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The map label for this gene is pgl [H]

Identifier: 37522749

GI number: 37522749

Start: 3389365

End: 3390093

Strand: Direct

Name: pgl [H]

Synonym: glr3180

Alternate gene names: 37522749

Gene position: 3389365-3390093 (Clockwise)

Preceding gene: 37522748

Following gene: 37522752

Centisome position: 72.75

GC content: 65.57

Gene sequence:

>729_bases
ATGCGCGGCGCCATCACCATCTTTCCGGATCTGGAGAGCCTGTCGCTGGAAGCGGCACAGCTATTCGAGGAGGCAGCCCA
CGCTGCCATCGCCCTGCACAACCGCTTTTGCGTGTCGCTCGCGGGCGGTTCGACGCCCAAACGGCTCTACCAGTTGCTCG
CCACCGAGCCGCACCGCTCCAAGTTGCCCTGGAATCAGATTCATCTATTCTGGGGCGACGAACGCTTCGTGCCGCCCGAT
GACCCGCAGAGCAACTACCGGATGGTCAAAGAGGCGCTGCTGGACCATGTCGCCATCCCCGTGGCGAACGTGCACGCGAT
GCCCGTGGGCAGCGACGATATCGAGGAAGCGGCCCGCCTGCACTCGGCCCAGTTGTCCGAGTTTTTTGGCGGCGACATTC
GCCTTGACCTGGCATTGATGGGTATGGGCGCCGACGGGCACACCGCCTCGCTCTTTCCAGGCGATGGCGCTCTGACCGTG
GACGATCGGCCGGTGGCGGCGGCCCGCCCCGCCTCCCAACCGACGGCCCGCCTGACCCTTACCTACCCGGTCTTCAACCG
CAGCCGCAAGGTGCTTTTTCTGGTGGCCGGTGCCGACAAAGCCGAGGTGCTGACCCGGGTGCTCGCCGGCGACACCACCT
ACCCGAGTGCCCTTATCGATCCCGCCGACGGCGAACGCTTCTGGATGCTCGATCAAGCCGCCGCCGCCAAGCTGCCACTT
CCTAGCTAA

Upstream 100 bases:

>100_bases
CCGAACAGTTGCTCAGCGAAGCGCTCAGAACCCCCGATCGCGACCCCATCTATGAGGAATCGCTCGAAGTGATCCACGAT
CTGATGCAGCTGAAGTAGCT

Downstream 100 bases:

>100_bases
CGCGTCGCTGCCACTTCGCGCACGACCGCCTCGATCGTCTCCGGAGCCAGGAAGTGGCCTGCCTCCATTGACAACCACAG
CCAGTACTCGCGATTGCCGG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MRGAITIFPDLESLSLEAAQLFEEAAHAAIALHNRFCVSLAGGSTPKRLYQLLATEPHRSKLPWNQIHLFWGDERFVPPD
DPQSNYRMVKEALLDHVAIPVANVHAMPVGSDDIEEAARLHSAQLSEFFGGDIRLDLALMGMGADGHTASLFPGDGALTV
DDRPVAAARPASQPTARLTLTYPVFNRSRKVLFLVAGADKAEVLTRVLAGDTTYPSALIDPADGERFWMLDQAAAAKLPL
PS

Sequences:

>Translated_242_residues
MRGAITIFPDLESLSLEAAQLFEEAAHAAIALHNRFCVSLAGGSTPKRLYQLLATEPHRSKLPWNQIHLFWGDERFVPPD
DPQSNYRMVKEALLDHVAIPVANVHAMPVGSDDIEEAARLHSAQLSEFFGGDIRLDLALMGMGADGHTASLFPGDGALTV
DDRPVAAARPASQPTARLTLTYPVFNRSRKVLFLVAGADKAEVLTRVLAGDTTYPSALIDPADGERFWMLDQAAAAKLPL
PS
>Mature_242_residues
MRGAITIFPDLESLSLEAAQLFEEAAHAAIALHNRFCVSLAGGSTPKRLYQLLATEPHRSKLPWNQIHLFWGDERFVPPD
DPQSNYRMVKEALLDHVAIPVANVHAMPVGSDDIEEAARLHSAQLSEFFGGDIRLDLALMGMGADGHTASLFPGDGALTV
DDRPVAAARPASQPTARLTLTYPVFNRSRKVLFLVAGADKAEVLTRVLAGDTTYPSALIDPADGERFWMLDQAAAAKLPL
PS

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=228, Percent_Identity=36.4035087719298, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI6912586, Length=247, Percent_Identity=34.8178137651822, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI115533058, Length=250, Percent_Identity=27.6, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI115533060, Length=250, Percent_Identity=27.6, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321957, Length=246, Percent_Identity=29.6747967479675, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321687, Length=253, Percent_Identity=30.8300395256917, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319918, Length=214, Percent_Identity=30.3738317757009, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324362, Length=214, Percent_Identity=30.3738317757009, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641119, Length=242, Percent_Identity=31.404958677686, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26218; Mature: 26218

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGAITIFPDLESLSLEAAQLFEEAAHAAIALHNRFCVSLAGGSTPKRLYQLLATEPHRS
CCCCEEEECCHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHCCCCCC
KLPWNQIHLFWGDERFVPPDDPQSNYRMVKEALLDHVAIPVANVHAMPVGSDDIEEAARL
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
HSAQLSEFFGGDIRLDLALMGMGADGHTASLFPGDGALTVDDRPVAAARPASQPTARLTL
HHHHHHHHCCCCEEEEEEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEE
TYPVFNRSRKVLFLVAGADKAEVLTRVLAGDTTYPSALIDPADGERFWMLDQAAAAKLPL
EEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEECHHHCCCCC
PS
CC
>Mature Secondary Structure
MRGAITIFPDLESLSLEAAQLFEEAAHAAIALHNRFCVSLAGGSTPKRLYQLLATEPHRS
CCCCEEEECCHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHCCCCCC
KLPWNQIHLFWGDERFVPPDDPQSNYRMVKEALLDHVAIPVANVHAMPVGSDDIEEAARL
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
HSAQLSEFFGGDIRLDLALMGMGADGHTASLFPGDGALTVDDRPVAAARPASQPTARLTL
HHHHHHHHCCCCEEEEEEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEE
TYPVFNRSRKVLFLVAGADKAEVLTRVLAGDTTYPSALIDPADGERFWMLDQAAAAKLPL
EEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEECCCCCCEEEEEECHHHCCCCC
PS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]