTCCCAGGAACGCCCTTTAGCCGGCATTC
GCATTTCCGCCTGCTGTCACGTCACGACCGAGACGGCCAACCTGGCTGTCGCCCTGAAGGCGGCTGGGGCCGACGCCTTG
CTTATCGCAAGCAACCCCCTTTCGACCCAGGACGATGTCGCCGCCTCGCTGGTGGTCGATCACGGCATTCCGGTCTTTGC
CCTCAAGGGTGAGGACACCGCCACCTACTTGCGTCATGTCCGTGTCGCCCTCGACCACCGGCCGCAGATCATCATCGACG
ACGGCTCCGATGTGGTGGCGACGATGATCAAAGACCGCCCCGATCTGATTGCCGGGGTGATCGGCACCACCGAGGAGACC
ACCACCGGCATCGTCCGCCTCAAGGCGATGCTCGCCGCCGGGGTGCTCACCTTTCCGGCGATGGCGGTCAACGACGCCGA
GACCAAGCACTTTTTCGACAACCGCTACGGCACCGGTCAATCGACCCTGGATGGCATTATCCGGGCCACCAACATTCTGC
TTGCGGGTAAGACGATCGTTGTCGCCGGTTACGGCTGGTGCGGCAAGGGTGTGGCCCTGCGCGCCCGCGGTATGGGGGCG
AATGTCGTCGTGACCGAGATCAACCCCGTGCGCGCCATCGAAGCGGCGATGGACGGCTTGCAGGTGATGCCGATGGCCGA
GGCCGCTTGCCTGGGTGACCTGTTCATCACCGTCACCGGCAACAAGCACGTCATCCGCCGCGAGCACTTCGCGATGATGA
AGGACGGCGCCATCGTCTGCAACTCCGGCCACTTTGACATCGAAATCGACTTGGTCGCCCTGGGCGAACTGTCCAGCGAG
CGCCGCATGGTCCGTCCTTTCACCGAGGAGTACACCCTCGAAGGGGGCAAATCGGTGATCGTGCTGGGCGAAGGCCGTCT
AATCAACCTGGCCGCCGCCGAGGGCCACCCCGCCTCGGTGATGGACATGAGCTTCGCCAACCAGGCTCTGGCCGTCGAGT
ACCTGATCAAGAACCAGGGCAAGCTCTCCCCGGGCATCTACAACATCCCCGAAGAACTCGACCGGCAAATCGCCGCCCTC
AAGCTCGCCGCCATGGGCATCGCCATCGACACCCTGACGCCCGACCAGCTCCACTACATCTCCTCGTGGGACGAAGGGAC
CGAATAG

Upstream 100 bases:

>100_bases
AAACGGCAATAAGGTATCCTAGTTTGAGTGACAGCCCTCATTCTGTCACGTTCCGTTTCTTGGTAACCCGGATTTTCCCA
CGTATTTTCAGGAGCATTTG

Downstream 100 bases:

>100_bases
TCCAAATCTCCAAGTGCTACCATCGGTTGGTAGCCTTGGGCACGTAGCTCAGCGGATAGAGCGTTCGCCTCCGGAGCGAA
AGGTCGTGGGTTCGATCCCC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTAVKTPIQVRYEVRNLELAAEGRQRIEWAAREMPVLKQLRQRFSQERPLAGIRISACCHVTTETANLAVALKAAGADAL
LIASNPLSTQDDVAASLVVDHGIPVFALKGEDTATYLRHVRVALDHRPQIIIDDGSDVVATMIKDRPDLIAGVIGTTEET
TTGIVRLKAMLAAGVLTFPAMAVNDAETKHFFDNRYGTGQSTLDGIIRATNILLAGKTIVVAGYGWCGKGVALRARGMGA
NVVVTEINPVRAIEAAMDGLQVMPMAEAACLGDLFITVTGNKHVIRREHFAMMKDGAIVCNSGHFDIEIDLVALGELSSE
RRMVRPFTEEYTLEGGKSVIVLGEGRLINLAAAEGHPASVMDMSFANQALAVEYLIKNQGKLSPGIYNIPEELDRQIAAL
KLAAMGIAIDTLTPDQLHYISSWDEGTE

Sequences:

>Translated_428_residues
MTAVKTPIQVRYEVRNLELAAEGRQRIEWAAREMPVLKQLRQRFSQERPLAGIRISACCHVTTETANLAVALKAAGADAL
LIASNPLSTQDDVAASLVVDHGIPVFALKGEDTATYLRHVRVALDHRPQIIIDDGSDVVATMIKDRPDLIAGVIGTTEET
TTGIVRLKAMLAAGVLTFPAMAVNDAETKHFFDNRYGTGQSTLDGIIRATNILLAGKTIVVAGYGWCGKGVALRARGMGA
NVVVTEINPVRAIEAAMDGLQVMPMAEAACLGDLFITVTGNKHVIRREHFAMMKDGAIVCNSGHFDIEIDLVALGELSSE
RRMVRPFTEEYTLEGGKSVIVLGEGRLINLAAAEGHPASVMDMSFANQALAVEYLIKNQGKLSPGIYNIPEELDRQIAAL
KLAAMGIAIDTLTPDQLHYISSWDEGTE
>Mature_427_residues
TAVKTPIQVRYEVRNLELAAEGRQRIEWAAREMPVLKQLRQRFSQERPLAGIRISACCHVTTETANLAVALKAAGADALL
IASNPLSTQDDVAASLVVDHGIPVFALKGEDTATYLRHVRVALDHRPQIIIDDGSDVVATMIKDRPDLIAGVIGTTEETT
TGIVRLKAMLAAGVLTFPAMAVNDAETKHFFDNRYGTGQSTLDGIIRATNILLAGKTIVVAGYGWCGKGVALRARGMGAN
VVVTEINPVRAIEAAMDGLQVMPMAEAACLGDLFITVTGNKHVIRREHFAMMKDGAIVCNSGHFDIEIDLVALGELSSER
RMVRPFTEEYTLEGGKSVIVLGEGRLINLAAAEGHPASVMDMSFANQALAVEYLIKNQGKLSPGIYNIPEELDRQIAALK
LAAMGIAIDTLTPDQLHYISSWDEGTE

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=415, Percent_Identity=43.3734939759036, Blast_Score=335, Evalue=7e-92,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=43.8461538461538, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI195539349, Length=415, Percent_Identity=39.2771084337349, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI298286489, Length=415, Percent_Identity=39.2771084337349, Blast_Score=288, Evalue=5e-78,
Organism=Homo sapiens, GI195539337, Length=415, Percent_Identity=39.2771084337349, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI24308043, Length=415, Percent_Identity=39.2771084337349, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI21361647, Length=415, Percent_Identity=38.7951807228916, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17506425, Length=418, Percent_Identity=42.822966507177, Blast_Score=325, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6320882, Length=439, Percent_Identity=41.4578587699317, Blast_Score=321, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24642172, Length=413, Percent_Identity=41.6464891041162, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24656245, Length=414, Percent_Identity=38.1642512077295, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI45553387, Length=414, Percent_Identity=38.1642512077295, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI45553385, Length=414, Percent_Identity=38.1642512077295, Blast_Score=258, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_GLOVI (Q7NGI6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926129.1
- ProteinModelPortal:   Q7NGI6
- SMR:   Q7NGI6
- GeneID:   2601584
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr3183
- NMPDR:   fig|251221.1.peg.3183
- HOGENOM:   HBG352029
- OMA:   FLFEQKY
- ProtClustDB:   PRK05476
- BioCyc:   GVIO251221:GLR3183-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 46151; Mature: 46020

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 62-62 BINDING 134-134 BINDING 159-159 BINDING 189-189 BINDING 193-193 BINDING 194-194 BINDING 246-246 BINDING 281-281 BINDING 349-349

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVKTPIQVRYEVRNLELAAEGRQRIEWAAREMPVLKQLRQRFSQERPLAGIRISACCH
CCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEE
VTTETANLAVALKAAGADALLIASNPLSTQDDVAASLVVDHGIPVFALKGEDTATYLRHV
EEECCCEEEEEEEECCCCEEEEECCCCCCCHHHHHEEEEECCCCEEEECCCCHHHHHHHH
RVALDHRPQIIIDDGSDVVATMIKDRPDLIAGVIGTTEETTTGIVRLKAMLAAGVLTFPA
HHEECCCCEEEEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
MAVNDAETKHFFDNRYGTGQSTLDGIIRATNILLAGKTIVVAGYGWCGKGVALRARGMGA
EEECCCCHHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCCCCCCEEEEECCCCC
NVVVTEINPVRAIEAAMDGLQVMPMAEAACLGDLFITVTGNKHVIRREHFAMMKDGAIVC
EEEEECCCCHHHHHHHHCCCEECCCHHHHEECEEEEEEECCCEEEEHHHHHHCCCCEEEE
NSGHFDIEIDLVALGELSSERRMVRPFTEEYTLEGGKSVIVLGEGRLINLAAAEGHPASV
CCCCEEEEEEEEEECCCCCCCHHHCCCCHHHEECCCCEEEEEECCEEEEEEECCCCCCCE
MDMSFANQALAVEYLIKNQGKLSPGIYNIPEELDRQIAALKLAAMGIAIDTLTPDQLHYI
EEHHHCCHHHEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEE
SSWDEGTE
CCCCCCCC
>Mature Secondary Structure 
TAVKTPIQVRYEVRNLELAAEGRQRIEWAAREMPVLKQLRQRFSQERPLAGIRISACCH
CCCCCCEEEEEEEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEE
VTTETANLAVALKAAGADALLIASNPLSTQDDVAASLVVDHGIPVFALKGEDTATYLRHV
EEECCCEEEEEEEECCCCEEEEECCCCCCCHHHHHEEEEECCCCEEEECCCCHHHHHHHH
RVALDHRPQIIIDDGSDVVATMIKDRPDLIAGVIGTTEETTTGIVRLKAMLAAGVLTFPA
HHEECCCCEEEEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
MAVNDAETKHFFDNRYGTGQSTLDGIIRATNILLAGKTIVVAGYGWCGKGVALRARGMGA
EEECCCCHHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCCCCCCEEEEECCCCC
NVVVTEINPVRAIEAAMDGLQVMPMAEAACLGDLFITVTGNKHVIRREHFAMMKDGAIVC
EEEEECCCCHHHHHHHHCCCEECCCHHHHEECEEEEEEECCCEEEEHHHHHHCCCCEEEE
NSGHFDIEIDLVALGELSSERRMVRPFTEEYTLEGGKSVIVLGEGRLINLAAAEGHPASV
CCCCEEEEEEEEEECCCCCCCHHHCCCCHHHEECCCCEEEEEECCEEEEEEECCCCCCCE
MDMSFANQALAVEYLIKNQGKLSPGIYNIPEELDRQIAALKLAAMGIAIDTLTPDQLHYI
EEHHHCCHHHEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEE
SSWDEGTE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292