Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 37522359

GI number: 37522359

Start: 2969974

End: 2970507

Strand: Direct

Name: hpt [H]

Synonym: glr2790

Alternate gene names: 37522359

Gene position: 2969974-2970507 (Clockwise)

Preceding gene: 37522358

Following gene: 37522360

Centisome position: 63.75

GC content: 59.93

Gene sequence:

>534_bases
GTGGTCAAAGTTTTGTACTCCGAAGAACAGATAGCAAAACAGGTTCAGCTATTGGCGGGCCAGATCAGCGTCCACTACGC
GCCGCTGGTGTCGATTTCCTACCCGCTGGTGGTTCTGCCGGTGCTCAAGGGAGCTTTCGTTTTCAGTTCCGATTTGTTGC
GGCGCTTGACAGTACCTTTGCGGGTCGAATTTCTGCGCGCGAGTAGCTACCGCGGGGGGACCGTCTCGGGCGGCCTCGAA
CTCGACATCCCGGAGACGGCCTTTTTGAGCGGCCACCACCTGCTGTTGCTCGAAGACATCATCGACACCGGCAAAACCGC
AAGCCAGATCCTCGCTGCCCTCAAAAGCTGCGGCCCGGCCTCGCTGCAAGTTTGTGCGCTGCTCGACAAGCCCGCGCGCC
GGGTGGCGCCTGTGGAGGTGGGTTTTCGGGGATTTACCGCCCCGGATCGCTTCGTCATCGGTTACGGCATGGATCTGGCC
GAGCGTTACCGGGAGTTGCCTTACGTGGGCGAACTGGAAGAATGCACCTTTTGA

Upstream 100 bases:

>100_bases
GTTTTTCGTATCCTGGGACGCAGATCTCGATTCCGGCGCGCGGAAGCGACTTCGGGAGCCGCTGCTGTACAGTAAGAAAA
CTTGCGCTCAAGGCCGCTCC

Downstream 100 bases:

>100_bases
TTCCCGCCGCCGGGCGCGGTAGCCGCATGGGCGCAGACGGCAACAAGCTGCTCTTGCCGCTGTCGGGCCGGCCGCTTCTG
GCCTGGACGCTCGCAGCAGC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MVKVLYSEEQIAKQVQLLAGQISVHYAPLVSISYPLVVLPVLKGAFVFSSDLLRRLTVPLRVEFLRASSYRGGTVSGGLE
LDIPETAFLSGHHLLLLEDIIDTGKTASQILAALKSCGPASLQVCALLDKPARRVAPVEVGFRGFTAPDRFVIGYGMDLA
ERYRELPYVGELEECTF

Sequences:

>Translated_177_residues
MVKVLYSEEQIAKQVQLLAGQISVHYAPLVSISYPLVVLPVLKGAFVFSSDLLRRLTVPLRVEFLRASSYRGGTVSGGLE
LDIPETAFLSGHHLLLLEDIIDTGKTASQILAALKSCGPASLQVCALLDKPARRVAPVEVGFRGFTAPDRFVIGYGMDLA
ERYRELPYVGELEECTF
>Mature_177_residues
MVKVLYSEEQIAKQVQLLAGQISVHYAPLVSISYPLVVLPVLKGAFVFSSDLLRRLTVPLRVEFLRASSYRGGTVSGGLE
LDIPETAFLSGHHLLLLEDIIDTGKTASQILAALKSCGPASLQVCALLDKPARRVAPVEVGFRGFTAPDRFVIGYGMDLA
ERYRELPYVGELEECTF

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=151, Percent_Identity=33.7748344370861, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI9910262, Length=175, Percent_Identity=29.1428571428571, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI87081689, Length=174, Percent_Identity=40.8045977011494, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17510817, Length=174, Percent_Identity=29.8850574712644, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19353; Mature: 19353

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVLYSEEQIAKQVQLLAGQISVHYAPLVSISYPLVVLPVLKGAFVFSSDLLRRLTVPL
CEEEEECHHHHHHHHHHHHHHHHEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
RVEFLRASSYRGGTVSGGLELDIPETAFLSGHHLLLLEDIIDTGKTASQILAALKSCGPA
HEEEEECCCCCCCEECCCEEECCCCHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHCCCCC
SLQVCALLDKPARRVAPVEVGFRGFTAPDRFVIGYGMDLAERYRELPYVGELEECTF
HHHHHHHHCCCHHHCCCCEECCCCCCCCCCEEEECCCHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MVKVLYSEEQIAKQVQLLAGQISVHYAPLVSISYPLVVLPVLKGAFVFSSDLLRRLTVPL
CEEEEECHHHHHHHHHHHHHHHHEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
RVEFLRASSYRGGTVSGGLELDIPETAFLSGHHLLLLEDIIDTGKTASQILAALKSCGPA
HEEEEECCCCCCCEECCCEEECCCCHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHCCCCC
SLQVCALLDKPARRVAPVEVGFRGFTAPDRFVIGYGMDLAERYRELPYVGELEECTF
HHHHHHHHCCCHHHCCCCEECCCCCCCCCCEEEECCCHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]