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The map label for this gene is glcD [H]

Identifier: 37522638

GI number: 37522638

Start: 3264924

End: 3266393

Strand: Direct

Name: glcD [H]

Synonym: gvip420

Alternate gene names: 37522638

Gene position: 3264924-3266393 (Clockwise)

Preceding gene: 37522637

Following gene: 37522640

Centisome position: 70.08

GC content: 64.63

Gene sequence:

>1470_bases
ATGATGCCCACCCTCACCAAGCGCAACTGGCGGGTCATCGCCCAGCAGATGGAACAAATTGTCGGCAAAAGCGGCGTCGT
CTGGACGCCGGAGGAATTGCTGGTCTTCGAGTGCGATGGGCTGACCAGCTACAAACAGCGCCCTGCCCTCGCCGTCCTGC
CGCGCACCACCGAAGAAGTCTCCCGGGTTCTCGCTTTGTGCTATCGGGAAGGATTGCCCTTTGTGGCGAGGGGCTCCGGT
ACGGGCCTCTCGGGTGGAGCATTGCCGGTCGAAGGGTGCGTGCTGGTGGTCACTGCGCGCATGAACCGGATTCTGGCCGT
CGACTTGGACAATCGCCAGGTGGTCGTGCAGCCGGGGGTCATCAACAACTGGGTCACCCAGGCGGTGAGCGGCGCCGGTT
TTTATTACGCCCCGGACCCCTCCAGCCAGAGCATCTGCTCCATTGGCGGCAACGTCGCCGAAAATTCCGGTGGCGTGCAC
TGCCTCAAGTACGGCGTCACCACCAACCACGTGCTCGGCCTCAAACTGGTCCTGCCGGACGGCGAGGTGGTCGACGTGGG
CGGTCGGGTGCCCGAGACGCCCGGGTACGACCTGGCGGGGGTGTTCGTGGGCTCCGAAGGCACCCTGGGGATCGCCACCG
AAATCACCCTGCGCCTGCTGAAGTCCGCCGAATCGATCCGGGTGTTGCTCGCCGATTTTGCCGCCATCGAGGAAGCGGGT
GCGGCGGTCACGGCCATCATCGCCGCCGGGATCGTGCCGGGAGGCATGGAGATCATGGACAACCTGAGCATCAATGCCGT
CGAAGATGTGGTGGCCACCGACTGCTATCCGCGCGACGCCGGGGCGATTTTGCTCGTCGAAGTGGACGGGCTTGCAGTCG
AAGTCGAGGCAGCGAGTGCCCGGGTGGAAGCCCTCTGCCTAGAGGCCGGAGCGCGCGCGGTGCGCACCGCCACCGACCCC
GCCGAGCGGCTCAAGCTCTGGAAGGGTCGCAAGGCCGCCTTTGCCGCCATGGGCCAGCGCGCCCCCAACTACTACGTACA
GGACGGGGTGATCCCGCGTACAAAATTGCAGTTTGTTCTTCAGCAGATTGAATTGCTGAGCGAAAAGCACGGCTACCCGG
TGGCGAACGTCTTTCACGCGGGCGACGGCAACCTGCATCCGCTGATTCTCTACGACGGGCGGATCGCCGGGGAACTCGAA
AAAGTCGAGCTTCTCGGAGGCGAGATCCTCAAGCTCTGCGTCGCGGTGGGCGGCAGCATCTCGGGCGAGCACGGCATCGG
TGCCGAAAAGCGCTGCTACATGAGCGACATGTTTACCCCGGCTGATCTAGAGACCATGCAGTGGGTGCGCACCGTGTTCG
ATCCGAAGGGCCTTGCCAACCCCACCAAGCTCTTTCCTACCCCGCGCACCTGCGGCGAAGCCGCCCGCGCCGAATCCACC
GCCCGCTTCCCCACGGTGGAACGGTTTTGA

Upstream 100 bases:

>100_bases
CTCCTGGACGGCGGGCCGTGCCTTCGGCGCCGCGCGCGCCGACCGCTTCATCCCCTGAAGCCGGGTCTACACTGAAGCCG
GAAGCCTCGCAACCCAAGCC

Downstream 100 bases:

>100_bases
GTACTCCTGCGAACCGATCCGACATTGACTCCGCGCGGGTTAGCCCTCTGGGCGGCTTGTTAAAAGCTCTGCGTTGCGGC
GCAGCAGATCGTCTTCGATA

Product: glycolate oxidase subunit

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MMPTLTKRNWRVIAQQMEQIVGKSGVVWTPEELLVFECDGLTSYKQRPALAVLPRTTEEVSRVLALCYREGLPFVARGSG
TGLSGGALPVEGCVLVVTARMNRILAVDLDNRQVVVQPGVINNWVTQAVSGAGFYYAPDPSSQSICSIGGNVAENSGGVH
CLKYGVTTNHVLGLKLVLPDGEVVDVGGRVPETPGYDLAGVFVGSEGTLGIATEITLRLLKSAESIRVLLADFAAIEEAG
AAVTAIIAAGIVPGGMEIMDNLSINAVEDVVATDCYPRDAGAILLVEVDGLAVEVEAASARVEALCLEAGARAVRTATDP
AERLKLWKGRKAAFAAMGQRAPNYYVQDGVIPRTKLQFVLQQIELLSEKHGYPVANVFHAGDGNLHPLILYDGRIAGELE
KVELLGGEILKLCVAVGGSISGEHGIGAEKRCYMSDMFTPADLETMQWVRTVFDPKGLANPTKLFPTPRTCGEAARAEST
ARFPTVERF

Sequences:

>Translated_489_residues
MMPTLTKRNWRVIAQQMEQIVGKSGVVWTPEELLVFECDGLTSYKQRPALAVLPRTTEEVSRVLALCYREGLPFVARGSG
TGLSGGALPVEGCVLVVTARMNRILAVDLDNRQVVVQPGVINNWVTQAVSGAGFYYAPDPSSQSICSIGGNVAENSGGVH
CLKYGVTTNHVLGLKLVLPDGEVVDVGGRVPETPGYDLAGVFVGSEGTLGIATEITLRLLKSAESIRVLLADFAAIEEAG
AAVTAIIAAGIVPGGMEIMDNLSINAVEDVVATDCYPRDAGAILLVEVDGLAVEVEAASARVEALCLEAGARAVRTATDP
AERLKLWKGRKAAFAAMGQRAPNYYVQDGVIPRTKLQFVLQQIELLSEKHGYPVANVFHAGDGNLHPLILYDGRIAGELE
KVELLGGEILKLCVAVGGSISGEHGIGAEKRCYMSDMFTPADLETMQWVRTVFDPKGLANPTKLFPTPRTCGEAARAEST
ARFPTVERF
>Mature_489_residues
MMPTLTKRNWRVIAQQMEQIVGKSGVVWTPEELLVFECDGLTSYKQRPALAVLPRTTEEVSRVLALCYREGLPFVARGSG
TGLSGGALPVEGCVLVVTARMNRILAVDLDNRQVVVQPGVINNWVTQAVSGAGFYYAPDPSSQSICSIGGNVAENSGGVH
CLKYGVTTNHVLGLKLVLPDGEVVDVGGRVPETPGYDLAGVFVGSEGTLGIATEITLRLLKSAESIRVLLADFAAIEEAG
AAVTAIIAAGIVPGGMEIMDNLSINAVEDVVATDCYPRDAGAILLVEVDGLAVEVEAASARVEALCLEAGARAVRTATDP
AERLKLWKGRKAAFAAMGQRAPNYYVQDGVIPRTKLQFVLQQIELLSEKHGYPVANVFHAGDGNLHPLILYDGRIAGELE
KVELLGGEILKLCVAVGGSISGEHGIGAEKRCYMSDMFTPADLETMQWVRTVFDPKGLANPTKLFPTPRTCGEAARAEST
ARFPTVERF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=424, Percent_Identity=32.5471698113208, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI37595754, Length=447, Percent_Identity=31.5436241610738, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI119964728, Length=457, Percent_Identity=29.5404814004376, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4501993, Length=223, Percent_Identity=26.0089686098655, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1789351, Length=467, Percent_Identity=51.8201284796574, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=25.1004016064257, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI48994907, Length=489, Percent_Identity=23.9263803680982, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71992373, Length=457, Percent_Identity=27.3522975929978, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71992381, Length=457, Percent_Identity=25.8205689277899, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71992392, Length=358, Percent_Identity=27.3743016759777, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17534361, Length=464, Percent_Identity=27.801724137931, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17556096, Length=219, Percent_Identity=23.7442922374429, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320027, Length=436, Percent_Identity=28.8990825688073, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320023, Length=452, Percent_Identity=26.3274336283186, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320764, Length=454, Percent_Identity=25.9911894273128, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18921117, Length=474, Percent_Identity=27.2151898734177, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24639277, Length=474, Percent_Identity=27.2151898734177, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24639275, Length=474, Percent_Identity=27.2151898734177, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24653753, Length=222, Percent_Identity=25.6756756756757, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52089; Mature: 52089

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPTLTKRNWRVIAQQMEQIVGKSGVVWTPEELLVFECDGLTSYKQRPALAVLPRTTEEV
CCCCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCHHCCCCEEECCCCHHHH
SRVLALCYREGLPFVARGSGTGLSGGALPVEGCVLVVTARMNRILAVDLDNRQVVVQPGV
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCEEEECCCC
INNWVTQAVSGAGFYYAPDPSSQSICSIGGNVAENSGGVHCLKYGVTTNHVLGLKLVLPD
HHHHHHHHHCCCCEEECCCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
GEVVDVGGRVPETPGYDLAGVFVGSEGTLGIATEITLRLLKSAESIRVLLADFAAIEEAG
CCEEECCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AAVTAIIAAGIVPGGMEIMDNLSINAVEDVVATDCYPRDAGAILLVEVDGLAVEVEAASA
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEHHHH
RVEALCLEAGARAVRTATDPAERLKLWKGRKAAFAAMGQRAPNYYVQDGVIPRTKLQFVL
HHHHHHHHHCCHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCEECCCCCCHHHHHHHH
QQIELLSEKHGYPVANVFHAGDGNLHPLILYDGRIAGELEKVELLGGEILKLCVAVGGSI
HHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCEECCCHHHHHHHHHHHHHHHHHHCCCC
SGEHGIGAEKRCYMSDMFTPADLETMQWVRTVFDPKGLANPTKLFPTPRTCGEAARAEST
CCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHCCCC
ARFPTVERF
CCCCCCCCC
>Mature Secondary Structure
MMPTLTKRNWRVIAQQMEQIVGKSGVVWTPEELLVFECDGLTSYKQRPALAVLPRTTEEV
CCCCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCHHCCCCEEECCCCHHHH
SRVLALCYREGLPFVARGSGTGLSGGALPVEGCVLVVTARMNRILAVDLDNRQVVVQPGV
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCEEEECCCC
INNWVTQAVSGAGFYYAPDPSSQSICSIGGNVAENSGGVHCLKYGVTTNHVLGLKLVLPD
HHHHHHHHHCCCCEEECCCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
GEVVDVGGRVPETPGYDLAGVFVGSEGTLGIATEITLRLLKSAESIRVLLADFAAIEEAG
CCEEECCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AAVTAIIAAGIVPGGMEIMDNLSINAVEDVVATDCYPRDAGAILLVEVDGLAVEVEAASA
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEHHHH
RVEALCLEAGARAVRTATDPAERLKLWKGRKAAFAAMGQRAPNYYVQDGVIPRTKLQFVL
HHHHHHHHHCCHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCEECCCCCCHHHHHHHH
QQIELLSEKHGYPVANVFHAGDGNLHPLILYDGRIAGELEKVELLGGEILKLCVAVGGSI
HHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCEECCCHHHHHHHHHHHHHHHHHHCCCC
SGEHGIGAEKRCYMSDMFTPADLETMQWVRTVFDPKGLANPTKLFPTPRTCGEAARAEST
CCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHCCCC
ARFPTVERF
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]