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The map label for this gene is merA [H]

Identifier: 37522440

GI number: 37522440

Start: 3064271

End: 3065623

Strand: Direct

Name: merA [H]

Synonym: glr2871

Alternate gene names: 37522440

Gene position: 3064271-3065623 (Clockwise)

Preceding gene: 37522434

Following gene: 37522445

Centisome position: 65.77

GC content: 67.33

Gene sequence:

>1353_bases
ATGGAAAAGGCGGATGTGATCGTGATCGGCAGCGGCCAGGGGGGCGTCCCGCTGGCGGTGGACCAGGCCCGTTCCGGGCG
GCGGGTGGTGCTCTTCGAGCGCGGGGCGCTGGGAGGAAGCTGTATCAACTACGGCTGCACGCCTTCAAAAGCCCTGCTGG
CCGCCGCCCATGCCGCCGGGCGGGCGCGACTGGCGGCTCCGCTGGGTATCCACGCCGAGGTGACGGTCGATTTTGCCCGG
GTCATGGAGCGGGTGCGGGGCATCCGCGCCAGTTTCCGCCAGGGCATCGAGCAGCGGCTCGCCGACGCAGGCGTGCAGAT
CGTGCATGCCGAGGCAAGCTTTGCGGGCTCCTCCACCGTTGTCGGCGGCGGGGTGGAAGTGCAGGCACCGCTGGTGGTCA
TCAACACCGGTACCGGGCCTACCATTCCCGAACTGCCCGGCCTGGCGGGGTTGCCTCTGCTCACCAACTTGAACATCTTC
GACCTCGAAACCCTGCCCAGGTGCACATTGATCCTGGGGGGCGGCTACATCGGCCTCGAACTCGGGCAGGGACTGGCGCG
CCTGGGCAGCGAGGTGCACATCGTCCATAACCACGAGCGCCTGCTCAACCACGAGGAACCGGAGGTGGGCGAAGTGTTGG
CTGAGGCCCTGCGCCGGGACGGCATCCACCTGCACCTGCAGAGCGAGGTGAGCCAGGCGGTGTACCAGGACGGTATCTGC
GCGCTTACCCTCGAAGACGGACAGATTTTGCGGGGGGAGGCGGCCCTGCTCGCCGCCGCCGGCCGCACGCCGAACACCGC
TGCCCTGGGCGCTCCGGCGGCGGGCATCGCCCTTGACAAGCAGGGCTACGTGGCCATCGACGAGCACTTTCGCACCACCG
CTGCGGGGGTGTACGCCATCGGCGATGTGGCCCGGCAGCCCGCCTTCACCCACGTCTCCTGGGAGGATTACCGGCGCTTG
CAGGCGATCTTGGGCGGCGAGGAGCGCACCCGCTCCGATCGGGTGCTGGGCTACGCGGTCTACACCGAACCGCAGGTCGG
GCGGGTGGGGCTGACGCTCGATCAGGCGCTGGCCAAGGGCCATCGGGCGCGCTCGGTGACCTTGCCCATGGCCCACATCG
CCCGGGCGATCGAGTGGGGACACGACCTTGGTTTCTATCGGCTGGTGGTGGACGAAGACACCGACAAAATTCTCGGGGCG
ACCCTGGTGGGTTACGAGGCGGCGGAAATCGTCCATGTGCTGCTCGCCCACATGCAGGCAGATTCAACCTGGAAGGTCCT
CGAACAATCCGTCCACATCCATCCGACTTACTGCGAAGCGCTACCCAGTTTGGCTCGACTGTTGAAACAGTAA

Upstream 100 bases:

>100_bases
ATCCGGCCCCGATGGATTCATTTGCGCGAAGGGCGACGGTGCTCATATCCCATCGGCGCGAAAACCGGAATAATCGTGGG
TGTAGAGCGGGGGCACGGCG

Downstream 100 bases:

>100_bases
GTTTAGGACAGAAGCAGCAGAATCAAAACTCTCTGCGACCGAAAACGGTAATGGCAAGAGCGAGCAGGATGCCGGTGTAG
AGAAGGCCGTAGGCTCCGGC

Product: hypothetical protein

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MEKADVIVIGSGQGGVPLAVDQARSGRRVVLFERGALGGSCINYGCTPSKALLAAAHAAGRARLAAPLGIHAEVTVDFAR
VMERVRGIRASFRQGIEQRLADAGVQIVHAEASFAGSSTVVGGGVEVQAPLVVINTGTGPTIPELPGLAGLPLLTNLNIF
DLETLPRCTLILGGGYIGLELGQGLARLGSEVHIVHNHERLLNHEEPEVGEVLAEALRRDGIHLHLQSEVSQAVYQDGIC
ALTLEDGQILRGEAALLAAAGRTPNTAALGAPAAGIALDKQGYVAIDEHFRTTAAGVYAIGDVARQPAFTHVSWEDYRRL
QAILGGEERTRSDRVLGYAVYTEPQVGRVGLTLDQALAKGHRARSVTLPMAHIARAIEWGHDLGFYRLVVDEDTDKILGA
TLVGYEAAEIVHVLLAHMQADSTWKVLEQSVHIHPTYCEALPSLARLLKQ

Sequences:

>Translated_450_residues
MEKADVIVIGSGQGGVPLAVDQARSGRRVVLFERGALGGSCINYGCTPSKALLAAAHAAGRARLAAPLGIHAEVTVDFAR
VMERVRGIRASFRQGIEQRLADAGVQIVHAEASFAGSSTVVGGGVEVQAPLVVINTGTGPTIPELPGLAGLPLLTNLNIF
DLETLPRCTLILGGGYIGLELGQGLARLGSEVHIVHNHERLLNHEEPEVGEVLAEALRRDGIHLHLQSEVSQAVYQDGIC
ALTLEDGQILRGEAALLAAAGRTPNTAALGAPAAGIALDKQGYVAIDEHFRTTAAGVYAIGDVARQPAFTHVSWEDYRRL
QAILGGEERTRSDRVLGYAVYTEPQVGRVGLTLDQALAKGHRARSVTLPMAHIARAIEWGHDLGFYRLVVDEDTDKILGA
TLVGYEAAEIVHVLLAHMQADSTWKVLEQSVHIHPTYCEALPSLARLLKQ
>Mature_450_residues
MEKADVIVIGSGQGGVPLAVDQARSGRRVVLFERGALGGSCINYGCTPSKALLAAAHAAGRARLAAPLGIHAEVTVDFAR
VMERVRGIRASFRQGIEQRLADAGVQIVHAEASFAGSSTVVGGGVEVQAPLVVINTGTGPTIPELPGLAGLPLLTNLNIF
DLETLPRCTLILGGGYIGLELGQGLARLGSEVHIVHNHERLLNHEEPEVGEVLAEALRRDGIHLHLQSEVSQAVYQDGIC
ALTLEDGQILRGEAALLAAAGRTPNTAALGAPAAGIALDKQGYVAIDEHFRTTAAGVYAIGDVARQPAFTHVSWEDYRRL
QAILGGEERTRSDRVLGYAVYTEPQVGRVGLTLDQALAKGHRARSVTLPMAHIARAIEWGHDLGFYRLVVDEDTDKILGA
TLVGYEAAEIVHVLLAHMQADSTWKVLEQSVHIHPTYCEALPSLARLLKQ

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=28.322440087146, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI50301238, Length=472, Percent_Identity=27.5423728813559, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=27.0742358078603, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI33519430, Length=459, Percent_Identity=23.3115468409586, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI33519428, Length=459, Percent_Identity=23.3115468409586, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI33519426, Length=459, Percent_Identity=23.3115468409586, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI148277065, Length=459, Percent_Identity=23.3115468409586, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI148277071, Length=459, Percent_Identity=23.3115468409586, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=23.0414746543779, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI291045268, Length=427, Percent_Identity=21.5456674473068, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=31.5904139433551, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=27.7161862527716, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=26.4367816091954, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=27.6824034334764, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=29.6296296296296, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983429, Length=432, Percent_Identity=28.2407407407407, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71983419, Length=432, Percent_Identity=28.2407407407407, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=27.7661795407098, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=493, Percent_Identity=25.3549695740365, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=459, Percent_Identity=27.0152505446623, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=28.7581699346405, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=25.1572327044025, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=25.1572327044025, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=25.1572327044025, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17737741, Length=490, Percent_Identity=26.1224489795918, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 47855; Mature: 47855

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKADVIVIGSGQGGVPLAVDQARSGRRVVLFERGALGGSCINYGCTPSKALLAAAHAAG
CCCCCEEEEECCCCCCCEEECCCCCCCEEEEEECCCCCCCEECCCCCCHHHHHHHHHHCC
RARLAAPLGIHAEVTVDFARVMERVRGIRASFRQGIEQRLADAGVQIVHAEASFAGSSTV
CEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEE
VGGGVEVQAPLVVINTGTGPTIPELPGLAGLPLLTNLNIFDLETLPRCTLILGGGYIGLE
ECCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHCCCCEEECCCCCCEEEEEECCEEEHH
LGQGLARLGSEVHIVHNHERLLNHEEPEVGEVLAEALRRDGIHLHLQSEVSQAVYQDGIC
HHHHHHHCCCEEEEEECHHHHCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCEE
ALTLEDGQILRGEAALLAAAGRTPNTAALGAPAAGIALDKQGYVAIDEHFRTTAAGVYAI
EEEECCCCEEECCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCHHHHHHHHHHEE
GDVARQPAFTHVSWEDYRRLQAILGGEERTRSDRVLGYAVYTEPQVGRVGLTLDQALAKG
HHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEECCHHHHHHHCC
HRARSVTLPMAHIARAIEWGHDLGFYRLVVDEDTDKILGATLVGYEAAEIVHVLLAHMQA
CCCCEEECCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHCC
DSTWKVLEQSVHIHPTYCEALPSLARLLKQ
CCHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKADVIVIGSGQGGVPLAVDQARSGRRVVLFERGALGGSCINYGCTPSKALLAAAHAAG
CCCCCEEEEECCCCCCCEEECCCCCCCEEEEEECCCCCCCEECCCCCCHHHHHHHHHHCC
RARLAAPLGIHAEVTVDFARVMERVRGIRASFRQGIEQRLADAGVQIVHAEASFAGSSTV
CEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEE
VGGGVEVQAPLVVINTGTGPTIPELPGLAGLPLLTNLNIFDLETLPRCTLILGGGYIGLE
ECCCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHCCCCEEECCCCCCEEEEEECCEEEHH
LGQGLARLGSEVHIVHNHERLLNHEEPEVGEVLAEALRRDGIHLHLQSEVSQAVYQDGIC
HHHHHHHCCCEEEEEECHHHHCCCCCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCEE
ALTLEDGQILRGEAALLAAAGRTPNTAALGAPAAGIALDKQGYVAIDEHFRTTAAGVYAI
EEEECCCCEEECCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCHHHHHHHHHHEE
GDVARQPAFTHVSWEDYRRLQAILGGEERTRSDRVLGYAVYTEPQVGRVGLTLDQALAKG
HHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEECCHHHHHHHCC
HRARSVTLPMAHIARAIEWGHDLGFYRLVVDEDTDKILGATLVGYEAAEIVHVLLAHMQA
CCCCEEECCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHCC
DSTWKVLEQSVHIHPTYCEALPSLARLLKQ
CCHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]