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The map label for this gene is trpB

Identifier: 37522327

GI number: 37522327

Start: 2937548

End: 2938792

Strand: Direct

Name: trpB

Synonym: gvip381

Alternate gene names: 37522327

Gene position: 2937548-2938792 (Clockwise)

Preceding gene: 37522324

Following gene: 37522328

Centisome position: 63.05

GC content: 65.06

Gene sequence:

>1245_bases
GTGTCCTTTACAATACAGACCGTGACTTTTACTGCCCCTCAACCCCTGGGCGCCCTGCCGGACAGTCGGGGCCGCTTCGG
CCGCTTCGGCGGCCAGTATGTCCCCGAGACGCTCATGAGCGCCCTGGCGCAACTGGAAGCCGCGTTCAATCAGTATAGGC
ACGATCCGCAATTTCTCGCCGAGTTCGCGGGCCATCTGCGCGACTTTGTCGGCCGGCCGACGCCGCTGTATTTTGCCGAG
CGCCTCACCGCCCACTGGGGCGGGGGGCGCATTTTTCTCAAGCGCGAAGATCTCAACCACACCGGCGCCCACAAGATCAA
CAATGCCCTCGGACAGGCACTGTTGGCGTTGCGCATGGGCAAGCGCCGGATCATCGCCGAGACCGGCGCCGGTCAGCATG
GGGTGGCGACGGCCACGGTCTGTGCCCGCTTTGGCCTGGAGTGCATTATCTATATGGGTGTGCACGACATCGAGCGCCAA
AAGCTCAACGTCTACCGCATGAAGCTGTTGGGAGCCGAGGTGCGTCCGGTGGCCGCGGGCACGGGCACCCTCAAAGACGC
CACCTCCGAGGCGATCCGCGACTGGGTCACCCACGTCGAAACCACCCACTACATCCTGGGTTCCGCCGCCGGTCCCCATC
CGTACCCTTTGATGGTGCGCGAATTCCAGGCGGTGATTGGCCGCGAGACCCGCGTCCAGTGCCTGGAGCGCCTTGGCCGT
CTGCCCGATGTGCTGATTGCCTGCGTAGGCGGCGGCTCCAACGCCATCGGGCTATTTCACGATTTTTTGGATGAACGGGC
GGTGCGCCTGGTGGGCATCGAGGCGGCGGGCGAAGGGATCGAGACCGGCAAACACGCCGCCACCCTCACCGCCGGCCGGG
CGGGGGTCCTGCACGGGGCGATGAGCTATGTGCTTCAAGACGAGCAGGGCCAGGTGCAAGAAGCCCATTCCCTCAGTGCC
GGGCTCGATTACCCGGGCGTCGGCCCCGAGCACAGCTATCTCAAAGACATCGGCCGCGCCGAGTACTACAGCGTCACCGA
CAGCGAAGCGCTCGCGGCCCTCTCCCTGGTGTGCTCCACCGAGGGAATCATCCCTGCCCTGGAGACGGCCCATGCCTTTG
CTTACCTGGGTATCCTCGCCTCCCAACTGCATTCGGAGCAAATCGTCGTGCTCAACTGCTCGGGGCGCGGCGACAAGGAC
ATGGGCACCGTCGCCCGTGCCATGGGCTGGGGCAAGGAGGAGTAA

Upstream 100 bases:

>100_bases
CCGGCAGCTAGGGATAGATACCGTCTTGCACTGCACATCCTAGTCGTCGCGGGCGGGCGGGTGCATGGGTCGGCAGTCTA
AACTCTGCGATATTCTAAAT

Downstream 100 bases:

>100_bases
AATCGGCGAAAGTCCGGTGATTCTCTCTGCGGATGCGCAGTTAGGCGCCTGGTCTCGTTCTTCGGGTACAAGCAAACTGC
AGCGAGCATCCTTAGGCTGA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSFTIQTVTFTAPQPLGALPDSRGRFGRFGGQYVPETLMSALAQLEAAFNQYRHDPQFLAEFAGHLRDFVGRPTPLYFAE
RLTAHWGGGRIFLKREDLNHTGAHKINNALGQALLALRMGKRRIIAETGAGQHGVATATVCARFGLECIIYMGVHDIERQ
KLNVYRMKLLGAEVRPVAAGTGTLKDATSEAIRDWVTHVETTHYILGSAAGPHPYPLMVREFQAVIGRETRVQCLERLGR
LPDVLIACVGGGSNAIGLFHDFLDERAVRLVGIEAAGEGIETGKHAATLTAGRAGVLHGAMSYVLQDEQGQVQEAHSLSA
GLDYPGVGPEHSYLKDIGRAEYYSVTDSEALAALSLVCSTEGIIPALETAHAFAYLGILASQLHSEQIVVLNCSGRGDKD
MGTVARAMGWGKEE

Sequences:

>Translated_414_residues
MSFTIQTVTFTAPQPLGALPDSRGRFGRFGGQYVPETLMSALAQLEAAFNQYRHDPQFLAEFAGHLRDFVGRPTPLYFAE
RLTAHWGGGRIFLKREDLNHTGAHKINNALGQALLALRMGKRRIIAETGAGQHGVATATVCARFGLECIIYMGVHDIERQ
KLNVYRMKLLGAEVRPVAAGTGTLKDATSEAIRDWVTHVETTHYILGSAAGPHPYPLMVREFQAVIGRETRVQCLERLGR
LPDVLIACVGGGSNAIGLFHDFLDERAVRLVGIEAAGEGIETGKHAATLTAGRAGVLHGAMSYVLQDEQGQVQEAHSLSA
GLDYPGVGPEHSYLKDIGRAEYYSVTDSEALAALSLVCSTEGIIPALETAHAFAYLGILASQLHSEQIVVLNCSGRGDKD
MGTVARAMGWGKEE
>Mature_413_residues
SFTIQTVTFTAPQPLGALPDSRGRFGRFGGQYVPETLMSALAQLEAAFNQYRHDPQFLAEFAGHLRDFVGRPTPLYFAER
LTAHWGGGRIFLKREDLNHTGAHKINNALGQALLALRMGKRRIIAETGAGQHGVATATVCARFGLECIIYMGVHDIERQK
LNVYRMKLLGAEVRPVAAGTGTLKDATSEAIRDWVTHVETTHYILGSAAGPHPYPLMVREFQAVIGRETRVQCLERLGRL
PDVLIACVGGGSNAIGLFHDFLDERAVRLVGIEAAGEGIETGKHAATLTAGRAGVLHGAMSYVLQDEQGQVQEAHSLSAG
LDYPGVGPEHSYLKDIGRAEYYSVTDSEALAALSLVCSTEGIIPALETAHAFAYLGILASQLHSEQIVVLNCSGRGDKDM
GTVARAMGWGKEE

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=380, Percent_Identity=58.1578947368421, Blast_Score=450, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321412, Length=385, Percent_Identity=57.1428571428571, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_GLOVI (Q7NGX9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925704.1
- ProteinModelPortal:   Q7NGX9
- SMR:   Q7NGX9
- GeneID:   2601159
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2758
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- ProtClustDB:   PRK04346
- BioCyc:   GVIO251221:GLR2758-MONOMER
- BRENDA:   4.2.1.20
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 44689; Mature: 44557

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTIQTVTFTAPQPLGALPDSRGRFGRFGGQYVPETLMSALAQLEAAFNQYRHDPQFLA
CCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EFAGHLRDFVGRPTPLYFAERLTAHWGGGRIFLKREDLNHTGAHKINNALGQALLALRMG
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
KRRIIAETGAGQHGVATATVCARFGLECIIYMGVHDIERQKLNVYRMKLLGAEVRPVAAG
CCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEECC
TGTLKDATSEAIRDWVTHVETTHYILGSAAGPHPYPLMVREFQAVIGRETRVQCLERLGR
CCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCC
LPDVLIACVGGGSNAIGLFHDFLDERAVRLVGIEAAGEGIETGKHAATLTAGRAGVLHGA
CHHEEEEEECCCCCHHHHHHHHHHHHHEEEEEEHHCCCCCCCCCCCEEEECCCHHHHHHH
MSYVLQDEQGQVQEAHSLSAGLDYPGVGPEHSYLKDIGRAEYYSVTDSEALAALSLVCST
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHCC
EGIIPALETAHAFAYLGILASQLHSEQIVVLNCSGRGDKDMGTVARAMGWGKEE
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SFTIQTVTFTAPQPLGALPDSRGRFGRFGGQYVPETLMSALAQLEAAFNQYRHDPQFLA
CEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EFAGHLRDFVGRPTPLYFAERLTAHWGGGRIFLKREDLNHTGAHKINNALGQALLALRMG
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
KRRIIAETGAGQHGVATATVCARFGLECIIYMGVHDIERQKLNVYRMKLLGAEVRPVAAG
CCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEECC
TGTLKDATSEAIRDWVTHVETTHYILGSAAGPHPYPLMVREFQAVIGRETRVQCLERLGR
CCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCC
LPDVLIACVGGGSNAIGLFHDFLDERAVRLVGIEAAGEGIETGKHAATLTAGRAGVLHGA
CHHEEEEEECCCCCHHHHHHHHHHHHHEEEEEEHHCCCCCCCCCCCEEEECCCHHHHHHH
MSYVLQDEQGQVQEAHSLSAGLDYPGVGPEHSYLKDIGRAEYYSVTDSEALAALSLVCST
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHCC
EGIIPALETAHAFAYLGILASQLHSEQIVVLNCSGRGDKDMGTVARAMGWGKEE
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292