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The map label for this gene is 37522343

Identifier: 37522343

GI number: 37522343

Start: 2952863

End: 2954290

Strand: Reverse

Name: 37522343

Synonym: gll2774

Alternate gene names: NA

Gene position: 2954290-2952863 (Counterclockwise)

Preceding gene: 37522345

Following gene: 37522340

Centisome position: 63.41

GC content: 66.81

Gene sequence:

>1428_bases
ATGGAAGTCAAAGAGCGCACCAACCCGGCTTGGGCGGGGGCAATCGCCCAACCCGGCCGCGAATTTGCCCCCGCACCGCT
GGCGGTGCTCGAAGGGAGCTTGCCTGTCGGATTGCGCGGCTCGCTCTACCGCAACGGGCCGGGGCGTCTGGAGCGTGGCG
GTGTGCGGGTCGGTCACTGGTTTGACGGCGACGGCGCCATCCTGGCGGTGCACTTCGGCGGGGGCGAAGCGCAGGGCGTC
TATCGCTACGTGCAGACCGCGGGCCTGCAGGCCGAGGAGCGCGCGGGCCGCTATCTCTATCCCAACTACGGCATGAGTGC
CCCCGGAGCGATCTGGGAGCGCTGGGGCAAACCGGTCAAAAACGCCGCCAACACCAGTGTCCTCGCTCTGCCGGATCGGC
TGCTCGCCCTCTGGGAAGGGGGGCTTCCCCACGCCCTCGACCTGCACACGCTCCAGACGCGCGGCCTCGACGCGCTGGGC
GGCCTCGGCCCGAGCGGCAGCTACTCCGCCCACCCCAAGCGCGACCCGCGCACGGGCGAAATCTACAACTTCGGCGTCGG
CATCGGGCCTGCCGCCGTGCTGCACCTCTACCGCAGCGACGCCACCGGCCGGGTGATCCAAAAAGGCAAAATCGCCCTAG
AGGGCATCCCGCTGGTGCACGATTTTGTGCTCGCGGGCCGCTATCTGGTCTTTTGCGTGCCGCCGGTGCGCATCAACCCG
CTGCCGGTGCTGTTGGGTCTTGCCAGTTTCAGCGAGGCGATGGCCTGGCAACCCGACAAGGGCACCGCCATCTATATCGT
CGACCGCGAGACACTCCAGTTGGTCGGCCGCGCCGAAGCGCCCGCCTGGTTCCAGTGGCACTTTGCCAACGGCCACGAGG
CCGGGGGCGAACTGGTGATCGCATTGTGCCGGTACGCAGATTTTGCCACCAATCGCTATCTGCAAGAATTTGCCGGCGGC
CGGACCCAGACCGCTTCGCCCTCGCAGTTGTGGCAGCTTCGCCTGGATGCGGCAACCGGCAGAGTACGAGGATTTGAACC
ACTGCTGGAACGGCCCTGCGAATTTCCGACCGTCGATCCGCGCAGTGTCGGCCTGCAAAGCCGGCACATTTATCTGGGCT
TGCACCGTGTCGGTTCTCAGGTGGGCAGCGACTTCTTCCAGGTGCTGGCCAGATTCGATTGCGACAGCGGCCAGGCGGTG
GAAACCCAGTTGGGCGACGGGCGCTATCCGTCTGAGCCGCTATTTGTAGCGGACGCCGACGAACCGGAGCGCGGCTGGGT
GTTGAGCGTCATCTACGACGCGGGTCTCCACCGCAGCGAACTGTGGATCTTCGATGCGGACGCCCTCGATGCCCCGCCGG
TCTGTCGCCTCGCCCTGCCGGAGGTGATTCCCCACAGCTTCCACGGCACCTGGCGACCGGTACCTTGA

Upstream 100 bases:

>100_bases
CGCTGACGACGGCGGGTTTGACGCGGGCATTTTCCATCGCATCCAGGCTAACCCAGGCTTCGGAGGCTAGGGTGGAAGGC
AGGCGGCACAGGGAGCAGGC

Downstream 100 bases:

>100_bases
AGTGTGCCGCTACTTGTACTGTCTAAGCACAGCTGCAACCTGCTCGGCCTGCTCGTCCGCTCCTTTTTGGCGGAAGATTT
CGAGTGCCTTTTGCCAGTCG

Product: hypothetical protein

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MEVKERTNPAWAGAIAQPGREFAPAPLAVLEGSLPVGLRGSLYRNGPGRLERGGVRVGHWFDGDGAILAVHFGGGEAQGV
YRYVQTAGLQAEERAGRYLYPNYGMSAPGAIWERWGKPVKNAANTSVLALPDRLLALWEGGLPHALDLHTLQTRGLDALG
GLGPSGSYSAHPKRDPRTGEIYNFGVGIGPAAVLHLYRSDATGRVIQKGKIALEGIPLVHDFVLAGRYLVFCVPPVRINP
LPVLLGLASFSEAMAWQPDKGTAIYIVDRETLQLVGRAEAPAWFQWHFANGHEAGGELVIALCRYADFATNRYLQEFAGG
RTQTASPSQLWQLRLDAATGRVRGFEPLLERPCEFPTVDPRSVGLQSRHIYLGLHRVGSQVGSDFFQVLARFDCDSGQAV
ETQLGDGRYPSEPLFVADADEPERGWVLSVIYDAGLHRSELWIFDADALDAPPVCRLALPEVIPHSFHGTWRPVP

Sequences:

>Translated_475_residues
MEVKERTNPAWAGAIAQPGREFAPAPLAVLEGSLPVGLRGSLYRNGPGRLERGGVRVGHWFDGDGAILAVHFGGGEAQGV
YRYVQTAGLQAEERAGRYLYPNYGMSAPGAIWERWGKPVKNAANTSVLALPDRLLALWEGGLPHALDLHTLQTRGLDALG
GLGPSGSYSAHPKRDPRTGEIYNFGVGIGPAAVLHLYRSDATGRVIQKGKIALEGIPLVHDFVLAGRYLVFCVPPVRINP
LPVLLGLASFSEAMAWQPDKGTAIYIVDRETLQLVGRAEAPAWFQWHFANGHEAGGELVIALCRYADFATNRYLQEFAGG
RTQTASPSQLWQLRLDAATGRVRGFEPLLERPCEFPTVDPRSVGLQSRHIYLGLHRVGSQVGSDFFQVLARFDCDSGQAV
ETQLGDGRYPSEPLFVADADEPERGWVLSVIYDAGLHRSELWIFDADALDAPPVCRLALPEVIPHSFHGTWRPVP
>Mature_475_residues
MEVKERTNPAWAGAIAQPGREFAPAPLAVLEGSLPVGLRGSLYRNGPGRLERGGVRVGHWFDGDGAILAVHFGGGEAQGV
YRYVQTAGLQAEERAGRYLYPNYGMSAPGAIWERWGKPVKNAANTSVLALPDRLLALWEGGLPHALDLHTLQTRGLDALG
GLGPSGSYSAHPKRDPRTGEIYNFGVGIGPAAVLHLYRSDATGRVIQKGKIALEGIPLVHDFVLAGRYLVFCVPPVRINP
LPVLLGLASFSEAMAWQPDKGTAIYIVDRETLQLVGRAEAPAWFQWHFANGHEAGGELVIALCRYADFATNRYLQEFAGG
RTQTASPSQLWQLRLDAATGRVRGFEPLLERPCEFPTVDPRSVGLQSRHIYLGLHRVGSQVGSDFFQVLARFDCDSGQAV
ETQLGDGRYPSEPLFVADADEPERGWVLSVIYDAGLHRSELWIFDADALDAPPVCRLALPEVIPHSFHGTWRPVP

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI32564756, Length=307, Percent_Identity=25.7328990228013, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71998242, Length=302, Percent_Identity=28.1456953642384, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646669, Length=314, Percent_Identity=23.8853503184713, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 51743; Mature: 51743

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKERTNPAWAGAIAQPGREFAPAPLAVLEGSLPVGLRGSLYRNGPGRLERGGVRVGHW
CCCCCCCCCCCCCHHHCCCCCCCCCCHHHCCCCCCCCCCCCEEECCCCCCCCCCEEEEEE
FDGDGAILAVHFGGGEAQGVYRYVQTAGLQAEERAGRYLYPNYGMSAPGAIWERWGKPVK
ECCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHCCCEECCCCCCCCCHHHHHHCCCHHH
NAANTSVLALPDRLLALWEGGLPHALDLHTLQTRGLDALGGLGPSGSYSAHPKRDPRTGE
HCCCCEEEECHHHHHHHHCCCCCCEEEEEHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCC
IYNFGVGIGPAAVLHLYRSDATGRVIQKGKIALEGIPLVHDFVLAGRYLVFCVPPVRINP
EEEECCCCCHHHHHHHHHCCCCCCEEECCCEEEECCCHHHHHHHHCCEEEEEECCCCCCC
LPVLLGLASFSEAMAWQPDKGTAIYIVDRETLQLVGRAEAPAWFQWHFANGHEAGGELVI
HHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHH
ALCRYADFATNRYLQEFAGGRTQTASPSQLWQLRLDAATGRVRGFEPLLERPCEFPTVDP
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECCCCCCCCCCHHHHCCCCCCCCCH
RSVGLQSRHIYLGLHRVGSQVGSDFFQVLARFDCDSGQAVETQLGDGRYPSEPLFVADAD
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
EPERGWVLSVIYDAGLHRSELWIFDADALDAPPVCRLALPEVIPHSFHGTWRPVP
CCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEVKERTNPAWAGAIAQPGREFAPAPLAVLEGSLPVGLRGSLYRNGPGRLERGGVRVGHW
CCCCCCCCCCCCCHHHCCCCCCCCCCHHHCCCCCCCCCCCCEEECCCCCCCCCCEEEEEE
FDGDGAILAVHFGGGEAQGVYRYVQTAGLQAEERAGRYLYPNYGMSAPGAIWERWGKPVK
ECCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHCCCEECCCCCCCCCHHHHHHCCCHHH
NAANTSVLALPDRLLALWEGGLPHALDLHTLQTRGLDALGGLGPSGSYSAHPKRDPRTGE
HCCCCEEEECHHHHHHHHCCCCCCEEEEEHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCC
IYNFGVGIGPAAVLHLYRSDATGRVIQKGKIALEGIPLVHDFVLAGRYLVFCVPPVRINP
EEEECCCCCHHHHHHHHHCCCCCCEEECCCEEEECCCHHHHHHHHCCEEEEEECCCCCCC
LPVLLGLASFSEAMAWQPDKGTAIYIVDRETLQLVGRAEAPAWFQWHFANGHEAGGELVI
HHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHH
ALCRYADFATNRYLQEFAGGRTQTASPSQLWQLRLDAATGRVRGFEPLLERPCEFPTVDP
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECCCCCCCCCCHHHHCCCCCCCCCH
RSVGLQSRHIYLGLHRVGSQVGSDFFQVLARFDCDSGQAVETQLGDGRYPSEPLFVADAD
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
EPERGWVLSVIYDAGLHRSELWIFDADALDAPPVCRLALPEVIPHSFHGTWRPVP
CCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]