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The map label for this gene is ilvC

Identifier: 37522226

GI number: 37522226

Start: 2817223

End: 2818221

Strand: Reverse

Name: ilvC

Synonym: gvip374

Alternate gene names: 37522226

Gene position: 2818221-2817223 (Counterclockwise)

Preceding gene: 37522233

Following gene: 37522224

Centisome position: 60.49

GC content: 63.16

Gene sequence:

>999_bases
ATGACCAGGGCGCGCATGTACTACGACGAGGACGCCGATCTGTCGGTACTCGACAACAAGACGATCGCCATCGTCGGCTA
CGGATCCCAGGGCCATGCCCACGCCCTGAATCTCAAAGACTCGGGAATCGACGTGATCGTGGGTCTGTACGAAGGCTCGC
GCTCCTGGGCGCGCGCCGAAAACGAGGGCCTTGCCGTCTATCCGACCGCTGAGGCGGCGGCCAAGGCGGATCTGGTGATG
ATTTTGTTGCCCGACGAAGTGCAGCGCGAGATCTACAACCGCGACATCGCCCCGCACCTGGGCACAGGCAAAACCCTCGC
CTTCGCCCACGGCTTCAATATTCATTTCTCCCAGATCGTCCCTTCCCAAGAGGTGGACGTGCTCATGGTCGCCCCCAAAG
GTCCCGGCCACCTGGTGCGCCGCGTGTTCACCGAAGGCAAGGGGGTACCGTGTCTGTTTGCCGTCGAGCAGGATGCGAGC
GGCCGGGCGCGCGCCACGGCGATGGCCTACGCCCGGGCGATCGGCGGCACGCGGGCGGGCATTTTGGAGACCACCTTTCG
AGAAGAAGCCGAGACGGACCTCTTCGGCGAGCAAACCGTGCTCTGCGGGGGGCTGACCGCCCTCATCAAGGCGGGCTTCG
AGACGCTGGTGGAGGCGGGCTACCAGCCGGAACTGGCTTACTTCGAGTGCCTGCACGAGGTGAAGCTGATCGTCGATTTG
ATCGTCGAGGGGGGACTGGCCAAGATGCGCGACTCGATCTCCAACACGGCCGAATTCGGCGATTACACCCGCGGCCCGCG
CATCGTCGATGAGCGCACCAAGGCTGAGATGAAAAAGATCCTGGCCGAAATCCAGAACGGTGAATTTGCCAAACAGTGGG
TGCTGGATAGCCAGGCCAATTACGCGAGCTTCAAGGCGATGCGCCGCCGCGAAGCCGAACACCCGATCGAAGAGGTGGGG
GCGGATCTGCGCAAGATGATGTCCTGGCTACGCCCCTGA

Upstream 100 bases:

>100_bases
CCATCGCAAGGATATGCTTTCCAGACGCGCCGTCGGCTCGCGCGTTCCTGACGGCTGGGGTAAGCTGTTATCCACCGTTT
TGCTTGGGAGCATCCAGTTT

Downstream 100 bases:

>100_bases
ATGCGCTTGAGAGCGGAGCCGGCCGACTGAAAATCCCAATTCGCCCAAACAGCCAATCGGAGCGCAGACAAAAACCCGCG
GGCAGAAGGACTCCGCCCGC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTRARMYYDEDADLSVLDNKTIAIVGYGSQGHAHALNLKDSGIDVIVGLYEGSRSWARAENEGLAVYPTAEAAAKADLVM
ILLPDEVQREIYNRDIAPHLGTGKTLAFAHGFNIHFSQIVPSQEVDVLMVAPKGPGHLVRRVFTEGKGVPCLFAVEQDAS
GRARATAMAYARAIGGTRAGILETTFREEAETDLFGEQTVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDL
IVEGGLAKMRDSISNTAEFGDYTRGPRIVDERTKAEMKKILAEIQNGEFAKQWVLDSQANYASFKAMRRREAEHPIEEVG
ADLRKMMSWLRP

Sequences:

>Translated_332_residues
MTRARMYYDEDADLSVLDNKTIAIVGYGSQGHAHALNLKDSGIDVIVGLYEGSRSWARAENEGLAVYPTAEAAAKADLVM
ILLPDEVQREIYNRDIAPHLGTGKTLAFAHGFNIHFSQIVPSQEVDVLMVAPKGPGHLVRRVFTEGKGVPCLFAVEQDAS
GRARATAMAYARAIGGTRAGILETTFREEAETDLFGEQTVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDL
IVEGGLAKMRDSISNTAEFGDYTRGPRIVDERTKAEMKKILAEIQNGEFAKQWVLDSQANYASFKAMRRREAEHPIEEVG
ADLRKMMSWLRP
>Mature_331_residues
TRARMYYDEDADLSVLDNKTIAIVGYGSQGHAHALNLKDSGIDVIVGLYEGSRSWARAENEGLAVYPTAEAAAKADLVMI
LLPDEVQREIYNRDIAPHLGTGKTLAFAHGFNIHFSQIVPSQEVDVLMVAPKGPGHLVRRVFTEGKGVPCLFAVEQDASG
RARATAMAYARAIGGTRAGILETTFREEAETDLFGEQTVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLI
VEGGLAKMRDSISNTAEFGDYTRGPRIVDERTKAEMKKILAEIQNGEFAKQWVLDSQANYASFKAMRRREAEHPIEEVGA
DLRKMMSWLRP

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=301, Percent_Identity=38.2059800664452, Blast_Score=157, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=34.5345345345345, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_GLOVI (Q7NH80)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925603.1
- ProteinModelPortal:   Q7NH80
- SMR:   Q7NH80
- GeneID:   2601058
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2657
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   GVIO251221:GLL2657-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36554; Mature: 36423

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: ACT_SITE 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRARMYYDEDADLSVLDNKTIAIVGYGSQGHAHALNLKDSGIDVIVGLYEGSRSWARAE
CCCCCEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCHHHHC
NEGLAVYPTAEAAAKADLVMILLPDEVQREIYNRDIAPHLGTGKTLAFAHGFNIHFSQIV
CCCEEEEECHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEHHHCC
PSQEVDVLMVAPKGPGHLVRRVFTEGKGVPCLFAVEQDASGRARATAMAYARAIGGTRAG
CCCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCH
ILETTFREEAETDLFGEQTVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IVEGGLAKMRDSISNTAEFGDYTRGPRIVDERTKAEMKKILAEIQNGEFAKQWVLDSQAN
HHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
YASFKAMRRREAEHPIEEVGADLRKMMSWLRP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRARMYYDEDADLSVLDNKTIAIVGYGSQGHAHALNLKDSGIDVIVGLYEGSRSWARAE
CCCCEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCEEEEEEECCCCCHHHHC
NEGLAVYPTAEAAAKADLVMILLPDEVQREIYNRDIAPHLGTGKTLAFAHGFNIHFSQIV
CCCEEEEECHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEHHHCC
PSQEVDVLMVAPKGPGHLVRRVFTEGKGVPCLFAVEQDASGRARATAMAYARAIGGTRAG
CCCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCH
ILETTFREEAETDLFGEQTVLCGGLTALIKAGFETLVEAGYQPELAYFECLHEVKLIVDL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
IVEGGLAKMRDSISNTAEFGDYTRGPRIVDERTKAEMKKILAEIQNGEFAKQWVLDSQAN
HHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
YASFKAMRRREAEHPIEEVGADLRKMMSWLRP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292