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The map label for this gene is ggt [H]

Identifier: 37522573

GI number: 37522573

Start: 3201670

End: 3203526

Strand: Reverse

Name: ggt [H]

Synonym: gvip413

Alternate gene names: 37522573

Gene position: 3203526-3201670 (Counterclockwise)

Preceding gene: 37522575

Following gene: 37522570

Centisome position: 68.76

GC content: 66.88

Gene sequence:

>1857_bases
GTGCGAATATCAGCGAATACCGACAGGATCGAAGCATTTTGTCAGGATAGCGGATCTGTGTGGAACCGACGCGGCGTGCA
TCGGTATGTTACACCTGGTTCGGAACATTTTCGGGATCGTCTTTTGAACCACCGAACGTTGCCGTTGCTGGCTGCCTTTG
TCATCGGATCGGCCGCGCCCGTGGCCGCCCTCGATGGCGTGGTGAGCACCGCTCATCCTTTGGCCACCGAGGCGGGTATC
GAGATGCTGCGCAAAGGCGGCAACGCCGTCGACGCCGCCATCGCCGCGAGCCTCGCCCTGGGTGTGGTCGAGCCGCAGTC
CTCGGGAATCGGCGGGGGCGGCTTCGCGCTGGTGTGGCTCGGGCGGACCGCCGAGGCGCGCGTTCTCGACTTTCGCGAAG
CGGCCCCGGGTCAAGCCGCCGCCGCGATGTATCTCGACAAGGCAGGCAAGGTGATCCCCCGGCTGTCGCTCGACGGTTAC
CGGGCGGCGGGGGTGCCCGGCCAGGCGGCGGGGCTGGTGAAATTGCAGCAAGCCTACGCGGCCTTGCCGCTTGCAACGCT
CGCTGAACCGGCCATCCGCCTGGCCAGGGAAGGCTTTTCACTCAGCGATCTGGTGCGCGGCCGGATCGAGGCTGCAGCCG
AGCGGCTGGGGCGAGATCCGGAGGCAAGCCGCGTCTTTCTGGTGGAGGGCAAAGCTCCCCCGGCGGGTTATCGCCTACGG
CAGCCGGATCTGGCCCGCACCCTCGAACTGTGGGTCAACAGCGGCGGCGACAGTTTTTATCGGGGCGAGACGGCGGCGGC
GATGGCGGCGGCGATGACTGAGCGCGGCGGGCTGGTCTCGCGCGCCGATCTCGAAAGCTACAGCCCTGTCTGGCGCACGC
CCCTGGTGGGCAGTTACCGGGGGGTGCCGGTGGTGACGATGCCGCCTCCAGGCAGCGGCGGGGTGCTCCTGGAGATGCTC
AATACCCTCGAAAACTTTGATCTGGCCGCCCAGACGCCGCTATTGCGCACCCACCTCACCGCCCAGGCGATGAGCCGCGC
CTACGCCGACCGCTCGCGCTTCTACGGCGACCCGGCCTTCGTGCCGGTGCCTCTCGCCGCGCTGGTGGCCAAAAGCTACG
GGGCGGCCCAGAAAAAAACGATCTCCCTCGAACGGGCCACCCCTTCAACCCAGATCGTGCCGGGCAGCTTGCTCAGCCCC
GCCCTCCTGGCCGGATTCCAGAGTTGGGAAGGCCCGCGGCCGGTCGAAAACACCAGCCACCTGAGCACCATGGACGCCGA
CGGCAACACCGTGGCCCTTACCCAGACGATCAACGGCGGCTTCGGCGCGGCGGTGGTCGCCCCCAAAACGGGCATCCTGC
TCAACAACGAGATGGACGATTTTGCCGTCGCCCCCGGCGTGCCCAACCTGTTCGGCCTGGTGGGCAGCAAGGCCAACGCC
ATCGCCCCCGGCAAGCGGCCGCTCTCCTCGATGACCCCGACGATATTGCTGAAAAACGGGCGACCCTGGATCGCTCTGGG
TAGCCCCGGCGGGGCGTTTATCACCAACGCCGTGCTGCAGACGATTCTGGGCGTGCTCGATTACCAATTGTCCCTGCCGG
AAGCCGTGAACGCTCCGCGCATCCACCACCAGTGGCAGCCCGACCGATTGTTCGTCGAAAAAGCTTATCCAGTTGCCCAG
GAAACCCTCTCTGCCCTGGGTTATGGTCTGCGCGCCATCGATGCGATGGGCAATGTCCAGGCAGTTCAGTACGCAGGCCG
GTTCGTGGGGGCGAGCGACGGGCGCCGCGAGGGCACCAGCGCCATCTGGCAAACGCCCGCTAGGGCTGCTTCTCCGGCTG
CTTCGCCGCGTCGCTGA

Upstream 100 bases:

>100_bases
TTGCCGCCGTCTTCGATCTCAAGCGTCTGTCCGGCGGCGGCCACCCGCAGGGTCAGGGCCGAGGCCGGGTCGTGCCGACC
GAATAGTCCAACGAGCGGCA

Downstream 100 bases:

>100_bases
TCTCAAGAGGCGGCGGCTGCACCGACTCGACGACGTCGTAGGACCGGTTGGGAGTGGTCTGCGTCACCGGGGGCTCGGCA
AATTCGCGCTTGACCTCGCG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MRISANTDRIEAFCQDSGSVWNRRGVHRYVTPGSEHFRDRLLNHRTLPLLAAFVIGSAAPVAALDGVVSTAHPLATEAGI
EMLRKGGNAVDAAIAASLALGVVEPQSSGIGGGGFALVWLGRTAEARVLDFREAAPGQAAAAMYLDKAGKVIPRLSLDGY
RAAGVPGQAAGLVKLQQAYAALPLATLAEPAIRLAREGFSLSDLVRGRIEAAAERLGRDPEASRVFLVEGKAPPAGYRLR
QPDLARTLELWVNSGGDSFYRGETAAAMAAAMTERGGLVSRADLESYSPVWRTPLVGSYRGVPVVTMPPPGSGGVLLEML
NTLENFDLAAQTPLLRTHLTAQAMSRAYADRSRFYGDPAFVPVPLAALVAKSYGAAQKKTISLERATPSTQIVPGSLLSP
ALLAGFQSWEGPRPVENTSHLSTMDADGNTVALTQTINGGFGAAVVAPKTGILLNNEMDDFAVAPGVPNLFGLVGSKANA
IAPGKRPLSSMTPTILLKNGRPWIALGSPGGAFITNAVLQTILGVLDYQLSLPEAVNAPRIHHQWQPDRLFVEKAYPVAQ
ETLSALGYGLRAIDAMGNVQAVQYAGRFVGASDGRREGTSAIWQTPARAASPAASPRR

Sequences:

>Translated_618_residues
MRISANTDRIEAFCQDSGSVWNRRGVHRYVTPGSEHFRDRLLNHRTLPLLAAFVIGSAAPVAALDGVVSTAHPLATEAGI
EMLRKGGNAVDAAIAASLALGVVEPQSSGIGGGGFALVWLGRTAEARVLDFREAAPGQAAAAMYLDKAGKVIPRLSLDGY
RAAGVPGQAAGLVKLQQAYAALPLATLAEPAIRLAREGFSLSDLVRGRIEAAAERLGRDPEASRVFLVEGKAPPAGYRLR
QPDLARTLELWVNSGGDSFYRGETAAAMAAAMTERGGLVSRADLESYSPVWRTPLVGSYRGVPVVTMPPPGSGGVLLEML
NTLENFDLAAQTPLLRTHLTAQAMSRAYADRSRFYGDPAFVPVPLAALVAKSYGAAQKKTISLERATPSTQIVPGSLLSP
ALLAGFQSWEGPRPVENTSHLSTMDADGNTVALTQTINGGFGAAVVAPKTGILLNNEMDDFAVAPGVPNLFGLVGSKANA
IAPGKRPLSSMTPTILLKNGRPWIALGSPGGAFITNAVLQTILGVLDYQLSLPEAVNAPRIHHQWQPDRLFVEKAYPVAQ
ETLSALGYGLRAIDAMGNVQAVQYAGRFVGASDGRREGTSAIWQTPARAASPAASPRR
>Mature_618_residues
MRISANTDRIEAFCQDSGSVWNRRGVHRYVTPGSEHFRDRLLNHRTLPLLAAFVIGSAAPVAALDGVVSTAHPLATEAGI
EMLRKGGNAVDAAIAASLALGVVEPQSSGIGGGGFALVWLGRTAEARVLDFREAAPGQAAAAMYLDKAGKVIPRLSLDGY
RAAGVPGQAAGLVKLQQAYAALPLATLAEPAIRLAREGFSLSDLVRGRIEAAAERLGRDPEASRVFLVEGKAPPAGYRLR
QPDLARTLELWVNSGGDSFYRGETAAAMAAAMTERGGLVSRADLESYSPVWRTPLVGSYRGVPVVTMPPPGSGGVLLEML
NTLENFDLAAQTPLLRTHLTAQAMSRAYADRSRFYGDPAFVPVPLAALVAKSYGAAQKKTISLERATPSTQIVPGSLLSP
ALLAGFQSWEGPRPVENTSHLSTMDADGNTVALTQTINGGFGAAVVAPKTGILLNNEMDDFAVAPGVPNLFGLVGSKANA
IAPGKRPLSSMTPTILLKNGRPWIALGSPGGAFITNAVLQTILGVLDYQLSLPEAVNAPRIHHQWQPDRLFVEKAYPVAQ
ETLSALGYGLRAIDAMGNVQAVQYAGRFVGASDGRREGTSAIWQTPARAASPAASPRR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=543, Percent_Identity=34.4383057090239, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI73915090, Length=543, Percent_Identity=34.4383057090239, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI73915096, Length=543, Percent_Identity=34.4383057090239, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI73915094, Length=543, Percent_Identity=34.4383057090239, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI113429324, Length=541, Percent_Identity=33.456561922366, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI113429326, Length=546, Percent_Identity=33.1501831501831, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI109148539, Length=540, Percent_Identity=32.2222222222222, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI153266885, Length=491, Percent_Identity=28.5132382892057, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI153266901, Length=492, Percent_Identity=28.6585365853659, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI153266907, Length=491, Percent_Identity=26.8839103869654, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI30581157, Length=190, Percent_Identity=41.0526315789474, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI30581155, Length=190, Percent_Identity=41.0526315789474, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI218505805, Length=190, Percent_Identity=39.4736842105263, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI310124095, Length=189, Percent_Identity=35.978835978836, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789856, Length=543, Percent_Identity=42.3572744014733, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI212646519, Length=516, Percent_Identity=32.7519379844961, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI72000294, Length=516, Percent_Identity=32.7519379844961, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI193208247, Length=511, Percent_Identity=32.8767123287671, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI193208245, Length=511, Percent_Identity=32.8767123287671, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17506189, Length=558, Percent_Identity=33.1541218637993, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17542894, Length=513, Percent_Identity=31.1890838206628, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI72001497, Length=236, Percent_Identity=28.8135593220339, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=236, Percent_Identity=28.8135593220339, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=577, Percent_Identity=30.3292894280763, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI18859893, Length=491, Percent_Identity=33.6048879837067, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI161077496, Length=514, Percent_Identity=31.5175097276265, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161077878, Length=522, Percent_Identity=30.8429118773946, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI45551474, Length=522, Percent_Identity=30.8429118773946, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI161077880, Length=522, Percent_Identity=30.8429118773946, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24642670, Length=522, Percent_Identity=30.8429118773946, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24642666, Length=522, Percent_Identity=30.8429118773946, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI18859741, Length=530, Percent_Identity=26.9811320754717, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64995; Mature: 64995

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISANTDRIEAFCQDSGSVWNRRGVHRYVTPGSEHFRDRLLNHRTLPLLAAFVIGSAAP
CCCCCCHHHHHHHHHCCCCCHHHCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCC
VAALDGVVSTAHPLATEAGIEMLRKGGNAVDAAIAASLALGVVEPQSSGIGGGGFALVWL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEE
GRTAEARVLDFREAAPGQAAAAMYLDKAGKVIPRLSLDGYRAAGVPGQAAGLVKLQQAYA
CCCCCCCEEEHHHCCCCHHHHHHHHHHCCCCCEEECCCCCEECCCCCCHHHHHHHHHHHH
ALPLATLAEPAIRLAREGFSLSDLVRGRIEAAAERLGRDPEASRVFLVEGKAPPAGYRLR
HCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
QPDLARTLELWVNSGGDSFYRGETAAAMAAAMTERGGLVSRADLESYSPVWRTPLVGSYR
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHCCCCCCCCCCCCCC
GVPVVTMPPPGSGGVLLEMLNTLENFDLAAQTPLLRTHLTAQAMSRAYADRSRFYGDPAF
CEEEEEECCCCCCHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
VPVPLAALVAKSYGAAQKKTISLERATPSTQIVPGSLLSPALLAGFQSWEGPRPVENTSH
CHHHHHHHHHHHCCCCCHHEEEEECCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
LSTMDADGNTVALTQTINGGFGAAVVAPKTGILLNNEMDDFAVAPGVPNLFGLVGSKANA
CEEECCCCCEEEEEEEECCCCCEEEECCCCCEEECCCCCCCEECCCCCHHHHHHCCCCCC
IAPGKRPLSSMTPTILLKNGRPWIALGSPGGAFITNAVLQTILGVLDYQLSLPEAVNAPR
CCCCCCCHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
IHHQWQPDRLFVEKAYPVAQETLSALGYGLRAIDAMGNVQAVQYAGRFVGASDGRREGTS
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCH
AIWQTPARAASPAASPRR
HHHCCCCHHCCCCCCCCC
>Mature Secondary Structure
MRISANTDRIEAFCQDSGSVWNRRGVHRYVTPGSEHFRDRLLNHRTLPLLAAFVIGSAAP
CCCCCCHHHHHHHHHCCCCCHHHCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCC
VAALDGVVSTAHPLATEAGIEMLRKGGNAVDAAIAASLALGVVEPQSSGIGGGGFALVWL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEEEEE
GRTAEARVLDFREAAPGQAAAAMYLDKAGKVIPRLSLDGYRAAGVPGQAAGLVKLQQAYA
CCCCCCCEEEHHHCCCCHHHHHHHHHHCCCCCEEECCCCCEECCCCCCHHHHHHHHHHHH
ALPLATLAEPAIRLAREGFSLSDLVRGRIEAAAERLGRDPEASRVFLVEGKAPPAGYRLR
HCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
QPDLARTLELWVNSGGDSFYRGETAAAMAAAMTERGGLVSRADLESYSPVWRTPLVGSYR
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHCCCCCCCCCCCCCC
GVPVVTMPPPGSGGVLLEMLNTLENFDLAAQTPLLRTHLTAQAMSRAYADRSRFYGDPAF
CEEEEEECCCCCCHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
VPVPLAALVAKSYGAAQKKTISLERATPSTQIVPGSLLSPALLAGFQSWEGPRPVENTSH
CHHHHHHHHHHHCCCCCHHEEEEECCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
LSTMDADGNTVALTQTINGGFGAAVVAPKTGILLNNEMDDFAVAPGVPNLFGLVGSKANA
CEEECCCCCEEEEEEEECCCCCEEEECCCCCEEECCCCCCCEECCCCCHHHHHHCCCCCC
IAPGKRPLSSMTPTILLKNGRPWIALGSPGGAFITNAVLQTILGVLDYQLSLPEAVNAPR
CCCCCCCHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
IHHQWQPDRLFVEKAYPVAQETLSALGYGLRAIDAMGNVQAVQYAGRFVGASDGRREGTS
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCH
AIWQTPARAASPAASPRR
HHHCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]