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The map label for this gene is ilvD

Identifier: 37522737

GI number: 37522737

Start: 3375583

End: 3377265

Strand: Reverse

Name: ilvD

Synonym: gvip437

Alternate gene names: 37522737

Gene position: 3377265-3375583 (Counterclockwise)

Preceding gene: 37522738

Following gene: 37522733

Centisome position: 72.49

GC content: 65.89

Gene sequence:

>1683_bases
ATGTCCGGCAATCTGCGCAGCCGCATCGTCACCCAGGGGGTGCAGCGCTCCCCCAACCGCGCCATGCTGCGGGCGGTGGG
TTTTGGCGACGGTGATTTCGAGCGGCCCATCGTGGGGGTGGCCAACGGCTTCAGCACGATTACCCCCTGCAATCTGGGCC
TGGGAGCTTTGGCGGAGCGGGCGGAGGCGGCGTTGCGCGCCGGCGGGGCGATGCCCCAACTATTCGGAACGATCACGATC
AGCGACGGCATCTCGATGGGTACCGAGGGGATGAAGTACTCGCTGGTGTCCCGCGAGGTGATCGCCGACAGCATCGAGAC
GGTCTGCAACGGTCAGAGCCTGGACGGGGTGCTCGCTATCGGCGGCTGCGACAAGAACATGCCGGGTGCGATGATCGCCA
TTGCCAGACTCAATATCCCGGCGGTCTTCGTCTACGGCGGCACGATCAAACCCGGCCGCTACCAGGATCAGGACCTCACG
GTCGTGAGCGCCTTCGAAGCGGTGGGCCAGTACAGCGCCGGCAAAATTGACCAGACGACCCTCGTCGAAATCGAGCGGCG
CGCCTGCCCGGGGGCGGGCTCCTGCGGCGGCATGTACACCGCCAATACGATGAGTTCGGCCTTCGAGGCGATGGGCATGA
GCTTGGTGTACTCCTCGACGATGGCCGCCGAGGATCCCGAAAAAGCGGACAGCACCGCCCTGTCGGCCAAGGTGCTGGTT
GAAGCGATCCAAGCGCAAATCCTGCCGAGCGCCATCCTGACGCGAAAAGCTTTCGAGAACGCCATCGCTGTGATCATGGC
CATCGGCGGCTCGACCAACGCCGTGCTGCACCTGCTTGCCATCGCCCACAGCGCCCGGGTGCCACTCGCACTGGATGACT
TCGAGTGCATCCGCGCGCGGGTGCCGGTGCTGTGCGATCTCAAGCCCAGCGGTCGCTTTGTCGCCACCGATCTGCACAGA
GCCGGGGGTATTCCCCAGGTGATGAAAATGTTGCTCGTGCGCGGGCTCCTCCACGGCGACGCCCTCACGGTAACCGGCCA
GACGGTCGCCGAGGTGCTGCGCGACGTACCCACAGAACCGCGCACCGACCAGGAGGTGATCCGTCCCTGGGACCGGCCTC
TCTACAGTTCGGGGCACCTGGCCATTTTGCGCGGCAACCTGGCGAGCGAAGGGGCGGTCGCCAAGATTACCGGCGTCAAA
AAGCCCCAGATCACTGGTCCTGCCCGCGTCTTCGACTCCGAAGAAAGCTGCATGGAAGCAATTCTGGCGGGCGCCATCCA
GCCGGGCGATGTGATCGTCATTCGCTACGAAGGCCCCAAGGGCGGTCCCGGCATGCGGGAGATGCTCTCGCCCACTTCGG
CCATCATCGGCGCGGGTCTGGGCGATGCGGTGGGACTGATCACCGACGGCCGCTTCTCGGGGGGCACCTACGGCATGGTC
GTGGGCCACGTCGCCCCGGAAGCCTTCGTGGGCGGCACCATCGCCCTGGTCGAAGCAGGAGATCTGATCACCATCGACGC
CCCGGCGCGCAAGATCGAGCTATTGGTGACCACAGACGAACTGGAGCGCCGACGCGCCGCCTGGCGGCCGCCTGCCCCCC
GTTACATCCGCGGGGTGCTCGCCAAGTACGCCCGTCAGGTGAACAGCAGCAGCCTCGGGGCGGTCACCGACGCCTTTATT
TGA

Upstream 100 bases:

>100_bases
ATGTTCGCAAGCTGCTGAAACTGAGTGCACCAACCGGGGATTTGCGCTCCACAGCCGATCCTGTTAGCCTACGAGTCCAA
GAGGGATTTGAGGAAAGGCC

Downstream 100 bases:

>100_bases
TGAATACCCGGTAGCTGCGCCAGGCCGCACCGCGCCAGGCGAGCCGAATCATGCTCTGCTTGCCGAGGCCCGAGCGGCGG
GTGGCCTGATCGACGGTGGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MSGNLRSRIVTQGVQRSPNRAMLRAVGFGDGDFERPIVGVANGFSTITPCNLGLGALAERAEAALRAGGAMPQLFGTITI
SDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVLAIGGCDKNMPGAMIAIARLNIPAVFVYGGTIKPGRYQDQDLT
VVSAFEAVGQYSAGKIDQTTLVEIERRACPGAGSCGGMYTANTMSSAFEAMGMSLVYSSTMAAEDPEKADSTALSAKVLV
EAIQAQILPSAILTRKAFENAIAVIMAIGGSTNAVLHLLAIAHSARVPLALDDFECIRARVPVLCDLKPSGRFVATDLHR
AGGIPQVMKMLLVRGLLHGDALTVTGQTVAEVLRDVPTEPRTDQEVIRPWDRPLYSSGHLAILRGNLASEGAVAKITGVK
KPQITGPARVFDSEESCMEAILAGAIQPGDVIVIRYEGPKGGPGMREMLSPTSAIIGAGLGDAVGLITDGRFSGGTYGMV
VGHVAPEAFVGGTIALVEAGDLITIDAPARKIELLVTTDELERRRAAWRPPAPRYIRGVLAKYARQVNSSSLGAVTDAFI

Sequences:

>Translated_560_residues
MSGNLRSRIVTQGVQRSPNRAMLRAVGFGDGDFERPIVGVANGFSTITPCNLGLGALAERAEAALRAGGAMPQLFGTITI
SDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVLAIGGCDKNMPGAMIAIARLNIPAVFVYGGTIKPGRYQDQDLT
VVSAFEAVGQYSAGKIDQTTLVEIERRACPGAGSCGGMYTANTMSSAFEAMGMSLVYSSTMAAEDPEKADSTALSAKVLV
EAIQAQILPSAILTRKAFENAIAVIMAIGGSTNAVLHLLAIAHSARVPLALDDFECIRARVPVLCDLKPSGRFVATDLHR
AGGIPQVMKMLLVRGLLHGDALTVTGQTVAEVLRDVPTEPRTDQEVIRPWDRPLYSSGHLAILRGNLASEGAVAKITGVK
KPQITGPARVFDSEESCMEAILAGAIQPGDVIVIRYEGPKGGPGMREMLSPTSAIIGAGLGDAVGLITDGRFSGGTYGMV
VGHVAPEAFVGGTIALVEAGDLITIDAPARKIELLVTTDELERRRAAWRPPAPRYIRGVLAKYARQVNSSSLGAVTDAFI
>Mature_559_residues
SGNLRSRIVTQGVQRSPNRAMLRAVGFGDGDFERPIVGVANGFSTITPCNLGLGALAERAEAALRAGGAMPQLFGTITIS
DGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVLAIGGCDKNMPGAMIAIARLNIPAVFVYGGTIKPGRYQDQDLTV
VSAFEAVGQYSAGKIDQTTLVEIERRACPGAGSCGGMYTANTMSSAFEAMGMSLVYSSTMAAEDPEKADSTALSAKVLVE
AIQAQILPSAILTRKAFENAIAVIMAIGGSTNAVLHLLAIAHSARVPLALDDFECIRARVPVLCDLKPSGRFVATDLHRA
GGIPQVMKMLLVRGLLHGDALTVTGQTVAEVLRDVPTEPRTDQEVIRPWDRPLYSSGHLAILRGNLASEGAVAKITGVKK
PQITGPARVFDSEESCMEAILAGAIQPGDVIVIRYEGPKGGPGMREMLSPTSAIIGAGLGDAVGLITDGRFSGGTYGMVV
GHVAPEAFVGGTIALVEAGDLITIDAPARKIELLVTTDELERRRAAWRPPAPRYIRGVLAKYARQVNSSSLGAVTDAFI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=39.2739273927393, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788157, Length=510, Percent_Identity=32.156862745098, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI2367371, Length=492, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786464, Length=463, Percent_Identity=33.9092872570194, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=563, Percent_Identity=47.4245115452931, Blast_Score=516, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_GLOVI (Q7NGK1)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926114.1
- ProteinModelPortal:   Q7NGK1
- SMR:   Q7NGK1
- GeneID:   2601569
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3168
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- ProtClustDB:   PRK00911
- BioCyc:   GVIO251221:GLL3168-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58648; Mature: 58517

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNLRSRIVTQGVQRSPNRAMLRAVGFGDGDFERPIVGVANGFSTITPCNLGLGALAER
CCCCHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AEAALRAGGAMPQLFGTITISDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVLAI
HHHHHHCCCCCCHHEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGAMIAIARLNIPAVFVYGGTIKPGRYQDQDLTVVSAFEAVGQYSAGKIDQTT
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHH
LVEIERRACPGAGSCGGMYTANTMSSAFEAMGMSLVYSSTMAAEDPEKADSTALSAKVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EAIQAQILPSAILTRKAFENAIAVIMAIGGSTNAVLHLLAIAHSARVPLALDDFECIRAR
HHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEECCHHHHHCC
VPVLCDLKPSGRFVATDLHRAGGIPQVMKMLLVRGLLHGDALTVTGQTVAEVLRDVPTEP
CCEEEECCCCCCEEEECHHHHCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCC
RTDQEVIRPWDRPLYSSGHLAILRGNLASEGAVAKITGVKKPQITGPARVFDSEESCMEA
CCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCHHHHHHH
ILAGAIQPGDVIVIRYEGPKGGPGMREMLSPTSAIIGAGLGDAVGLITDGRFSGGTYGMV
HHHCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCEEEEE
VGHVAPEAFVGGTIALVEAGDLITIDAPARKIELLVTTDELERRRAAWRPPAPRYIRGVL
EECCCCHHHCCCEEEEEECCCEEEECCCCCEEEEEEECHHHHHHHHCCCCCCHHHHHHHH
AKYARQVNSSSLGAVTDAFI
HHHHHHCCCCCCCCHHHHCC
>Mature Secondary Structure 
SGNLRSRIVTQGVQRSPNRAMLRAVGFGDGDFERPIVGVANGFSTITPCNLGLGALAER
CCCHHHHHHHHHHHCCCCHHEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AEAALRAGGAMPQLFGTITISDGISMGTEGMKYSLVSREVIADSIETVCNGQSLDGVLAI
HHHHHHCCCCCCHHEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGAMIAIARLNIPAVFVYGGTIKPGRYQDQDLTVVSAFEAVGQYSAGKIDQTT
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHH
LVEIERRACPGAGSCGGMYTANTMSSAFEAMGMSLVYSSTMAAEDPEKADSTALSAKVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EAIQAQILPSAILTRKAFENAIAVIMAIGGSTNAVLHLLAIAHSARVPLALDDFECIRAR
HHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEECCHHHHHCC
VPVLCDLKPSGRFVATDLHRAGGIPQVMKMLLVRGLLHGDALTVTGQTVAEVLRDVPTEP
CCEEEECCCCCCEEEECHHHHCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCC
RTDQEVIRPWDRPLYSSGHLAILRGNLASEGAVAKITGVKKPQITGPARVFDSEESCMEA
CCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCHHHHHHH
ILAGAIQPGDVIVIRYEGPKGGPGMREMLSPTSAIIGAGLGDAVGLITDGRFSGGTYGMV
HHHCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCEEEEE
VGHVAPEAFVGGTIALVEAGDLITIDAPARKIELLVTTDELERRRAAWRPPAPRYIRGVL
EECCCCHHHCCCEEEEEECCCEEEECCCCCEEEEEEECHHHHHHHHCCCCCCHHHHHHHH
AKYARQVNSSSLGAVTDAFI
HHHHHHCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292